http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오감(五感)적 요소를 접목한 브랜드 스페이스 연출 계획 -마임 화장품 프레쉬가든을 중심으로-
김소현,임하영,장효실,최혜원,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
인간이 갖고 있는 감각 기관은 시각, 청각, 후각, 촉각, 미각의 총 다섯 가지로, 이를 모두 활용 할 때 이상적 공간 상호작용이 가능하다. 본 연구는 화장품의 공간 연출 계획 시 오감적 요소를 접목하여 브랜드 이미지를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출디자인> 수업에서 진행된 수업의 결과물로서 작업물을 정리하였다. 그 결과 본 연구는 제품이나 서비스를 직접 경험할 수 있도록 다양한 엔터테인먼트적 요소를 결합하여 기능적 만족감과 더불어 체험적 만족감 제공하는 오감적 디스플레이를 제안하였다. 본 연구는 오감을 활 용한 뷰티 쇼룸으로 감각을 공간에 어떠한 방식으로 적용할 것인지에 대한 정립을 했다는 데에 의의가 있다. 아울러 다양한 매체와 공간의 개념이 일반화 되어 가는 오늘날 기업 환경 속에서 오감적 체험을 기반으로 한 공간연출은 가상의 공간속에서도 유연하게 적용 가능한 디스플레이 요소로 확인되었다. 또한 본 연구는 향후 이와 관련된 쇼룸 공간 개발에 있어서 기초 자료로 활용될 것으로 기대된다.
Kim Eun Sil,Yoon Bo Hyun,Lee Seung Min,Choi Min,Kim Eun Hye,Lee Byong-Wook,Kim Sang-Yeob,Pack Chan-Gi,Sung Young Hoon,Baek In-Jeoung,Jung Chang Hee,Kim Tae-Bum,Jeong Jin-Yong,Ha Chang Hoon 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Despite the strong influence of the gut microbiota on atherosclerosis, a causal relationship between atherosclerosis pathophysiology and gut microbiota is still unverified. This study was performed to determine the impact of the gut microbiota on the pathogenesis of atherosclerosis caused by genetic deficiency. To elucidate the influence of the gut microbiota on atherosclerosis pathogenesis, an atherosclerosis-prone mouse model (C1q/TNF-related protein 9-knockout (CTRP9-KO) mice) was generated. The gut microbial compositions of CTRP9-KO and WT control mice were compared. Fecal microbiota transplantation (FMT) was performed to confirm the association between gut microbial composition and the progression of atherosclerosis. FMT largely affected the gut microbiota in both CTRP9-KO and WT mice, and all transplanted mice acquired the gut microbiotas of the donor mice. Atherosclerotic lesions in the carotid arteries were decreased in transplanted CTRP9-KO mice compared to CTRP9-KO mice prior to transplantation. Conversely, WT mice transplanted with the gut microbiotas of CTRP9-KO mice showed the opposite effect as that of CTRP9-KO mice transplanted with the gut microbiotas of WT mice. Here, we show that CTRP9 gene deficiency is related to the distribution of the gut microbiota in subjects with atherosclerosis. Transplantation of WT microbiotas into CTRP9-KO mice protected against the progression of atherosclerosis. Conversely, the transplantation of CTRP9-KO microbiotas into WT mice promoted the progression of atherosclerosis. Treating atherosclerosis by restoring gut microbial homeostasis may be an effective therapeutic strategy.
Heavy Metal Risk Management: Case Analysis
Kim, Ji-Ae,Lee, Seung-Ha,Choi, Seung-Hyun,Jung, Ki-Kyung,Park, Mi-Sun,Jeong, Ji-Yoon,Hwang, Myung-Sil,Yoon, Hae-Jung,Choi, Dal-Woong Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.3
To prepare measures for practical policy utilization and the control of heavy metals, hazard control related institutions by country, present states of control by country, and present states of control by heavy metals were examined. Hazard control cases by heavy metals in various countries were compared and analyzed. In certain countries (e.g., the U.S., the U.K., and Japan), hazardous substances found in foods (e.g., arsenic, lead, cadmium, and mercury) are controlled. In addition, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) recommends calculating the provisional tolerable weekly intake (PTWI) of individual heavy metals instead of the acceptable daily intake (ADI) to compare their pollution levels considering their toxicity accumulated in the human body. In Korea, exposure assessments have been conducted, and in other countries, hazardous substances are controlled by various governing bodies. As such, in Korea and other countries, diverse food heavy metal monitoring and human body exposure assessments are conducted, and reducing measures are prepared accordingly. To reduce the danger of hazardous substances, many countries provide leaflets and guidelines, develop hazardous heavy metal intake recommendations, and take necessary actions. Hazard control case analyses can assist in securing consumer safety by establishing systematic and reliable hazard control methods.
Clinical Characteristics of Smoking Asthmatics
Ha, Eun Sil,Kim, Hye Ok,Lee, Kyoung Ju,Lee, Eun Joo,Hur, Gyu Young,Jung, Ki Hwan,Lee, Sung Yong,Kim, Je Hyeong,Lee, Sang Yeub,Shin, Chol,Shim, Jae Jeong,Kang, Kyung Ho,Yoo, Se Hwa,In, Kwang Ho The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6
Background: The smoking prevalence in asthma patients are similar to those in the general population. Asthma and active cigarette smoking can interact to create more severe symptoms, an accelerated decline in lung function and impaired therapeutic responses. Accordingly, asthmatics with a history of smoking were examined to define the clinical characteristics and lung function of smoking asthmatics. Methods: The medical records of 142 asthmatics with a known smoking history were reviewed. The patients were divided into three groups according to their smoking history - current smokers, former smokers and non-smokers. The clinical characteristics, lung function, and annual declines of the forced expiratory volume in one second ($FEV_1$) were compared. Results: Fifty-three of the 142 patients (37%) were current smokers, 24 were former smokers (17%) and 65 were non-smokers (45%). The patients with a hospital admission history during the previous year included 16 current smokers (30%), 4 former smokers (17%) and 7 non-smokers (11%) (p=0.02). The mean $FEV_1$ (% predicted) was 76.8${\pm}$19.8%, 71.6${\pm}$21.1% and 87.9${\pm}$18.7% for current smokers, former smokers and non-smokers, respectively (p< 0.001). The $FEV_1$/forced vital capacity (FVC) (ratio, %) values were 63.6${\pm}$12.6%, 59.3${\pm}$14.9% and 72.1${\pm}$11.8% in current smokers, former smokers and non-smokers, respectively (p<0.001). The corresponding mean values for the individual $FEV_1$ slopes were not significant (p=0.33). Conclusion: Asthmatic smokers demonstrated higher hospital admission rates and lower lung function. These findings suggest that the smoking history is an important predictor of a poor clinical outcome in asthma patients.
Kim, Bu-Yeo,Kim, Minjeong,Jeong, Ji Seong,Jee, Sun-Ha,Park, Il-Hyun,Lee, Byung-Chul,Chung, Sun-Ku,Lim, Kyung-Min,Lee, Yun-Sil Elsevier 2019 Environmental research Vol.173 No.-
<P><B>Abstract</B></P> <P>Bisphenol A (BPA), a synthetic monomer commonly included in the daily products, has a structure similar to the estrogen receptor agonist. Therefore BPA has been anticipated to interfere with the hormone metabolisms and cause diverse pathological conditions. But the effects of BPA on the genetic landscapes of liver or hepatic cells have not been fully established. Gene expressional changes induced by low- or high-dose of BPA were evaluated in 3D cultured human hepatoma cells (HepG2 spheroids) <I>in vitro</I> at 0, 0.5, 5 and 200 μM and liver of rats exposed to BPA at 0, 0.5 and 250 mg/kg for 90 days <I>in vivo</I>. Functional enrichment analysis, pathway activity measurement and network analysis were performed using BPA-responsive genes. Treatment with BPA changed a lot of gene expressions in both HepG2 spheroids and rat livers depending on doses of BPA. Functional enrichment and pathway analysis show that lipid or steroid metabolism-related functions were altered by BPA in both HepG2 spheroids and livers of rats. Lipid metabolism-related functions altered by BPA formed a large cluster encompassing lipid biosynthesis, steroid metabolic process and cholesterol regulation process. It was also observed that distribution of pathway activities was correlated between HepG2 spheroids and rat livers at low-dose of BPA. Distance distribution in protein-protein interaction network also evidenced the closeness of BPA-responsive genes to metabolism pathways which include lipid metabolism. Collectively, we demonstrated that BPA greatly influenced overall gene expression and biological functions in both human hepatoma spheroids and rat liver, in which lipid- or steroid metabolism-associated genes were significantly altered by the exposure to BPA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> BPA induced transcriptomic changes associated with lipid and sterol metabolism in HepG2 spheroids and rat liver. </LI> <LI> Functional enrichment, pathway, pathway activity and protein-protein interaction network analyses coherently support low dose effects of BPA on lipid metabolism. </LI> <LI> The effects on lipid metabolisms are well in line with human metabolomics and epidemiological studies. </LI> <LI> The altered lipid metabolism pathways by BPA were demonstrated in both human cells and animals. </LI> </UL> </P>
김영수,박성실,박정미,선미정,손원경,전향이,정현주,주진이,하진경 연세대학교 생활과학대학 1989 婦學 Vol.22 No.-
The Purpose of this study was to compare children´s competence in moral judgement according to birth order and sex of child. The subjects of this study were 67 9and 10year old children who have two brothers. The instrument for measuring children's moral judgement competence was Kohlberg's moral dilemma situation modified by Kim and Lee(1976). The data were analyzed with oneway ANOVA and ttest. The results showed that 910 children´s competence in moral judgement were lst and 2st grade. That is children ofthis age judge by authority and naive egolitarianism. there were no significant differences in moral judement competence according to birth order or sex of child.
COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury
Kim, Duk Hoon,Jung, Yu Jin,Lee, Ae Sin,Lee, Sik,Kang, Kyung Pyo,Lee, Tae Hwan,Lee, Sang Yong,Jang, Kyu Yun,Moon, Woo Sung,Choi, Kyu-Sil,Yoon, Kwon-Ha,Sung, Mi Jeong,Park, Sung Kwang,Kim, Won International Society of Nephrology 2009 Kidney international Vol.76 No.11
During sepsis endothelial dysfunction is an important pathogenetic mechanism in acute kidney injury (AKI). Lipopolysaccharide (LPS)-induced endotoxemia is associated with renal hemodynamic changes such as alterations of renal blood flow (RBF), vascular resistance, and glomerular filtration rate. We used adenoviral delivery of an engineered variant of native angiopoietin-1 (COMP-angiopoietin-1) containing anti-inflammatory and anti-permeability functions, to determine if regulation of renal endothelial cell dysfunction may have a beneficial role in preventing AKI during LPS-induced endotoxemia in mice. This treatment prevented the endotoxin-induced decrease of RBF and mean arterial pressure while improving glomerular filtration rate. Treatment also mitigated the effects of LPS on renal intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 protein expression, the number of ER-HR3-positive macrophages that infiltrated the kidney, serum nitrate/nitrite levels, renal inducible nitric oxide synthase protein expression, the induction of tubular epithelial reactive oxygen and nitrogen species, and renal microvascular permeability. Our findings show that COMP-angiopoietin-1, an endothelium-oriented therapeutic agent, protects against AKI caused by endotoxemia.