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천명이 있으면서 정상 폐환기 기능 성적을 보인 천식 환자의 임상 분석
최인선,임호,고영일,정세웅 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : Wheezing is one of the characteristics of asthma. Intensity of wheezing is correlated with the severity of airway obstruction. However, some asthmatic patients may show wheezing despite normal ventilatory function. Objective : To determine the cause of wheezing in asthmatic patients with normal ventilatory function. Methods : Thirty-eight consecutive asthmatic patients with wheezing despite FEV 180% of predicted value were retrospectively examined for clinical data. Results : Twenty-seven patients (71.1%) were women. Sixteen patients (42.1%) showed airway obstruction based on the Intermountain Thoracic Society criteria. Patients with airway obstruction had significantly lower FEF50% than did those without it (F<.001). When the patients with no wheezing were re-examined by the pulmonary function test, 14 patients (48.3%) showed a significant bronchodilation. In patients without airway obstruction, FEF50/FIF50 was significantly higher than in those with it(F<.01). and FEF50/FIF50 >1 suggesting upper airway obstruction was observed in 7 of 16 (43.8%) patients. Associated diseases were rhinitis in 21 (55.3%) patients, sinusitis in 18 (47.4%), and postnasal drip syndrome in 3 (7.9%). Conclusions : Wheezing despite normal ventilatory function in asthma occurs more often in women. It may be related to reversible airway obstruction in nearly half patients and to upper airway obstruction such as rhinitis, in considerable numbers of the remaining patients. (J Asthma Allergy Clin Immunol 24 : 85-93, 2004)
Antioxidant Responsiveness in BALB/c Mice Exposed to Ozone
Jang, An-Soo,Choi, Inseon-S.,Yang, Sung-Yeul,Kim, Young-Gon,Lee, June-Hyuk,Park, Sung-Woo,Park, Choon-Sik S. Karger AG 2005 Respiration Vol.72 No.1
<P><I>Background:</I> A single, acute exposure to ozone has been shown to modify the antioxidant defense mechanism in the respiratory tract. <I>Objective:</I> The aim of this study was to evaluate the effects of ozone exposure on antioxidant response in BALB/c mice. <I>Methods:</I> We measured enhanced pause of breathing (Penh) as a marker of airway obstruction using barometric whole-body plethysmography before and after ozone exposure [groups (n = 6): filtered air, 0.12 ppm, 0.5 ppm, 1 ppm, 2 ppm] for 3 h. Antioxidant levels were measured using high-performance liquid chromatography with electrochemical detection in bronchoalveolar lavage (BAL) fluid and lung tissue homogenates. <I>Results:</I> Malondialdehyde concentrations in lung tissue homogenates were significantly increased in the group exposed to 2-ppm ozone compared to the filtered air group. Uric acid and γ-tocopherol concentrations in BAL fluid were significantly increased in the ozone exposure group compared to the filtered air group (p < 0.01). Uric acid concentrations were increased in a concentration-dependent manner according to ozone concentration to which the animals were exposed. Increases in Penh after ozone exposure were significantly higher in an ozone concentration-dependent manner. The proportion of neutrophils in BAL fluid was significantly higher in the group exposed to 2 ppm than in the filtered air and the group exposed to 0.12 ppm (p < 0.01, respectively). The level of ascorbate correlated with the level of γ-tocopherol. <I>Conclusion:</I> These findings suggest that antioxidant responses may serve as a protective mechanism against a range of oxidants in BALB/c mice exposed to ozone. </P><P>Copyright © 2005 S. Karger AG, Basel</P>
BALB/c 생쥐에서 천식 발생에 대한 dehydroepiandrosterone의 억제효과
최용,최인선,고영일,고영아,이현철 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : Dehydroepiandrosterone(DHEA). and adrenal androgen, may regulate Th1/Th2 cytokines. Objective : To determine whether DHEA have a preventive effect against the development of asthma, a Th2-associated disease. Materials and methods : Female BALB/c mice were fed with a standard diet incorporated with 0.1% (w/w) of DHEA for 1 week before sensitization with ovalbumin(OVA. 20㎍ i.p. twice with 2-week intervals). Enhanced pause (Penh) was monitored after 1% OVA inhalations for 3 successive days, and then the methacholine bronchoprovocation tests were performed using a whole-body plethysmography system. Analyses of inflammatory cells, cytokines, and OVA-specific IgE were carried out. Results : Both the excessive airway narrowing (maximum Penh) and the airway hypersensitivity (PC200, ㎎/mL) to methacholine were significantly suppressed with the DHEA pretreatment (F<.05 and F<.01, respectively). However, the numbers of the inflammatory cells and the levels of interleukin(IL)-4, IL-5, and IFN-γ in the bronchoalveolar lavage fluid, the production of IL-4, IL-5, and IFN-γ by Con A-stimulated splenocytes, and the serum IgE level in DHEA group were not significantly different from those in asthma group. Conclusion : DHEA pretreatment could suppress the development of asthmatic airway hyperresponsiveness without suppression of Th2 cytokines and airway inflammation. (J. Asthma Allergy Clin Immunol 24 : 116-26, 2004)
알레르기 진단에 있어서 morphine 피부단자시험의 임상적 가치
박석채,강광원,최인선 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3
Background: Few studies have demonstrated an enhanced skin responsiveness to opiates in atopic subjects. Objective: To determine whether the skin response to morphine is increased in atopics and to assess the clinical usefulness of morphine skin prick test in diagnosis of allergic diseases. Method: Allergy skin prick tests were performed using 55 common allergens, histamine, and morphine in 158 patients with allergic diseases. Results: Wheal and flare sizes for morphine (1mg/mL) were significantly related to and smaller than those for histamine (1mg/mL). Although the proportion of subjects with allergic rhinitis and the level of serum total IgE were not different between responders (wheal >- 2mm) and nonresponders to morphine, the positive response rate to allergens was significantly lower in nonresponders. The flare sizes for morphine were significantly higher in positive allergen test group (A/H ratio >- 0.5). Among positive allergen test group, the subjects with atopy score >- 5 showed a larger flare size for morphine than those with atopy score < 5 while the sizes for histamine were not different. Conclusion: Morphine skin prick test is helpful for detecting false negative responses to allergens, and morphine skin test responses are increased in highly atopic patients probably due to enhanced mast cell releasability.
여천공단지역의 아이소시아네이트 노출작업자에서 기도과민성
문재동,이강진,이숭,장안수,서정평,최인선,양승원 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3
Objective: To investigate the prevalence of airway hyperresponsiveness induced by isocyanate at one petrochemical industry complex in Yeochon, Korea. Methods: Questionnaires, allergic skin prick test, toluene diisocyanate (TDI)-specific IgE, and non-specific airway hyperresponsiveness (AHR) were studied in 73 exposed workers and 27 control subjects. Methacholine challenge tests were done and bronchial responsiveness (BR index) was defined as log (% fall of FEV1)/ log (last concentration of methacholine +10). Results: Twenty-three workers (31.5% ) had respiratory symptoms, 21 had nasal symptoms, and eight had skin symptoms. Exposed workers with respiratory symptoms (n=22) had significantly higher BR index than those without them (0.82+-0.06 vs 0.60+-0.02, p<0.05). Exposed workers tended to have higher BR index than controls (0.67+-0.03 vs 0.62+-0.02). Three exposed workers had PC20 methacholine <2.0 mg/ml. There were no significant differences in atopy score between exposed workers and controls (p)0.05). Specific IgE antibodies were found in 19.7% of exposed workers. FEV, showed a significant negative correlation with BR index (r =-0.25, p<0.05). Poor correlation was noted between BR index and atopy, smoking status, or exposure duration. Conclusion: These findings suggest that workers exposed to isocyanates are at higher risk of airway hyperresponsiveness.