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난소종양에서 Cyclooxygenase - 2 의 발현
손우석(Woo Seok Sohn),민봉식(Bong Sik Min),김창모(Chang Mo Kim),김성주(Sung Joo Kim),강정배(Jung Bae Kang),박혜림(Hye Rim Park),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumorigenesis of gastrointestinal and other cancers. This was the study to determine whether COX-2 was also expressed in benign and malignant ovarian tumors. Methods: We studied the expression of COX-2 in various ovarian tumors [ Benign epithelial tumors (n=10), borderline epithelial tumors (n=12), malignant epithelial tumor (n=12), nonepithelial tumors(n=10) ] by immunohistochemistry. Results of immunoreactivity was classified semiquantitatively based on the proportion and intensity of tumor cell immunostaining. Results: In the epithelial ovarian tumors, the intensity of immunostaining was stronger in the malignant tumors than the benign and borderline tumors (p<0.001). Especially all serous and mucinous malignant tumors (n=9) showed weak and strong immunoreactivity, with 66.7% strong reactivity. None of the nonepithelial ovarian tumors expressed COX-2 immunoreactivity. Conclusion: These preliminary data indicate that COX-2 may have a role in carcinogenesis of epithelial ovarian tums, especially in the serous and mucinous types. COX-2 maybe a target for future research in the tumorigenesis of the epithelial ovarian malignancies.
자궁내막증이 있는 불임환자에서 복강액내의 Cytokine에 관한 연구
강정배,박제용,김범,김성주,손우석,김현태,장봉림,Kang, Jeong-Bae,Park, Je-Yong,Kim, Bum,Kim, Sung-Joo,Sohn, Woo-Seok,Kim, Hyun-Tae,Jang, Pong-Rheem 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.1
Objective: The presence of the various cytokines in human peritoneal fluid has been evaluated incompletely. Changes in cytokine levels may be related to activation of peritoneal macrophage and T-lymphocyte, development of endometriosis, and infertility. This study assesses peritoneal fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in infertile women with endometriosis and normal women without endometriosis. Design: Prospective and case-control study in university hospital. Materials and Methods: Cytokine levels in peritoneal fluid obtained during laparotomy or laparoscopy from 21 patients in infertile patients with endometriosis and 24 controls undergoing laparotomy or laparoscopy with no evidence of pelvic endometriosis were determined by enzyme-linked immunosorbent assay. Results: The mean levels of interleukin-6 in infertile patients with endometriosis and controls were $72.7{\pm}23.7$ pg/ml and $18.5{\pm}9.7$ pg/ml respectively (p=0.02). Similarly, the mean levels of interleukin-8 in infertile patients with endometriosis was significantly higher than that of controls ($445.0{\pm}89.6$, vs $45.1{\pm}48.4$, p=0.04). The mean concentration of interleukin-10 in infertile patients with endometriosis was significantly lower than that of controls ($1.09{\pm}0.04$ vs $2.19{\pm}0.03$, p=0.03). The level of tumor necrosis factor-${\alpha}$ was not significantly different between the two study groups. Conclusions: Increased IL-6 and IL-8 and decreased IL-10 levels in the peritoneal fluid may be related to pathogenesis in the endometriosis and infertility, suggesting that partially contribute to the disturbed immune regulation observed in infertili women with endometriosis.
자궁경부암에서 Cyclooxygenase - 2 의 발현과 혈관신생
민봉식(Bong Sik Min),손우석(Woo Seok Sohn),장기택(Kee Taek Jang),이성원(Sung Won Lee),김홍배(Hong Bai Kim),이용우(Yong Woo Lee),강성원(Sung Won Kang),박양서(Yang Suh Park),장봉림(Pong Rheem Jang) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objective: A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumor growth and angiogenesis of gastrointestinal and other cancers. This was the study to determine the relationship between tumor vascularity and COX-2 expression in invasive cervical cancer. Methods: We examined the expression of COX-2 and microvessel density (MVD) by immunohistochemical staining in 21 specimens collected from invasive cervical cancer patients. Results: All specimens showed weak and strong immunoreactivity, with 52.4%strong reactivity. Microvessel count was higher (median 136) in the strong COX-2 immunoreactivity specimens than the weaks (median 90),and MVD was significantly correlated with the COX-2 immunoreactivity (P=0.002). Conclusion: These preliminary data indicate that overexpression of COX-2 may play an important role in carcinogenesis of cervical cancer and this could be partially attributable to modulation of angiogenesis by COX-2.COX-2 maybe a target for future research in the tumorigenesis of the invasive cervical cancer.
이상욱 ( Sang Wook Yi ),손우석 ( Woo Seok Sohn ),박한뫼 ( Han Moie Park ),이상수 ( Sang Soo Lee ),임명철 ( Myoung Cheol Lim ),엄대운 ( Dae Woon Eom ),강길현 ( Gil Hyun Kang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
Small cell carcinoma of ovary is extremely rare. This neoplasms compose predominantly or exclusively of small round cells with scant cytoplasm. There are two types of primary small cell carcinoma of ovary described in the literature : the hypercalcemic type and the pulmonary type. The first 11 patients with a primary ovarian small cell carcinoma of the pulmonary type were described by Eichorn et al. in 1992. The prognosis of this tumor is very poor and only limited data on the treatment of this tumor type are available. In the present case report, we describe a patient with the pulmonary type of small cell carcinoma associated with huge mucinous cystadenocarcinoma with a brief review of the concerned literatures.
이상수 ( Sang Soo Lee ),손우석 ( Woo Seok Sohn ),박한뫼 ( Han Moie Park ),김용만 ( Young Man Kim ),목정은 ( Jung Eun Mok ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
목적: 본 연구의 목적은 향후 세포 면역치료시 사용할 수 있는 T 림프구를 제대혈로부터 분리하여 체외 배양하는데 필요한 최적 조건을 확립하기 위하여, 기존에 사용하던 FBS와 자가 제대혈장 (autologous cord blood plasma, ACBP), 동종 제대혈장 (homologous cord blood plasma, HCBP)을 각각 T 림프구 체외 배양 배지의 영양공급원으로 사용하여, T 림프구의 증폭, 증폭 전후의 T 림프구의 면역학적 특성 Objective: The objective of this study was to establish a clinically applicable culture system by investigating the use of autologous cord blood plasma (ACBP) instead of fetal bovine serum (FBS) for the ex vivo expansion of umbilical cord blood (UCB) T-ly
박제용(Je Yong Park),김성주(Sung Joo Kim),손우석(Woo Seok Sohn),강정배(Jung Bae Kang),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
Actinomycosis is a chronic, progressive, suppurative disease which appears to be difficult to establish a correct preoperative diagnosis. Most of pelvic actinomycosis in women are related to a long time intrauterine device(IUD) inserted state. The causative agent is a branching, gram-positive anaerobic or microaerobic organism, not fungi. Ascending infection of the upper genital tract by actinomycosis may be clinically inapparent. We experienced a case of clinically inapparent tuboovarian actinomycosis in a 47-year-o]d women with IUD, discovered pathologically after laparotomy.
임신 1 삼분기중 Nuchal Translucency 와 free β-hCG , PPP -A 를 이용한 염색체 이상진단의 선별검사로서의 유용성
김성주(Sung Joo Kim),민봉식(Bong Sik Min),김창모(Chang Mo Kim),손우석(Woo Seok Sohn),강정배(Jung Bae Kang),장봉림(Pong Rheem Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objectives: The aim of this study is to determine the efficacy of nuchal translucency in combination with free β-hCG, PAPP-A in the first trimester screening for chromosomal anomaly in general population. Methods: Between April 1998 and December 1999, we evaluated 263 pregnant women undergoing first trimester screening test for fetal chromosomal anomaly using nuchal translucency combined with free β -hCG, PAPP-A. We confirmed the pregnancy outcomes through chorionic villi sampling, amniocentesis or term delivery. We excluded 15 pregnant women because of their obscure pregnancy outcomes. Statistical analysis w; considered significant when P value was lower than 0.05. Results: With a risk cut-off of 1 in 400, 24 pregnancies(9.7%) of 248 cases were screen positive and 224 pregnancies(90.3%) were screen negative. 2 cases of Down syndrome and 1 case of Tumer syndrome were detected in screen positive group. No chromosomal anomalies were detected in screen negative group. Conclusion: In this study, 8.57% of false positive rate and 12.5% of positive predictive value were obtained in the first trimester screening for chromosomal anomaly using nuchal translucency and serum markers.