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정윤섭,이삼열 대한감염학회 1990 감염 Vol.22 No.3
Serious Candia albicans infection is now well recognized problem among the compromised patients. Cryptococcus neoformans meningitis, a rare disease previously, became more frequently encountered. For the treatment of fungal infections not many agents were available. In this study, activities of fluconazole, amphotericin B and 5-fluorocytosine against clinical isolates of C. albicans and C. neoformans were tested by the agar dilution test using high resolution medium. Against C. albicans, the MIC range of fluconazole was 0.4-12.5 ㎍/㎖. ?? and ?? were 1.6 ㎍/㎖ and 3.1㎍/㎖, respectively. The MIC range of amphotericin B was 0.2-0.8 ㎍/㎖. MIC range of 5 5-fluorocytosine was 0.4->100 ㎍/㎖ and ?? and ?? were 1.6 and > 100 ㎍/㎖, respectively. Against C. neoformans, MIC range of fluconazole was 3.1-50 ㎍/㎖. Both ?? and ?? were 50 ㎍/㎖. Growth of all isolates were inhibited by 0.4㎍/㎖ of amphotericin B. MIC range of 5-fluorocytosine was 25->100 ㎍/㎖ and both ?? and MIC?? were 50 ㎍/㎖. Although in vitro test results of fluconazole seldome predicts in vivo efficacy, by comparing our in vitro data to those of those of others, who did both in vitro test and clinical trials, it was concluded that fluconazole could be effectively used for the treatment of most of the C. albicans and C. neoformans infections in Korea.
胎兒赤芽球症生成機轉에 있어서의 交叉反應性抗體에 關한 硏究
李三悅 中央醫學社 1941 中央醫學 Vol.10 No.2
In 1960, the first proven case among Korean babies of Rh-sensitized and five cases 4 ABO-sensitized erythroblastosis fetalis were reported by the present author. Attention was paid to the fact that all of those ABO-cases happened exclusively in group-O mothers. Seeking the explanation of this phenomenon, the author was interested in the role of the so-called "Cross-reacting antibody", which importance in 'tithe' development of ABO-erythroblastosis fetalis was postulated by Wiener and Zuelzer (1955). Employing the technique of antibody-absorption and elution introduced by Dodd (1952) the author made the following observations using both clinical materials of Korean population and experimental animal materials. 1. Antibody responses to a same antigen stimulation was greater in group-O persons than in any other group persons, and this was true in both natural and immune antibody productions. 2. Group-O persons might possess a so-called cross-reacting antibody, anti-C, in addition to the ordinary anti-A and anti-B; and its frequencies among Koreans were 70 to 77%a in male and 65 to 80'% in pregnant female. 3. The cross-reacting antibody reacted better at 37C than at 4 C and better in colloidal medium than in saline medium. 4. The cross-reacting antibody reacted best with an indirect Coombs technique among the ordinary three titration techniques; and in this regard this antibody belonged to an incomplete antibody. 5. In contrast to immune anti-A or anti-B sera, the cross-reacting antibody was neutralized by soluble group specific substances but this phenomenon did not happen on an immune animal origin cross-reacting antibody. 6. It was demonstrated that blood-free placental emulsion absorbed hemagglutinins in vitro including the cross-reacting antibody; and the same phenomenon appeared to occur in vivo as demonstrated in a group-A fetal placenta delivered from a group-O mother. ; These observations were discussed to find the possible role of the cross-reacting antibody in the pathogenesis of ABO-erythroblastosis fetalis and the author reached the conclusion that the reasons why ABO-erythroblastosis fetalis is apt to occur in eases of group-O mothers would be: they are prone to produce more hemagglutinins than any other group persons, in general, and they produce so-called cross-reacting antibody readily, which would not be possibly produced in any other group persons. Furthermore, the cross-reacting antibody possesses many immunohematologically advantageous characteristics which would induce an erythroblastosis fetalis. On the other hands the reasons why all group-O mothers do not develop erythroblastosis fetalis in their heterospecific pregnancies would be the cross-reacting antibody is absorbed by placenta, a fact which is quite different from that in the cases of Rh-antibodies, and the cross-reacting antibody is neutralized by soluble group specific substances in the fetus. These fetal protective mechanisms would weaken the offending potency of the cross-reacting antibody.
중성자 collimator의 제작 및 Am-Be 중성자 파고스펙트럼 측정
윤정란,노태익,민영기,이삼열 東亞大學校 1997 東亞論叢 Vol.34 No.-
The neutron collimator, 20cm width, 30cm length, 15cm height and 1cm diameter of hole was constructed by using polyethylene block which includes 15% boric acid. The total cross section of average 7.7MeV neutrons for Al, Cu, Au, Pb samples and the scattering angular distribution of the same energy for Al sample were measured by using 10mCi Am-Be fast neutron source. The range of average 7.7MeV neutron energy were selected from 6.45 MeV to 8.95MeV at the measured pulse height spectrum.2"Φ×2" NE-213 organic liquid scintillation detector was used on the measurement of neutron flux. The Pulse Shape Discrimination(P.S.D.) methods were used for the spectra separation of neutron with r-ray at the mixed field. The results of measurement of total cross section and scattering angular distribution for average 7.7MeV neutrons were compared with other researcher’ and ENDF/B-VI, respectively.