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A Study of the Endocrine Disrupting Activity of Phthalate Esters using Human Cancer Cell Lines
Han, Sang-Kuk 木浦海洋大學校 2002 論文集 Vol.10 No.1
Phthalate esters have recently been added to the list of chemicals which mimic the female hormone estrogen. However, they have been tested for estrogenic activity only to a very small extent. In this study, therefore, we test to estrogenic and androgenic agonists and antagonists of phthalate esters by E-Screen and A-Screen bioassay. In the E-Screen assay, butylbenzyl phthalate (BBP), di-n-butyl phthalate (DBP), diethyl phthalate (DEP), and di-2-ethylhexyl phthalate (DEHP) showed all weakly estrogenic activity, comparing with β-estradiol-17-acetate (E₂) as positive control. Also, all of them stimulated maximally the proliferation of MCF-7 cells at a concentration of 10 μM. Other phthalate esters tested not showed estrogenic activity. In the A-Screen assay, all of phthalate esters tested showed no androgen agonistic activity. However, BBP and DBP were antiandrogenics in the antagonist assay. Our results demonstrate that hormone mimicking chemicals can have multiple hormonal activities, which may make it difficult to interpret their mechanisms of action in vivo.
Han, Sang-Kuk Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.12
Generation of hydroxyl radical, one of their major active species in ozonation of water was directly observed with spin-trapping/electron spin resonance (ESR) technique using 5,5-dimethyl-pyrrolidine-1-oxyl (DMPO) as a spin-trapping reagent. Hydroxyl radical was trapped with DMPO as a stable radical, DMPO-OH. 80 mM of ozone produced $1.08{\times}10^{-6}$M of DMPO-OH, indicating that 1.4% of ${\cdot}$OH is trapped with DMPO if ${\cdot}$OH is produced stoichiometrically from ozone. Humic acid suppressed DMPO-OH generation in a dose-dependent manner. Generation rate of DMPO-OH was determined with ESR/stopped-flow measurement. Phenol derivatives increased the amount and generation rate of DMPO-OH, indicating that phenol derivatives enhance·OH generation during ozonation of water.
Sung Soo Kim,Hyun Kuk Kim,Hyung Wook Park,Myung Ho Jeong,임경섭,Hae Jin Kee,Yu Hee Ryu,Han Byul Kim,Joo-Young Na,Young-Jae Ki,Keun-Ho Park,Dong-Hyun Choi,Ki Hong Lee,Nam Sik Yoon,Jeong Gwan Cho 대한심장학회 2020 Korean Circulation Journal Vol.50 No.1
Background and Objectives: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular arrhythmia (VA) after AMI in a porcine model. Methods: Twenty pigs were randomly divided into 2 groups based on RDN (RDN, n=10; Sham, n=10). After implanting a loop recorder, AMI was induced by occlusion of the middle left anterior descending coronary artery. Catheter-based RDN was performed for each renal artery immediately after creating AMI. Sham procedure used the same method, but a radiofrequency current was not delivered. Electrocardiography was monitored for 1 hour to observe VA. One week later, the animals were euthanized and the loop recorder data were analyzed. Results: Ventricular fibrillation event rate and the interval from AMI creation to first VA in acute phase were not different between the 2 groups. However, the incidence of premature ventricular complex (PVC) was lower in the RDN than in the Sham. Additionally, RDN inhibited prolongation of the corrected QT (QTc) interval after AMI. The frequency of non-sustained or sustained ventricular tachycardia, arrhythmic death was lower in the RDN group in the early period. Conclusions: RDN reduced the incidence of PVC, inhibited prolongation of the QTc interval, and reduced VA in the early period following an AMI. These results suggest that RDN might be a therapeutic option in patients with electrical instability after AMI.
Chironomidae (Diptera) Fauna of Seoul-Gyeonggi Area in Korea
( Kuk Bon Na ),( Han Il Ree ),( Sang Woo Jung ),( Yeon Jae Bae ) 고려대학교 한국곤충연구소 2010 昆蟲硏究誌 Vol.26 No.-
The Chironomidae (Diptera) fauna of the Seoul-Gyeonggi area in Korea was investigated during 2003-2004. As a result, 41 species in 23 genera and 4 subfamilies including 19 new Korean records, as follows, were identified: Microtendipes tamaogouti Sasa, Microtendipes truncatus Kawai and Sasa, Paracladopelma tamahikawai Sasa, Polypedilum pedestre (Meigen), Stictochironomus sp., Micropsectra shouharasima Sasa, Neozavrelia bicoliocula (Tokunaga), Rheotanytarsus tamaquartus Sasa, Tanytarsus tamaoctavus Sasa, Tanytarsus sp., Euryhapsis subviridis (Siebert), Paratrichocladius rufiventris (Meigen), Conchapelopia quatuormaculata Fittkau, Conchapelopia sp.1, Conchapelopia sp.2, Rheopelopia maculipennis (Zetterstedt), Trissopelopia longimana (Staeger), Potthastia gaedii (Meigen), and Potthastia montium (Edward). List of species was provided with bibliographic sources and material data.