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고원진,박원영,조준형,조주영,Weon Jin Ko,Won Young Park,Jun-Hyung Cho,Joo Young Cho 대한소화기암연구학회 2014 Journal of digestive cancer reports Vol.2 No.2
We report a case with dysphagia for solids. A 51-year-old man with benign esophageal stricture was transferred for endoscopic treatment. He had lye ingestion history at 9 years old and underwent esophagectomy with right colonic interposition for the treatment of the benign esophageal stricture. But his symptom was acting up 2 years ago and lasted afterward even though he had underwent endoscopic treatments for dysphagia several times, including balloon dilation and stent insertion. He had polypoid enhancing wall thickening around anastomosis site of stomach with perigastric soft tissue density and suspicious nodular extension to omentum on the small bowel computed tomography. So he had a surgical resection of small bowel and jejunojejunostomy, and the pathological result was adenocarcinoma, intestinal type with soft tissue infiltration. Later he underwent total gastrectomy with segmental resection of interpositional colon and segmental resection of duodenum and ileo-colic anastomosis revision. And recently he has been on chemotherapy.
내시경점막하박리술의 적응증을 넘어선 조기위암의 미세침습 치료 후 장기 추적 결과
고원진,조주영,Weon Jin Ko,Joo Young Cho 대한소화기암연구학회 2017 Journal of digestive cancer reports Vol.5 No.1
Background: Recently, endoscopic submucosal dissection (ESD) with laparoscopic sentinel lymph node dissection, named ESN or endoscopic full-thickness gastric resection with laparoscopic sentinel lymph node dissection, named Hybrid-natural orifice transluminal endoscopic surgery (NOTES) was suggested the possibility of minimally invasive treatment for patients with early gastric cancer (EGC) who were beyond the indication of ESD. This study aimed to evaluate the outcomes of ESN or Hybrid-NOTES. Methods: We retrospectively analyzed patients treated with these therapies from January 2009 to May 2013 in terms of short- and long-term outcomes. Each patient was diagnosed with EGC but was not included in ESD indications and had the high risk of lymph node metastasis (LNM). Results: A total of 42 patients with EGC treated by ESN or Hybrid-NOTES. Of the 21 patients who underwent ESN, a total of 4 patients underwent additional gastrectomy, 1 with LNM, 1 with surgical complication, and 2 with noncurative resection. Of the 21 patients who underwent Hybrid-NOTES, a total of 5 patients underwent additional surgery, 1 with LNM, 2 with surgical complication, and 2 with noncurative resection. Overall survival was 100% over a mean follow-up of 75 months, but 3 patients underwent ESD or gastrectomy with metachronous lesion. And 1 patient who had received ESN was found to have a metastatic lymph node and undergo palliative chemotherapy. Conclusion: ESN or Hybrid-NOTES showed favorable short-and long-term outcomes. These methods may be utilized as a bridge between ESD and gastrectomy in the case of EGC which is more likely to have LNM beyond the ESD indications.
고원진 ( Weon Jin Ko ),이병무 ( Byoung Moo Lee ),박원영 ( Won Young Park ),김진녕 ( Jin Nyoung Kim ),조준형 ( Jun Hyung Cho ),이태희 ( Tae Hee Lee ),홍수진 ( Su Jin Hong ),조주영 ( Joo Young Cho ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.6
A 49-year-old woman visited our hospital with dysphagia and chest pain. In another hospital, she was diagnosed as reflux esophagitis. Although she had taken proton pump inhibitor and prokinetics drugs for a long time, she was not relieved of any symptoms. On the basis of high resolution manometry and endoscopic ultrasonography findings, Jackhammer esophagus was diagnosed. In this patient, peroral endoscopic myotomy (POEM) was performed for long myotomy of thickened circular muscle. During the procedure, there were no significant complications and she was discharged uneventfully. Symptoms were completely improved during three months after POEM. Here, we report on a case of Jackhammer esophagus treated by POEM. (Korean J Gastroenterol 2014;64:370-374)
동종 조혈모세포 이식 이후 고빌리루빈혈증과 경막하출혈을 보인 증례
고원진 ( Weon Jin Ko ),김태영 ( Tae Young Kim ),박소영 ( So Young Park ),최은용 ( Eun Yong Choi ),김시영 ( Si Young Kim ),윤휘중 ( Hwi Joong Yoon ),조경삼 ( Kyung Sam Cho ),정재헌 ( Jae Heon Jeong ),백선경 ( Sun Kyung Baek ) 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
Hyperbilirubinemia is commonly observed following allogenic hematopoietic stem cell transplantation (HSCT). It is sometimes associated with severe complications after HSCT with a major impact on transplant outcomes. Here, we describe a case of a Ph-positive acute lymphoblastic leukemia (ALL) patient with moderate thrombocytopenia who developed subdural hemorrhage (SDH) following allogenic HSCT. He presented with hyperbilirubinemia after a HSCT, so drugs that were known to cause hepatotoxicity were stopped and his situation was reexamined to rule out other causes. But the hyperbilirubinemia was continuous, and we came to the conclusion that hyperbilirubinemia was caused by the blood from the ruptured blood vessel that occurred with the appearance of increased intracranial pressure.
기획헬리코박터 파일로리 감염 연관 위염에서의 위암 발생: 우회를 통한 위암 예방
이상환 ( Sang Hwan Lee ),박종민 ( Jong Min Park ),한영민 ( Young Min Han ),고원진 ( Weon Jin Ko ),함기백 ( Ki Baik Hahm ) 대한소화기학회 2015 대한소화기학회지 Vol.66 No.6
As a commensal or a pathogen, Helicobacter pylori can change the balance of a complex interaction that exists among gastric epithelial cells, microbes, and their environment. Therefore, unraveling this complex relationship of these mixtures can be expected to help prevent cancer as well as troublesome unmet medical needs of H. pylori infection. Though gastric carcinogenesis is a multi-step process, precancerous lesion can be reversible in the early phase of mucosal damage before reaching the stage of no return. However, biomarkers to predict rejuvenation of precancerous atrophic gastritis have not been identified yet and gastric cancer prevention is still regarded as an impregnable fortress. However, when we take the journey from H. pylori-associated gastritis to gastric cancer, it provides us with the clue for prevention since there are two main preventive strategies: eradication and anti-inflammation. The evidence supporting the former strategy is now ongoing in Japan through a nation-wide effort to eradicate H. pylori in patients with chronic gastritis, but suboptimal apprehension to increasing H. pylori resistance to antibiotics and patient non-compliance still exists. The latter strategy has been continued in the author`s research center under siTRP (short-term intervention to revert premalignant lesion) strategy. By focusing on the role of inflammation in the development of H. pylori-associated gastric carcinogenesis, this review is intended to explain the connection between inflammation and gastric cancer. Strategies on H. pylori eradication, removal of inflammation, and reverting preneoplastic lesion will also be introduced. In the end, we expect to be able to prevent gastric cancer by take a detour from the unpleasant journey, i.e. from H. pylori-associated gastritis to gastric cancer.(Korean J Gastroenterol 2015;66:303-311)
면역기능이 정상인 환자에서 저용량 스테로이드를 복용 후 발생한 폐 효모균증 1례
장나은 ( Na Eun Jang ),신아리 ( A Ri Shin ),김혁 ( Hyuck Kim ),이정훈 ( Jung Hoon Lee ),조주희 ( Joo Hee Cho ),고원진 ( Weon Jin Ko ),김태영 ( Tae Young Kim ),김이형 ( Ee Hyung Kim ),유지홍 ( Jee Hong Yoo ),박명재 ( Myung Jae Par 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
Cryptococcus neoformans is an organism that mainly causes opportunistic infection in immunocompromised patients. It can also cause various infections in immunocompetent patients including pulmonary cryptococcosis, but it is rare. Steroids are used in clinical practice for treatment of a wide array of disease, because of their anti-inflammatory or immunosuppressive action. But, steroids use predisposes patients to a variety of infection by interfering with host defense mechanism. Infections associated with steroids are dependent on the route of administration, dose, and duration of therapy. Generally, the rate of infection is not increased in patients receiving low dose and limiting periods administration. We presented a case of pulmonary cryptococcosis obscured by cryptogenic organizing pneumonia (COP) in 68-year old female with an immunocompetent patient after low dose and short duration of steroid therapy and review all published casese.
미분화 암의 동시 항암 화학-방사선 요법 후 발생한 후신경아세포종 1례
김태영 ( Tae Young Kim ),성지연 ( Ji Youn Sung ),이주희 ( Ju Hie Lee ),이정훈 ( Jung Hoon Lee ),고원진 ( Weon Jin Ko ),최은용 ( Eun Yong Choi ),조주희 ( Joo Hee Cho ),김시영 ( Si Young Kim ),윤휘중 ( Hwi Joong Yoon ),조경삼 ( Kyun 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
Olfactory neuroblastoma (ONB) is a rare, malignant tumor of the olfactory epithelium. Especially, radiation induced ONB is extremely rare and only 4 cases were published. We present a case of ONB that occurred after concurrent chemo radiotherapies of undifferentiated carcinoma then treated with surgical resection and combination chemotherapy. And we reviewed the 5 cases of radiation induced ONB including this case. Radiation therapy is increasing in the large percentage of the oncology population. So close observation and suspicion of second primary malignancy including ONB is necessary.
만성 신부전과 갑상선 기능 저하증이 있는 환자에게 동반된 반응성 천공성 교원증 1 례
김혁 ( Hyuck Kim ),소예리 ( Ye Ri So ),이정훈 ( Jung Hoon Lee ),윤현아 ( Hyun A Yun ),석화영 ( Hwa Young Seok ),손정일 ( Jung Il Son ),박소영 ( So Young Park ),조주희 ( Joo Hee Cho ),고원진 ( Weon Jin Ko ),최은용 ( Eun Young Choi 전북대학교 의과학연구소 2012 全北醫大論文集 Vol.36 No.2
Reactive perforating collagenosis is one of a range of essential perforating disorders and is characterized by the transepithelial elimination of altered collagen. Two types have been recognized: the inherited, or childhood form and the acquired, or adult form. Acquired reactive perforating collagenosis is associated with systemic diseases, especially chronic renal failure, diabetes mellitus and/or hypothyroidism. Recently, resolution of lesions in acquired reactive perforating collagenosis by allopurinol has been reported. We report that an allopurinol showed dramatic effects on acquired reactive perforating collagenosis, which was associated with chronic renal failure and hypothyroidism.