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( Hyung Rae Sohn ),( Bo Young Min ),( Mun Hyuk Seong ),( Sang Soo Lee ),( Jin Wook Kim ),( Sook Hyang Jeong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Current goals of antiviral therapy in chronic hepatitis B patients are ALT normalization, undetectable HBV DNA level and HBsAg loss. However, HBsAg loss rarely occurs during oral nucleos(t)ide analogue (NA) therapy, and it is not certain how long NA should be maintained in patients who obtain virologic response but still have HBsAg in the serum. Thus, the aim of this study was to determine the relapse rate and the predicting factors of sustained virologic response after withdrawal of oral NA therapy in chronic hepatitis B patients. Methods: CHB patients who were withdrawn from NA (entecavir, lamivudine, clevudine) after at least 6 months of undetectable HBV DNA were enrolled in this retrospective study. The clinical, biochemical and virologic data was obtained and compared in patients with or without viral relapse. The cummulative relapse rate was assessed by Kaplan-Meier method, and multivariate analysis with predictors of sustained viral response by logistic regression analysis. Results: Total 105 CHB patients discontinued NA therapy between April 2003 and March 2012. Among CHB patients, 75, 16, 14 were treated with entecavir, lamivudine and clevudine, respectively. Overall 3, 6, 12 month relapse rates after NA withdrawal were 25.9%, 61.7% and 75.3%, respectively. The 6 month relapse rate was 58.8% in entecavir group, 68.7% in lamivudine group, 69% in clevudine group (p=0.571). In multivariate analysis, duration of oral NA treatment after achievement of virologic response was the only significant predicting factor associated with sustained virologic response. (p=0.042,HR ; 0.001) Conclusions: Early withdrawal of oral NA therapy is associated with high relapse rate regardless of clinical characteristic, biochemical and virologic factors. Prolonged NA therapy may increase the chance for sustained virologic response after withdrawal of NA in CHB.
( Hyung Rae Sohn ),( Bo Young Min ),( Mun Hyuk Seong ),( Sang Soo Lee ),( Jin Wook Kim ),( Sook Hyang Jeong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Current goals of antiviral therapy in chronic hepatitis B patients are ALT normalization, undetectable HBV DNA level and HBsAg loss. However, HBsAg loss rarely occurs during oral nucleos(t)ide analogue (NA) therapy, and it is not certain how long NA should be maintained in patients who obtain virologic response but still have HBsAg in the serum. Thus, the aim of this study was to determine the relapse rate and the predicting factors of sustained virologic response after withdrawal of oral NA therapy in chronic hepatitis B patients. Methods: CHB patients who were withdrawn from NA (entecavir, lamivudine, clevudine) after at least 6 months of undetectable HBV DNA were enrolled in this retrospective study. The clinical, biochemical and virologic data was obtained and compared in patients with or without viral relapse. The cummulative relapse rate was assessed by Kaplan-Meier method, and multivariate analysis with predictors of sustained viral response by logistic regression analysis. Results: Total 105 CHB patients discontinued NA therapy between April 2003 and March 2012. Among CHB patients, 75, 16, 14 were treated with entecavir, lamivudine and clevudine, respectively. Overall 3, 6, 12 month relapse rates after NA withdrawal were 25.9%, 61.7% and 75.3%, respectively. The 6 month relapse rate was 58.8% in entecavir group, 68.7% in lamivudine group, 69% in clevudine group (p=0.571). In multivariate analysis, duration of oral NA treatment after achievement of virologic response was the only significant predicting factor associated with sustained virologic response. (p=0.042,HR ; 0.001) Conclusions: Early withdrawal of oral NA therapy is associated with high relapse rate regardless of clinical characteristic, biochemical and virologic factors. Prolonged NA therapy may increase the chance for sustained virologic response after withdrawal of NA in CHB
P281 : Clinicopathologic features of progressive macular hypomelanosis in Korea
( Hyun Soo Lee ),( Seong Hyang Sohn ),( Hee Young Kang ),( Eun So Lee ),( You Chan Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The progressive macular hypomelanosis(PMH) is relatively recently described disorder, which was first described in 1988, and more references are considered to be needed. Objectives: The purpose of the study is to document the clinicopathological and ultrastructural features of PMH in Korean patients. Methods: Patients were enrolled who diagnosed as PMH from July 2009 to June 2014 in our hospital. Skin biopsy specimen were obtained from lesional and normal skin and stained with hematoxylin and eosin, Brown and Brenn Gram stain, Fontana-Masson stain, and immunohistochemical stain such asgp-100, Melan-A and MITF. In two patients, electron microscopy was also performed. Results: During 5 years, 16 patients presented with ill-defined hypopigmented macules involving trunk and upper extremities. The mean age was 28.4±9.0 and male to female ratio was about 1:4. Histopathologically, lesional skin showed reduced pigmentation with preserved the number of melanocytes. Electron microscopy demonstrated smaller and less melanized melanosome in lesional keratinocyte. Only one patient showed suspicious bacterial colonization in pilosebaceous duct. Conclusion: PMH is hypopigmentary disorder, which is characterized by loss of melanosome without the damage of melanocyte. There are several reports about the relation between P. acnes and PMH, but it is still unclear.
Qiang Wanga,Ji Hyang Sohn,So Ye Park,Jin Seong Choi,Joo Young Lee,정종식 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.1
Pure phase K4Zr5O12 is synthesized via solid state method in the present work. Various K/Zr ratios and temperatures are applied, and the synthesis process is investigated in detail by means of X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Its catalytic activity for soot oxidation is studied by temperature programmed oxidation with different types of soot/catalyst contacts. It is revealed that K4Zr5O12 is very active in the presence of 2–10% O2 for both tight and loose contacts (Tp(tight) = 335 oC, Tp(ethanol) = 355 oC and Tp(shaking) = 370 oC). Thermal stability study shows that K4Zr5O12 is highly stable up to at least 900 oC.
계절에 따른 Electron Microscopic Block 상태의 변화
손성향,유창규,최임순,Sohn, Seong-Hyang,Yoo, Chang-Kyu,Choe, Rim-Soon 한국현미경학회 1989 Applied microscopy Vol.19 No.2
The specimens for electron microscopic observation made in different seasons have different qualities even though they are made by the same procedure. We observed the various specimens made in each four season. As the results, we concluded that the different specimen conditions were caused by the humidity and penetrability of various solution into the block. In spring, fall and winter, the quality of specimen is good and the difference with one another is not found. But in summer, the specimen have worse quality than in other seasons and not good for sectioning process and observation. In summer with high humidity, we can gain better specimens by eliminating the humidity as much as possible in all processes, thus increasing penetration of various solutions into the specimen.
Reliability and validity of Korean version of modified-Yale preoperative anxiety scale
Kyuwhan Jung,Mi-Hyang Im,Jeong-Min Hwang,Ah-Young Oh,Moon Seok Park,Woo-Jin Jeong,Seong-Chan Kim,Sun-Woo Jung,Hyejin Sohn,Mi-Ok Yoon,Mi-Suk Jang,Suk-Bae Moon 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.1
Purpose: The modified Yale Preoperative Anxiety Scale (mYPAS) was developed for evaluating the level of preoperative anxiety in children. The purpose of this study was to develop a Korean version of the mYPAS (K-mYPAS) and to establish its validity and reliability based on the Korean preoperative pediatric patients. Methods: K-mYPAS was made through stringent back-translation procedure. Total enrolled 102 patients answered questionnaires of Korean version of State-Trait Anxiety Inventory for Children (K-STAIC), and were videotaped for 2 to 5 minutes before induction of anesthesia. Three observers of experienced psychiatrist, surgeon, and nurse analyzed videotape with K-mYPAS comparing to K-STAIC. The inter- and intraobservers reliability, concurrent and construct validity, sensitivity, specificity, and predictive value were analyzed. Results: The value of Cronbach a for interobservers reliability was 0.939 and intraobserver reliability was statistically significant (P < 0.001). Concurrent and construct validity were also statistically significant (P < 0.001 and P < 0.001, respectively). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 81.3%, 91.4%, 81.3%, 91.4%, and 88.2%, respectively. Conclusion: The K-mYPAS had good psychometric properties and can be used as a reliable and valid instrument for the assessment of preoperative anxiety in children.