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      • KCI등재

        채취방법에 따른 자궁경부세포진검사의 위음성률 비교

        강승룡 ( Seung Ryong Kang ),박찬규 ( Tchan Kyu Park ),이정필 ( Jung Pil Lee ),김정연 ( Jung Yeon Kim ),원종건 ( Jong Gun Won ),김수녕 ( Soo Nyung Kim ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

        In recent years a number of devices have been designed to improve the quality of cervical cytologic smears. The Lonstenn, a new cervical cytology sampling device, was prospectively evaluated. The population consists of 191 patients who visited the outpatient dispensary for cervical cytologic smears at the department of Obstetrics and Gynecology, Yonsei Medical Center from August through December, 1993. The subjects were assigned to one of three techniques: the Lonstenn alone(group 1), a combination of Cytobrush plus spatula(group 2), and a combination of cotton swab plus spatula. The cervix was inspected colposcopically and sampled by biopsy in all patients. The histopathologic findings were compared with the findings of cervical cytologic smears obtained by the three sampling techniques. Bethesda system was used in the classification of cervical cytologic smears, higher grade than LGSIL was defined as a positive finding. Higher grade than CIN I was defined as a positive finding in colposcopic directed biopsy. The results are as follows: 1. Comparing the distribution of patient age among the three groups, 69 patients sampled by Lonstenn alone ranged from 30 to 63 years(mean 46.2 years), 74 patients by Cytobrush plus spatula ranged from 25 to 76 years(mean 46.2 years), and 48 patients by cotton swab plus spatula ranged from 25 to 75 years(mean 44.2 years). 2. Comparing the results of positive cytologic smears and dysplastic or cancer cells seen in colposcopic directed biopsy, the sensitivity and specificity was 67 % and 96 % in the group sampled by Lonstenn alone, 79 % and 96 % in the group sampled by Cytobrush plus spatula, and 62 % and 96% in the group sampled by cotton swab plus spatula, respectively. 3. The false-negative rate was 33 % in the Lonstenn group, 21 % in the Cytobrush plus spatula group, and 38 % in the cotton swab plus spatula group, respectively. 4. The positive predictive value was 80 % in the Lonstenn group, 92 % in the Cytobrush plus spatula group, and 80 % in the cotton swab plus spatula group, respectively. 5. In postmenopausal patients, both Lonstenn group and Cytobrush plus spatula group showed the highest sensitivity in obtaining dysplastic or cancer cells. In premenopausal patients, Cytobrush plus spatula group showed the highest sensitivity in obtaining dysplastic or cancer cells. The above results suggest that the combination of Cytobrush plus spatula is the most adequate screening method for detection of dysplastic or cancer cells.

      • KCI등재

        임신중 발생한 포진상 농가진 1예

        김동현 ( Dong Hyun Kim ),한승경 ( Sung Kyung Hann ),김세광 ( Sei Kwang Kim ),강승룡 ( Seung Ryong Kang ),이지원 ( Ji Won Yi ),김재욱 ( Jae Wook Kim ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

        Impetigo herpetiformis is a rare disease, which traditionally has been classified among the unique dermatoses of pregnancy. It is associated· with severe maternal and fetal complications in case of misdiagnosis and delayed treatment. Diagnosis is based on the overall clinical, laboratory, and histological features. Promt and aggressive treatment is needed, and termination was effective in severe case. This pregnant woman was 32-years-old multigravida with transverse lie of fetus. At 24 weeks gestation, she developed erythematous scaly annular patchs with papules and pustules on inner thigh. The skin lesion was aggravated at 31 gestational weeks. The skin of the affected area was biopsied and the result was consisitent with impetigo herpetiformis. Treatment commenced with intravenous fluids, intravenous dexamethasone under the careful fetal well being monitoring. Cesarean section was done due to transverse lie of fetus, and a normal healthy baby was delivered, following which the patient condition improved rapidly. At one month after the delivery, the skin lesions of the patient was fully recovered.

      • KCI등재

        태아 손의 선천성 절단이 동반된 양막외임신

        박동수 ( Dong Su Park ),정용욱 ( Yong Wook Jung ),이지은 ( Jee Eun Lee ),김영주 ( Yonng Joo Kim ),장태기 ( Tae Kee Jang ),강승룡 ( Seung Ryong Kang ),이건호 ( Gun Ho Lee ) 대한주산의학회 2012 Perinatology Vol.23 No.1

        Extra-amniotic pregnancy, which is caused by rupture of amniotic membranes only, is a rare event during pregnancy. This differs from extra-membranous pregnancy in which both chorionic and amniotic membranes rupture. Extra-amniotic pregnancy requires attention by an obstetrician not to miss fetal anomalies because extra-amniotic pregnancy may accompany with fibrous band syndrome. We experienced a case of extraamniotic pregnancy with congenital amputation of bilateral fetal hands. And we report it with brief review of literatures.

      • KCI등재

        증례: 선천성 근진장성 근이영양증과 연관된 재발성 양수과다증 1예

        양옥현 ( Ok Hyun Yang ),이민규 ( Min Kyu Lee ),이건호 ( Geun Ho Lee ),공두식 ( Du Sik Gong ),장태기 ( Tae Gee Jang ),백종우 ( Jong Woo Baek ),강승룡 ( Seung Ryong Kang ),백영일 ( Young Il Back ) 대한주산의학회 2005 Perinatology Vol.16 No.3

        선천성 근긴장성 이영양증은 상염색체 우성으로 유전되는 근긴장성 이영양증의 드문 형태로, 발생율이 신생아 10만 명당 13명 정도이다. 이환된 신생아는 자궁내 발육지연, 조산, 가사, 호흡곤란이 있고, 전신적인 근긴장 저하는 항상 동반이 된다. 수유장애가 흔하여 단백질 손실 장염, 태아수종증(hydrops fetalis), 신생아 폐동맥 고혈압 지속증(persistent pulmonary hypertension of newborn)이 동반된다. 약 25%가 18개월 이내 사망하게 된다. 분자생물학적으로 Dystrophia myotonica-protein kinase(DMPK)에 관여하는 염색체 19q 13.3의 CTG 삼핵산의 불안정한 상염기 반복시의 변이에 의해 생긴다. 병의 중증도는 CTG 확장 길이와 연관있다. 양수과다증과 태동의 감소, 조기분만, 분만 후, 근긴장 저하 등의 소견과 같은 과거력이 있을 시에는 가족력과, 부모, 신생아의 근긴장성 이 영양증에 대한 PCR을 시행하여야 하겠다. 근긴장성 근이영양증의 산전진단은 태아의 융모막 생검이나 양수검사에 의한 PCR의 검사를 통하여 가능하다. 저자들은 두 번의 조산을 경험한 산모에 있어, 세 번째 임신에서 PCR을 통해 재발된 선천성 근긴장성 이영양증 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Congenital myotonic dystrophy is an autosomal dominantly inherited myotonic dystrophy, rare form, with an incidence estimated to be 13/100,000 liveborns. Affected newborns can present with intrauterine growth retardation, prematurity, birth asphyxia, respiratory distress, and always exhibit generalized muscular hypotonia. Feeding problems are common and an association with protein losing enteropathy, hydrops fetalis, and persistent pulmonary hypertension of the newborn has been described. Twenty-five percent of the affected infants die within the first 18 months of life. The molecular basis is an unstable DNA fragment consisting of a variable expansion of a CTG triplet, Dystrophia myotonica-protein kinase (DMPK) which is localized on chromosome 19q 13.3 The severity of the disease is directly correlated to the length of the CTG sequence. Women with idiopathic polyhydroamnios, decreased fetal movement, prematurity, hypotonia, should be counselled family, and mother, father and baby should be evaluated congenital myotonic dystrophy, as PCR (polymerase chain reaction). It is possible to diagnose congenital myotonic dystrophy, by PCR, antenatal test, such as CVS, amniocentensis. We experienced a case of recurrent congenital myotonic dystrophy, with neonatal death, twice, and report with a review of related literatures.

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