http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성
주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-
Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.
數 種 韓藥의 아세틸콜린에스터레이즈 酵素活性에 대한 효과
최재환,김미영,김현미,최훈,전훈,김대근,임종필,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
아세틸콜린에스터레이즈(AChE)는 신경조직에 분포하는 효소로 신경전달물질 중 아세틸콜린(ACh)을 분해하는 효소로 시냅스 신호전달체계에 있어 중요한 역할을 하는 효소이다. 현재 알츠하이머병과 치매치료에 사용하는 서양약물은 AChE의 활성을 저해하는 작용기전을 가진다. 목적 : 전통적으로 기억력 감퇴, 치매 등 치료에 사용되어 온 한약의 AChE에 대한 작용을 밝히기 위해 본 실험이 구상되었다. 방법 : 생쥐 대뇌신경세포의 균질 혼합액으로부터 효소의 활성을 Ellman 방법을 개선한 엘리자(ELISA)법을 이용하여 측정하였다. 결과 : 실험결과 天花? 의 6종이 2.5㎎/㎖의 농도에서 우수한 효소활성저해력을 보였고, 50% 효소활성 저해농도(ID_50)를 구한 결과, 天花?의 ID_50은 1.5㎎/㎖이었고, ??? 1.2 ㎎/㎖, ?? 2.0 ㎎/㎖, ??草 1.2 ㎎/㎖, ??? 1.0 ㎎/㎖, ??生 1.7㎎/㎖, 및 大?皮 2.0 ㎎/㎖를 나타내어 忍冬?의 저해력이 가장 우수하였다. 결론 : 치매 및 기억력감퇴 증상을 치료하는 한약의 작용기전 중 AChE 효소활성억제효과는 忍冬? 의 6종에서 나타났으며, 이는 전통적인 한방치료에 과학적인 기초자료를 제공할 것으로 생각한다.
Hyun Dong-Wook,Lee Jae-Yun,Kim Min-Soo,Shin Na-Ri,Whon Tae Woong,Kim Kyung Hyun,Kim Pil Soo,Tak Euon Jung,Jung Mi-Ja,이준영,Kim Hyun Sik,Kang Woorim,Sung Hojun,Jeon Che Ok,Bae Jin-Woo 한국미생물학회 2021 The journal of microbiology Vol.59 No.8
Viridans group streptococci are a serious health concern because most of these bacteria cause life-threatening infections, especially in immunocompromised and hospitalized individuals. We focused on two alpha-hemolytic Streptococcus strains (I-G2 and I-P16) newly isolated from an ileostomy effluent of a colorectal cancer patient. We examined their pathogenic potential by investigating their prevalence in human and assessing their pathogenicity in a mouse model. We also predicted their virulence factors and pathogenic features by using comparative genomic analysis and in vitro tests. Using polyphasic and systematic approaches, we identified the isolates as belonging to a novel Streptococcus species and designated it as Streptococcus ilei. Metagenomic survey based on taxonomic assignment of datasets from the Human Microbiome Project revealed that S. ilei is present in most human population and at various body sites but is especially abundant in the oral cavity. Intraperitoneal injection of S. ilei was lethal to otherwise healthy C57BL/6J mice. Pathogenomics and in vitro assays revealed that S. ilei possesses a unique set of virulence factors. In agreement with the in vivo and in vitro data, which indicated that S. ilei strain I-G2 is more pathogenic than strain I-P16, only the former displayed the streptococcal group A antigen. We here newly identified S. ilei sp. nov., and described its prevalence in human, virulence factors, and pathogenicity. This will help to prevent S. ilei strain misidentification in the future, and improve the understanding and management of streptococcal infections.
Evaluation of CT Imaging Characteristics and Effect of CTDI Phantom Size on Contrast Materials
Pil-Hyun Jeon,Cheol-Ha Baek 한국자기학회 2020 Journal of Magnetics Vol.25 No.4
Recently, there have been several physics and clinical studies on the use of lower tube potentials in CT imaging, with the purpose of improving image quality or further reducing radiation dose. We investigated an experimental study using a series of different sized, polymethyl methacrylate (PMMA) phantoms, demonstrating the potential strategy for dose reduction and to distinguish component of plaque by imaging their energy responses using CT. We investigated the relationship between different sizes of cylinderic PMMA equivalent phantoms with diameter of 12, 16, 20, 24, and 32 cm and used contrast at various tube voltages (80, 100, 120, and 140 kVp) using a 16–detector row CT scanner. The contrast represented CT numbers as different materials for the water, calcium chloride, and iodine. Phantom insertions also allow quantitative measures of image noise, contrast, contrast-to-noise ratio (CNR) and figure of merit (FOM). When evaluating FOM, it was found that the lower kVp provided the better CNR. An experimental study was performed to demonstrate reduced dose for both dose efficient and practical feasibility for different patient sizes and diagnostic tasks by relating achievable CNR and the volume CT dose index (CTDI vol). The use of spectra optimized to the specific application could provide further improvements of distinguishing iodine, calcium and plaque component for patient size. The purpose of this study was to evaluate variations in image noise and contrast using different tube potentials in a CTDI phantom on contrast imaging.