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폐포 대식세포 및 단핵구가 Interleukin-2 Enhanced Natural Killer 및 LAK Activity에 미치는 영향
조철호 ( Jo Cheol Ho ),김병일 ( Kim Byeong Il ),김세규 ( Kim Se Gyu ),천선희 ( Cheon Seon Hui ),김형중 ( Kim Hyeong Jung ),장준 ( Jang Jun ),안철민 ( An Cheol Min ),김성규 ( Kim Seong Gyu ),이원영 ( Lee Won Yeong ),윤정구 ( Yun J 대한내과학회 1992 대한내과학회지 Vol.42 No.5
저자들은 폐포 대식세포 및 말초혈액내의 단핵구가 NK 활성도 및 LAK 활성도에 미치는 영향을 보기위하여, 임파구에 여러 가지 농도(0, 100 : 1, 10 : 1, 1 : 1)의 폐포 대식세포와 단핵구를 넣어 IL-2 enhanced NK 활성도 및 LAK 활성도를 비교하여 다음과 같은 결과를 얻었다. 1) 여러 가지 농도의 단해구는 IL-2 enchanced NK 활성도 및 LAK 활성도에 영향을 미치지 않았다. 2) 동량의 페포대식세포(임파구 : 폐포 대식세포= 1 : 1)는 IL-2 enhanced NK 활성도를 의의있게 억제하였으나(p<0.05), 소량의 폐포대식세포(임파구 : 폐포 대식세포-10 : 1과 100 : 1)는 IL-2 enhanced NK 활성도를 억제하지 못하였다. 3) 임팍와 폐포 대식세포의 비율이 1 : 1과 10 : 1에서는 LAK 활성도를 의의있게 억제하였으나, 소량의 폐포대식세포(임파구 : 폐포 대식세포=100 : 1)는 LAK 활성도를 억제하지 못하였다(p<0.05). 이상의 결과로 IL-2 enhanced NK 활성도 및 LAK 활성도는 폐포 대식세포의 양에 비례하여 억제되었으나, 말초혈액내의 단핵구에 의해서는 영향받지 않는 것을 알 수 있었다. Alveolar macrophages (AM) are thought to function as primary effector cells against tumors growing in the lung. Systemic administration of lymphokine activated killer (LAK) cells and IL-2 resulted in partial antitumor response in patients with advanced cancer. LAK activity is influenced by various factors. We studied the effects of AM and blood monocytes from healthy donors on IL-2 enhanced NK activity against K-562 cells and LAK activity against Raji cells utilizing a 4h ^(51)Cr release assay. The following results were obtained: 1) The addition of different doses of human blood monocytes showed no suppression or enhancement of IL-2 enhanced NK and LAK activity. 2) The addition of high dose of AM (Lymphocyte: AM=1:1) significantly suppressed IL-2 enhanced NK activity. Smaller doses of AM (Lymphocyte: AM= 10:1and 100:1) did not suppress IL-2 enhanced NK activity. 3) The addition of high dose of AM (Lymphocyte: AM = 1:1 and 10:1) significantly suppressed LAK activity. The smallest dose of AM (Lymphocyte: AM= 100:1) did not suppress LAK activity. In conclusion, IL-2 enhanced NK and LAK activity were dose-dependently suppressed by human alveolar macrophages. However IL-2 enhanced NK and LAK activity were not suppressed by blood monocytes.
반사형 디지털 홀로그래피 현미경 시스템에서의 조사면적 및 재생면적의 확대기록
최규환,김성규,조동현,윤선규,Choi, Kyu-Hwan,Kim, Sung-Kyu,Cho, D.,Yoon, Seon-Kyu 한국광학회 2006 한국광학회지 Vol.17 No.4
마이켈슨 간섭계 시스템에 두 개의 Convex Lens를 추가함으로서 평면파 참조광을 유지 시키며, 물체에 조사되는 물체광의 조사면적을 증대시킬 수 있는 변형된 마이켈슨 간섭계를 제작하였다. 변형된 마이켈슨 간섭계를 반사형 디지털 홀로그래피 현미경 시스템(Digital Holography Microscope System)에 적용한 결과 두 개의 Convex Lens를 추가하지 않은 고전 마이켈슨 간섭계를 사용한 디지털 홀로그래피 현미경 시스템 보다 넓은 영역에 대해 물체를 기록 할 수 있으며 또한 보다 넓은 영역을 재생 할 수가 있다. A modified Michelson interferometer type digital holography microscopy system is developed. There is a problem about recording and numerical reconstruction area at the microscopy application of Michelson type interferometer structure in the digital holography field. In this paper, to overcome this problem, we developed a new reflection type digital holography microscope system and increased recording and numerical reconstruction area of target object.
원저 : 폐결핵 환자의 기관지폐포세척액에서 Adenosine Deaminase 활성도에 관한 연구
천선희 ( Seon Hee Cheon ),조철호 ( Chul Ho Cho ),김병일 ( Byung Il Kim ),장상호 ( Sang Ho Jang ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),한지숙 ( Jee Sook Hahn ),이원영 ( Won Young Lee ),권오헌 ( Oh Hun Kwon ) 대한결핵 및 호흡기학회 1991 Tuberculosis and Respiratory Diseases Vol.38 No.1
천선희(Seon Hee Cheon),김세규(Se Kyu Kim),장준(Joon Jang),장상호(Sang Ho Jang),홍천수(Chein Soo Hong),김성규(Sung Kyu Kim),이원영(Won Young Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.4
N/A MVV/ FEU₁, is used frequently in disability evaluation as an independent check on the subjects performance and motivation. MVV/ FEU₁, values are often reported to be reduced in subjects with poor muscle strength or endurance, extrathoraicc upper airway obstruction, and in the presence of suboptimal effort during pulmonary function testing, and/or asthma. Deep inspiration commonly causes bronchoconstriction in asthmatics and a series of rapid deep inspirations causes a greater increase in respiratory resistance and bronchomotor tone than does a slow deep inspiration. So the MVV decrease is greater than the FEV₁. In this study the MVV/ FEV₁, ratio studied and compared with the methacholine challenge test. The results were as follows: 1) The mean value of the MVV/ FEV₁, ratio was 34. 5±5.8(min-), in all subjects. 2) The MVU/ FEV₁, ratio for the methacholine negative group was 36.5±5.3 (min-) and 32.1±5.3 (min-) for the methacholine positive group. The value of the methacholine positive group was significantly lower than the negative group(p<0.05). 3) Of the MVV/ FEV₁, ratio 32 or less is diagnostic for positivity of the methacholine test (sensitivity 66%, specificity 66%). 4) There was no correlation between MVV/ FEV₁, and PC20 in subjects with positive methacholine test or asthma. From the above results, PC20 in asthmatic subjects with lower MVV/ FEV₁, ratios was no loss than that in those whose ratios were within the normal limits. Hovever the MVV/ FEV₁, ratio is usuful in screening estimates of positive methacholine tests.
인체 폐암세포주에서 다약제내성유전자 표현과 Buthionine Sulfoximine 투여가 Cisplatin 및 Adriamycin 의 세포독성도에 미치는 영향
천선희(Seon Hee Cheon),유내춘(Nae Chun Yoo),김주항(Joo Hang Kim),김성규(Sung Kyu Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
N/A Objectives: Cisplatin and adriamycin have been proven to be the most effective drugs for lung cancer, However, repeated courses of chemotherapy frequently result in a decreased therapeutic response because of the emergence of an acquired drug-resistance. Recently it has been demonstrated that the resistance to cisplatin, adriamycin or alkylating agents may be due to elevated intracellular glutathione levels in human and rodent tumor cell lines. This study was aimed to investigate any relationship between intracellular glutathione levels and sensitivity to cisplatin and adriamycin, and whether cytotoxicity to cisplatin and adriamycin could be in- creased with buthionine sulfoximine. Methods: We used human SCLC cell line, NCI-H209, and three human NSCLC cell lines, NCI-H727, NCI- H810 and NCI-H1299. The multidrug resistance gene expression was investigated by RNA slot blot analysis. The intracellular glutathione levels was examined before and after administration of buthionine sulfoximine. Drug sensitivity assays were performed using a modified MTT method. Results: 1) The resistance to adriamycin and cisplatin in human lung cancer ce11 lines was closely related to MDR1 expression level rather than that of intracellular glutathione level. Cisplatin resistance seemed to be related to the glutathione level above some concentrations. 2) 5-Fluorouracil resistance seemed not to be related to MDR1 expression or glutathione level. 3) Buthionine sulfoximine was not effective on adriamycin and cisplatin cytotoxicity in MDR1 positive cells, but effective in MDR1 negative cells. Conclusion: It is suggested that buthionine sulfoximine is an effective supplement to adriamycin and cisplatin in MDR1 negative cells. And its effectiveness in human lung cancer patients needs a further clinical studies.