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Development of antiviral therapy for avian influenza
송창선(C.S. Song),J.S. Kwon,H.J. Lee,Y.J. Lee,J.B. Lee,S.Y. Park,I.S. Choi 한국실험동물학회 2006 한국실험동물학회 학술발표대회 논문집 Vol.2006 No.-
Influenza A virus infection causes substantial annual morbidity and mortality worldwide, particularly for infants, the elderly, and the immunocompromised. A growing concern is the recent identification of H5N1 subtypes of avian influenza A in Asia that were previously thought to infect only wild birds and poultry, but have now infected humans, cats, pigs, and other mammals, often with fatal results, in an ongoing outbreak. A human pandemic with H5N1 virus could potentially be catastrophic because most human populations have negligible antibody-mediated immunity to the H5 surface protein and this viral subtype is highly virulent. Vaccination is the effective means to control the impact of influenza. The 2004 Asian H5N1 epizootic outbreak indicates the urgent need for vaccines against avian influenza viruses. Some influenza antiviral drugs are available for early treatment and prophylaxis of influenza for human only. Neuraminidase inhibitors, such as zanamivir and oseltamivir, are effective in prevention studies and are highly active against a broad range of influenza A viruses of both human and avian origin, including amantadin-resistant strains. However, there are no available agents for early treatment and prophylaxis of influenza to control current avian influenza endemics in domestic and wild birds. The commercially available inactivated avian influenza vaccines are effective for preventing clinical signs and death but not effective for preventing infection. Therefore, alternative prophylactic and/or therapeutic methods are required to human as well as animals. To prevent and treat influenza viruses, many kinds of antiviral drugs are developing. There is great interest in the identification of novel antiviral agents from chemical and natural compounds. Recent efforts for developing antiviral therapy for avian influenza will be discussed.
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양시용(S. Y. Yang),홍영호(Y. H. Hong),송창선(C. S. Song) 한국가금학회 2010 한국가금학회 심포지움 Vol.2010 No.5
축산물은 사람의 주요 식품원으로서 중요하지만, 식중독균의 주요 매개체이기도 하다. FAO/WHO(2002) 보고에 따르면 유럽에서 발생하는 식중독의 약 26 %가 닭고기 및 계란을 포함한 가금유래로서, 식중독 발생의 77.1 %가 살모넬라균이 원인으로 나타났으며, 특히, S.enteritidis가 1/3 이상을 차지하는 것으로 나타났다. 전 세계적으로 살모넬라 오염 가금생산물의 공중보건학적 위험을 해결하기 위한 제어방안과 프로그램에 대한 관심이 확산되고 있으며, EU와 미국을 중심으로 살모넬라 제어를 위해 사육단계에서부터 도축 및 가공단계까지 전 과정에서의 살모넬라 제어프로그램을 적용 확대해가고 있다. 식품 안전에 대한 요구가 증가되고 있는 현 시점에서 제시한 바와 같은 살모넬라 차단방역 시스템 설계, 현장에 쉽게 적용할 수 있는 수준의 가이드라인 개발 및 백신과 유기산, 경쟁적배제제, 프로바이오틱스, 박테리오파아지 등과 같은 살모넬라 저해제의 적용을 포함한 살모넬라 부재 가금 및 안전 계육 생산기법의 개발이 필요하다. Salmonella infections cause the disease in poultry and some zoonotic. Salmonella can be transmitted to human through poultry products, resulting in foodborne disease. The FAO/WHO report on foodborne diseases in EU reported that about 26 % of foods involve in outbreaks involves poultry and poultry products. Salmonella is the most frequently reported causal agent of outbreaks in the EU, being possible for 77.1 % of outbreaks. Of these, more than one third were confirmed to be caused by Salmonella enteritidis. Salmonella infections in birds are increasingly worldwide subject to control measures and programs due to the public health threats by Salmonella contaminated poultry products. The US and EU have initiated control programmes to reduce Salmonella in poultry. Control programmes include the whole poultry production chain, and include measures of biosecurity, Salmonella-free feed, management systems, hygiene and disinfection. Salmonella control programmes may include vaccinations and feed additives such as organic acids, competitive exclusion products, probiotics, prebiotics, essential oils and bacteriophages.
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김재홍,성환우,권용국,이윤정,최준구,조성준,김민철,이은경,장환,위성환,모인필,송창선,박종명,Kim, J.H.,Sung, H.W.,Kwon, Y.K.,Lee, Y.J.,Choi, J.G.,Cho, S.J.,Kim, M.C.,Lee, E.K.,Jang, H.,Wee, S.H.,Mo, I.P.,Song, C.S.,Park, J.M. 한국가금학회 2004 韓國家禽學會誌 Vol.31 No.2
Highly Pathogenic Avian Influenza (HPAI) is a very acute systemic disease in poultry, particularly in chickens and turkeys caused by HPAI viruses. An outbreak of HPAI caused by subtype H5N1, was first reported in a broiler breeder farm on December 10, 2003 in Korea, although there had been twenty one outbreaks of the disease reported in the world before. Since mid-December 2003, eight Asian countries have confirmed outbreaks of HPAI due to the same subtype. The outbreak has also resulted in at least twenty three fatal human cases in Vietnam and Thailand as of May 17, 2004 according to the WHO. Regarding the first outbreak of recent Asian HPAI, it has been suspected that some Asian countries with the exception of Korea and Japan veiled the fact of HPAI outbreaks since the last half of 2003, even though it was first reported in Korea. There have been total nineteen outbreaks of HPAI among chicken and duck farms in 10 provinces in Korea since Dec. 2003 and approximately 5,280,000 birds were slaughtered from 392 farms for eradication of the disease and preemptive culling. The origin of the H5Nl HPAI virus introduced into the country are unknown and still under epidemiological investigation. Current status of outbreaks and characteristics of HPAI will be reviewed and discussed on the basis of genetic, virological, clinicopathological, and ecological aspect, as well as future measures for surveillance and prevention of the disease in Korea.
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