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Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats
Mihye Jeong,Young-Won Kim,Jeong-Ran Min,Min Kwon,Beom-Suk Han,Jeong-Gyu Kim,Sang-Hee Jeong 한국독성학회 2012 Toxicological Research Vol.28 No.3
Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-α), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.
On-cue detachment of hydrogels and cells from optically transparent electrodes
Kim, Mihye,Lee, Ji Youn,Shah, Sunny S.,Tae, Giyoong,Revzin, Alexander Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.39
<P>The goal of the present communication was to develop a strategy for detachment of cells and biomaterial constructs from indium tin oxide (ITO) electrodes.</P> <P>Graphic Abstract</P><P>This communication describes on-cue electrochemical desorption of heparin-based hydrogels from ITO electrodes. Release of viable cells integrated into a biomaterial scaffold is also demonstrated suggesting future applications in cell analysis and tissue engineering. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b909169f'> </P>
Mihye Kim 한국콘텐츠학회 2015 International Journal of Contents Vol.11 No.4
There has been a significant paradigm shift in the book industry from print to digital, with the increased use of electronic books (ebooks) on e-book readers. The major online booksellers and publishers are devoting their energies to the growth of the e-book market, resulting in an upward spiral in e-book usage, and a resultant increase in the number of downloaded e-books in an e-book reader library. However, there are comparatively few features for e-book management and search in most e-book reader libraries, particularly in smartphone environments. In addition, the user interfaces of e-book management in e-book readers are highly diverse, which has led to major usability issues. In this paper, we analyze user preferences for e-book management and search in the libraries of the five most commonly used e-readers for the Android smartphone platform via a questionnaire survey. Then, we suggest ideal alternatives in addition to user-friendly features based on user preferences for managing e-book libraries, to allow users to more easily browse collections, thereby enhancing the usability of e-book readers.
Mineralogical Characteristics of Na- and Ca-bentonite
Mihye Kong,Gha-Young Kim,Minsoo Lee,Junhyuk Jang,Jin-Seop Kim 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
Buffer materials play an important role in preventing the leakage of radionuclides from the residue. The mineralogical properties of these buffer materials are critical in repository design. This study presents the fundamental properties of Na-type MX80 and a novel Ca-type Bentonil- WRK. The CaO to MgO ratio in Bentonil-WRK was approximately 1:1, and the CaO to Na2O ratio was approximately 2.8:1. These results suggest that Bentonil-WRK demonstrates a lower swelling index compared to Gyeongju bentonite due to its CaO-to-MgO ratio’s proximity to 1:1, despite having a higher montmorillonite content than Gyeongju bentonite. The results of this research can provide useful foundational data for the evaluation of the thermal-hydraulic-mechanical-chemical behavior of buffer materials.
Broadcasting Algorithms of Three-Dimensional Petersen-Torus Network
Kim, Jong-Seok,Lee, Hyeong-Ok,Kim, Mihye,Kim, Sung Won Hindawi Limited 2014 Journal of applied mathematics (JAM) Vol.2014 No.-
<P>The three-dimensional Petersen-torus network 3PT is based on the Petersen graph and has recently been proposed as an interconnection network. 3PT is better than the well-known 3D torus and 3D honeycomb mesh in terms of diameter and network cost. In this paper, we propose one-to-all and all-to-all broadcasting algorithms for 3PT(l;m;n) under SLA (single-link available) and MLA (multiple-link available) models.</P>