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The role of Oxytocin and Oxytocin Receptor in Human Placenta according to Gestational age
( Ka-yeong Yun ),( Hyun-nyung Jo ),( Young-joo Lee ),( Seung Chul Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Oxytocin (OXT) is a peptide hormone that has a central role in the regulation of parturition and lactation in uterus. OXT signals is mediated by the OXT receptor (OXTR) that are demonstrated by a species-specific expression. In the present study, we examined the synthesis of OXT and OXTR in human placenta tissue according to gestational age. 방법: Depending on gestational age, 48 placentas were divided into early preterm, late preterm, and term groups, and the expression of OXT and OXTR was evaluated. First of all, we revealed that OXT and OXTR mRNA and protein were present in normal placenta tissue via Q-PCR, Dot-blot assay, and Western blot assay. In order to explore the regulatory mechanism, the placental BeWo cells were administrated with E2, or P4 and the expression of OXT and OXTR was tested. In addition, in order to confirm estrogen receptor (ER) signaling, we administrated ER antagonists on BeWo cells. 결과: Both OXT and OXTR levels in normal placenta were increased gradually at the late stage of pregnancy, suggesting that local OXT may have a critical role in the function of placenta. The mRNA and protein levels of OXT and OXTR were increased by E2, while P4 did not. As a results, both OXT and OXTR were significantly altered by ERα antagonist (MPP), while ERβ antagonist (PHTPP) was not widely changed. 결론: These results suggested that OXT and OXTR were controlled by mainly E2 in placenta, thereby, may play physiological functions in human placenta at late stage of pregnancy.
Pregnancy-related osteoporosis and spinal fractures
( Ka Yeong Yun ),( Si Eun Han ),( Seung Chul Kim ),( Jong Kil Joo ),( Kyu Sup Lee ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.1
Pregnancy-related osteoporosis is a very rare condition characterized by the occurrence of fracture during pregnancy or the puerperium. Despite its relative rarity, it can be a dangerous condition that causes severe back pain, height loss and disability. Normal physiologic changes during pregnancy, genetic or racial difference, obstetrical history and obstetrical disease, such as preterm labor or pregnancy-induced hypertension, are presumed risk factors of pregnancy-related osteooporosis. However, exact etiology and pathogenesis are uncertain. The management and natural history are still poorly defined. Traditional medications for osteoporosis are calcium/vitamin D and bisphosphonate. Concerns with bisphosphonate include accumulation in bone and fetal exposure in subsequent pregnancies. The newly developed medication, teriparatide, has shown good results. We report six cases of pregnancy-related osteoporosis and spinal fracture with literature review.
OB-39 : A case of amniotic fluid embolism
( Ka Yeong Yun ),( Si Eun Han ),( Young Joo Lee ),( Seung Chul Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Amniotic fluid embolism(AFE) is rare but fatal complication of pregnancy that can be characterized into immediate circulatory collapse, acute respiratory distress, disseminated intravascular coagulation defect. The diagnosis is made by identifying clinical symptoms. The mortality rates of AFE have been estimated at between 37 and 80%. We experienced a survival case of 32-years-old woman who presented with sudden onset of hypotension, massive uterine bleeding after vaginal birth. So we report it with a review of the literature.
( Ka Yeong Yun ),( Yoon Hwa Kim ),( Byung Su Kwon ),( Dong Soo Suh ),( Ki Hyung Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Tumor microenvironment reportedly plays critical roles in drug resistance and proliferation of CSCs; however, the functional role of CSC-secreted factors has not been clarified. 방법: We isolated cancer stem cells (CSCs) through sphere culture of A2780 epithelial ovarian cancer (EOC) cells and primary human EOC cells, and identified lysophosphatidic acid (LPA) as a CSC-derived autocrine factor using mass spectrometry. 결과: LPA treatment stimulated CSC-like properties, including drug resistance and high tumorigenic potential. CSCs were enriched in aldehyde dehydrogenase- high subpopulation, in which autotaxin, an LPA-producing enzyme, was highly expressed. LPA signaling was mediated through LPA receptor 1-dependent activation of the PI3K-AKT pathway. Abrogation of autotaxin-LPA-LPA receptor 1-AKT signaling axis significantly suppressed CSC characteristics, which provides a potential target for CSC treatment. EOC shows high mortality due to development of resistance to chemotherapy and relapse. 결론: CSCs have been implicated in drug resistance and relapse of ovarian cancer. Our findings suggested that ATX-LPA-LPAR1-AKT1 signaling axis is critical for maintenance of cancer stem-like characteristics in an ovarian CSC subpopulation through an autocrine loop. Inhibiting ATX-LPALPAR1- AKT1 signaling axis by chemical inhibitor or knockdown of gene expression increased the sensitivity of CSCs to chemotherapeutic reagents. Our findings provide therapeutic opportunities for development of relapse-free treatment of EOC.