PET/CT 검사에서 Stomach의 추가 촬영을 줄이기 위한 수분 섭취의 유용성

이승환,배성복,정병곤,이규찬,이광철,배원규,Lee, Seung-Hwan,Bae, Seong-Bok,Jeong, Byeong-Gon,Lee, Gyu-Chan,Lee, Gwang-Cheol,Bae, Won-Gyu 대한핵의학기술학회 2011 핵의학 기술 Vol.15 No.1

암 환자의 영상에서 stomach의 병변과 분비물을 구분하기란 쉽지 않다. 이 연구의 목적은 검사 전 충분한 수분 섭취로 stomach의 병변과 분비물의 분별력을 높임으로서 추가 촬영을 줄이기 위하여 시행하였고 본 연구는 총 228명의 암 환자로 2010년 8월 18일부터 2010년 9월10일까지 진행하였으며, 2010년 8월 18일부터 2010년 8월 31일까지는 수분섭취 제한환자가 115명이었고, 2010년 9월 1일부터 2010년 9월 10일까지는 촬영 직전 수분을 500 cc 정도 섭취한 후 검사를 진행한 환자로 113명이었다. 이 검사를 시행한 결과 전체 암 환자 228명을 대상으로 촬영 수분 섭취 제한 환자는 총 115명이고, 이중 추가 촬영이 없는 환자가 89명이었고, stomach 추가 촬영을 진행한 환자가 13이었으며, 기타 추가 촬영을 진행한 환자는 13명이었다. 그리고 촬영 직전 수분을 500 cc 정도 섭취한 후 검사를 진행한 환자 113명 중 추가 촬영이 없는 환자가 109이었고, stomach 추가 촬영을 진행한 환자가 1명이었으며, 기타 추가 촬영을 진행한 환자는 3명에 해당하였다. 이와 같은 결과로도 수분을 500 cc 정도 섭취하고 검사를 진행한 환자에게서 추가 촬영이 줄었음을 알 수 있었으나, 정확한 유의성을 알기 위하여 pearson의 chi-square test를 시행한 결과 유의확률이 0.05보다 작은 0.001이었으므로 두 집단은 유의한 관련성이 있음을 알 수 있고 최소 기대빈도가 6.94로서 5보다 작은 기대빈도가 없었으므로 pearson의 정확한 검정을 할 필요는 없었고, 위의 연구로 인하여 물을 검사 직전 약 500 cc 정도 섭취하고 촬영을 진행하면 stomach 추가 촬영을 현저히 줄일 수 있으며 기타 추가 촬영 또한 줄일 수 있음을 알 수 있었고 검사 지연 시간 또한 줄일 수 있을 것으로 사료된다. Purpose: With the introduction of PET since 1994, test methods have made rapid progress. Accordingly, the studies on the diagnosis and treatment of cancer as well as treatment response evaluation PET test are useful. However, it is difficult to divide stomach lesions and secretion. The purpose of this study is to reduce additional shooting by dividing lesions and secretion of stomach. Materials and Method: This study aiming at total 228 cancer patients was conducted from Aug 18 to Sep. 10, 2010. Among them, 115 patients had a test without water intake before shooting from Aug. 8 to 31 and 113 had a test after drinking 500 cc water right before shooting from Sep. 1 to 10 The Discovery ST PET/CT (GE Healthcare, USA) was used, and pearson's chi-square test was conducted to analyze significance through SPSS (Ver.18). Results: Among the total 228 cancer patients, there were 115 who had a test without water intake before shooting, 89 who had no double additional shooting, 13 who had stomach additional shooting and 13 who had other additional shooting. In addition, 109 had no additional shooting among 113 who had a test after taking 500 cc water, 1 had stomach additional shooting and 3 had other additional shooting. According to the findings above, the patients who had a test without water intake show reduced additional shooting, but for more exact significance, pearson's Chi-square test was carried out and the significance percentage was 0.001 that is smaller than 0.05, which means two groups have a significant relationship. As the minimum expectation frequency was 6.94 and there was no expectation frequency smaller than 5, so that it doesn't need to carry out pearson's exact verification. Conclusion: The above analysis has found that if one drinks 500cc water before the test, not only stomach additional shooting but also other additional shooting can be dramatically reduced, and test delay can be also reduced.

공황장애 치료에 대한 중의학의 임상연구 동향

이승환 ( Seung Hwan Lee ),성우용 ( Woo Yong Seong ),임정화 ( Jung Hwa Lim ) 대한한방신경정신과학회 2015 동의신경정신과학회지 Vol.26 No.2

Objectives: This study was performed to review the research trends in the treatment of panic disorder in traditional Chinese medicine (TCM). Methods: We searched articles in the China National Knowledge Infrastructure (CNKI) from 2004 to 2014. Search key words were ‘驚恐’ and ``panic disorder``, and we selected eight studies except for non-clinical, unrelated studies, tests on animals. Results: We finally selected eight articles, and the results were as follows. CCMD-3 was most frequently used as a diagnostic criterion and HAMA was mostly used for outcome measurement. In TCM there are various ways, such as herbal medicine, acupuncture and psychotherapy, to treat panic disorder. Most of the studies showed effective results. Most of the treatment group reported that they had less side effects than the control group. However, the quality of these clinical studies was low. Conclusions: In TCM, research on panic disorder was being conducted more actively than in Korean medicine. According to this study, it seems that in TCM, the treatment of panic disorder might be more effective and have some advantages. Therefore, with this study, we hope to activate more clinical research on the treatment of panic disorder in Korean medicine.

세리아가 첨가된 니켈 치환 하이드로탈사이트로부터 유도된 촉매에 의한 메탄의 부분산화

이승환(Lee, Seung-Hwan),김미소(Kim, Mi-So),곽정훈(Kwak, Jung-Hun),임태훈(Lim, Tae-Hoon),남석우(Nam, Suk-Woo),홍성안(Hong, Seong-Ahn),윤기준(Yoon, Ki-June) 한국신재생에너지학회 2008 신재생에너지 Vol.4 No.2

Partial oxidation of methane was carried out by ceria-promoted Ni-substituted hydrotalcite-derived catalysts (Ce_xNi₃-HTlc ; x=0.3{sim}1.2) in a fixed-bed reactor. The Ce/Ni ratio of 0.3/3 in the catalyst showed the best catalytic activity but the Ce/Ni ratio became higher above 0.3/3, the catalyst became less active in short-term tests. No ceria promoted catalyst was started to decrease CH₄ conversion after 20 h but the Ce/Ni ratio 0.3/3 catalyst was kept its stability in long-term tests.

국내 한의학 학회지에 게재된 질적 연구 보고 분석

이승환 ( Seung Hwan Lee ),성우용 ( Woo Yong Seong ),임정화 ( Jung Hwa Lim ) 대한한방신경정신과학회 2016 동의신경정신과학회지 Vol.27 No.2

Objectives: This study was aimed to analyze the reports of qualitative research published in domestic Korean medicine journals. Methods: Eleven published qualitative research studies were selected for analysis. Selected reports were analyzed by Consolidated Criteria for Reporting Qualitative Research (COREQ), a reporting guideline for qualitative research. Results: In the 1st domain, descriptions of personal characteristics, interviewer`s bias or assumption were insufficient. In the 2nd domain, descriptions such as presence of non-participants, research questions for the interview guidelines, data saturation and transcript return to participants were insufficient. In the 3rd domain, descriptions of items related to number of data coder, participants evaluating the finding, and clarity of minor themes were insufficient. Conclusions: Qualitative studies in Korean Medicine have increased. COREQ should be considered by investigators who report qualitative research, in order to improve the quality of research.

한우 FASN 유전자변이와 한우 지방형질 및 지방산조성과의 연관성 분석

이승환(Seung-Hwan Lee),김형철(Hyeong-Cheol Kim),조원모(Won-Mo Cho),장선식(Sun-Sik Chang),김범수(Bum-Soo Kim),장길원(Gul-Won Chang),이준헌(Jun-Hun Lee),연성흠(Seong-Heum Yeon),홍성구(Seong-Koo Hong) 충남대학교 농업과학연구소 2011 농업과학연구 Vol.38 No.2

The aim of this study was to identify the polymorphism on fatty acid synthase (FASN) gene and its association with fat traits and fatty acid composition in Hanwoo. We genotyped a SNP (g.16024G → A) detected in Exon34 of FASN on 90 Hanwoo steers by PCR RFLP. A linear mixed model revealed an association of g.16024G → A with total body fat contents (P=0.006), while there is no significant effect between g.16024G → A and other traits (IMF, BF and fatty acid composition). Regression coefficient and R² of the SNP was -1.5 ㎏ and 0.36 in this anslysis. Expecially, AA type of g.16024G → A bas a less amount of body fat (1.5 ㎏) than GG type of the SNP in Hanwoo. In conclusion, this study indicates an important role for FASN gene in determining body fat content in Hanwoo.

한우 지방산결합단백질 4(FABP4) 유전자 조절영역내 단일염기변이(SNP)와 도체형질간 연관성 분석

이승환(Seung Hwan Lee),김남국(Nam Kuk Kim),김승창(Seung Chang Kim),최봉환(Bong Hwan Choi),허강녕(Kang Neung Heo),이창수(Chang Soo Lee),김언현(Oun Hyun Kim),이준헌(Jun Heon Lee),김형철(Hyeong Cheul Kim),홍성구(Seong Koo Hong) 충남대학교 농업과학연구소 2011 농업과학연구 Vol.38 No.4

The aim of this study was to identify the polymorphism on fatty acid binding protein (FABP4) gene promoter region and its association with carcass traits in Hanwoo. We performed PCR-direct sequencing of FABP4 promoter region to identify single nucleotide polymorphism (SNPs) using unrelated 24 Hanwoo bulls. Four SNPs (-298A>G, -472A>G, -887A>G, -862A>G) were detected in the promoter region and genotyped on 583 Hanwoo steers. A linear mixed model revealed an association of three SNPs (-298A>G, -472A>G and ?862A>G) with carcass weight and marbling score in dominance model (P<0.05). The animals with AA genotypes for the three SNPs were heavier carcass weight (5 kg) than animals with GG genotypes in the statistical analysis. For the marbling score, the AA genotype was lower effect of marbling score (0.21) than GG genotypes. In conclusion, this study indicates an important role for three SNPs detected in promoter region of FABP4 in determining carcass weight and marbling score in Hanwoo.

파킨슨병 환자에서의 폐 기능 이상

이승환(Seung-Hwan Lee),최윤선(Youn Seon Choi),고성범(Seong-Beom Koh) 대한임상노인의학회 2011 대한임상노인의학회지 Vol.12 No.2

연구배경: 파킨슨병의 운동계 증상은 잘 알려져 있으나, 운동계 증상 이외에 다른 여러 증상에 대해서는 많은 연구가 부족한 상황이다. 본 연구에서는 파킨슨병의 환자에서 폐 기능 이상 여부를 알아보며, 폐기능 이상과 파킨슨병의 주된 운동계 증상과의 관련성을 알아보고자 한다. 방법: 76명의 파킨슨병 환자를 대상으로 하였다. 환자 군을 떨림이 주증상인 군(33명)과 자세불안정 및 강직이 주증상인 군(43명)으로 나누어 폐 기능 검사를 시행하였다. 파킨슨병의 임상 정도는 호엔-야병기와 통합파킨슨척도검사를 이용하여 평가하였다. 결과: 떨림 주증상군과 자세불안정 및 강직 주증상군 사이에 폐 기능검사상 차이는 없었다. 파킨슨병의 임상 척도가 나쁠수록 강제폐활량(FVC)과 강제폐활량 검사 중 처음 1초 동안 호기량(FEV1)이 유의하게 감소하였다(P<0.05). FEV1/FVC비는 통합파킨슨척도 검사 결과 및 호엔야병기와 유의한 상관관계를 보였다. 결론: FVC와 FEV1은 파킨슨병 환자에서 주된 운동계 증상의 종류와 무관하게 병의 심한 정도를 반영하는 인자가 될 수 있을 것으로 생각된다. 본 연구를 통해서 폐 기능검사 결과가 파킨슨병의 운동기능 심각도를 평가하는 데 유용한 지표가 될 수 있을 것으로 생각한다. Background: Motor deficits associated with Parkinson’s disease (PD) have been well described, yet little attention has been paid to non-motor miscellaneous symptoms. In this study, we identified pulmonary dysfunction in patients with PD. We also investigated the relationship between pulmonary function and parkinsonian motor signs. Methods: A total 76 patients were recruited. We enrolled 33 patients with tremor dominant (TD) PD patients and 43 patients with postural instability and gait disturbances dominant (PIGD) PD patients without symptoms of pulmonary dysfunction. A pulmonary function test (PFT) was performed in all patients. The Hoehn & Yahr stage was determined and the degree of disease severity was quantified by activities of daily living and motor score of the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: There was no significant difference in PFT between patients with TD motor abnormalities and patients with PIGD. Individual clinical disability scales showed a strong negative correlation with forced vital capacity (FVC) and volume of air expired during the first second of the FVC test (FEV1) (P<0.05). The FEV1/FVC ratio showed a significant correlation with motor score of the UPDRS and the Hoehn-Yahr stage. Conclusion: We suggest that the FVC and FEV1 could reflect a subject’s clinical disability regardless of dominant clinical features. Additionally, the FEV1/FVC ratio could be an indicator for motor score of the UPDRS or disease stages in general. Therefore, we suggest that PFT could be used to evaluate the clinical disability of patients with PD or prevent them from developing pulmonary complications.

불안장애 치료에 관한 최근 임상연구 동향

이승환 ( Seung Hwan Lee ),강민정 ( Min Jeong Kang ),임정화 ( Jung Hwa Lim ),성우용 ( Woo Yong Seong ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.2

Objectives: This study is set out to discover more about the treatment of anxiety disorder in Traditional Chinese Medicine. Methods: We searched the database-China Academic Journals (CAJ). For papers published since 2007-2011, which are classified in categories. Results: We have finally selected 23 articles, and the results were as follows: 1, Stages of Anxiety disorder are discussed in various aspects, 2, Diagnostic criteria and evaluation criteria were the same, especially, in the CCMD and HAMA was used most frequently. Adverse effects were reported using TESS. 3. There are various ways, such as Herbal medicine, acupuncture, electroacupuncture stimulation, acupoints injection, and abdominal massage therapy to treat Anxiety disorders in TCM. 4. Zizyphus jujuba, Poligala tenuifolia, Poria cocos are mainly used in herbal medicine. Sinmun (HT7), Sameumgyo (SP6), Naegwan (PC6) are mainly used in acupuncture points. 5. The treatment group, cured by herbal medicine or acupuncture, was similar in its therapeutic efficiency to that of the control group, which was cured by western medicine. In some cases, the treatment group was better off than the control group. Herbal medicines have been reported that they have less side effects and drug addiction than the western medicines. We predict that herbal medicine in the treatment for anxiety disorders will have an advantage. Conclusions: There are a wide range of approaches in the treatments for Anxiety disorders in TCM, In some aspects, herbal medicine is more effective than that of the western medicine, According to this study, we predict that herbal medicine in the treatment for anxiety disorders, has some advantage, Therefore, there is a need for more clinical research for this disorder in Korean traditional medicine.

시각장애인의 정보 접근성 향상을 위한 모바일 신문 어플리케이션 인터페이스

이승환(Lee Seung Hwan),홍성호(Hong Seong Ho),고승희(Ko Seung Hee),최희연(Choi Hee Yeon),황성수(Sung Soo Hwang) 한국HCI학회 2016 한국HCI학회 논문지 Vol.11 No.3

최근 TTS(Text-to-Speech)기능을 활용한 시각 장애인의 스마트폰 사용이 계속 증가하고 있다. TTS기능은 어플리케이션 내부의 문자 정보를 음성정보로 전환하며, 어플리케이션 내 정보를 순차적으로만 접근할 수 있다. 이러한 이유로 어플리케이션 내부의 버튼 및 콘텐츠의 배치가 효과적으로 이루어져야 한다. 그러나 기존에 제안된 모바일 어플리케이션, 특히 다양한 콘텐츠가 포함된 신문 어플리케이션의 경우 TTS 사용 환경을 고려하지 않았다. 따라서 시각 장애인들이 이용하기에 매우 어려운 상황이다. 또한 전맹인 이외에도 저시력 장애인을 고려한 인터페이스가 필요한 상황이다. 따라서 본 논문은 다양한 시각장애인의 접근성과 요구를 반영한 모바일 신문 어플리케이션 인터페이스를 제안한다. 제안하는 인터페이스는 TTS 사용 환경을 고려한 버튼 배치 및 검색 기능 및 이미 읽은 기사분류 기능을 통해 빠르게 어플리케이션을 사용할 수 있게 하였다. 또한 잘못 발음되는 단어를 필터링하고 버튼에 대한 충분한 설명을 통해 어플리케이션을 원활하게 사용할 수 있게 하였다. 마지막으로 저시력 장애인을 위해 글자 크기 확대, 화면 반전 기능 등을 구현하였다. 실험 결과 제안하는 인터페이스가 일반 신문 어플리케이션 및 기존에 제안된 시각장애인용 인터페이스보다 기사 검색 속도 및 어플리케이션 사용성 측면에서 높은 성능을 나타내는 것을 확인하였다. The number of visually-impaired people using a smartphone is currently increasing with the help Text-to-Speech(TTS). TTS converts text data in a mobile application into sound data, and it only allows sequential search. For this reason, the location of buttons and contents inside an application should be determined carefully. However, little attention has been made on TTS service environment during the development of mobile newspaper application. This makes visually-impaired people difficult to use these applications. Furthermore, a mobile application interface which also reflects the desire of the low vision is necessary. Therefore, this paper presents a mobile newspaper interface which considers the accessibility and the desire of various visually impaired people. To this end, the proposed interface locates buttons with the consideration of TTS service environment and provides search functionality. The proposed interface also enables visually impaired people to use the application smoothly by filtering out the words that are pronounced improperly and providing the proper explanation for every button. Finally, several functionalities such as increasing font size and color reversal are implemented for the low vision. Simulation results show that the proposed interface achieves better performance than other applications in terms of search speed and usability.

O/C비 변화에 따른 세리아가 첨가된 니켈치환 하이드로탈사이트로부터 유도된 촉매에 의한 디젤의 부분산화

이승환(Lee, Seung-Hwan),윤광우(Yoon, Kwang-Woo),곽정훈(Kwak, Jung-Hun),임태훈(Lim, Tae-Hoon),남석우(Nam, Suk-Woo),홍성안(Hong, Seong-Ahn),윤기준(Yoon, Ki-June) 한국신재생에너지학회 2009 한국신재생에너지학회 학술대회논문집 Vol.2009 No.06