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( Kwanghee Won ),( Suyeon Jo ),( Yejin Lee ),( Sungeun Chang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Tyrosine kinase inhibitors are associated with various adverse cutaneous reactions including pigmentary change. Radotinib is a novel and selective BCR-ABL1 tyrosine kinase inhibitor which has shown activity and safety in the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia. A 69-year-old Korean man presented with lentiginosis after taking radotinib for 6 months. On histopathologic examination, the numbers of melanocytes and melanin pigment were increased due to c-KIT activation, consequently up-regulating MITF. It is discordant with mechanisms of previously reported tyrosine kinase inhibitors inhibiting c-KIT.
뼈에 발생한 악성 림프종 환자의 치료 효과 판정에서 ^(18)F-FDG Positron Emission Tomography의 유용성
김남돈,박연희,기승석,박용진,김형준,류백렬,김흥태,김성은,천기정,최창운,임상무 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5
원발성골림프종은 매우 드문 질환이기는 하나, 복합항암요법이나 방사선 치료등에 높은 반응율을 보이며, 좋은 예후를 가지는 림프절의 비호지킨 림프종의 일종이다. 그러나, 치료 효과 판정에 있어 골병변의 특이성에 의한 모호한 방사선학적 특징으로 어려움이 있어 왔다. 본 증례는 위와 같은 원발성골림프종 환자에서 PET 스캔을 사용하여 민감하게 완전 반응을 평가할 수 있었던 예로, 앞으로 다른 고식적인 방법과 함께 이 질환의 진단과 치료 평가 있어 유용하게 사용 될 수 있을 것으로 전망할 수 있었다. Purpose: Accurate assessment of the lesion after treatment of patients with bone lymphoma is difficult. In this patient who demonstrated complete remission after chemotherapy, the regions of fluorine-18 fluorodeoxyglucose (^(18)FFDG)PET uptake diminished more rapidly following therapy, indicating a complete response at much earlier stage than did Magnetic Resonance Imaging (MRI) or CT based findings. With the conventional methods, such as MRI and CT. It was difficult to assess whether the residual tumor tissue was viable or not. Decision to complete response is very important in patients with ymphoma to plan the further treatment. We experienced a patient with primary lymphoma of bone who revealed complete response to chemotherapy on ^(18)FFDGPET while CT showed persistent destructive bone lesion. Thus, ^(18)FFDGPET study after therapy may be superior to CT in the evaluation of response to treatment in primary lymphoma of bone.
P212 The treatment of pigmentary skin lesions using 1,927nm thulium laser “Lavieen<sup>R</sup>”
( Sungeun Chang ),( Hojeong Shin ),( Woojin Lee ),( Chonghyun Won ),( Jeeho Choi ),( Miwoo Lee ),( Sunyoung Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: The treatment of pigmentary skin lesions has always been a challenge for dermatologists. Fractional 1927nm Thullium laser (Lavieen<sup>R</sup>) has shown effectiveness in treating melasma, postinflammatory hyperpigmentation and seborrheic keratosis. Objectives: We aimed to treat refractory cases of diverse pigmentatry lesions using the fractional 1927nm Thullium laser. 8 patients with melasma, PIH, seborrheic keratosis, pigmented contact dermatitis were treated. Methods: A total of 8 patients with refractory pigmentary lesions were included. A single treatment session using the fractional 1927nm Thullium laser was carried out in 5 patients and 2 sessions with a 4-week interval were done in 3 of the patients. In a subset of patients, post-procedural topical application of polydeoxyribonucleotide (Placentex<sup>R</sup>) was performed. Clinical efficacy was assessed using pre- and post-treatment clinical photographs. Results: All patients exhibited mild to moderate therapeutic responses with high levels of satisfaction. No serious adverse event was reported. Interestingly, the post-procedural application of whitening agents significantly improved the clinical outcome, probably owing to the facilitation of active agents`` delivery to the dermis. Conclusion: Overall, fractional 1927nm Thullium laser (Lavieen<sup>R</sup>) seems to be an effective therapeutic option to treat a variety of pigmentary lesions with minimal downtime and could also be a promising tool to boost dermal drug delivery.
Lee, Gyu Hyun,Jin, Youngeup,Lee, Sungeun,Lee, Jong Gun,Kim, Jin Young,Lee, Kwanghee,Jin, Sung-Ho,Ha, Chang-Sik,Won, Mi-Sook,Kang, Shin-Won,Suh, Hongsuk 부산대학교 유전공학연구소 2002 분자생물학 연구보 Vol.18 No.-
There have been extensive research efforts on organic electroluminescent devices (OELDs) with the aim of application for the flat panel display (FPD). OELDs have also attracted much interest because of their particular low driving voltage, convenient design of the device structures, possible control of emission band, and low fabrication cost compared with any other devices. OELDs can be classified as either molecular or polymer-based. Molecular-based devices consist of vacuum deposited fluorescent emitter layers whereas polymer-based devices consist of either spinor dip-coated layers. Most of the research in the field of polymer-chain conducting polymers such as poly(plenylene vinylene) (PPV), poly(p-phenylene) (PPP), their copolymers and soluble derivatives. Other groups have reported non-conjugated polymers with pendant chromophores for OELDs. The attachment of the fluorophore as the pendant group of a random-coil polymer presents several advantages: (1) the synthetic route would be simpler than that used for main-chain polymers; (2) the moderate solubility could be obtained by the nature of the backbone; (3) the emission wavelength would be easily controllable. We, recently, reported the PU polymer with the 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM) dye as the pendant. Even though it is known that the PU backbone have many quenching sites, the turn-on voltage of the PU-DCM device was ca. 5 V. Also, the change of the fluorophores in the side chain from para-cyanostilbene(PU-CN) to DCN (PU-DCM) caused the shift of PL emission wavelength. For the PL emission spectra of PU-CN and PU-DCM, the maximum peaks were at ca. 520 and 630 nm, respectively, corresponding to the maximum PL peaks. Therefore, EL, and PL properties can be changed using different lumophore pendant groups possibly caused by the electron withdrawing effect of the DCM prndant. In the present work, PU derivatives with stilbene pendant. In the present work, PU derivatives with stilbene pendant containing one or two fluoro group were introduced on the stilbene side chain. OELDs using polyurethane derivatives with stilbene pendants were fabricated to investigate the effect of the electron withdrawing substituents of the lumophore pendant on the EL and PL properties. Since PU derivatives possess different electron withdrawing substituents on the stilbence pendant, the shift of emission wave-length is expected.
Suicide rates among working-age adults in South Korea before and after the 2008 economic crisis
Chan, Chee Hon,Caine, Eric D,You, Sungeun,Fu, King Wa,Chang, Shu Sen,Yip, Paul Siu Fai BMJ Publishing Group Ltd 2014 Journal of epidemiology & community health Vol.68 No.3
<P><B>Background</B></P><P>Multiple studies have shown that macroeconomic factors are associated with changes in suicide rates. We investigated how changes in economic conditions associated with the recent economic crisis in South Korea influenced suicide rates among working-age adults.</P><P><B>Methods</B></P><P>Time-series analyses were performed to examine the temporal associations of national unemployment rates and sex-employment-specific suicide rates in South Korea from 2003 to 2011, with particular attention to the increases of suicides that occurred during the recessionary period that began in 2008. We also compared the relative risk of suicide among different occupations.</P><P><B>Results</B></P><P>National unemployment rates were positively associated with suicide rates among employed and unemployed men and women, with a 2-month to 3 month lagged period. Significant increases of suicide rates among working-age adults during the recession were detected in most of the subgroups stratified by age, sex and employment status. Forty-three per cent of the increase of suicides was derived from the employed population. Compared with workers in elementary occupations, the relative risk of suicide for mangers increased by threefold during the recessionary period. Among those who were employed, half of the increases in suicides occurred among clerks and workers involved in sales and services.</P><P><B>Conclusions</B></P><P>Changes in macroeconomic conditions are tied to population-level suicide risks for employed and unemployed persons. However, these associations vary depending on sex, employment status and occupational roles. In advance of future economic crises, it is important to develop prevention initiatives intended to reach the diverse populations potentially exposed to the adverse effects of sudden economic disruptions.</P>
Cho, Chang-Won,Ahn, Sungeun,Lim, Tae-Gyu,Hong, Hee-Do,Rhee, Young Kyoung,Yang, Deok-Chun,Jang, Mi Carfax 2017 MEDIATORS OF INFLAMMATION Vol.2017 No.-
<P>We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related molecular mechanisms of a crude polysaccharide (HMFO) obtained from HMF of CW in mice with dextran sulfate sodium- (DSS-) induced colitis and in lipopolysaccharide-induced RAW 264.7 macrophages. HMFO ameliorated the pathological characteristics of colitis and significantly reduced production of proinflammatory cytokines in the serum. Histological analysis indicated that HMFO improved the signs of histological damage such as abnormal crypts, crypt loss, and inflammatory cell infiltration induced by DSS. In addition, HMFO inhibited iNOS and COX-2 protein expression, as well as phosphorylated NF-<I>κ</I>B p65 levels in the colon tissue of mice with DSS-induced colitis. In macrophages, HMFO inhibited several cytokines and enzymes involved in inflammation such as prostaglandin E<SUB>2</SUB>, nitric oxide, tumor necrosis factor-<I>α</I>, interleukin-6, inducible nitric oxide synthase, and cyclooxygenase-2 by attenuating nuclear factor-<I>κ</I>B (NF-<I>κ</I>B) and mitogen-activated protein kinases. HMFO attenuated inflammation both in vitro and in vivo, primarily by inhibiting NF-<I>κ</I>B activation. Our findings indicate that HMFO is a promising remedy for treating inflammatory bowel diseases, such as colitis.</P>