Individualized Treatment of Allergic Rhinitis According to Nasal Cytology

Jianjun Chen,Yue Zhou,Li Zhang,Yanjun Wang,Amber N. Pepper,Seong H. Cho,Weijia Kong 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.5

Purpose: Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. Methods: Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of neutrophils and eosinophils. Results were subdivided into the following categories: AR(Eos), eosinophil ≥50% of the whole inflammatory cells; AR(Neu), neutrophils ≥90%; AR(Eos/Neu), 10%≤ eosinophil <50%; AR(Low), grade 0/1 inflammatory cell quantity. Nasal cytology-guided treatment was implemented: all AR(Eos) patients (n=22) and half of the AR(Neu) patients (AR[Neu1], n=22) were treated with mometasone furoate spray and oral loratadine. Another half of the AR(Neu) patients (AR[Neu2], n=22) were treated with oral clarithromycin. Visual analog scale (VAS), symptom scores, and nasal cytology were evaluated 2 weeks before and after treatment. Results: There were 224/468 (47.86%) AR(Eos), 67/468 (14.32%) AR(Neu), 112/468 (23.93%) AR(Eos/Neu), and 65/468 (13.89%) AR(Low) of the AR patients studied. There were no significant differences in clinical characteristics among these subgroups, except that the nasal blockage score was higher in AR(Eos) patients than in AR(Neu) patients (1.99 vs 1.50, P=0.02). Comparing AR(Eos) patients with AR(Neu1) patients 2 weeks after treatment, nasal symptoms and VAS were significantly lower in AR(Eos) patients, except for nasal blockage symptoms (P<0.05 of nasal itching and sneezing; P<0.01 for nasal secretion, total scores, and VAS). Comparing AR(Neu1) with AR(Neu2) patients, nasal symptoms, and VAS were significantly lower in AR(Neu2), except for nasal blockage and nasal itching symptoms (P<0.05 for nasal secretions, sneezing, total score, and VAS). Conclusions: Nasal cytology may have important value in subtyping AR and optimizing AR treatment. Treating neutrophils is very important in AR patients with locally predominant neutrophils.

High Sustained Virologic Response with Daclatasvir plus Asunaprevir in HCV GT-1b Chinese, Korean and Taiwanese without Baseline NS5A Polymorphisms

( F. Mcphee ),( L. Wei ),( Q. Xie ),( Y. Suzuki ),( J. Toyota ),( Y. Karino ),( K. Chayama ),( Y. Kawakami ),( M. L. Yu ),( S. H. Ahn ),( N. Zhou ),( H. Kumada ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Daclatasvir (DCV) plus asunaprevir (ASV) has demonstrated highsustained virologic response (SVR) in HCV genotype (GT-)1b infection.NS5A-Y93H and NS5A-L31 resistance-associated polymorphisms(RAPs) to DCV are known to impact DCV+ASV response in GT-1b-infectedJapanese. The effect of RAPs on SVR at posttreatment week12 (SVR12) to DCV+ASV was explored in mainland Chinese, Korean,and Taiwanese.Methods: Pooled data from 2 studies of DCV (60 mg daily) + ASV(100 mg capsule, twice-daily) for 24 weeks in GT-1b-infected interferon/ribavirin-naive and -experienced patients from mainland China,Korea, and Taiwan. Similar Japanese data (4 studies; n=445) werepooled for comparison. SVR12 with versus without baseline Y93Hand/or L31 RAPs was compared by age (<65 vs ≥65 years), cirrhosisstatus, and baseline HCV-RNA.Results: SVR12 and baseline NS5A sequences were available for 282patients (126 mainland Chinese [45%〕, 80 Koreans [28%〕, 76Taiwanese [27%〕). NS5A-Y93H and/or -L31 RAPs were observed pretreatmentin 8% mainland Chinese, 14% Korean, and 18%Taiwanese patients, compared with 19% in Japanese. SVR12 in allnon-Japanese patients is shown (Figure); rates were broadly similarbetween countries and with Japanese data (Japanese: 96% overallwithout RAPs, 41% with RAPs). Responses were lower among patientswith baseline RAPs. By contrast, SVR12 in patients without RAPs washigh (92-100%), irrespective of cirrhosis, age, or baseline HCV-RNA.Conclusions: At least 95% of HCV GT-1b-infected patients from mainlandChina, Korea or Taiwan without baseline NS5A-Y93H or -L31polymorphisms who had HCV-RNA ≤7 log10 IU/mL achieved SVR12on DCV+ASV, regardless of cirrhosis status and age.

Subtraction Method for an Effective Quasi-monoenergetic Neutron Beam by Using Continuous Energy Spectra

In Eun Jin,Min Kyung Joo,Bak Sang-In,Kim Do Yoon,함철민,Shim Chungbo,Zhou Yujie,Hong Seung-Woo,Park Tae-Sun,Shin Jae Won,Bhoraskar V. N. 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.9

The cross sections of 89Y(n,3n)87m,87gY and 209Bi(n,4n)206Bi reactions at a neutron energy of 30 MeV are measured by making use of neutron beams of continuous energy spectra and a subtraction method. By impinging proton beams of 30 and 35 MeV to a thick beryllium target, neutron beams of continuous and broad energy spectra are produced and are guided to Y and Bi sample targets. The difference between the two neutron spectra generated by two neighboring proton energies is found to be peaked in a narrow energy range and thus can be regarded as quasi-monoenergetic, which can be used to extract (n,xn) cross sections. The uncertainty in the neutron fluence is reduced by analyzing the activities of aluminum and niobium reference samples placed on top of the Y and Bi samples. The use of a subtraction method by employing neutron beams of continuous energy spectra gives us the 89Y(n,3n)87m,87gY and 209Bi(n,4n)206Bi cross sections in fair agreement with the existing experimental data and nuclear data libraries.

Luminescent Properties of Europium-Doped Lanthanum Silicon Nitride Phosphor

Zoltán Lencéš,Monika Hrabalová,Adriana Czímerová,Pavol Šajgalík,You Zhou,Kiyoshi Hirao 한국세라믹학회 2012 한국세라믹학회지 Vol.49 No.4

Europium-doped LaSi3N5 phosphor was synthesized from LaSi/Si/Si3N4/Eu2O3 mixture by nitridation at 1390oC and additional annealing at 1650oC for 4 h. The phosphor shows emissions in the green light region with a maximum at 560 nm. With increasing europium content in the general formula La1-zEuzSi3N5-zO1.5z from z = 0.01 to 0.06 there was a maximum emission for z = 0.04 followed by concentration quenching for the highest europium content (z = 0.06).

Emodin accentuates atrial natriuretic peptide secretion in cardiac atria

Zhou, G.H.,Zhang, F.,Wang, X.N.,Kwon, O.J.,Kang, D.G.,Lee, H.S.,Jin, S.N.,Cho, K.W.,Wen, J.F. North-Holland ; Elsevier Science Ltd 2014 european journal of pharmacology Vol.735 No.-

Emodin, an active anthraquinone constituent isolated from the rhubarb, a traditional Chinese herbal medicine which is widely used in clinical treatment, has cardiovascular protective properties. However, it remains unclear whether the cardiovascular protective actions of emodin are related to an activation of cardiac natriuretic hormone secretion. The purpose of the present study was to explore the effect of emodin on the secretion of ANP, a member of the family of cardiac natriuretic hormones, and its mechanisms involved. Experiments were performed in isolated perfused beating rabbit atria allowing measurement of ANP secretion, atrial pulse pressure, and stroke volume. Emodin increased ANP secretion concomitantly with a decrease in atrial pulse pressure and stroke volume in a concentration-dependent manner. These effects were reversible. Inhibition of K<SUP>+</SUP> channels with tetraethylammonium and glibenclamide attenuated the emodin-induced changes in ANP secretion and atrial dynamics. Furthermore, the emodin-induced changes in ANP secretion and atrial dynamics were attenuated by inhibition of L-type Ca<SUP>2+</SUP> channels with nifedipine. Atropine, methoctramine, tertiapin-Q, and pertussis toxin had no significant effect on the emodin-induced changes in ANP secretion and mechanical dynamics. The present study demonstrates that emodin increases ANP secretion via inhibition of L-type Ca<SUP>2+</SUP> channels through an activation of K<SUP>+</SUP><SUB>ATP</SUB> channel in isolated beating rabbit atria. The results also provide a rationale for the use of emodin in the treatment of impairment of the regulation of the cardiovascular homeostasis.

Design of Neutron Targets with the 4 MeV Cyclotron for BNCT

B. N. Lee,J. A. Park,Y. S. Lee,H. S. Song,H. W. Kim,T. Zhou,S. H. Lee,H. J. Choi,J. H. Oh,Y. H. Yeon,야신카디,채종서 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

For more than 40 years Boron neutron capture therapy(BNCT) has been studied by thermalneutrons at nuclear reactor facilities. There are many advantages in using accelerator for BNCT as safety, adjustment of both energy and beams. In this paper the development of thin neutron target with cooling fin for 4 MeV proton beams and target with water cooling system was carried out. For testing new target system, we have used not only FLUKA based MCNP for the etermination of target thickness but also CFD and CTA for thermal analysis. The R & D has been undertaken to enhance the use of the high current solid targets for p-n reaction. Wide distribution and variation of the incident angle is required to obtain higher yields of neutrons comparable to previous one. The goal of this research aims to improve the target technology to intensify the production capability of epithermal neutrons. The commercial code, ANSYS, was used for the thermal dynamic simulation. The expected irradiating beam current is 2 mA at 2.5 MeV. The application of this neutron source has prominent significance in nuclear technology research, biology, physics, chemistry and industries including neutron radiography.

Validation of primary formaldehyde gas standards prepared by dynamic thermogravimetry through a tri-national comparison of gaseous formaldehyde amount fraction

Panda, N.,Kim, M.,Aoki, N.,Zhou, Z.,Shimosaka, T.,Kim, Y.,Lee, S.,Kim, D. Springer Science + Business Media 2016 Accreditation and quality assurance Vol.21 No.4

<P>A validation study for primary formaldehyde gas standards was performed at three National Metrology Institutes: the Korea Research Institute of Standards and Science (KRISS), the National Metrology Institute of Japan (NMIJ) and the National Institute of Metrology of China (NIM). The studied materials had a nominal amount fraction of 2 mu mol/mol formaldehyde in nitrogen balance and were prepared in 10-L aluminum cylinders by KRISS. The impurities in the materials were analyzed using a gas chromatograph/atomic emission detector and a Fourier-transform infrared spectrometer (FTIR). The stability of the materials was assessed for 1 year by KRISS using paraformaldehyde as a source for the primary standard gas and a cavity ring-down spectrometer (CRDS) instrument as the measurement method. The amount fraction of formaldehyde in the materials decreased linearly by 0.74 % each month. The studied materials that exhibited similar linear rates of decline were distributed to the participants. After the measurement was completed by the participants, the materials were returned to KRISS and the stability analysis based on the primary standard maintained at KRISS was repeated. NMIJ analyzed the materials using paraformaldehyde as the source of the primary standard of formaldehyde and FTIR analysis, whereas NIM used trioxane as the primary standard gas source and CRDS analysis. The results of the comparison revealed good agreement between the results and were within the expanded uncertainty of 2 % although each of them used different combinations of methods in the generation of primary gas standards and measurements.</P>

Atomic-Scale Spectroscopy of Gated Monolayer MoS₂

Zhou, Xiaodong,Kang, Kibum,Xie, Saien,Dadgar, Ali,Monahan, Nicholas R.,Zhu, X.-Y.,Park, Jiwoong,Pasupathy, Abhay N. American Chemical Society 2016 NANO LETTERS Vol.16 No.5

<P>The electronic properties of semiconducting monolayer transition-metal dichalcogenides can be tuned by electrostatic gate potentials. Here we report gate-tunable imaging and spectroscopy of monolayer MoS<SUB>2</SUB> by atomic-resolution scanning tunneling microscopy/spectroscopy (STM/STS). Our measurements are performed on large-area samples grown by metal–organic chemical vapor deposition (MOCVD) techniques on a silicon oxide substrate. Topographic measurements of defect density indicate a sample quality comparable to single-crystal MoS<SUB>2</SUB>. From gate voltage dependent spectroscopic measurements, we determine that in-gap states exist in or near the MoS<SUB>2</SUB> film at a density of 1.3 × 10<SUP>12</SUP> eV<SUP>–1</SUP> cm<SUP>–2</SUP>. By combining the single-particle band gap measured by STS with optical measurements, we estimate an exciton binding energy of 230 meV on this substrate, in qualitative agreement with numerical simulation. Grain boundaries are observed in these polycrystalline samples, which are seen to not have strong electronic signatures in STM imaging.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2016/nalefd.2016.16.issue-5/acs.nanolett.6b00473/production/images/medium/nl-2016-004733_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl6b00473'>ACS Electronic Supporting Info</A></P>

Transport and thermodynamic properties ofSr3Ru2O7near the quantum critical point

Zhou, Z. X.,McCall, S.,Alexander, C. S.,Crow, J. E.,Schlottmann, P.,Bianchi, A.,Capan, C.,Movshovich, R.,Kim, K. H.,Jaime, M.,Harrison, N.,Haas, M. K.,Cava, R. J.,Cao, G. American Physical Society 2004 Physical review. B, Condensed matter and materials Vol.69 No.14

Joint Stiffness Analysis for Robot Calibration

N.H. Nhan,Zhou Jian,강희준(Hee-Jun Kang),노영식(Young-Shick Ro) 한국정밀공학회 2008 한국정밀공학회 학술발표대회 논문집 Vol.2008 No.11월