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( Soo Jung Um ),( Su Mi Lee ),( Soo Keol Lee ),( Choon Hee Son ),( Mee Kyung Ko ),( Mee Sook Roh ),( Ki Nam Lee ),( Pil Jo Choi ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.4
Background: It is well-known that cell-free nucleic acids rise in patients with many types of malignancies. Several recent experimental studies using cancer cell lines have shown that changes in cell-free RNA are predictive of the response to chemotherapy. The objective of this study was to determine whether quantification of free RNA can be used as a biomarker for clinical responses to chemotherapy in patients with lung cancer. Methods: Thirty-two patients with lung cancer (non-small cell lung cancer, n=24; small cell lung cancer, n=8) were divided into 2 groups according to their responses to chemotherapy (response group, n=19; non-response group, n=13). Blood samples were collected before and after two cycles of chemotherapy. Real-time quantitative RT-PCR was used for transcript quantification of the glyceraldehyde-3-phosphate dehydrogenase gene. Results: The pre chemotherapy values (Response group 41.36±1.72 vs. Non-response group 41.33±1.54, p=0.78) and post chemotherapy values (Response group 39.92±1.81 vs. Non-response group 40.41±1.47, p=0.40) for cell free RNA concentrations, expressed as Ct GAPDH (threshold cycle glyceraldehyde-3-phosphate dehydrogenase gene) levels, was not different between the two groups. There was no significant relationship between changes in the cell free RNA level clinical responses after chemotherapy (p=0.43). Conclusion: We did not find a correlation between quantification of serum cell free RNA levels and clinical responses to chemotherapy in patients with lung cancer. Further investigations are needed to determine whether the cell free RNA level is a useful predictor of responses to chemotherapy in patients with lung cancer.
A Transient Modeling Of A Fluorescent Lamp At Startup Time
Jung-Keol Ham,Soo Young Lee,Soo Hyun Baek,Ki Young Lee 전력전자학회 1995 ICPE(ISPE)논문집 Vol.1995 No.10
Fluorescent lamps are widely accepted to energy efficient commercial lighting applications. In designing a fluorescent lamp system, a ba11ast des ign heavi1y re1ies on the characterist ic of a fluorescent 1 amp under cons i derat i on. Espe-cially, at startup time, the transient characteristic of a fluorescent lamp puts much tighter specifications of a design.<br/> In this paper, based on the transient characteristic at the startup time, a transient behavioral model of a fluorescent lamp is presented wi th an equivalent circuit. The model is applicable to the wide range of f1uorescent 1 amps provided by different manufacturers.<br/> The experimental results are compared with the results provided by PSPICE simulation. The result shows the mode 1 i s effect ive i n practice. As a result, we could identify more accurate startup constraints to decide the design of either an electromechanical or an electronic ballast.
악성 종양 표지자가 상승된 만성 흉수를 동반한 종격동 기형종
엄수정 ( Soo Jung Um ),양두경 ( Doo Kyung Yang ),이수걸 ( Soo Keol Lee ),손춘희 ( Choon Hee Son ),노미숙 ( Mee Sook Roh ),김기남 ( Ki Nam Kim ),이기남 ( Ki Nam Lee ),최필조 ( Pil Jo Choi ),방정희 ( Jung Heui Bang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.2
Most mediastinal teratomas are histologically well-differentiated tumors and benign. The majority of patients with a mediastinal teratoma are asymptomatic and their tumors are usually discovered incidentally on chest radiography. On rare occasions this tumor will rupture spontaneously into the adjacent organs. A 72-year-old female patient was admitted for dyspnea and she had a multiloculated pleural effusion in the left lung field. Although repeated pleural biopsy and pleural fluid cytology did not prove the presence of malignancy, we assumed that this was a malignant effusion because it revealed consistently high levels of carcinoembryonic antigen and carbohydrate antigen 19-9, and the chest CT scan did not show typical fat or bone density in the mass. Secondary infection and an uncontrolled septic condition due to pleural empyema finally compelled the patient to undergo a surgical operation. Mature teratoma was the final diagnosis and she has done well without recurrence for 2 months.