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만성정신분열증 환자에서 Cholecystokinin의 치료효과
이창욱,김보연,최중철,백인호 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.2
This study was designed to investigate antipsychotic properties of cholecystokinin-octapeptide(CCK-8) in schizophrenic patients. Subjects were 30 chronic schizophrenics with residual symptoms following stablization with antipsychotic drugs. CCK-8(0.2㎍/㎏) or placebo was administered intravenously single injection with double-blind method while patients received constant dose of antipsychotic drugs. The clinical effect of CCK-8 was evaluated with BPRS which was applied to patients 2 hours before and 3 and 7 days after drug administration. Results showed no significant differences between CCK-8 group and placebo group.
이재익,박정하,김준영,조영완,진한영,강명주,정은욱,박석주,양성연 인제대학교 2006 仁濟醫學 Vol.27 No.-
Anisakiasis refers to parasitic infestation by nematode larvae that belongs to the subfamily Anisakinae, and this condition is seen in people who eat inadequately prepared or raw salt-water fish. While gastric anisakiasis is commonly diagnosed by endoscopic technique, intestinal anisakiasis is rare because it is less common and the clinical and radiologic features are poorly understood. The authors report a case of human anisakiasis involving the ileocecal valve in 62-year-old man who had the history of eating raw cuttlefish.
김정인,김상용,신병철,김경남,서영욱,이범주,김진화,배학연 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Hypoparathyroidism is usually the result of an inadvertent surgical removal of all the parathyroid glands, In some instances, not all the tissues are removed, but the remainder undergoes vascular supply compromise secondary to the fibrotic changes in the neck after surgery, Previously, the surgery for hyperthyroidism was the most frequent cause of acquired hypoparathyroidism. Idiopathic hypoparathyroidism is a relatively rare disease that is characterized by hypocalcemia and hyperphosphatemia due to a parathyroid hormone deficiency of an unknown cause, It usually develops at a young age, and shows various clinical symptoms and signs accompanied with hypocalcemia. In addition, it is rarely associated with polyglandular autoimmune syndrome during the follow-up. Hypocalcemia and idiopathic hypoparathyroidism associated with labor and lactation are rarely reported condition previously. We here describe a case of a woman in whom the symptomatic severe hypocalcemia appeared after her delivery. We reviewed all the previously reported cases and suggest a possible physiological explanation for the association between pregnancy, lactation, and the appearance of symptomatic hypocalcemia.
Yoen Kyung Lee,Su Youn Yim,Seung Eun Jung,Ji Ha Kim,Ji Eun Kim,Eon Pil Lee,Hae Wook Choi,Hong Sung Kim,Jae Ho Lee,Young Jin Jung,Jung Sik Cho,Chung-Yeol Lee,Hong Joo Son,Dae Youn Hwang 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.3
Selenium (Sel) is widely distributed through the body, and performs a crucial role in the regulation of organ function. In this study, in order to determine whether Sel treatment and selenoprotein M (SelM) overexpression could affect the extracellular signal-regulated protein kinase (ERK) mitogen-activated protein kinase (MAPK) pathway, the level of ERK phosphorylation was assessed in various tissues of CMV/ EGFP-hSelM Tg rats after Sel treatment. Herein, our results demonstrated that SelM overexpression induces a slight increase in the ERK MAPK pathway in the heart, liver, and intestine, while no changes were detected in the brain, lung, and kidney. After Sel treatment, the liver and intestine evidenced higher levels of ERK activation than were induced by SelM overexpression. In particular, costimulation with SelM overexpression and Sel treatment induced a dramatic increase in the phosphorylation of ERK in the brain, heart, liver, and intestine, while a reduction in ERK phosphorylation was noted in the kidneys. The results of this study suggest that Sel and SelM may contribute to the regulation of a variety of functions via the induction of ERK phosphorylation in different organs of CMV/EGFP-hSelM Tg rats.
Topical Application of Selenium Can Significantly Relieve UV-induced Skin Aging in Hairless Mice
So Hee Nam,Seung Eun Jung,Yoen Kyung Lee,Ji Eun Kim,Eon Pil Lee,Hae Wook Choi,Hong Sung Kim,Jae Ho Lee,Young Jin Jung,Chung Yeol Lee,Hong Ju Son,Hyun Woong Lee,Jung Sik Cho,Byeong-Cheol Kang,Dae Youn 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.1
Ultraviolet (UV) irradiation is an environmental factor that causes skin aging, and is also a major factor leading to cumulative alterations of skin structure, function and appearance. To investigate the effects of Selenium (Sel) on UV-induced skin aging, hairless mice were treated for 4 weeks with UV irradiation and topical application of Sel. Then, the effects of Sel were measured in the skin of these mice via histological analysis and Western blotting. According to the results of wrinkle formation analysis, the topical application of Sel induced a reduction in wrinkling formation in the damaged skin of the UV-irradiated mice. Additionally, our histological analysis demonstrated that the skin thickness in the Sel-treated group was less than in the UV-irradiated group. Furthermore, in an effort to investigate the mechanisms underlying the effects of Sel, the expression levels of matrix-metalloproteinase (MMP) and MAPK protein were assessed in both groups. The application of Sel induced a reduction in MMP-1 expression levels to the levels observed in the non-irradiated group. However, the expression level of MMP-9 was increased slightly in the Sel application group as compared with the vehicle application group. Additionally, the levels of ERK phosphorylation were increased by the application of Sel, but the levels of JNK and p38 were not altered by Sel treatment. These results suggest the possibility that Sel should be considered as a skin aging-protective and therapeutic drug candidate, which functions via the regulation of MMP expression levels.
Moesin Is a Biomarker for the Assessment of Genotoxic Carcinogens in Mouse Lymphoma
Yoen Jung Lee,권호정,In-Kwon Choi,신윤용,Sue Nie Park 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.2
1,2-Dibromoethane and glycidol are well known genotoxic carcinogens, which have been widely used in industry. To identify a specific biomarker for these car-cinogens in cells, the cellular proteome of L5178Y mouse lymphoma cells treated with these compounds was ana-lyzed by 2-dimen-sional gel electrophoresis (2-DE) and MALDI-TOF mass spectrometry (MS). Of 50 protein spots showing a greater than 1.5-fold increase or decrease in intensity compared to control cells on a 2-D gel, we fo-cused on the candidate biomarker moesin. Western analysis using monoclonal rabbit anti-moesin confirmed the identity of the protein and its increased level of expression upon exposure to the carcinogenic compounds. Moesin expression also increased in cells treated with six additional genotoxic carcinogens, verifying that moesin could serve as a biomarker to monitor phenotypic change upon exposure to genotoxic carcinogens in L5178Y mouse lymphoma cells.
Jung, Hae Yoen,Cho, Hyundeuk,Oh, Mee-Hye,Lee, Ji-Hye,Lee, Hyun Ju,Jang, Si-Hyong,Lee, Moon Soo The Korean Gastric Cancer Association 2015 Journal of gastric cancer Vol.15 No.1
Purpose: Recent studies have revealed recurrent alterations in the cell adhesion gene FAT4, a candidate tumor suppressor gene, in cancer. FAT atypical cadherin 4 (FAT4) is a transmembrane receptor involved in the Hippo signaling pathway, which is involved in the control of organ size. Here, we investigated the loss of FAT4 expression and its association with clinicopathological risk factors in gastric cancer. Materials and Methods: We assessed the expression of FAT4 by using immunohistochemistry on three tissue microarrays containing samples from 136 gastric cancer cases, radically resected in the Soonchunhyang University Cheonan Hospital between July 2006 and June 2008. Cytoplasmic immunoexpression of FAT4 was semi-quantitatively scored using the H-score system. An H-score of ${\geq}10$ was considered positive for FAT4 expression. Results: Variable cytoplasmic expressions of FAT4 were observed in gastric cancers, with 33 cases (24.3%) showing loss of expression (H-score <10). Loss of FAT4 expression was associated with an increased rate of perineural invasion (H-score <10 vs. ${\geq}10$, 36.4% vs. 16.5%, P=0.015), high pathologic T stage (P=0.015), high tumor-node-metastasis stage (P=0.017), and reduced disease-free survival time (H-score <10 vs. ${\geq}10$, mean survival $62.7{\pm}7.3$ months vs. $79.1{\pm}3.1$ months, P=0.025). However, no association was found between the loss of FAT4 expression and tumor size, gross type, histologic subtype, Lauren classification, lymphovascular invasion, or overall survival. Conclusions: Loss of FAT4 expression appears to be associated with invasiveness in gastric cancer.
( Jung Yoen Lee ),( Sang Heun Lee ),( Beom Kyung Kim ),( Seung Up Kim ),( Jun Yong Park ),( Do Young Kim\ ),( Hye Jin Ku ),( Chae Yoon Chon ),( Kwang Hyub Han ),( Sang Hoon Ahn ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aims: Tenofovir disoproxil fumarate (TDF) has demonstrated high antiviral efficacy in treatment-naive patients with chronic hepatitis B (CHB) in the western world. However, the data of TDF efficacy on rapid viral suppression is not reported in Korean patients with CHB and HBV genotype C. Therefore, we investigated the viral kinetics and outcomes in Korean CHB patients treated with TDF monotherapy. Methods: From December 2012 to April 2013, 47 CHB treatment- naive patients were treated with TDF as a first line and followed up at least 12 weeks. The HBV DNA reduction rate and virologic response (HBV DNA concentration < 20 IU/mL) were analyzed 12 weeks after treatment. Results: 47 treatment-naive patients were consecutively treated with TDF and enrolled in this prospective cohort study. The median age was 49 years (range: 26-67) and males were 28 (59.6%). The patients with cirrhosis were 25 (53.2%) and HBe- Ag positive were 29 (61.7%). After TDF monotherapy, the median values of HBV DNA decreased over the 12weeks. The HBV DNA level was changed 6.4 log10IU/mL of baseline to 0.8 1og10IU/mL at Week 12 with significant reduction and the mean change of HBV DNA level between baseline and Wee 12 was 5.5 (range: 2.8-7.9) (P<0.001). Virologic response was achieved in 8 (17.0%) patients at Week 12 of TDF treatment. Conclusion: TDF monotherapy showed strong and rapid viral suppression in treatment-naive chronic hepatitis B in Korea