체외충격파 쇄석술 시행 후 5년 뒤 발생한 요관 협착 및 농신장 1예

이현승,권균홍,조용건,김봉진,임창섭,김자영,허동,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

A 40-years-old woman was admitted to this hospital with flank pain and high grade fever for 2 weeks. As a matter of her past history, extracorporeal shock wave lithotripsy (ESWL) was performed for treatment of renal stones 5 years ago. Her abdominal CT findings were hydronephrosis with pyonephrosis and renal stones. Antibiotics administered for 5 days had no effects on her symptom improvement. A right ureteral stricture was noticed by ultrasonography follow up. We inserted double J stent and continued antibiotics therapy for 10 days, and then her fever was disappeared and flank pain was improved. ESWL is one of the most important treatment of renal and ureteral stone. However, its complications should not be negligible including bleeding, pain, ureteral obstruction, infection and so on. Complications of ESWL can be divided into acute and chronic courses. When we treat pyelonephritis patient with past history of ESWL, possibility of ureteral stricture must also be considered. In this study we report a case of pyelonephritis caused by ureteral stricture, possibly as a chronic complication of ESWL performed 5 years earlier

POSTERS / PM-024 : THE ROLE OF PHOSPHOLIPASE C IN SPHINGOSINE 1-PHOSPHATE MEDIATED SIGNAL TRANSDUCTION

(Kyun Heo),(Jong Ik Hwang),(Sung Ho Ryu),(Pann Ghill Suh) 한국생화학분자생물학회 (구 한국생화학회) 1999 6th IUBMB SEOUL CONFERENCE Vol.- No.-

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies

Heo, Kyun,Min, Sung-Won,Sung, Ho Jin,Kim, Han Gyul,Kim, Hyun Jung,Kim, Yun Hee,Choi, Beom Kyu,Han, Sewoon,Chung, Seok,Lee, Eun Sook,Chung, Junho,Kim, In-Hoo Elsevier 2016 Journal of controlled release Vol.229 No.-

<P><B>Abstract</B></P> <P>Aptamers have recently emerged as reliable and promising targeting agents in the field of biology. However, their therapeutic potential has yet to be completely assessed due to their poor pharmacokinetics for systemic administration. Here, we describe a novel aptamer-antibody complex, designated an “oligobody” (<U>oligo</U>mer+anti<U>body</U>) that may overcome the therapeutic limitations of aptamers. To provide proof-of-principle study, we investigated the druggability of oligobody <I>in vivo</I> using cotinine conjugated t44-OMe aptamer, which is specific for the sequence of pegaptanib, and an anti-cotinine antibody. The antibody part of oligobody resulted in extended <I>in vivo</I> pharmacokinetics of the aptamer without influencing its binding affinity. Moreover, the aptamer of oligobody penetrated deeply into the tumor tissues whereas the anti-VEGF antibody did not. Finally, the systemic administration of this oligobody reduced the tumor burden in a xenograft mouse model. Together, these results suggested that our oligobody strategy may represent a novel platform for rapid, low-cost and high-throughput cancer therapy.</P> <P><B>Graphical abstract</B></P> <P> <B>Aptamer-antibody hybrid complex</B>: Because the oligobody requires only a single antibody and utilizes a simple antigen–antibody reaction, it could offer the benefits of aptamers and antibodies, and may be a potentially valuable tool for cancer therapeutics.</P> <P>[DISPLAY OMISSION]</P>

Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells

( Kyun Heo ),( Kyung A Park ),( Yun Hee Kim ),( Sun Hee Kim ),( Yong Seok Oh ),( In Hoo Kim ),( Sung Ho Ryu ),( Pann Ghill Suh ) 생화학분자생물학회 2009 BMB Reports Vol.42 No.10

Nematicidal activity of Kaempferia galanga rhizome-derived materials toward root-knot nematode (Meloidogyne incognita)

Tae-Kyun Hong,Jae-Kook Lee,Jae-Won Heo,Soon-Il Kim,Dong-Ro Choi,Young-Joon Ahn 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05

The nematicidal activity of Kaempferia galanga rhizome-derived materials (methanol extract, steam distillate, and powder) toward M. incognita second-stage juveniles (J2) was examined using residual contact toxicity and pot bioassays. In residual contact toxicity bioassays with J2, the active principles of K. galanga rhizome were identified as the phenylpropanoids ethyl cinnamate (EC, 1) and ethyl-p-methoxycinnamate (EMC, 2) by spectroscopic analysis. EC exhibited 95% and 49% mortality at 0.06 and 0.04 mg/ml toward J2, respectively, whereas EMC showed 98% and 63% mortality at 0.1 and 0.08 mg/ml. In pot tests with J2, K. galanga rhizome methanol extract gave 92% and 82% mortality at 100 and 20 mg/50g soil, respectively. Steam distillate gave 88% and 68% mortality at 85 and 42.5 mg/50g soil, respectively, whereas rhizome powder provided 83% and 62% mortality at 400 and 200 mg/50g soil. K. galanga rhizome-derived materials, particularly EC and EMC, merit further study as potential root-knot nematode control agents or leads because of their great activity as a nematicide.

오픈에어 피트니스를 위한 개인용 스테퍼-모빌리티 제품과 서비스

허균(Kyun Heo),안성희(SungHee Ahn) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2

COVID-19 펜데믹이 초래한 재택격리와 ‘거리두기’ 라는 초유의 사태로 인해 야외활동에 대한 갈망과 같은 심리적인 부작용의 발생 이외에도 사람들의 체력저하 경향이 관찰된다. 본 연구는 문제해결을 위하여 최근 이용이 증가하고 있는 퍼스널 모빌리티(이하 PM)를 대상으로 하여 이것이 가진 기능적 특성 가운데 단순한 이동성을 넘어선 확장된 경험으로써의 이동경험과 외부활동 경험을 만족시키면서, 야외 체력증진 활동이 가능한 융합적 기능을 갖춘 개인형 오픈에어 피트니스 서비스 개발연구를 사용자 경험 연구 프로세스에 포커싱하여 진행하였다. 근미래의 ‘헬스케어 기능에 중점을 둔 모빌리티 제품과 서비스’로서의 PM 의 확장성에 관한 연구 개발 과정을 통해 그에 적합한 스테퍼 구동방식을 차용한 ‘PAS 하이브리드 킥스쿠터’ 제품디자인을 진행하였고 제품과 연동하는 앱 서비스를 함께 개발하여 종합적인 헬스케어 중심 모빌리티 서비스디자인을 제안하고자 하였다.

Toxicity of Kaempferia galanga Rrhizome-Derived Materials to Meloidogyne incognita Juveniles and Eggs and Their Effects on Lycopersicon esculentum Germination and Growth

Tae-Kyun Hong,Jae-Kook Lee,Jae-Won Heo,Soon-Il Kim,Dong-Ro Choi,Young-Joon Ahn 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05

The toxicity of Kaempferia galanga rhizome-derived methanol extract (RME), powder (RP) and steam distillate (RSD) to Meloidogyne incognita second-stage juveniles (J2) and eggs and their effects on Lycopersicon esculentum germination and growth were examined in vitro and in pot experiments. Results were compared with those of three nematicides. In contact+fumigant bioassays with J2, RME applied at 1, 0.5 and 0.25mg/g soil exhibited 92, 88, and 73% mortality, respectively. The lethality of RME was almost similar to that of carbofuran but lower than that of either fosthiazate or metam-sodium. RSD and RP were less active than RME. In vapor-phase mortality bioassayswith J2, the test materials were effective in closed container than in open one, indicating that mode of delivery was, in part, a result of vapor action. RME, RSD, and fosthiazate treatments resulted in 91, 100, and 95% inhibition of egg hatch at 250μg/ml and 82, 88, and 81% inhibition of egg hatch at 100μg/ml, respectively. In filter-paper bioassays with L. esculentum seed at 8.8μg/cm2, RME and RP did not cause germination inhibition, while RSD and fosthiazate treatments resulted in 84 and 13% germination inhibition. In pot tests, RME and RSD applied at 8mg/g soil reduced galling caused by M. incognita significantly and fosthiazate at 0.02mg/g soil reduced galling completely. Rhizome materials did not cause any adverse effect on growth of L. esculentum, while fosthiazate application caused significantly reduced root weight. K. galanga rhizome-derived materials, particularly methanol extract, merit further study as potential nematicides and hatching inhibitors for the control of M. incognita populations as fumigants with contact action.

연속탄소섬유를 적용한 충격 흡수 구조체의 낙하 충격하중에 대한 성능 평가

허진명(Jinmyeong Heo),박거락(Georak Park),김준범(Jun Beom Kim),송규(Kyu Song),조락균(Nak-Kyun Cho),김충수(Chung-Soo Kim),김도균(Do Kyun Kim) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11

情報化社會에 있어서 프라이버시 保護에 대한 法的 考察

許永敏,申洋均 전북대학교 법학연구소 1989 法學硏究 Vol.16 No.-

Von den letzten Ha¨lften des 1970’s ab ist die Akkumulation und Erledigung der Information in unserem Land durch EDV. nicht nur bei o¨ffentlicher Sektion sondern nur bei privater Sektion. Computer hat daher auch in unserem Land wichtige und feste Stellung als Lo¨we des zuku¨nftien Gesellschafts, anderseits bedroht er mit ultramodi - schem Technik perstinlichen und privaten Lebensgebiet. Schon im Ausla¨nder hat sich die gesetzliche Beka¨mpfung gegen Privacy (Geheimhaltung-) verletzung auseinander - gesetzt, insbes. bei, Schweden in der Gestalt von Privacyschutzgesetz(1973). Heute erscho¨pf sich Privacyrecht nicht in Geheimhaltungsrecht (Right to be let alone). sondern bedeutet es umfassendes und positives Recht, das Umlauf der Informations u¨ber sich selbst steuren kann. A¨nderseits herrscht fast ausschlieβich offentliche Anstalten oder Privatunternehmen Informationsquelle und muβ die Gesetze sie zu Informationsverto¨ffentlichung verpflichten, unter den Umsta¨nde des Informationmonopols um das Recht zu wissen zu gewa¨hrleisten. Die Pmblematik der neuen durch Computeri zation begleiteten Privacyverletzung und deren Schutz muβ daher unter Beru¨cksichtigung auf diesen beiden Aspekten untersucht werden. Im voriegenden Aufsatz hat sich das Thema auseinandergesetzt folgend: Im ersten Teil : 1. Enhicklung des Informationsgesellschaft 2. Informationsvero¨ffentlichung und Privacyschutz 3. Neue Gestaltung der Privacyverletzung 4. Strafrechtliche Arna¨hrung zum Privacyschutz Im zweiten Teil 1. Begriff der Computerkriminalita¨t 2. Typisierung des Computerkrirninalita¨t 3. Zusammenha¨nge zwischen Computerkriminalita¨t und Privacyverletzung Im dritten Teil (Privacyverletzung durch Computer) 1. Gegenstand der Auseinandersetzung 2. Unrechtliche Akkumulation der privaten Information 3. Unrechtliche Benutzung der privaten Information 4. Unrechtliche Umlauf der privaten Information Als Ergebnis, es ist vor allem auf der verwaltungsrechtlichen Seite notwendig. das Gesetz fu¨r Infomtionsvero¨ffentlichung und Privacyschutz zu geben, um das Recht von Privacy und Wissen zu gewshrleisten. Auf der strafrechtlichen Seite'ist es wichtig, die Grenzen der strafrechtlichen Regelung richtig nach Tendenzen der Neukriminalisierung und kriminalpolitischen Forderung zu bestimmen. Aber es muβ immer berucksichtigt weden, daβ diese zwei Aufgabe zueinander nicht andere Frage sind. So ist dringend die interdisziplina¨re Auseindersetzung zwischen Strafrechtlem und Verwaltungsrechtlern gefordert.

Fabrication of Transparent Dielectric Green Sheet for Plasma Display Panel

Heo, Sung-Cheol,Park, Duck-Kyun,Oh, Young-Jei The Korean Ceramic Society 2004 한국세라믹학회지 Vol.41 No.4

Plasma Display Panel(PDP) 상판용 투명유전체의 green sheet를 제조코자 투명유전체 슬러리의 분산특성 및 유기물의 함량과 조성비에 따른 밀도와 기계적 특성을 연구하였다. 비수계 시스템에서 슬러리의 완전분산을 위한 분산제의 종류와 분산제의 양을 결정하기 위해 침강실험, 점도측정을 행하여 최적의 분산조건을 구하였다. 조성물 변수로서 투명유전체조성 분말/(투명유전체조성 분말+유기물)의 비와 결합제/(결합제+가소제)의 비를 각각 변화시켜 green sheet를 제조하였다. 제조된 tape casting 슬러리의 대부분은 의가소성(pseudoplastic) 거동을 보이는데, 의가소성 거동은 shear thinning의 효과를 가지는 것으로 기술 할 수 있다. 각각의 조성을 가지는 슬러리는 모두 전단속도가 증가함에 겉보기 점도가 감소하는 shear thinning 효과를 보여 주었다. Green sheet의 특성을 조사한 결과 유기물의 함량 및 조성이 green sheet의 밀도와 기계적 특성을 결정하는 중요한 인자가 되었다. To fabricate green sheet of transparent dielectric for PDP front panel, dispersion of transparent dielectric slurry, density, and mechanical properties of green sheets have been investigated as a function of amount and composition of organic additives. Measurements of sedimentation and viscosity were employed to determine a proper dispersant and its amount for a well dispersed transparent dielectric powders in non-aqueous system. Green sheets, having various ratios of transparent dielectric powders to transparent dielectric powders+ binder+plasticizer and binder to binder+plasticizer, were fabricated. All the tape casting slurries showed shear thinning effect, that is, the apparent viscosity decreased with the increase of shear rate. It was found that the amount and composition of organic additives were main variables to affect densities and mechanical properties of transparent dielectric green sheets for PDP.