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CaO-SiO<sub>2</sub>-B<sub>2</sub>O<sub>3</sub>계 결정화 유리의 제조와 in-vitro법을 이용한 생체활성 평가
류현승,서준혁,김환,홍국선,김득중,이재협,이동호,장봉순,이춘기,Ryu, Hyun-Seung,Seo, Jun-Hyuk,Kim, Hwan,Hong, Kug-Sun,Kim, Deug-Joong,Lee, Jae-Hyup,Lee, Dong-Ho,Chang, Bong-Soon,Lee, Choon-Ki 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.5
$CaO-SiO_2-B_2O_3$계의 결정화유리의 소결 특성 및 기계적 특성, 생체활성을 알아보았다. 이 조성의 결정화유리는 750-830${\circ}$ 사이에서 소결 되었으며 치밀한 미세구조를 보였다. 이 결정화 유리는 단사정계 월라스토나이트(monoclinic wollastonite), 칼슘보레이트(Calcium borate, $CaB_2O_4$) 결정상과 보로실리케이트(borosilicate) 유리 기지상(matrix)의 3상으로 구성되었다. 기계적 강도는 지금까지 알려진 다른 생체활성 세라믹스보다 우수하였으며 특히 압축강도(2813 MPa), 파괴인성($3.12 MPa{\cdot}m^{1/2}$)이 높았다. 생체활성은 결정화유리 중 calcium borate와 보로실리케이트 유리의 양에 의존하였는데, 용해도가 높은 calcium borate는 의사체액(SBF)의 칼슘이온의 과포화도를 상승시키고 borosilicate 유리는 탄산아파타이트 핵생성에 필요한Si-OH기를 형성시켜 탄산아파타이트 층이 빨리 생성되기 때문으로 판단된다. 따라서 $CaB_2O_4$와 borosilicate 유리가 많을수록 결정화유리의 생체활성이 뛰어난 것으로 생각된다. Sintering property, mechanical property and bioactivity of $CaO-SiO_2-B_2O_3$ glass-ceramics were investigated. This glass-ceramics was sintered at 750-830${\circ}$ and showed nearly pore-free microstructure. The glass-ceramics consisted of three phases, i.e. monclinic-wollastonite, calcium borate and borosilicate glass matrix. The mechanical strength was higher than that of other bioactive ceramics, especially compressive strength(2813 MPa) and fracture toughness($3.12 MPa{\cdot}m^{1/2}$). Bioactivity of the glass-ceramics depends on amount of $CaB_2O_4$ and borosilicate glass matrix. It might be likely that more soluble $CaB_2O_4$ raises supersaturation of Ca ion in SBF solution and borosilicate glass forms Si-OH group that presents nucleation site of hydroxycarbonate apatite(HCA) layer. So, glassceramics of more $CaB_2O_4$ and borosilicate glass showed better bioactivity.
홍지연 ( Ji Yeon Hong ),서준혁 ( Joon Hyuk Suh ),이갑석 ( Kapsok Li ),서성준 ( Seong Jun Seo ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.7
Focal acral hyperkeratosis (FAH) is a rare genodermatosis inherited by autosomal dominant transmission; however, some sporadic cases have also been reported. FAH is characterized by multiple late-onset crateriform hyperkeratotic papules with a yellow color on the border of the hands and feet. A 31-year-old man presented with yellowish discrete flat-topped papules on the lateral side of his palms and fingers. The patient had a family history of similar lesions throughout three generations. The histological findings revealed hyperkeratosis with mild hypergranulosis in the epidermis, and the dermis showed no specific changes including elastorrhexis. These clinicopathologic findings were consistent with the diagnosis of FAH. Herein, we report a rare case of FAH with autosomal dominant inheritance. (Korean J Dermatol 2018;56(7):443∼446)
Methotrexate로 치료한 타카야수 동맥염에 동반된 괴저성 농피증
김종근 ( Jong Keun Kim ),서준혁 ( Jun Hyuk Seo ),윤준철 ( Jun Cheol Yoon ),박도회 ( Do Hwae Park ),조민재 ( Min Jae Jo ),이찬우 ( Chan Woo Lee ),백애란 ( Ae Lan Paik ),민복기 ( Pok Kee Min ),나건연 ( Gun Yoen Na ),오동호 ( Dong Ho 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1
Pyoderma gangrenosum (PG) is a vasculitic process, often associated with systemic diseases, including Takayasu`s arteritis (TA), rheumatoid arthritis, and inflammatory bowel disease. Most cases of PG associated with TA have been observed in Japan. However, this association is not commonly observed in North American and European patients. PG is often refractory to therapy, requiring high dosages of glucocorticoids. Here, we describe a case of recalcitrant PG that was associated with TA and successfully treated with methotrexate.
임성택 ( Seung Taek Lim ),오동호 ( Dong Ho Oh ),이상우 ( Sang Woo Lee ),김종근 ( Jong Keun Kim ),김영호 ( Young Ho Kim ),서준혁 ( Jun Hyuk Seo ),윤준철 ( Jun Cheol Yoon ),이찬우 ( Chan Woo Lee ),이태우 ( Tae Woo Lee ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Juvenile onset ankylosing spondylitis is a chronic inflammatory arthritis showing oligoarthritis and enthesopathy of the peripheral and axial skeleton. This have been shown to have different clinical presentation and outcome from adult onset ankylosing spondylitis. Takayasu arteritis is a uncommon, chronic inflammatory disease of elastic arteries such as the aorta, its larger branches and the pulmonary artery trunk. Although, it has rare report about association between ankylosing spondylitis and Takayasu arteritis, there was no report of juvenile onset ankylosing spondylitis with Takayasu arteritis. Thereby, we report a patient with Takayasu arteritis who had juvenile onset ankylosing spondylitis in the course of his disease.