대황황련해독탕의 항고지혈증 작용

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-

ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.

자원봉사자들의 탈북자 지원 경험 분석 : 설문결과를 중심으로

강성록,김형중,윤덕룡,전우택,민성길 연세대학교 통일연구원 2001 통일연구 Vol.5 No.1

Objectives: Since 1994, the number of North Korean defectors, escaping North Korea and entering South Korea, has in creased rapidly.The Government has provided most of te support for the defectors' adaptation to their new society.But as the number of defectors has increased, and the support needs have become more various, the support of volunteers from non-governmental organization(NGO) has become very important.To raise the level of the success and effectiveness of the support from the volunteers, their experiences were surveyed and analyzed. Methods: This study surveyed 83 volunteers of 7 NGOs involved in helping North Korean defectors' adaptation to South Korean society-48 men and 34 women. Results: In their relationships with defectors, women volunteers have more difficulties in their first 3 months.However volunteers in their 50s and 60s tend to have more stable and better relationships with defectors than younger volunteers.Many volunteers statedexperiences of human difficulties with defectors, for example, mistrust and anxiety in human relationship (n=34, 41.0%), psychological maladjustment(n=19, 22.9%), different ways of thinking and culture(n=17, 20.5%), economic difficulties(n=10, 12.0%), and lack of independence spirit(n=6, 7.2%).The volunteers said they have feelings of goddwill toward defectors when defectors showed warm heart(n=30, 36.1%), politeness(n=30, 36.1%), positive and active character (n=24, 28.9%), strong will(n=17, 20.5%), and plainness (n=14, 16.0%).The volunteers stated an absence of goodwill feelings to defectors when defectors showed uncompromising and aggressive attitudes (n=29, 34.9%), lack of independent will (n=28, 33.7%), selfishness (n=18, 21.7%), and avoidance of making human relationship (n=16, 19.3%).as for adequate training before commencing activity, 5 volunteers(6.0%) said they had received enough education before their activity, 31(37.3%) relatively enough, 38 (45.8%) relatively not enough, and 9 (10.8%) absolutely not enough education.If they were the owners of al company, 27 volunteers (51.9%) sanid they would want to thire defectors even if the defectors did not have the required ability. Conclusion: These results showed that NGO's volunteers have a friendlier attitude to defectors than policemen n charge and public officials, which is their strong point.Women volunteers experience more difficulties in their early relationships with defectors, suggesting the need for a specific pre-education program for women volunteers.Furthermore, NGOs would benefit from an increase in the number of volunteers in their 50's and 60's.Both volunteers and defectors need to understand each othe to a deeprer extent and the characteristics to which South Korean volunteers feel goodwill need to be used n their education.

濟州道 農外所得 增大方案에 관한 硏究

金炯吉,金昌中,金範國 濟州大學校 社會科學大學 社會發展硏究所 1987 社會發展硏究 Vol.3 No.-

非晶質 Chalcogenide 薄膜의 電氣傳導

김영기,이형재,정길환 全北大學校 文理科大學 1976 論文集 Vol.4 No.-

The Ⅰ-Ⅴ, characteristics in high electric fields have been investigated on vitreous As-Te-Ge films prepared by vacuum evaporation. The characteristics are analysed in terms of space-charge-limited current, Poole-Frenkel effect, and small-polaron mechanism. A simple SCLC model does not appear to explain the conduction properties. The other two mechanisms show good agreements with our experimental results. From these agreements, acceptor-like localized states are assumed to exist in the band gap. The field-assisted-thermal emission of electrons from the localized states in the valence band tail into the assumed states in the gap is likely to explain the electrical properties. Small activation energy E=0ㆍ43ev(Ⅰ~exp(E-/kT)) compared with optical absorption edge E_opt=1ㆍ34ev gives the evidence that the amorphous material cannot be treated as a simple intrinsic semiconducor.

Mirizzi 증후군의 변형된 분류와 치료

김형철,강길호,채만규,김성용,백무준,이문수,박상흠,이문호,김창호,송옥평,조무식,박희주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Purpose : The Mirizzi syndrome is relatively rare and preoperative diagnosis of this disease is difficult. In 1978, Morelli suggested the subclassification of the Mirizzi syndrome into acute or chronic form. We experienced 5 cases of acute form. We analysed clinical features, preoperative radiologic findings and operative findings of 18 cases including acute forms which were diagnosed as Mirizzi syndrome and should suggest the modified classification of Mirizzi syndrome for choice of appropriate treatment. Method : From January 1995 to December 1998, 18 cases, of which 8 cases were diagnosed at Soonchunhyang University Chunan Hospital, and 10 cases were reported in the Korean Journal were retrospectively analysed with regard to clinical features, preoperative radiologic findings and operative findings. According to the clinical features, whole cases were divided into type Ⅰ(acute form) and type Ⅱ(chronic form) and then each type of cases were subclassified according to preoperative radiologic findings and operative findings. Results : Of 18 cases there were 5 cases in type Ⅰ(27.8%), 13 cases in type Ⅱ(72.2%). Type Ⅱb was most common. Type Ⅰa cases were treated only with cholecystectomy. We applied cholecystectomy, T-tube choledochostomy and patch technique in type Ⅰb and thpe Ⅰc cases. Cholectystectomies including removal of gallstones and internal drainage procedures were done in type Ⅱ chronic forms. Conclusion : The acute form(Type Ⅰ) of Mirizzi syndrome was suggested by Morelli might be subclassified into typeⅠa,Ⅰb and Ⅰc following the presence of the necrotic defect in common hepatic duct. Through the modified classification of Mirizzi syndrome based on clinical feature, preoperative radiologic findings and operative findings, we can choice appropriate treatment.

자가유화 약물전달시스템을 이용한 이부프로펜의 용출개선 및 흰쥐에서의 생체이용률 평가

김형수,이상길,최성업,박혜숙,전현주,최영욱 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1

A self-microemulsifying drug delivery system(SMEDDS) composed of Cremophor EL^?? Labrasol^?? and Lauroglycol FCC^?? was prepared for the enhancement of solubility, dissolution rate and bioavailability of ibuprofen(IBP), which is water-insoluble but soluble in oils and surfactants. Phase diagram with various regions including microemulsion area was depicted. The SMEDDS was encapsulated in soft gelatin capsules and their dissolution characteristics in various media were observed in comparison to the generic products commercially available in the market. Soft capsules of SMEDDS formulation showed better dissolution profiles, especially in acidic condition, than the others. For the period of 1 hr dissolution in pH 1.2 medium, it reached over 70% dissolution from soft capsules, compared to less than 40% dissolution from commercial reference tablets. On the other hand, in vivo pharmacokinetic parameters were obtained after oral administrations of different IBP preparations to Sprague Dawley rats. SMEDDS formulation showed higher C_max and greater AUC_0-5hr than the suspension of reference tablet or IBP powder. Therefore, it is possible to conclude that a newly developed soft capsules employing SMEDDS provides an alternative preparation to improve oral bioavailability of IBP.

Centerless Feeder 장치의 개발

강형모,권경우,김기길,정의식,허영환 한밭대학교 산업과학기술연구소 1994 논문집 Vol.2 No.-

This paper presents results of the development of centerless feeding system which are applicable to bearing metal processes. As a result, the feeding system can be applied to automatic surface finishing on the bearing metal process such as bush, and has greatly effects on the increase of the prodnctiving and the decrease of the man power an effect on increase the productivity and decrease the man power and effect on increase the productivity and decrease the man power of the bush machining process.

교대근무와 수면 : Sleep Pattern of Psychiatric Nurses on Two-Daily Phase Delay(Day/Evening/Night) Rotating Shift Schedule 2일 간격 지연상(주간/저녁/야간)의 순환교대근무제로 일하는 정신과 간호사의 수면양상

이형영,김원길,윤진상 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

The rapid industrialization is associated with an increase in shift systems. Sleep problem is a major complaint of shift workers. This study was undertaken as one of a series of researches on shift workers and sleep. The purpose was to understand the sleep pattern and to offer basic data in order to improve a sleep regimen. The sleep log was administered to a relatively homogenous group of 38 psychiatric nurses who were on the two-daily phase delay(day/evening/night) rotating shift schedule. Some possible influencing factors to sleep pattern(age, sex, marital status, work duration, drug use, and physical and psychiatric diseases including sleep disorders) were controlled. The sleep measures were main sleep(starting time, latency, number of awakenings, length and subjective quality). Each measure was analyzed and compared accross the rest times at which the workers can take sleep and nap. Also, the possible relationships between the main sleep(quality and length) and naps(number and length) were analyzed. The following results are based on the data of 33 of the 38 subjects. Five of the subjects who did not sleep during the rest time after the second night shift were classified seperately. 1) The beginning of the main sleep phase was delayed during the rest times after day, evening, and night shift, while advanced during the rest times after days off. 2) The sleep measures were significantly different across the rest times; for latency(F(7.224)=2.12, p〈.05), quality(F(7.224)=8.97, P〈.001), length(F(7.224)=41.13, p〈.001) of main sleep, and number of nap(F(7.224)=19.27, P〈.001) and length of nap(F(7.224)=12.79, P〈.001). The main sleep taken in the day time after night shift was generally poorer quality and shorter length than that in the night time after day and evening shifts and days off. Nap was relatively longer and more frequent during the rest time after night shifts than during the rest time after day and evening shifts and days off. 3) There were significantly negative relationships between the total length of main sleep and total number of nap(r= -.3632, p〈.001) and between the total length of main sleep and total length of nap(r= -.2253, P〈.001) across the rest times.

Neural Oscillator를 이용한 강인한 피치추적에 관한 연구

임성길,김형호 대불대학교 2002 論文集 Vol.8 No.1

This Paper treats on the Method for robust pitch tracking on neural oscillator. We used the method which was modified LEGION(Locally Exitator Globally Inhibitory Oscillator Network) algorithm for neural oscillator. The proposed pitch tracking method was evaluated on a man and woman's clean voice which was recoded in the lab and news reporter's voice which has noice signal.