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이세훈 가톨릭대학 산업의학센타 산업의학연구소 1981 韓國의 産業醫學 Vol.20 No.3
유기용제나 혹은 다른 xenobiotics폭로와 관련하여 각 물질이 어떻게 호흡기나 소화기관 혹은 피부를 통해 흡수되며 그에 계속하여 신체 각 부분에 대한 그 물질의 분포 및 대사(생체전환)과정은 어떻게 되고 궁극적으로는 어떻게 배설되는지에 대한 지식은 필수적이라 하겠다. 즉 이 모든 단계들에 대한 지식은 중독작용의 기전과 용량-반응관계에 대한 이해를 돕는데 있어서 중요하며 또한 정당한 기초를 갖춘 위생 기준을 마련하는데 도움이 되기도 한다. 본 란에서는 흔히 사용되는 유기용제에 대한 현재의 지식을 요약하고 생체전환에 관한 연구의 필요성을 서술하기로 한다.
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고형암 환자에서 항암화학요법 후 발생한 호중구감소증에 대한 류코그린Ⓡ(G-CSF)의 제3상 다기관 공동 임상시험
이세훈 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.1
Background : Neutropenia is the main cause of therapy-related mortality in the patients who receive cytotoxic chemotherapy. Granulocyte colony-stimulating factor (G-CSF) can reduce the neutropenic severity and duration after cytotoxic chemotherapy. We performed a randomized, controlled, cross-over study of two G-CSF (LeucogreenⓇ and control drug) in the solid tumor patients who would receive cytotoxic chemotherapy. Methods : Patients received LeucogreenⓇ in the first cycle and control drug in the second cycle, or vice versa. They should have received at least two cycles of same chemotherapy for their solid tumor. They were administered G-CSF 50μg/m2 daily for 10 days since 24 hours after the last dose of chemotherapy. Results : Eighty-three patients received at least one dose of G-CSF, and 61 patients completed two cycles of G-CSF without major protocol violation. The prophylactic rate of neutropenia (<1,000/mm3) of test drug is 70.5%, and 95% confidence interval (CI) of the rate is 59.3-81.7%, which is included within the identical borderline (rate of control drug ± 20%, 48.9-88.9%). Two drugs did not show any significant difference in respect of incidence of abnormal neutrophil count (<2,000/mm3), nadir neutrophil count, duration of neutropenia and duration of abnormal neutrophil count. Mild to moderate cause-related adverse events were observed during trial period and no significant difference in incidence and severity between two drugs. Conclusion : LeucogreenⓇ showed similar efficacies for chemotherapy-induced neutropenia to control G-CSF and could safely be given.
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요량과 요중 연 ALA 및 coproporpgyrin과의 관계
김정만,이병국,이광묵,이세훈 가톨릭대학산업의학센타 산업의학연구소 1980 韓國의 産業醫學 Vol.19 No.1
In order to study the effect of urine volume on the alteration of urinary excretion of lead. ALA and coproporphyrin of thirty Korean albino rabbits in accordance with the intensity of the lead intoxication, authors calculated the Spearman's rank correlation between seventy-two hours urine volume and the other parameters. Thrity rabbits were divided equally into two groups of fifteen rabbits each. Lead acetate was injected subcutaneously six times a week for six weeks with total amount of 1.8 milligrams per killogram oof bodyweight for group I, and 18 milligrams per kilogram of bodyweight for group II. The results were as follows; 1. The urinary excretion of lead was significantly correlatr\ed with the urine volume in all experimental groups (p<0.05-0.001). And also, the Spearman's rank correlation was lowered in accrdance with increment of urinary excretion of lead 2. All groups but group Ii, the urinary excretion of ALA was significantly correlated with the urine volume (p<0.01-0.001). 3. In all groups, urinary excretion of coproporphyrin was significantly correlated with the urine volume (p<0.05-0.01).
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이세훈,Lee, Se-Hoon 대한예방의학회 1980 Journal of Preventive Medicine and Public Health Vol.13 No.1
In order to study the effect of lead exposure on the hematocrit and hemoglobin values in accordance with the level of lead exposure, twenty-four Sprague-Dawley rats were equally divided into four groups of six rats each. Lead acetate disolved in glucose was injected intraperitoneally six times a week, for four weeks with dose of 0.05 mg/kg/day for group I, 0.5 mg/kg/day for group II, and 5 mg/kg/day for group III. Control group was injected glucose only. Blood samples for the checking of the hematocrit and hemoglobin values, were taking from tail vein of rats before lead injection and on the third, seventh, fourteenth, twenty-first, and twenty-eighth days after lead injection. And also, the concentration of lead and ALA in urine were checked for evaluating the lead absorption. The results were as follows: 1. The alteration of the hematocrit and hemoglobin values of the group I was not significant as that of the control group. 2. In group II, the hematocrit values were significantly decreased from the fourteenth day after lead injection, and the hemoglobin values were decreased from the twenty-first day after lead injection when the concentration of lead in urine was elevated more than $260{\mu}g/liter$. 3. In group III, the hematocrit values were decreased from the seventh day after lead injection, and the hemoglobin values were decreased even from the third day after lead injection. And the hemoglobin values were more rapidly decreased than the hematocrit values. 4. In all groups, the correlation coefficient between hematocrit and hemoglobin was highly significant. And the difference between the correlation coefficient of the group III and that of the others was highly significant.
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이세훈 가톨릭대학산업의학센타 산업의학연구소 2002 韓國의 産業醫學 Vol.41 No.1
Contents for the clinical evaluation on the occupational neurotoxic disorders among workers occupationally exposed industrial harmful agents in the mass screening test was suggested in this text through literature review reported in the national and international journals. Particularly, though the World Health Organization's reports on chronic toxic encephalopathy and on periperal polyneuropathy. Reportedly, cases of severe chronic toxic encephalopathy was found only among so called solvent sniffers, and oreganic affective syndrome and mild chronic toxic encephalopathy are the cases found among workers occupationally exposed to industrial neurotoxic agents. Great emphasis should be put on detailed clinical interview and on history for the diagnosis of chronic toxic encephalopathy for the elimination of the confounding factors including age and education, and for ruling out other possible causes of nervous system disorders.
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