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침윤성 췌관내 유두상 점액종양의 임상적 특징과 치료 결과
백광열(Kwang Yeol Paik),정준철(Jun Chul Jung),허진석(Jin Seok Heo),최성호(Seong Ho Choi),최동욱(Dong Wook Choi),김용일(Yong Il Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.4
Purpose: Histologically, IPMN (intraductal papillary mucinous neoplasm) includes various grades of lesion, from hyperplasia and adenoma to adenocarcinoma. The prognosis is different for each histological grade. The malignant IPMN contain in-situ and invasive carcinoma. The purpose of this study was to investigate the clinicopathologic features and outcome of invasive IPMN. Methods: 18 patients with invasive IPMN underwent surgical treatment between October 1994 and December 2005 at Samsung Medical Center. The clinical, biochemical and pathologic features were retrospectively analyzed. Survival and the clinicopathologic features were compared between invasive IPMN and PDAC of the well differentiated type (wd, n=27) and carcinoma in-situ (CIS, n=10). Results: The preoperative CA19-9 level and total bilirubin level of invasive IPMN patients was statistically higher than those of the CIS patients. The tumor size of invasive IPMN was larger than that of PDAC (wd) (P=0.038). The median survival of patients with invasive IPMN was 31.0 month. The 5-year survival rates of patients with PDAC (wd) and invasive IPMN were 35.5% and 41.7%, respectively (P=0.237). Conclusion: there were no differences for invasive IPMN and PDAC (wd) except for tumor size. The survival in patients with surgical resected invasive IPMN was similar to that of the patients with surgical resected PDAC (wd).
갑상선유두암에서 갑상선전절제술과 중심경부림프절절제술 후 발생하는 저칼슘혈증 예측 인자 연구
이옥주(Ok Joo Lee),김형철(Hyung Chul Kim),임철완(Cheol Wan Lim),신응진(Eung Jin Shin),조규석(Gyou Suk Cho),정준철(Jun Chul Jung),정귀애(Gui Ae Jung),김지선(Zisun Kim),정재홍(Jae Hong Jeong),최규성(Kyusung Choi),한선욱(Sun Wook Han),허 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.3
Purpose: Total thyroidectomy with central lymph node dissection (CLND) is a treatment modality of choice for thyroid cancer. Hypocalcemia is the most common complication after total thyroidectomy. The aim of the current study was to determine the association between surgery-related clinical factors and postoperative hypocalcemia. Methods: A prospective analysis was performed for 101 patients who underwent total thyroidectomy with CLND for papillary cancer from June 2013 to June 2014. Correlation between clinicopathologic factors and postoperative hypocalcemia was analyzed. Results: Based on the postoperative day-2 calcium, 56 patients (55%) developed hypo-calcemia and 45 patients (45%) were normal. No significant differences in histopathologic (tumor size, tumor focality, histologic type, number of retrieved lymph nodes, metastatic lymph node, thyroiditis, retrieved parathyroid gland) findings were observed between the hypocalcemia group and normal calcium group. Mean value of the postoperative day-0 parathyroid hormone (PTH) was significantly lower in the hypocalcemia group (hypoca1cemia group: 14.3±9.4 pg/mL; normal group: 25.0±16.4 pg/mL; P<0.001). In logistic regression analysis, postoperative PTH was a factor significantly affecting postoperative hypocalcemia (OR 0.93; CI: 0.90-0.97; P<0.001). In ROC analysis, the cut-off value of PTH was 19.965 (sensitivity 79%, specificity 58%), and area under the curve (AUC) was 0.709 (95% CI: 0.607-0.811). Conclusion: Postoperative PTH was a factor predicting hypocalcemia after total thyroidectomy with CLND. Use of postoperative PTH as a screening tool for prediction of postoperative hypocalcemia would be useful in management of patients with hypocal-cemia.
바터팽대부암에 대한 근치적 수술 후 발생한 원격성 재발과 Ki-67, ㎚23-H1, VEGF 발현 및 임상병리학적 요인들과의 관련성
조성호(Sungho Jo),허진석(Jin Seok Heo),최성호(Seong Ho Choi),장기택(Kee-Taek Jang),오미정(Mi Jung Oh),최동욱(Dong Wook Choi),정준철(Jun Chul Chung),이승규(Sung Gyu Lee),김용일(Yong Il Kim) 대한외과학회 2006 Annals of Surgical Treatment and Research(ASRT) Vol.71 No.2
유방암 환자의 수술 전 액와림프절 전이 여부 평가를 위한 영상의학적 검사의 효용성
김경덕(Kyeong Deok Kim),인정진(Jeong Jin In),장윤희(Yun Hee Jang),김지선(Zisun Kim),국중철(Jung Cheol Kuk),최규성(Kyu Sung Choi),정재홍(Jaehong Jeong),허성모(Sung Mo Hur),정귀애(Gui Ae Jeong),정준철(Jun Chul Chung),조규석(Gyu Seok Ch 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.2
Purpose: The purpose of this retrospective study was to identify the diagnostic performance of positron emission tomography/computed tomography (PET/CT) compared to conventional modalities, such as ultrasonography (US) and contrast-enhanced computed tomography (CT) in detecting axillary lymph node metastasis (ALNM) in patients with breast cancer. Methods: Two hundred thirty-three consecutive patients diagnosed with primary breast cancer who had not been treated with neoadjuvant chemotherapy and had been examined by US, CT, and PET/CT before surgery were included. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each imaging modality and combinations of modality according to tumor size were obtained, and were compared with the histopathological results of sentinel lymph node biopsy or axillary lymph node dissection. Results: ALNM was confirmed in 32.6% (76/233) of patients. The sensitivity, specificity, PPV, NPV, and accuracy of US for detecting ALNM were 65.8%, 86.6%, 70.4%, 84.0%, and 79.8%, respectively. The sensitivity, specificity, PPV, NPV, and accuracy of CT were 72.4%, 72.6%, 56.1%, 84.4%, and 72.5%, respectively. The sensitivity, specificity, PPV, NPV, and accuracy of PET/CT were 69.7%, 86.0%, 70.7%, 85.4%, and 80.7%, respectively. The combination of US and PET/CT showed the most accurate results with specificity, PPV and accuracy values of 93.6%, 81.5%, and 82.0%, respectively. Conclusion: The diagnostic performance of PET/CT was comparable to that of US and CT. Combination of US and PET/CT could be a reliable strategy for determining preoperative ALNM in patients with operable breast cancer.