양안에 발생한 홍채낭종 1예

김무상,진경현,김동희.Moo-Sang Kim. M.D.. Kyung-Hyun Jin. M.D.. Dong-Hee Kim. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.7

Purpose: Iris cyst is a rare condition and there has been no Korean report of bilateral iris cyst. The authors present the first Korean report of a patient with bilateral iris cysts. Methods: A 62-year-old man presented with intermittent visual field disturbance of the left eye when exposed to bright light. The patient underwent visual field examination and slit lamp examination. On slit lamp examination, a dark-brown mass was revealed along the lateral pupillary margin in the left eye. In the right eye, the shape of the iris was convex at the 8 o`clock direction. Ultrasound biomicroscopy, confirmed the presence of a mass. Results: The patient showed no specific abnormality in visual field examination. Ultrasound biomicroscopy showed the objects to be cystic, with a thin-walled homogenous hypoechoic lesion on the posterior surface of the iris in both eyes. There were two cysts in each eye measuring 4.35 mm×1.13 mm and 1.47 mm×1.11 mm in the left eye, and 1.05 mm×1.02 mm and 1.90 mm×1.05 mm in the right eye. Conclusions: Asymptomatic iris cyst does not need to undergo treatment, but careful examination is nevertheless required required at regular intervals in case a complication develops.

다리뇌출혈로 인해 발생한 양방향 수평주시마비 1예

김무상,박인기.Moo-Sang Kim. M.D.. In-Ki Park. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.10

Purpose: To report a case of bilateral horizontal gaze palsy associated with pontine hemorrhage. Methods: A 51-year-old man developed a sudden decrease in consciousness. Computed tomography reveal a pontine hemorrhage and infarctions of both basal ganglia. The mentality was recovered after conservative treatment, but he complained of difficulty in moving his eyes. We performed ophthalmic and radiologic evaluations to confirm a diagnosis of bilateral horizontal gaze palsy and to reveal the condition. Results: On ophthalmic examination, his eye showed complete bilateral horizontal gaze palsy, but convergence and vertical eye movements were normal. Radiologic evaluation revealed a pontine hemorrhage, and the hemorrhagic area was consistent the bilateral paramedian pontine reticular formation (PPRF).

미세각막절개도를 이용하여 얻은 돼지눈 표층이식편의 두께 및 지름 예측성

김무상,이승찬,이승준,진경현,Moo Sang Kim,Seung Chan Lee,Seung Jun Lee,Kyung Hyun Jin 대한안과학회 2007 대한안과학회지 Vol.48 No.4

시험모델 정밀도가 공력성능 예측에 미치는 영향에 관한 연구

김무상(Moo-Sang Kim),기정도(Jung-Do Kee),오민수(Min-Su Oh) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

Vehicle aerodynamic performance is developed using both full-scale wind tunnel as well as quarter scale model at Hyundai-Kia Nam_yang R&D Center. The model wind tunnel is a relatively useful tool compared to the full-scale wind tunnel especially when the aerodynamic performance of a new vehicle is being predicted during the styling stage for a new vehicle. Model scale test can provide valuable aerodynamic data well before the prototype or pilot vehicle construction stage if the geometry and Reynolds similarities are considered properly for the scale model. The prediction accuracy of vehicle aerodynamic performance depends on the detailing of the test model such as underbody and engine room geometry.

An Experimental Study on the Aerodynamic Characteristics around Moving Bodies near the Ground

Moo-Sang Kim(김무상),Tae-Yoon Kim(김태윤),Jung-Do Kee(기정도),Dong-Ho Lee(이동호) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

The objective of present study is to compare the flow characteristics around moving bodies near the ground. The influence of the gap height and ground conditions, the moving and fixed grounds, on the aerodynamic forces as well as the dynamic behavior of the wake flow around the square cylinder near a ground is investigated. The model wind tunnel experiments were carried out in an open circuit low turbulence subsonic wind tunnel. The wind tunnel is equipped with moving belt system to simulate the ground effect. The mean velocity and the turbulent field around a square cylinder were measured using a two-component Particle Image Velocimetry (PlV). From the velocity profiles in wake region, the pressure recovery on a moving ground decreases due to the high momentum supply, finally causing the drag to increase from the fixed ground, while the lift has opposite pattern. Through the full scale wind tunnel testing, aerodynamic force difference occurs under ground conditions and increases as yaw angle increases. Therefore the adequate ground simulation is necessary to enhance the control stability under the transient crosswind.

서울근교 약수터에서 분리한 Pseudomonas속균의 혈청생화학적 특성 및 항균제 감수성

박석기,김무상,함희진,김은정,황광호,Park, Seog-Gee,Kim, Moo-Sang,Ham, Hee-Jin,Kim, Eun-Jung,Hwang, Kwan-Ho 한국식품위생안전성학회 1998 한국식품위생안전성학회지 Vol.13 No.3

서울시내 약수에서 Pseudomonas속균의 균종분포, 생화학적 특성, 혈청학적 특성 및 항생제 감수성을 조사하기 위하여 약수 57개소에 대하여 봄, 여름, 가을에 걸쳐 조사하였다. 총 57개 약수를 조사한 결과, 33개 (57.9%)의 약수에서 Pseudomonas속균이 검출되었다. 봄, 여름, 가을에 모두 검출된 곳은 1곳(1.8%) 이었으며, 2회에 걸쳐 검출된 곳은 9곳 (15.8%)이었으며, 1회만 검출된 곳은 13곳 (22.8%)이었다. 지역별로는 청계산이 50%의 검출율을 나타내었으며, 북한산, 35.7&, 대모산 33.3%, 도봉산 29.6%, 수락산 25.9%, 우면산 22.2%, 불암산 7.4% 순이었다. 분리된 균종은 Ps. putidark 22주(50%)로 가장 많았으며, Ps. aeruginosa, Ps. fluorescens 및 Ps. mendocins 각 6주(13.6%), Ps.aureofaciens 4주(9.1%)이었다. 분리된 Ps. aeruginosa6주의 혈청형은 모두 5종으로 A형 2주 , B, C,E 및 G형 각 2주씩이었다. 분리된 Ps. aeruginosa의 항생제에 대한 내성은 Amoxicillin 90.9%, Chloramphenicol 84.1%, Carbenicillin 81.8%, Nalidixic acid 68.2%, Neomycin 38.6%, Streptomycin 31.8%, Gentamicin 4.6%, Kanamycin 4.6% 그리고 Colistin 2.3%이었다. Ps.aeruginosa는 다른 슈도모나스균에 비해 carbenicillin에 대한 감수성이 있으나 kanamycin에 대한 내성이 높았다. Ps. aureofaciens는 다른 슈도모나스균에 비해 streptomycin에 대하여 내성이 없었다. 분리된 Ps.aeruginosa의 항생제에 대한 다제내성양상은 5제내성이 31.8%로 가장 높았으며, 내성양상에서는 NA-CB-CTE-AMC가 18.2%로 가장 높게 나타났다. In order to investigate the species, serobiological characteristics and antibiotic sensitivity of Pseudomonas spp, we isolated Pseudomonas spp from 57 spring waters around Seoul area for spring, summer and autumn and identified Pseudomonas spp by biochemical characteristics and serological method. And also we tested the antibiotic sensitivity test by discdiffusion method. Of 57 spring waters tested, Pseudomonas spp were isolated from 33 spring waters(57.9%). Isolation rate of Pseudomonas spp in spring season was 28.1%, summer 21.1% and autumn 28.1%. Only 1 spring water was detected Pseudomonas spp in all seasons and 9 (15.8%) were detected for 2 seasons and 13 (22.8%) were for only 1 season. Isolation rate of Pseudomonas spp at Mt. Cheonggye was 50% and followed by Mt. Bookhan 35.7%, Mt. Daemo 33.3%, Mt. Dobong 29.6%, Mt. Surak 25.9%, Mt. Woomyun 22.2% and Mt. Bulam 7.4%. Of 44 Pseudomonas spp, 22 strains (50%) were identified by Ps. putida, Ps. aeruginosa, Ps. fluorescens and Ps. mendocina were identified 6 strains (13.6%), respectively. 4 strains (9.1%) were identified by Ps. aureofaciens. Of 6 Ps. aeruginosa, serotype A was 2 strains, B, E, G, and K was 1 strain, respectively. Of 44 Pseudomonas spp, resistance rate to amoxicillin was 90.9% and followed by chloramphenicol 84.1%, tetracycline 84.1%, carbenicillin 81.8%, nalidixic acid 68.2%, neomycin 38.6%, streptomycin 31.8%, gentamicin 4.6%, kanamycin 4.6% and colistin 2.3%. Ps. aeruginosa was more sensitive to carbenicillin than other Pseudomonas spp isolated from spring waters in Seoul area but more resistant to kanamycin, and Ps. aureofaciens was no resistant to streptomycin. Among multiple drug resistance, resistance to 5 drugs was 31.8%, 4 drugs 15.9%, 7 drugs 13.6%, 1 drug and 2 drugs 4.6%, and 8 drugs 2.3%, respectively. The multiple resistance patterns detected highestly were NA-CB-C-TE-AMC (18.2%), NA-CB-N-C-TE-AMC (13.6%), CBC-TE-AMC (11.4%) and NA-CB-N-C-TE-AMC-S (9.1%).

서울지역 집단식중독 환자에서 검출된 노로바이러스의 유행양상

김은정,김무상,채영주,천두성,Kim, Eun-Jeung,Kim, Moo-Sang,Chae, Young-Zoo,Cheon, Doo-Sung 한국미생물학회 2012 미생물학회지 Vol.48 No.2

Fecal specimens from acute gastroenteritis in Seoul from 2003 to 2007 were collected and then tested for the presence of Norovirus by RT-PCR. Among a total of 4,685 samples investigated, 383 samples (8.2%) were positive. The analysis of outbreaks related norovirus contamination occurred from 2003 to 2007 in Seoul revealed 57 cases happened during investigated period. Seasonal prevalence showed winter season predominant characteristics of pattern of epidemics by long term investigation for norovirus infections. The incidence of norovirus infection in the case of acute gastroenteritis by catering food in school were 32%, by food in general restaurant were 29%. This epidemiological investigation in Seoul was strongly needed for control and prevention of outbreaks related with norovirus by forecasting disease epidemics. 2003년부터 2007년까지 서울지역 집단식중독 환자에 대하여 RT-PCR을 이용하여 노로바이러스를 검출하였으며, 총 4,685건 중 노로바이러스가 383건(8.2%)이 검출되었다. 식중독 발생 사례는 2003년부터 2007년까지 57사례가 발생하였다. 계절별 유행양상은 겨울철에 가장 많이 검출되었다. 섭취장소별 유행양상은 학교급식 중 위탁경영에 의한 발생이 32%로 나타났으며, 일반음식점에 의한 발생이 29%로 나타났다. 본 연구는 서울지역 노로바이러스성 식중독 관리를 위한 기초자료로 활용될 수 있을 것으로 기대된다.

서울지역 설사환자로 부터 분리된 Shigella flexneri의 성상과 유전적 특성

승현정,김무상,오영희,최병현,채희선,초가기,전무형,Seung, Hyun-Jung,Kim, Moo-Sang,Oh, Young-Hee,Choi, Byung-Hyun,Chae, Hee-Sun,Chu, Jiaqi,Jun, Moo-Hyung 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.4

The shigellae are common etiological agents of bacillary dysentery in humans and primates. During four years from 2002 to 2005, 22 strains of Shigella spp. were isolated from the diarrheic patients in Seoul region. All of them were identified as S. flexneri by biochemical tests and serotyping. The prevalence of serotypes were variable by year, but the major serotypes were 2a and 3a. In an antimicrobial susceptibility test, all of the isolates were resistant to streptomycin and tetracycline, and susceptible to amikacin, kanamycin, cefoxitin, and gentamicin. All of the isolates showed the multi-resistant patterns over 3 drugs. By analysis of the plasmid profile the isolates were classified into 7 groups (P1~P7). Serotypes 2a and 2b were distributed to P1, P2, P3, and P4. Serotype 3a was differentiated to P5 and serotype 3b, to P6 and serotype 4a, to P7. PCR results showed that all isolates were positive for two virulence genes, ipaH and ial, but none of the strains had stx gene. The set1A and set1B genes were detected from 12 isolates (54.5%) that belonged to serotype 2a and 2b. The sen gene was detected from 19 isolates (86.4%). The 22 isolates showed 12 to 17 DNA fragments in the sizes ranging from 20.5 kb to 1135 kb, resulting in 13 patterns by the PFGE with Not I digestion. The PFGE patterns of the isolates showed the close relation with the serotypes, but no relations with year of isolation and antimicrobial resistance.

망막정맥폐쇄와 당뇨망막병증에서 황반부종 치료를 위한 유리체내 베바시주맙 주입술의 효과

이승원,김무상,김응석,곽형우,유승영,Seung Won Lee,MD,Moo Sang Kim,MD,Eung Suk Kim,MD,Hyung Woo Kwak,MD,Seung Young Yu,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To evaluate the long-term results of intravitreal bevacizumab injection for macular edema (ME) due to retinal vein obstruction (RVO) and diabetic retinopathy (DR). Methods: The objects of study were patients with decreased visual acuity due to ME with RVO and DR for whom intravitreal injections of 1.25 mg (0.05 ml) bevacizumab were repeated three times with an interval of six weeks and who were available for a follow-up period of more than 12 months. The patients underwent additional bevacizumab injections if ME increased as assessed by optical coherence tomography (OCT). Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline and follow-up visits. Results: There were 16 patients with RVO and 18 patients with DR. In the RVO group, the mean length of follow-up was 12.4±1.1 months, the mean baseline BCVA was 0.75±0.32 and the final BCVA was 0.42±0.25, a difference that was statistically significant (p<0.05). The mean CMT at baseline was 588.5±301.0 μm and this decreased to a mean of 191.8±112.0 μm at the end of the follow-up period (p<0.05). In the DR group, the mean length of follow-up was 15.4±3.2 months, the mean baseline BCVA was 0.63±0.33 and the final BCVA was 0.61±0.37, a difference that was not statistically significant (p>0.05). The mean CMT at baseline was 462.0±195.0 μm and decreased to a mean of 282.2±177.3 μm at the end of the follow-up period (p<0.05). Conclusions: In RVO and DR, three injections of intravitreal bevacizumab with an interval of six weeks and additional injections as indicated were effective in reducing ME and showed especially good results in improvement of visual acuity for ME due to RVO.

서울지역 급성위장관염 환자 및 지하수에서 분리한 A형 로타바이러스의 유전자형

김은정,김무상,채영주,천두성,Kim, Eun-Jeung,Kim, Moo-Sang,Chae, Young-Zoo,Cheon, Doo-Sung 한국미생물학회 2011 미생물학회지 Vol.47 No.4

2009년부터 2010년까지 서울지역에서 산발적으로 발생한 급성위장관염 환자에 대하여 효소면역측정법(ELISA)을 이용하여 로타바이러스를 검출하였다. 총 1,916건 중 로타바이러스는 354건(18.4%)이 검출되었다. RT-PCR을 이용하여 유전자형 분석을 실시한 결과 P6G[4] (35%), P8G[3] (28%), P8G[1] (24%), P4G[2] (10%), P8G[9] (3%)로 나타났다. 서울지역 지하수 70지점을 대상으로 효소면역측정법을 이용하여 로타바이러스를 조사한 결과 2 지점에서 양성으로 검출되었으며, RT-PCR을 이용하여 유전자형 분석을 실시한 결과 P8G[3]로 나타났다. 이러한 연구결과는 서울지역 로타바이러스 질환의 예방을 위한 기초자료로 활용될 것으로 기대된다. Fecal specimens from acute gastroenteritis in Seoul from 2009 to 2010 were collected and then tested for the presence of Group A Rotavirus by ELISA. Among a total of 1,916 samples investigated, 354 samples (18.4%) were positive. The predominant genotypes of positive samples were confirmed as P6G[4] (35%), P8G[3] (28%), P8G[1] (24%), P4G[2] (10%), P8G[9] (3%), respectively. Among a total of 70 ground water samples investigated, 2 samples (2.8%) were positive. The genotypes of positive samples were confirmed as P8G[3] (100%). By this molecular investigation, genotypic distribution associated with rotavirus will be used for control and prevention of rotavirus related diseases.