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임상 ; 조기분만 시 융모양막염 유무에 따른 제대정맥혈장내 Interleukin-6, C-reactive Protein 및 지질과산화물의 변화
강명선 ( Myoung Seon Kang ),김윤하 ( Yoon Ha Kim ),김철홍 ( Cheol Hong Kim ),김기민 ( Ki Min Kim ),조문경 ( Moon Kyoung Cho ),김종운 ( Jong Woon Kim ),김조헌 ( Jo Heon Kim ),남종희 ( Jong Hee Nam ),양성렬 ( Sung Yeul Yang ),안봉환 대한주산의학회 2007 Perinatology Vol.18 No.4
목적: 조기분만 시 제대정맥혈장내 Interleukin-6(IL-6)와 C-reactive protein (CRP) 및 지질과산화물을 측정하여 조직학적 융모양막염 유무에 따른 이들의 변화와 주산기 예후에 어떤 역할을 하는가 규명하고자 하였다. 방법: 양막파열이 없는 조기분만 임부 39명(조기분만군), 만삭전 조기양막파열 임부 27명(양막파열군)에서 분만시 태반조직과 제대정맥혈을 채취하여 IL-6, CRP, 지질과산화물 농도를 측정하고 비교하였고, 태반조직의 병리학적 소견을 얻었다. 결과: 조기분만군 39예 중 8예, 양막파열군 27예 중 16예에서 조직학적 융모양막염이 있었으며, 양막파열군에서 조기분만군보다 증가하였다. 조기분만군과 양막파열군 간에 IL-6, CRP, 지질과산화물의 차이가 없었다. 조직학적 융모양막염이 있는 군에서 없는 군보다 IL-6, CRP, 지질과산화물 농도가 증가하였다. 조직학적 융모양막염이 있는 조기분만군에서 없는 조기분만군보다 IL-6, CRP, 지질과산화물 농도가 증가하였다. 조직학적 융모양막염이 있는 양막파열군에서 없는 양막파열군에 비해 CRP는 증가하였으나, IL-6와 지질과산화물 농도는 차이가 없었다. 선천성 패혈증이 의심스러웠던 태아 3명의 IL-6와 지질과산화물 농도가 증가된 소견을 보였다. 조직학적 제대염을 동반한 경우의 IL-6 농도는 동반하지 않은 경우보다 증가하였으며, 제대염이 있었던 6예 중 신생아 패혈증 의증 2명, 호흡곤란증후군 1명, 뇌실내출혈 1명으로 주산기 이환율이 높았다. 결론: 조직학적 융모양막염이 동반된 조기분만에서 제대정맥내 IL-6, CRP 및 지질과산화물이 증가하였으며, 이에 따라 주산기 이환율이 영향을 받을 것으로 사료된다. Objective: To investigate interleukin-6 (IL-6), C-reactive protein (CRP), and lipid peroxide levels in the umbilical venous plasma of preterm birth with or without histologic chorioamnionitis and to evaluate their roles in the pathophysiology in preterm labor and perinatal outcome. Methods: This cohort study included 66 cases of preterm delivery with preterm labor and intact membranes (PTL) (n=39) and preterm premature rupture of membranes (PPROM) (n=27). The umbilical venous blood samples were collected at the time of delivery. IL-6, CRP, and lipid peroxide levels were measured by ELISA Kit, latex agglutination assay, and thiobarbituric acid reaction. Histologic chorioamnionitis was diagnosed by the presence of neutrophil infiltration into the subamnionic space. Results: The prevalence of histologic chorioamnionitis was significantly higher in PPROM (59.3%, 16/27) than in PTL (20.5%, 8/39). IL-6, CRP, and lipid peroxide levels in the umbilical venous plasma of histologic chorioamnionitis were significantly higher than those without histologic chorioamnionitis. IL-6, CRP, and lipid peroxide levels in the umbilical venous plasma of PTL with histologic chorioamnionitis were significantly higher than those of PTL without histologic chorioamnionitis. CRP levels in the umbilical venous plasma of PPROM with histologic chorioamnionitis were significantly higher than those of PPROM without histologic chorioamnionitis. Three suspected neonatal sepsis patients have increased IL-6 and lipid peroxide levels in the umbilical venous plasma compared with patients without neonatal sepsis. IL-6 levels in the umbilical venous plasma of histologic funisitis were significantly higher than those without funisitis. Conclusion: Preterm birth with chorioamnionitis is associated with an increased level of IL-6, CRP, and lipid peroxide in umbilical venous blood. Preterm birth with chorioamnionitis may have an effect on perinatal outcome.
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유방에 발견한 원발신 악성 림프종의 세침흡인 세포학적 소견 - 1예 보고 -
김현중,이경화,김조헌,심민근,최찬,이지신,Kim, Hyun-Joong,Lee, Kyung-Hwa,Kim, Jo-Heon,Shim, Min-Keun,Choi, Chan,Lee, Ji-Shin 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.2
Lymphoproliferative disorders, manifesting either as a primary lesion or as part of a generalized process, rarely involve the breast. The primary malignant lymphoma of the breast is rare. The cytologic features of this neoplasm have not been reported in Korea thus far. We described a case of primary malignant lymphoma of the breast, as diagnosed by fine needle aspiration cytology (FNAC) in an 84-year-old female. FNAC smears showed high cellularity. The main cytologic feature observed was a carpeting of monotonous, atypical, enlarged lymphoid cells. These lymphocytes showed relatively round elliptical nuclei with some indentation. One or more prominent nucleoli were seen. Biopy from the breast mass revealed diagnostic features of non-Hodgkin's lymphoma, diffuse large B-cell type.
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제주 지역에서 23S rRNA 점 돌연변이와 관련된 Clarithromycin 내성 Helicobacter pylori
김태윤 ( Taeyun Kim,),송현주 ( Hyun Joo Song ),신선영 ( Sun Young Shin ),김조헌 ( Jo Heon Kim ),나수영 ( Soo Young Na ),부선진 ( Sun Jin Boo ),최은광 ( Eun Kwang Choi ),조유경 ( Yoo Kyung Cho ),김흥업 ( Heung Up Kim ),송병철 ( Byu 대한소화기학회 2013 대한소화기학회지 Vol.61 No.5
Background/Aims: The point mutations in 23S rRNA gene accounts for the majority of the clarithromycin resistance of Helicobacterpylori. This study aimed to investigate the association between the clarithromycin-resistance of H. pylori and the failure of primary H. pylori eradication therapy in Jeju Island. Methods: Between April 2011 and October 2012, 6,937 patients underwent endoscopy, and H. pylori infection was evaluated in 2,287 patients (33.0%). Total of 110 patients with H. pylori infection were treated with proton pump inhibitor (PPI)-based triple therapy. The result of eradication was evaluated with urea breath test, histology and PCR which were conducted 4 weeks from the last dose of medicine. Results: The patients who had point mutations were 33 (26.0%). A2142G and A2143G mutations were observed in 10 patients (7.9%) and 23 patients (18.1%). Among 110 patients treated with PPI-based triple therapy, the success rate of the eradication therapy was 52.7% (58/110) and 70.7% (58/82) by intention-to-treat and per-protocol analysis, respectively. Fifteen of the 24 patients who failed the eradication therapy showed point mutations; 1 patient (4.2%) showed A2142G mutation and 14 patients (58.3%) showed A2143G mutation. Patients with A2143G mutation H. pylori showed higher failure rate of 87.5%. Patients with A2142G mutation H. pylori showed similar failure rate compared to those of the patients with wild type H. pylori. Conclusions: In Jeju Island, the frequency of 23S rRNA point mutations is similar (26.0%) with other regions of Korea (15.8-31.3%). A2143G mutation is associated with the failure of H. pylori eradication.
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김재구(Jae Gu Kim),홍아람(A Ram Hong),김조헌(Jo Heon Kim),이동훈(Dong Hoon Lee) 대한두경부종양학회 2020 대한두경부 종양학회지 Vol.36 No.2
Paraganglioma is a rare benign neuroendocrine tumor arising from the paraganglia of the autonomic nervous system. Paraganglioma occurs mainly in the carotid body, jugular foramen, and vagus nerve in the head and neck region. Herein, we report a case of paraganglioma of the submandibular region that has not been reported. This case highlights paraganglioma as a rare differential diagnosis for submandibular region tumors.
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