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김정욱 ( Kim Jeong Ug ),전우규 ( Jeon U Gyu ),윤중원 ( Yun Jung Won ),박동일 ( Park Dong Il ),조용균 ( Jo Yong Gyun ),성인경 ( Seong In Gyeong ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),김병익 ( Kim Byeong Ig ),김은정 ( 대한소화기학회 2004 대한소화기학회지 Vol.43 No.2
Background/Aims: Increased intestinal permeability has been possible contributing factors to the pathogenesis of alcoholic liver disease. Moreover, it can contribute to the development of bacterial infection and intestinal endotoxemia in patients with liver cirrhosis. This study aimed to examine the difference of intestinal barrier dysfunction between alcoholic and viral liver disease patients through the comparison of the intestinal permeabilities of patients with clinical characteristics. Methods: Intestinal permeabilities were measured in 18 healthy controls, 41 patients with alcoholic liver disease (17 cases of alcoholic liver disease without cirrhosis and 24 cases of alcoholic liver cirrhosis) and 46 patients with viral liver disease (14 cases of chronic viral hepatitis and 32 cases of viral liver cirrhosis) by measuring 24 hour urine excretion of 51Cr-EDTA. Results: The intestinal permeability was significantly increased in the patients with alcoholic liver disease without cirrhosis (5.62±80%), alcoholic liver cirrhosis (5.29±48%) and viral liver cirrhosis (3.15±39%) compared with that in control subjects (1.99±53%). On the contrary, it was not increased in the patients with chronic viral hepatitis (2.05±57%) versus controls. The significant correlation was not found between intestinal permeability and clinical and laboratory findings. Conclusions: The intestinal permeability was elevated in patients with alcoholic liver disease compared to those with viral liver cirrhosis. The pathophysiology of liver injury secondary to intestinal epithelial damage may be different between alcoholic and viral liver diseases. (Korean J Gastroenterol 2004; 43:104-111)
만성 B형 간질환에서 Adefovir Dipivoxil의 적용과 효능
조용균 ( Jo Yong Gyun ),김병익 ( Kim Byeong Ig ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
In therapy of chronic hepatitis B, there are new and exciting developments in antivirals such as nucleotide analogues. Adefovir dipivoxil is an oral prodrug of adefovir, a nucleotide analogue of adenosine monophosphate. This agent has a potent in vitro and in vivo effect against herpes virus, retroviruses, and hepadnaviruses. In the hepatitis B virus (HBV) setting, adefovir dipivoxil inhibits both the wild type and lamivudine-resistant HBV strains. The safety profile of adefovir dipivoxil 10 mg is excellent, but higher doses can produce renal tubular damage, particularly when the drug is used for prolonged therapy. Adefovir dipivoxil is an important new addition to the current first-line treatments for HBeAg positive and negative chronic hepatitis B, as well as being rescue therapy for lamivudine-resistant HBV strains. It is also licensed for use in adults with decompensated liver disease, as well as compensated liver disease where there is evidence of active viral replication, persistently elevated serum alanine aminotransferase levels and active liver inflammation and fibrosis. However, a longer follow-up is needed to establish the long term safety and efficacy of adefovir dipivoxil in patients with chronic HBV infection.(Korean J Gastroenterol 2003;42:357-362)
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; Lamivudine 치료 후 만성 B형 간염환자의 혈청내 Nitric Oxide(NO) 대사체 농도의 감소
조용균 ( Jo Yong Gyun ),김병익 ( Kim Byeong Ig ),황상태 ( Hwang Sang Tae ),김정욱 ( Kim Jeong Ug ),이준행 ( Lee Jun Haeng ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),모지원 ( Mo Ji Won ),박창신 ( Pa 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
대간간학회지 제6차 춘계학술대회 초록집 : 포스터 전시 ; 만성 비대상성 간경변증, 만성간염, 간세포성 간암환자에서 혈청 Thrombopoietin과 비장종대와의 관계
구은실 ( Gu Eun Sil ),김병익 ( Kim Byeong Ig ),조용균 ( Jo Yong Gyun ),김창섭 ( Kim Chang Seob ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),정을순 ( Jeong Eul Sun ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
갑상선 기능 저하증 환자에서의 혈중 Insulin과 C-peptide의 변화
이화영 ( Lee Hwa Yeong ),김광조 ( Kim Gwang Jo ),김천중 ( Kim Cheon Jung ),김병익 ( Kim Byeong Ig ),전우규 ( Jeon U Gyu ),이만호 ( Lee Man Ho ),정을순 ( Jeong Eul Sun ),이상종 ( Lee Sang Jong ) 대한내과학회 1993 대한내과학회지 Vol.44 No.1
연구배경 : 갑상선 호르몬이 인슐린과 C-peptide 대사에 영향을 미친다는 여러 연구결과들이 보고되고 있으나 아직 상반된 결과들이 많다. 방법 : 저자들은 1989년 3월부터 1992년 4월 사이에 본병원 내과에 입원한 정상대조군 14예와 갑상선 기능저하증 환자 19예에서 경구적 당부하후에 공복시, 1시간 및 2시간에 각각 혈청 C-peptide, 혈청 인슐린, 혈당치 및 C-peptide/인슐린비를 측정하였다. 결과 : 1) 혈청 C-peptide치는 갑상선 기능 저하증 환자군에서 공복시에는 정상대조군과 유사하였으나 당부하 2시간에서 의미있게 증가하였다(p<0.05). 2) 혈청 인슐린치는 갑상선 기능 저하증 환자군에서 정상대조군과 비교해 공복시보다는 당부하후 1시간, 2시간에 의미있게 증가되었다(p<0.05). 3) 혈당치는 갑상선 기능저하증 환자군에서 정상대조군과 비교시 당부하 1시간에 의미있게 증가되었다(p<0.05). 4) C-peptide/인슐린비는 양군에서 통계학적 의의는 없었다. 결론 : 이상의 결과에서 갑상선 기능저하증 환자군에서 정상대조군과 비교할 때 혈청C-peptide 및 혈청 인슐린의 충분한 분비에도 불구하고 혈당치가 증가되어 있음을 보여준다. 이는 혈청 C-peptide와 혈청 인슐린는 갑상선 기능저하증에 기인되는 대사율의 저하에 의한 결과로 추정되나 앞으로 이에 대한 연구가 계속되어야 할 것으로 생각된다. Background : Studies for the effect of thyroid hormones on secretion of insulin and glucose metabolism have been reported, but those results appear to be controversial. Methods : We have investignated the levels of serum C-peptide and insulin following the oral glucose load in 19 patients with hypothyroidism and 14 normal subjects. Results : 1) T도 mean fating level of serum C-peptide in hypothyroidism was somewhat elevated. The response of serum C-peptide was significantly enhanced 2 hours after oral glucose tolerance test in hypothyroid patients (5.16±2.31 Vs 2.01±1.05 ng/ml) (p<0.05). 2) Serum insulin response was exaggerated after oral glucose tolerance test in hypothyroidism. (GTT 1 hour : 90.74±33.56 Vs 61.19±22.91uU/ml, GTT 2 hour : 74.23±36.47 Vs 49.30±0.83 uU/ml) (p<0.05). 3) Blood glucose response has been significantly augmented in hypothyroid patients after oral glucose tolerance test. (GTT 1 hour : 129.47±40.20 Vs 98.21±9.10mg/dl) (p<0.05). 4) The ratio of C-peptide to insulin had no significant difference between patients with hypothyroidism and normal subjects statistically. Conclusion : These results suggested that the slowing of C-peptide and insulin degradation due to hypometabolism in hypothyroidism could be contributed to higher serum levels of the C-peptide and insulin.
변재원 ( Byeon Jae Won ),박근태 ( Park Geun Tae ),이장한 ( Lee Jang Han ),김선일 ( Kim Seon Il ),최호순 ( Choe Ho Sun ),안동현 ( An Dong Hyeon ),김병익 ( Kim Byeong Ig ),이민호 ( Lee Min Ho ) 대한내과학회 2004 대한내과학회지 Vol.66 No.2
목적 : 간성뇌증은 급만성 간질환에서 주의집중력, 인지기능 및 운동기능의 장애를 유발할 수 있는 합병증으로 경중에 따라 1-4기까지 구별된다. 최소증상 간성뇌증은 일반적인 진찰 또는 검사로는 이상을 발견할 수 없고 신경인지 검사에서만 이상소견을 보인다. 따라서 논란은 있지만 환자들은 집중력이 요구되거나 정밀한 운동 기술이 요구되는 생활에 지장을 초래하게 되므로 조기진단 및 치료가 중요하다고 여러 연구에서 보고 되고 있다. 현재까지 이 질환의 조기 진단법 Background : Minimal (subclinical) hepatic encephalopathy (mHE) currently diagnosed by psychometric tests or neurophysiological test adversely affects daily functioning. In view of its sociomedical relevance, simple and reproducible tests for routine diag