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Crocin 첨가 결핵균 배지상의 색소형성에 의한 비정형 Mycobacteria 의 분류
이현수,김재학,윤용덕,최철순,이택주 대한미생물학회 1974 大韓微生物學會誌 Vol.9 No.1
On the basis of pigment production and growth rate on L-J medium containing crocin, differentiation of opportunist mycobacteria belonging to photochromogens, scotochromogens, nonchromogens and rapid grower has been investigated. Among photochromgens, positive pigmentation of M. kansasii was differentiated from negative strain of M. marinum. Scotochromogen M. aquae was positive whereas M. scrofulaceum was negative. Rapid grower M. fortuitum was positive at 3 days test whereas M. smegmatis was negative. Subdivision of opportunist mycobacteria into four groups on the basis of growth rate ad pigment production on L J medium containing gardenia extraction appeared to be a valuable adjunct to the Runyon's classification for the rapid presumptive identification of opportunist mycobacteria of different clinical significance.
이현수 한국장애아동인권학회 2013 장애아동인권연구 Vol.4 No.2
본 연구는 장애아동 학교폭력 예방을 위해 법적인 측면의 개선 방안을 제시하는데 있다. 장애아동에도 학교폭력이 발생하는 원인은 개인적․환경적․법과 제도적 요인 등 다양하지만 무엇보다 ‘사전예방’이 중요할 것이다. 그렇다면 장애학생에 대한 학교폭력이 발생되지 않도록 영유아기부터 고등학교까지 체계적인 장애인 이해교육과 법적인 측면에서 개선이 이루어져야 한다. 학교폭력 문제는 인권 침해의 문제이며 이를 해결하기 위해선 법 개정이 수반되어야한다.
이현수 한국세라믹학회 2013 한국세라믹학회지 Vol.50 No.2
Zinc crystal glaze has its limits in practical use of commercial glaze due to the controlling crystal. In order to overcome this limit,and to heighten the practical usage, this study is aimed to develop artificially controlling willemite (Zn2SiO4) zinc crystalline glaze. For this purpose, it has experimented with the effect of anatase form and rutile form using TiO2 known as nucleating agent. In zinc glaze, adding TiO2 resulted with anatase form becoming more effective at nucleating formation and growth of willemite than the rutile form. Furthermore, it turned out that using the TiO2 - anatase form, with synthetic seeds (zinc silicate), the numbers and positions of crystals can be controlled artificially.
이현수,이동헌,김경훈 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.2
It is easy to overlook osteochondral lesions (OCLs) of the ankle in patients with chronic lower limb pain, such as complex regional pain syndrome (CRPS) or thromboangiitis obliterans (TAO, Buerger’s disease). A 57-year-old woman diagnosed with type 1 CRPS, and a 58-year-old man, diagnosed with TAO, complained of tactile and cold allodynia in their lower legs. After neurolytic lumbar sympathethic ganglion block and titration of medications for neuropathic pain, each subject could walk without the aid of crutches. However, they both complained of constant pain on the left ankle during walking. Focal tenderness was noted; subsequent imaging studies revealed OCLs of her talus and his distal tibia, respectively. Immediately after percutaneous osteoplasties, the patients could walk without ankle pain. It is important to consider the presence of a hidden OCL in chronic pain patients that develop weight-bearing pain and complain of localized tenderness on the ankle.
주걱송편버섯(Pycnoporus cinnabarinus SCH-3)의 Laccase에 의한 Acridine 산화
이현수,한만덕,윤경하,Lee, Hyoun-Su,Han, Man-Deuk,Yoon, Kyung-Ha 한국미생물학회 2008 미생물학회지 Vol.44 No.2
Acridine은 fungal laccase의 기질이 아님에도 불구하고 acridine을 Pycnoporus cinnabarinus SCH-3 배양액에 첨가했을 때 acridone으로 산화되었다. P. cinnabarinus SCH-3균주는 배양 중에 다량의 laccase와 3-hydroxyanthranilic acid (3-HAA)와 cinnabarinic acid (CA)를 생성했다. 정제된 laccase와 acridine을 완충용액에서 직접 반응시켰을 때 acridine은 변화되지 않았다. 그러나 laccase의 기질인 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)나 3-HAA를 laccase와 acridine 혼합액에 첨가했을 경우에는 acridine이 acridone으로 산화되었다. 특히 ABTS 첨가구는 3-HAA 첨가구보다 acridine 산화율이 2배 이상 높았다. 한편 정제된 laccase와 3-HAA를 완충액에서 반응시켰을 때 3-HAA는 CA로 전환되었다. 이와 같은 실험결과들은 P. cinnabarinus SCH-3의 laccase가 배양중에 생산된 3-HAA를 매개체로 사용하여 acridine을 acridone으로 산화하고 CA는 laccase에 의하여 3-HAA로부터 합성됨을 나타낸다. Acridine was not a substrate for fungal laccase but it was oxidized to acridone in the culture medium of P. cinnabarinus SCH-3. During the cultivation of P. cinnabarinus SCH-3, Laccase was the predominant extracellular phenoloxidase, and 3-hydroxyanthranilic acid (3-HAA) was produced in the early culture. Cinnabarinic acid (CA) was observed to accumulate in the culture medium. When P. cinnabarinus was grown in the culture medium containing acridine, acridine was oxidized to acridone. But when the laccase purified from the culture medium of P. cinnabarinus directly reacted with acridine in sodium tartrate buffer (pH 3.0), The oxidation of acridine did not happen. In contrast, when 3-HAA was added to the buffer that was mixed with laccase and acridine, the acridine was oxidized to acridone. While in vitro studies, the CA was formed from 3-HAA in the presence of purified laccase. The results suggest that the acridine should be oxidized to the acridone through the mediation of 3-HAA by the laccase in the culture medium of P. cinnabarinus SCH-3.
조현병 환자의 아동기 외상 경험에 따른 정신병리 및 임상적 특성
이현수,정유란,유태영,이주연,이수인,김재민,윤진상,김성완 대한조현병학회 2017 대한조현병학회지 Vol.20 No.2
Objectives : This study was aimed to investigate the associations of childhood trauma with psychopathology and clinical characteristics in patients with schizophrenia. Methods : This study enrolled 66 inpatients with schizophrenia. Korean Childhood Trauma Questionnaire (K-CTQ) and Life Event Questionnaire (LEQ) were administered to assess childhood trauma. Psychopatholgy and clinical characteristics were assessed with the Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI), Korean Version of Internalized Stigma of Mental Illness (K-ISMI), Perceived Stress Scale (PSS), and visual analogue scale of EuroQoL-5 Dimension Index (EQ-5D). Results : Total scores on K-CTQ were positively associated with scores on the BDI, K-ISMI, PSS, and PANSS and negatively associated with the score on the EQ-5D. Among subscales of K-CTQ, emotional abuse was significantly associated with all measures for psychopathology and clinical characteristics. Patients with physical abuse (36.5%), emotional abuse (30.2%), or bullying (30.6%) according to the LEQ showed sighificanlty higher the ISMI score and lower EQ-5D score. Emotional abuse and bullying were also significantly associated with higher scores on BDI and/or PSS. Conclusion : Our results suggest that childhood trauma negatively influences on internalized stigma, depression, perceived stress and quality of life in patients with schizophrenia. Clinicians should carefully evalute and manage childhood traumatic experience of patients with schizophrenia.