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음식물 의존성 운동 유발성 아나필락시스: 국내 다기관 후향적 연구
임재형 ( Jae Hyoung Im ),권혜윤 ( Hea Yoon Kwon ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ),김태범 ( Tae Bum Kim ),최길순 ( Gil Soon Choi ),김주희 ( Joo Hee Kim ),장광천 ( Gwang Cheon Jang ),김미경 ( Mi Kyung Kim ),허규영 ( 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: To investigate the causes, clinical features and characteristics of food-dependent exercise-induced anaphylaxis (FDEIA) in Korea. Methods: A retrospective medical chart review was performed on the patients diagnosed with anaphylaxis between 2007 and 2011 in 14 hospitals in Korea. Cases with FDEIA were subsequently identified among anaphylaxis patients, and subgroup analyses were done to assess clinical characteristics of FDEIA. Results: A total of 62 subjects with FDEIA (male, 72.6%; aged 16 to 70 years) were enrolled in 10 hospitals. Wheat (69.3%) was the most common cause of FDEIA, followed by meat (8.1%), seafood (6.5%), and vegetables (6.5%). The clinical manifestations were cutaneous (100%), respiratory (64.5%), cardiovascular (61.3%), and gastrointestinal (9.7%), respectively. In severity assessment, approximately 40% of FDEIA were classified as severe anaphylaxis. Portable epinephrine auto-injector was prescribed to 17.2% of patients, and about one fifth of the patients experienced redevelopment of anaphylactic symptoms during follow-up period. There was no significant difference of age, gender, latent period, total immunoglobulin E, and past history of allergic disease between patients with severe anaphylaxis group and patients with mild-to-moderate group. Conclusion: Wheat is the most common cause of FDEIA in Korea. Because significant number of patients with FDEIA experienced anaphylactic symptoms after diagnosis of FDEIA, more comprehensive therapeutic and educational approaches will be required to prevent recurrent development of anaphylaxis. (Allergy Asthma Respir Dis 2013;1:203-210)
음식물 의존성 운동 유발성 아나필락시스: 국내 다기관 후향적 연구
임재형 ( Jae Hyoung Im ),권혜윤 ( Hea Yoon Kwon ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ),김태범 ( Tae Bum Kim ),최길순 ( Gil Soon Choi ),김주희 ( Joo Hee Kim ),장광천 ( Gwang Cheon Jang ),김미경 ( Mi Kyung Kim ),허규영 ( 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: To investigate the causes, clinical features and characteristics of food-dependent exercise-induced anaphylaxis (FDEIA) in Korea. Methods: A retrospective medical chart review was performed on the patients diagnosed with anaphylaxis between 2007 and 2011 in 14 hospitals in Korea. Cases with FDEIA were subsequently identified among anaphylaxis patients, and subgroup analyses were done to assess clinical characteristics of FDEIA. Results: A total of 62 subjects with FDEIA (male, 72.6%; aged 16 to 70 years) were enrolled in 10 hospitals. Wheat (69.3%) was the most common cause of FDEIA, followed by meat (8.1%), seafood (6.5%), and vegetables (6.5%). The clinical manifestations were cutaneous (100%), respiratory (64.5%), cardiovascular (61.3%), and gastrointestinal (9.7%), respectively. In severity assessment, approximately 40% of FDEIA were classified as severe anaphylaxis. Portable epinephrine auto-injector was prescribed to 17.2% of patients, and about one fifth of the patients experienced redevelopment of anaphylactic symptoms during follow-up period. There was no significant difference of age, gender, latent period, total immunoglobulin E, and past history of allergic disease between patients with severe anaphylaxis group and patients with mild-to-moderate group. Conclusion: Wheat is the most common cause of FDEIA in Korea. Because significant number of patients with FDEIA experienced anaphylactic symptoms after diagnosis of FDEIA, more comprehensive therapeutic and educational approaches will be required to prevent recurrent development of anaphylaxis. (Allergy Asthma Respir Dis 2013;1:203-210)
Anti-wrinkle efficacy and safety of micro-spicule containing epidermal growth factor
( Jeong Min Ha ),( Kyuboem Han ),( Jong Cheon Ha ),( Hae Eul Lee ),( Young Lee ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ),( Myung Im ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Microneedle patch recently have been used to increase skin permeability improving drug delivery and for cosmetic purposes. However, such treatment may fail if skin penetration is insufficient reducing drug delivery or if compliance is reduced by discomfort.Objectives: : To evaluate the efficacy and the safety of microspicules containing epidermal growth factor (MS-EGF) used to treat periorbital wrinkles. Methods: Twenty health volunteers were enrolled in a randomized, controlled, split-face study. One periorbital area was treated daily with soluble MS-EGF and the other with EGF cream, for 4 weeks; all subjects underwent 8 weeks of follow-up. Efficacy was assessed using a wrinkle severity rating scale (WSRS), subjective satisfaction scores, digital skin image analysis, examination of skin replicas, and ultrasonic measurement of dermal depth and density. Results: Both the MS-EGF and EGF alone yielded positive effects on digital skin image analysis, skin replica examination, and ultrasound. However, the MS-EGF groupexhibited significant improvements in dermal depth and density, and on replica analysis, compared to theEGF-only group (P < 0.05). In addition, the MS-EGF group showed a significantly greater change in WSRS score compared to baseline than the EGF-alone group. Both treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periorbital wrinkles.
Park, Sungmin,Heo, Jin Hyuck,Cheon, Cheol Hong,Kim, Heesuk,Im, Sang Hyuk,Son, Hae Jung The Royal Society of Chemistry 2015 Journal of materials chemistry. A, Materials for e Vol.3 No.48
<▼1><P>We report a new hole transporting material (HTM) based on [2,2]paracyclophane triarylamine. Due to its higher charge mobility compared with spiro-OMeTAD, the solar cell device incorporating the new HTM achieved a high photovoltaic performance with a PCE of 17.6%.</P></▼1><▼2><P>We report the development of a novel hole transporting material (HTM), PCP-TPA, based on [2,2]paracyclophane. In comparison to the well-known HTM, spiro-OMeTAD, PCP-TPA could be prepared using a simple synthesis and showed a higher hole mobility due to effective intermolecular aggregation in the film state. When used as a HTM in perovskite solar cells, the power conversion efficiency reached 17.6%. PCP-TPA will potentially replace spiro-OMeTAD and advance the development of cost-effective and practical perovskite solar cells.</P></▼2>
The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
( Jeong-min Ha ),( Cho-ah Lim ),( Kyuboem Han ),( Jong-cheon Ha ),( Hae-eul Lee ),( Young Lee ),( Young-joon Seo ),( Chang-deok Kim ),( Jeung-hoon Lee ),( Myung Im ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2
Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may of-ten have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. Objective: We evaluated the efficacy and the safety of soluble micro-spi-cule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a random-ized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects under-went 8 weeks of follow-up. Efficacy was assessed using an ul-trasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for peri-ocular wrinkles and subjective satisfaction. Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles. (Ann Dermatol 29(2) 187∼ 193, 2017)
( Hee Yeon Kim ),( Chang Wook Kim ),( Jin Ah Kim ),( Mi Ju Cheon ),( Chan Ran You ),( Sang Wook Choi ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: This study aimed to assess the efficacy of tenofovir (TDF) monotherapy in lamivudine (LAM)-resistant chronic hepatitis B (CHB) patients with a complete virological response to LAM plus adefovir (ADV). Methods: This is an investigator initiated open label, randomized controlled, non-inferiority trial. LAM-resistant CHB patients on LAM plus ADV therapy with undetectable hepatitis B virus (HBV) DNA were randomized (1:1) to TDF or LAM plus ADV and followed with serum biochemistry and HBV DNA every 12 weeks for 96 weeks. The primary endpoint was the proportion of patients with sustained undetectable HBV DNA at week 48. Results: A total of 76 CHB patients including 26 compensated cirrhosis were enrolled in this study. Thirty-eight patients were randomized to TDF and 38 patients to LAM plus ADV arm. There were no significant differences between two groups in baseline characteristics. Three (7.9%) patients in LAM/ADV group and 7 (18.4%) patients in TDF group were HBeAg-positive. Three patients (2 in LAM/ADV group and 1 in TDF group) dropped out of the study before the 48-week follow-up. Two patients achieved HBsAg seroconversion in LAM/ADV group (2/38, 5.3%). HBeAg loss rate at week 48 was 33.3% (1/3) in LAM/ADV group and 14.3% (1/7) in TDF group. The proportion of patients with sustained complete virological response at week 48 was not significantly different between two groups by per protocol analysis (100% vs 100%) as well as intention-to-treat analysis (94.7% in LAM/ADV group vs 97.2% in TDF group). Conclusions: Switching to TDF monotherapy showed a comparable efficacy to continuing combination therapy in LAM-resistant CHB patients with undetectable HBV DNA to LAM plus ADV combination therapy.
( Hee Yeon Kim ),( Chang Wook Kim ),( Jin Ah Kim ),( Mi Ju Cheon ),( Chan Ran You ),( Sang Wook Choi ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: This study aimed to investigate the efficacy of tenofovir (TDF) monotherapy in multiple drug-resistant chronic hepatitis B (CHB) patients with a complete virological response to TDF plus entecavir (ETV). Methods: This is an investigator initiated open label, randomized controlled, non-inferiority trial. Multiple drug-resistant CHB patients on TDF plus ETV therapy with undetectable hepatitis B virus (HBV) DNA were randomized (1:1) to TDF or TDF plus ETV and followed with serum biochemistry and HBV DNA every 12 weeks for 96 weeks. The primary endpoint was the proportion of patients with sustained undetectable HBV DNA at week 48. Results: A total of 50 CHB patients including 9 compensated cirrhosis were enrolled in this study. Twenty-five patients were randomized to TDF and 25 patients to TDF plus ETV arm. Baseline characteristics were not statistically different between two groups. Thirteen (52%) patients in TDF group and 13 (52%) patients in TDF/ETV group were HBeAg-positive. One patient in TDF group dropped out of the study before the 48-week follow-up. The proportion of patients with sustained complete virological response at week 48 was not significantly different between two groups by per protocol analysis (100% vs 100%) as well as intention-to-treat analysis (100% in TDF group vs 96% in TDF/ETV group). Conclusions: Switching to TDF monotherapy showed a comparable efficacy to continuing combination therapy in multiple drug-resistant CHB patients with undetectable HBV DNA to TDF plus ETV combination therapy.
The Anti-Stress Effect of <i>Mentha arvensis</i> in Immobilized Rats
Tian, Weishun,Akanda, Md Rashedunnabi,Islam, Anowarul,Yang, Hae-Dong,Lee, Sang-Cheon,Lee, Jeong-Ho,Kim, Sang-Ki,Choi, Yu-Jin,Im, So-Yeon,Park, Byung-Yong MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.2
<P>Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. <I>Mentha arvensis</I> (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats. We studied the lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells and rats were immobilized for 2 h per day for 14 days using a restraining cage. MA (100 mg/kg) and FMA (100 mg/kg) were orally administered to rats 1 h prior to immobilization. Using high-performance liquid chromatography (HPLC) analysis, we determined the rosmarinic acid content of MA and FMA. The generation of malondialdehyde (MDA) and nitric oxide (NO) in RAW 246.7 cells were suppressed by both MA and FMA. In rats, MA and FMA notably improved the body weight, daily food intake, and duodenum histology. MDA and NO level were gradually decreased by MA and FMA treatment. MA and FMA significantly controlled the stress-related hormones by decreasing corticosterone and β-endorphin and increasing serotonin level. Moreover, protein expression levels of mitogen activated protein kinases (MAPK) and cyclooxygenase-2 (COX-2) were markedly downregulated by MA and FMA. Taken together, MA and FMA could ameliorate immobilized-stress by reducing oxidative stress, regulating stress-related hormones, and MAPK/COX-2 signaling pathways in rats. Particularly, FMA has shown greater anti-stress activities than MA. </P>
( Jae Kwon Choi ),( Yoon Bok Lee ),( Kyun Hee Lee ),( Hae Cheon Im ),( Yun Bae Kim ),( Ehn Kyoung Choi ),( Seong Soo Joo ),( Su Kil Jang ),( Nam Soo Han ),( Chung Ho Kim ) 한국응용생명화학회(구 한국농화학회) 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.2
The extract of white rose petals has an antioxidant effect and can be used to treat allergic disease. The purpose of this study was to identify optimal conditions for extracting antioxidative compounds from white rose petals with 2,2-diphenyl-1- picrylhydrazyl scavenging activities. A response surface methodology based on a central composite design was used to investigate the effects of three independent variables: ethanol concentration (X1), extraction temperature (X2), and extraction time (X3). The estimated optimal conditions for obtaining phenolic compounds with antioxidant activities were as follows: ethanol concentration of 42% (X1), extraction time of 80 min (X3), and extraction temperature of 75oC (X2). The estimated optimal conditions for obtaining flavonoid compounds with antioxidant effects were an ethanol concentration of 41% (X1), extraction time of 119 min (X3), and an extraction temperature of 75oC (X2). Under these conditions, predicted response values for the phenolic and flavonoid contents were 243.5 mg gallic acid equivalent/g dry mass and 19.93 mg catechin equivalent (CE)/g dry mass, respectively.