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Won Jin Lee,Mi Joon Lee,Sang Gwon Kang,Yun Yi Bang 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.6
Open heart surgery patients exhibit greater prevalence of delirium and moderate or higher level of anxiety. These symptoms may hinder postoperative recovery and health, and may even lead to complications. The objective of this study was to determine the effects of preoperative video information on delirium, anxiety, and nursing satisfaction of open heart surgery patients. This quasiexperimental study utilized a nonequivalent control group with a non-synchronized design, and was conducted from March 15, 2012 to December 1, 2014. The subjects consisted of 50 patients, of whom 25 comprised the experimental group and 25 the control group. On the day prior to surgery, the experimental group was provided with informative videos while the control group was provided with information through traditional medium. Delirium was diagnosed through CAM-ICU, while anxiety levels and Nursing Satisfaction were determined through STAI and questionnaire, respectively. Data was analyzed through SPSS WIN 21.0. The results showed no statistically significant difference (p=.260) in delirium incidences, but improvements were observed in anxiety levels (p=.028) and nursing satisfaction (p=.004). Thus, this study recommends the use of video information as part of nursing intervention for open heart surgery patients so as to reduce their anxiety levels and improve nursing satisfaction.
Kang, Seji,Seo, Sang Won,Kim, Joon Hyun,Shin, Y. American Physical Society 2017 Physical Review A Vol.95 No.5
<P>We investigate the phase-transition dynamics of a quasi-two-dimensional antiferromagnetic spin-1 Bose-Einstein condensate from the easy-axis polar phase to the easy-plane polar phase, which is initiated by suddenly changing the sign of the quadratic Zeeman energy q. We observe the emergence and decay of spin turbulence and the formation of half-quantum vortices (HQVs) in the quenched condensate. The characteristic time and length scales of the turbulence generation dynamics are proportional to vertical bar q vertical bar(-1/2) as inherited from the dynamic instability of the initial state. In the evolution of the spin turbulence, spin-wave excitations develop from large to small length scales, suggesting a direct energy cascade, and the spin population for the axial polar domains exhibit a nonexponential decay. The final equilibrated condensate contains HQVs, and the number is found to increase and saturate with increasing vertical bar q vertical bar. Our results demonstrate the time-space scaling properties of the phase-transition dynamics near the critical point and the peculiarities of the spin-turbulence state of the antiferromagnetic spinor condensate.</P>
( Won Seok Kang ),( Joon Seok Lim ),( Jae Hee Cheon ),( Yong Chan Lee ),( Won Ho Kim ),( Sang Kil Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Stomach cancer is the most common from of cancer, and is the second leading cause of cancer related death in Korea. 3.4% of stomach cancer patients have synchronous of metachronous cancer with colorectal cancer as the most common type (0.6%). Patients with stomach cancer might carry a high risk for colorectal cancer that requires surveillance colonoscopy. CT colonography (CTC) provides for effective and relatively noninvasive risk stratification as a method for colon cancer screening. This study aims at determining the usefulness of CTC as a postoperative follow-up surveillance study after stomach cancer surgery. Methods: From May 2006 to April 2007, contrast-enhanced CTC was performed in Yonsei University severance Hospital for detection of recurrent lesions in 410 consecutive patients (275 male, 135 female) who have had surgery for stomach cancer CTC interpretation was performed with primary three-dimensional polyp detection. Patients with polyp(s) measuring 6mm or larger were referred for optical colonoscopy (OC). Results: Of 410 stomach cancer postoperative patients, recurrence of stomach cancer was not noted and 45 colorectal polyp(s) were detected on CTC in 36 (8.8%) patients. OC was recommended in these patients and concordant lesions were identified in 27 (60.0%) of 45 polyps. Eighty-six polyps were detected on OC in 31 patients, and no polyps were detected on OC in 5 patients. Four colorectal carcinomas were detected in 4 patients CTC. Sensitivity and positive predicitive value of CTC for polyp detection were 60.0% and 62.8%, respectively. Total 46 polyps were missed on CTC. The most common site of missed polyps was sigmoid colon. Eighteen (39.1%) were larger than 6 mm and 1 carcinoma was included in the missed polyps. Conclusion: For patients who have undergone surgical treatment for stomach cancer, CTC is clinically useful as their follow-up surveillance study. However, more efforts are needed to find the ways to improve the low sensitivity of CTC.
( Won Jung Hwang ),( Joon Pyo Jeon ),( Seung Hee Kang ),( Hyun Sik Chung ),( Ji Yong Kim ),( Chul Soo Park ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.3
Background: The pre-transplant model for end-stage liver disease (pre-MELD) score is controversial regarding its ability to predict patient mortality after liver transplantation (LT). Prominent changes in physical conditions through the surgery may require a post-transplant indicator for better mortality prediction. We aimed to investigate whether the post-transplant MELD (post-MELD) score can be a predictor of 1-year mortality. Methods: Perioperative variables of 269 patients with living donor LT were retrospectively investigated on their association with 1-year mortality. Post-MELD scores until the 30th day and their respective declines from the 1st day post-MELD score were included along with pre-MELD, acute physiology and chronic health evaluation (APACHE) II, and sequential organ failure assessment (SOFA) scores on the 1st post-transplant day. The predictive model of mortality was established by multivariate Cox`s proportional hazards regression. Results: The 1-year mortality rate was 17% (n=44), and the leading cause of death was graft failure. Among prognostic indicators, only post-MELD scores after the 5th day and declines in post-MELD scores until the 5th and 30th day were associated with mortality in univariate analyses (P<0.05). After multivariate analyses, declines in post-MELD scores until the 5th day of less than 5 points (hazard ratio 2.35, P=0.007) and prolonged mechanical ventilation ≥24 hours were the earliest independent predictors of 1-year mortality. Conclusions: A sluggish decline in post-MELD scores during the early post-transplant period may be a meaningful prognostic indicator of 1-year mortality after LT. (Korean J Anesthesiol 2010; 59: 160-166)
Joon Ha Park,Tae Kyeong Lee,Ji Hyeon Ahn,Bich Na Shin,Jeong Hwi Cho,In Hye Kim,Jae Chul Lee,Jong Dai Kim,Young Joo Lee,Il Jun Kang,Seong kweon Hong,Yang Hee Kim,Yong Hwan Jeon,Yun Lyul Lee,Moo Ho Won 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.4
The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of Populus species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from Populus tomentiglandulosa (Korea poplar) in the hippocampal cornu ammonis (CA1) area of gerbils subjected to 5 minutes of transient global cerebral ischemia. Pretreatment with 200 mg/kg of P. tomentiglandulosa extract effectively protected CA1 pyramidal neurons from transient global cerebral ischemia. In addition, glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium binding adapter molecule 1 immunoreactive microglia were significantly diminished in the ischemic CA1 area by pretreatment with 200 mg/kg of P. tomentiglandulosa extract. Briefly, our results indicate that pretreatment with P. tomentiglandulosa extract protects neurons from transient cerebral ischemic injury and diminish cerebral ischemia-induced reactive gliosis in ischemic CA1 area. Based on these results, we suggest that P. tomentiglandulosa can be used as a potential candidate for prevention of ischemic injury.
Joon-Won Kang,Wooil Kim,최상일 아시아심장혈관영상의학회 2020 Cardiovascular Imaging Asia Vol.4 No.3
The severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2) pandemic still makes a significant burden on healthcare systems, including radiology departments. Considering important role of cardiovascular imaging in modern healthcare, and the specific value of cardiopulmonary radiology in COVID-19 patients, organization and imaging programs require to be modified during the pandemic. The uninterrupted availability of cardiovascular radiology imaging is, particularly during the current pandemic period, essential for the initial evaluation and follow-up of patients with suspected or known cardiovascular diseases for avoiding unnecessary complications. Suspected or established COVID-19 patients may also have concomitant cardiovascular symptoms and require further imaging. This review summarized the statements by the European Society of Cardiovascular Radiology, North American Society of Cardiovascular Imaging, Society of Cardiovascular Computed Tomography, and Society of Cardiovascular Magnetic Resonance for providing information on measures for guidelines of safety and recommendations for cardiovascular imaging during the pandemic.
Kang Kyoung-Ah,Lee Kyoung-Hwa,Chae Sung-Wook,Kim Jeong-Ki,Seo Jung-Yeon,Ham Yong-Ho,Lee Kee-Ho,Kim Bum-Joon,Kim Hee-Sun,Kim Dong-Hyun,Hyun Jin Won The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.1
Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the $G_1$ phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity.