원저 : 갑상선 질환에서 갑상선 자극호르몬 결합억제 면역 글로불린 측정의 의의 및 그 생성장소에 관한 연구 ( Original Article : The TSH - Binding Inhibiting Immunoglobulin ( TBII ) Assay in Patients with Thyroid Diseases and The Evidence of TBII Originated fr

장주희(Joo Hee Jang),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),김선우(Sun Woo Kim),최영길(Young Kil Choi) 경희대학교 경희의료원 1986 慶熙醫學 Vol.2 No.1

Ultraviolet-C 조사에 의한 복숭아의 저장 중 품질변화

장주희(Joo-Hee Jang),박재희(Jae-Hee Park),반기은(Ki-Eun Ban),이경행(Kyung-Haeng Lee) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.12

국내산 복숭아에의 저장성 증진을 위하여 0~10.0 kJ/㎡의 선량으로 UV-C를 처리하고 저장 중 부패율, 이화학적 변화 및 기호도의 변화를 측정하였다. 대조군 및 2.5 kJ/㎡ UV-C 처리군의 경우 부패율은 저장 4일까지는 부패된 것이 하나도 없었으나 저장 6일 이후부터는 부패된 복숭아를 보이기 시작하였으며 저장 10일에는 각각 29.17% 및 25.0%의 부패율을 나타내었다. 그러나 5.0, 7.5 및 10 kJ/㎡의 UVC 처리군에서는 저장 10일에 각각 41.67, 50.00 및 58.33%로 조사선량이 높을수록 더 많은 부패율을 나타내었다. 무게 변화의 경우 대조군과 2.5 kJ/㎡ UV-C 처리군은 저장 10일 동안 변화폭이 가장 적었으나 5.0 kJ/㎡ 이상의 처리군에서는 이들보다 많은 변화를 보였다. 복숭아의 pH 변화에서는 UV-C 처리에 의한 차이를 보이지 않았으며 저장기간 중 pH가 증가하였으나 모든 실험군에서 유의적인 차이가 없는 것으로 나타났다. 경도에서는 UV-C 처리 직후에는 모든 실험군에서 차이가 없었으나 저장 6일까지는 2.5 kJ/㎡ 처리군이 대체적으로 대조군과 비슷하거나 약간 높은 경도를 보였으며 저장 8일 이후에는 대조군보다 감소하였다. 그러나 5.0 kJ/㎡ 이상의 처리군에서는 저장 4일 이후부터는 빠르게 경도가 감소하는 것으로 나타났다. 명도 변화에서는 UV-C 처리 및 저장 중 모든 실험군에서 큰 차이를 보이지는 않았으며 적색도는 처리 직후에는 차이가 없었으며 대체적으로 저장 중 대조군과 마찬가지로 증가하는 경향이었다. 황색도는 UV-C 처리에 의하여 다소 황색도가 낮아졌으며 저장 중에는 모든 실험군이 약간 증가하였으나 유의적인 차이를 보이지는 않았다. 맛, 향, 색, 조직감 및 종합적 기호도의 변화에서는 UV-C 처리에 의한 변화는 없는 것으로 나타났다. 그러나 저장 중 모든 실험군에서 2일 혹은 4일차에 가장 높은 기호도를 보였으며 그 후부터는 기호도값이 감소하였다. 전반적으로 대조군과 2.5 kJ/㎡ UV-C 처리군이 가장 기호도가 높은 것으로 나타났다. To prolong the shelf-life of domestic peaches, samples were treated with UV-C (0~10.0 kJ/㎡) and the spoiling rate and changes in physico-chemical and sensory properties were investigated. No spoiled peaches were observed within the first four days of storage in the control and 2.5 kJ/㎡ UV-C treatment groups. However, spoilage was observed in these groups on day six, and 29.17% and 25.0% of the samples showed spoilage on 10 day, respectively. Moreover, samples treated with greater than 5.0 kJ/㎡ of UV-C showed a higher percentage (41.67% or higher) of spoilage than those of the control or 2.5 kJ/㎡ UV-C treatment groups on 10 day. Additionally, weight changes in the peaches were the lower in the control group and 2.5 kJ/㎡ UV-C treatment group than in those treated with 5.0 kJ/㎡ of UV-C treatment or higher during 10 days of storage. There was no difference in pH among treatments, regardless of storage time. The hardness of the samples was not changed immediately after UV-C treatment, but that of samples treated with 5.0~10.0 kJ/㎡ of UV-C decreased rapidly after four days, when compared to the control and 2.5 kJ/㎡ UV-C treatment groups. No significant changes in the lightness and redness of the samples were observed in response to UV-C treatment, however, UV-C treatment led to a slight decrease in the yellowness of the samples. The initial taste, flavor, color, texture, and overall acceptance did not differ among control and UV-C treatments. The sensory score of the samples was the highest after 2 and 4 days of storage, while it decreased thereafter. In general, samples in the control and the 2.5 kJ/㎡ UV-C treatment groups showed higher sensory quality than those treated with UV-C at 5.0 kJ/㎡ or higher.

본태성 고혈압환자의 혈장 Catecholamine 농도에 관한 연구

이종원(Long Won Lee),장주희(Joo Hee Jang),김병호(Byung Ho Kim),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),배종화(Jong Hoa Bae),송정상(Jung Sang Song) 대한내과학회 1986 대한내과학회지 Vol.30 No.6

N/A In order to evaluate the significance of sympathetic nerve activity in the pathophysiology and pathogenesis of essential hypertension, plasma norepinephrine concentration(PNE), plasma epinephrine concentration(PE) and plasma renin activity(PRA) at supine rest and after 30 minutes ambulation were evaluated in 107 patients with sustained essential hypertension(EHT), 39 patients with borderline hypertension(BHT) and 51 normal controls(NT) The results were as follows; 1) Age dependent increase of PNE was observed in NT group, but not in EHT and BHT groups. 2) In supine resting state; PNE levels of patients with EHT and BHT were significantly higher than that of NT in young and middle age groups. 3) In supine resting state, PNE levels of patients with BHT were higher than that of patients with EHT, but only significant in old age group. 4) Postambulatory PNE levels were higher in patients with EHT and BHT than that of NT in all age groups. 5) Postambulatory PNE levels of patients with BHT were significantly higher than that of patients with EHT in middle and old age groups. 6) PE levels of both the NT and hypertensive group were not related to age and there was no difference in PE levels between NT and hypertensive group. 7) There was no correlation between PRA and PNE level in both NT and EHT groups but postambulatory PNE levels were significantly higher in patients with NRH than that of patients with LRH. From the results observed in this study, it is suggested that increased sympathetic neural activity might play an importantt role in the pathogenesis and maintenance of a high blood pressure of essential hypertension, especially in young, mild or renin unsuppressed patients.

복숭아 저장성 증진을 위한 저선량의 UV-C 조사 효과

이경행 ( Kyung Haeng Lee ),박재희 ( Jae Hee Park ),이유진 ( Yu Jin Lee ),반기은 ( Ki Eun Ban ),장주희 ( Joo Hee Jang ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.1

국내산 복숭아의 저장성 증진을 위하여 저선량(0∼3.0kJ/㎡)의 UV-C를 조사하고, 저장기간 동안 부패율, 이화학적 변화 및 기호도의 변화를 측정하였다. 부패율의 경우, 대조군은 4일 이후부터는 부패된 복숭아를 보이기 시작하였으며, 저장 8일에는 50.00%의 부패율을 나타내었다. 저선량의 UV-C 처리군은 대조군보다 낮은 부패율을 보였으며, 특히 1.0 및 2.0kJ/㎡의 UV-C 처리군이 가장 낮은 부패율을 나타내었다. 무게 변화의 경우, 대체적으로 대조군 및 UV-C 처리군 모두 저장기간 동안 큰 차이를 보이지는 않았다. pH 변화에서는 UV-C 처리에 의한 차이를 보이지 않았으며, 저장기간 중 pH가 증가하였으나 모든 실험군에서 차이가 없는 것으로 나타났다. 경도의 경우, UV-C 처리 직후에는 모든 실험군에서 차이가 없었으나, 저장 중 대조군의 변화가 가장 많았으며, UV-C 처리군의 경도 변화는 적은 것으로 나타났다. 색도 변화(명도, 적색도 및 황색도)에서는 UV-C 처리 및 저장 중 모든 실험군에서 큰 차이를 보이지는 않는 것으로 나타났다. 맛, 향, 색에 대한 기호도의 변화에서는 UV-C 처리에 의한 변화를 보이지 않았으며, 저장 중 기호도는 감소하였으나 모든 실험군에서 차이가 없는 것으로 나타났다. 조직감 및 종합적 기호도에서는 UV-C 처리에 의한 변화를 보이지 않았으나 저장 중 대조군의 기호도값이 가장 많이 감소하였고, UV-C 처리군의 변화는 적은 것으로 나타났다. 전반적으로 대조군보다는 저선량의 UV-C 처리군이 기호도가 높은 것으로 나타났다. For shelf-life improvement of the domestic peach, a treatment with low dose UV-C (0∼3.0kJ/㎡) irradiation was performed and the spoilage rate and changes of physico-chemical and sensory properties of the peach were investigated. Control showed spoilage at day 4, and then 50% of control showed spoilage at day 8. However, samples treated with low dose UV-C showed lower percentage of spoilage than those of control at day 8. Weight changes of control and the samples with UV-C treatment showed no difference during the storage period. There was no difference in pH of samples among the treatments but they were increased by storage time. Hardness of samples was not different among treatments at initial stage of storage after UV-C treatment. However, the hardness of control sample was decreased faster than those of the samples with low dose UV-C treatment after 6 days of storage. No significant changes in lightness, redness and yellowness of the samples by UV-C treatment were observed. The sensory parameters including taste, flavor, and color at initial and during storage period were not different among treatments except for texture and overall acceptance. The scores for texture and overall acceptance of control were decreased faster than those of UV-C treatments during storage. In general, samples treated with low dose UV-C showed higher sensory quality than control.

Mesangial IgM Nephropathy

양문호 ( Moon Ho Yang ),김명재 ( Myung Jae Kim ),임천규 ( Chun Gyoo Ihm ),신현호 ( Hyun Ho Shin ),장주희 ( Joo Hee Jang ),이병욱 ( Byung Wook Lee ) 대한내과학회 1985 대한내과학회지 Vol.29 No.2

임상적 징후와 정규 교환에 의한 말초정맥관 교환이 정맥염과 혈류감염 발생에 미치는 영향

윤지선(Yun, Ji Seon),김은옥(Kim, Eun Ok),서유선(Seo, Yu Sun),고은아(Koh, Eun Ah),이수열(Lee, Su Yeol),장주희(Jang, Joo Hee),김한나(Kim, Han Nah),김연희(Kim, Yeon Hee) 한국근거기반간호학회 2016 근거와 간호 Vol.4 No.1

Purpose: The purpose of this study is to compare the efficacy of the current evidence based practice on peripheral venous catheter replacement. Methods: After ethics approval, 140 patients (480 intravenous devices) were enrolled in our survey. Data were analyzed by statistical methods such as t-test, frequency analysis, χ2 square, Fisher’s exact test, Kaplan-Meier survival analysis using SPSS 21 program. Results: First, the average number of inserted peripheral venous catheters in the experimental group was 2.7 (3.0 in the control group), the number of days of maintenance of the peripheral venous catheters was 3.0 days (1.8 in the control group), and the maximum maintenance day of the peripheral venous catheter was 8 days. Second, there were no differences in the incidence of phlebitis and bloodstream infection between the two groups. Third, the risk of phlebitis in the experimental group increased sharply from the 6th day after insertion of peripheral venous catheter. Conclusion: As a result of this study, peripheral venous catheter replacement by clinical signs is recommended, and after 6 days, side effects should be carefully observed. We propose an iterative study on the effect of clinical signs on peripheral venous catheter replacement by expanding the number of patients.

분만후 갑상선 기능 이상에 관한 연구

최영길 ( Young Kil Choi ),김영설 ( Young Seol Kim ),김진우 ( Jin Woo Kim ),김선우 ( Sun Woo Kim ),김광원 ( Kwang Won Kim ),양인명 ( In Myung Yang ),권오선 ( O Sun Kwon ),이종익 ( Jong Ik Lee ),장주희 ( Joo Hee Jang ) 대한내과학회 1985 대한내과학회지 Vol.28 No.5

Technetium-99m Diisopropyl Iminodiacetic Acid(Tc-99m DISIDA)를 이용한 십이지장위 역류검사

장린,민영일,장영운,우정택,장주희,방익수,박충기,최학림 대한내과학회 1986 대한내과학회지 Vol.30 No.4

For evaluation of diagnostic value and usefulness of the duodenogastric reflux test using Tc-99 m DISIDA in gastric ulcer disease, the scintigraphy was performed in 10 gastric ulcer patients, in 10 duodenal ulcer patients and 15 normal controls at Kyung Hee University Hospital during the period from Nov, 19$4 to SeP 1985. Results are summerized as follow; 1) Duodenogastric reflux was more commonly observed in patients with gastric ulcer than in duodenal ulcer(p$lt;0.25) and normal controls(p$lt;0.01). 2) Total radioactivity of refluxing Tc-99 m DISIDA in patients with gastric ulcer(6.76±3.42%) was higher than that in duodenal ulcer(2.68±2.39%) and normal controls(1.43±0.97%). In conclusion, duodenogastric reflux test using Tc-99m DISIDA can be a useful method to quantify duodenogastric reflux. And duodenogastric reflux may play 'a role in pathogenesis of gastric ulcer disease,

갑상선 질환에서 갑상선자극호르몬 결합억제 면역글로불린 측정의 의의 및 그 생성장소에 관한 연구

김진우,최영길,김영설,김광원,김선우,양인명,김정아,장주희 대한내분비학회 1986 Endocrinology and metabolism Vol.1 No.1

To delineate clinical significance of TBII in Graves' disease and to determine whether thyroid gland is the main site of TBII production, the author performed TBII assay by radioreceptor assay method in 48 patients with Graves' disease, 8 patients with Hashimoto's thyroiditis, 13 patients with nontoxic goiter and 21 normal controls. And to find the evidence that the thyroid gland might be source of TBII in Graves' disease, TBII assay were performed in blood obtained from thyroid vein and a peripheral vein during the operation in 11 patients with Graves' disease and 3 patients with thyroid cancer. The results were as follows:1) In normal control the mean TBII index was 2.32±3.16. Two standard deviation above mean was approximately 10, so 10 was regarded as the cut-off value of TBII positivity. 2) The positive rate of TBII was 60.42% in patients with Graves' disease and 12.5% in patieints with Hashimoto's thyroiditis. There was no detectable case in patients with nontoxic goiter. 3) In Graves' disease group poitive rate of TBII and mean TBII index tend to be decreased with treatment. In untreated group, TBII was positive in 72.72% and mean TBII index was 24.38±23.25, and treated but still active hyperthyroidism group, mean TBII index was 18.67±15.1 and positive in 63.32%, In euthyroid treated group, mean TBII index was decreased to 12.06±5.29 and positive in 38.46%. In group of recurrent Graves' disease, the mean TBII index was 42.7±24.95. 4) There were no significant correlation between TBII index and serum T3, T4, TSH concentration in patients with Graves' disease.5) The mean TBII index of thyroid vein of Graves' disease was 39.1±17.5 and was significantly higher than that of peripheral vein 22.49±19.83. In 2 cases, the TBII were not detectable in peripheral blood but were high level in thyroid vein. Ther were no detectable TBII in peripheral vein and thyroid vein of thyroid cancer.These data reconfirmed are contributed to the pathogenesis of Graves' disease, and the levels of antibody tend to reflect the tes of underlying disease. Detection of TBII in hypothyroid patients with Hashimoto's thyroiditis indicated the presence of heterogenous TBII such as blocking antibodies. The TBII index of thyroid vein was higher than that of peripheral which suggested that thyroid gland is the main site of antibody production.

인체 갑성선세포 단층배양법에 대한 경험 : TSH에 의한 cAMP 생성반응 Adenosine 3`,5` Cyclic Monophosphate Response to Thyrotropic Hormone

김진우,최영길,김영설,김광원,양인명,서광식,장주희 대한내분비학회 1986 Endocrinology and metabolism Vol.1 No.1

To observe the usefulness of the monolayer cell culture system, we compared the TSH stimulated cAMP production in this system with that in the dispersed cells.Increases in cyclic AMP levels in monolayer thyroid cell culture and dispered thyroid cells were proportional to the TSH concentration. cAMP levels reached doubling the basal values at a TSH concentration of 1 mU/ml in the nomolayer cell culture, in contrast, at a TSH concentration of 20 mU/ml in the dispersed thyroid cells. A double-reciprocal plot of net cAMP concentration versus TSH concentration is linear. These data indicate that the monolayer cell culture system is a more useful method for the boiassay of TSH and thyroid stimulating immunoglobulins.