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      • 犬에 發生한 小腦無形症의 一例

        趙聲煥,金德煥,柳時潤,金敎準,李哲浩 충남대학교 농업과학연구소 1988 農業技術硏究報告 Vol.15 No.-

        A one-month-old female mixed-breed dog showing nervous sign characterized by ataxia was admitted to the veterinary Teaching Hospital of Chungnam National University. This dog was submitted for autopsy, and the cerebellar agenesis was diagnosed on the basis of clinical and pathological findings. Clinically, the patient was unable to stand and showed the swaying movement of legs. At necropsy, there was complete absence of the cerebellum. No definite gross lesions were noted any of the internal organs. Histopathologically, degenerative cells were observed in gray matt of the cerebrum, pons and spinal cord.

      • Nicotine이 발생중인 鷄胎의 體重 成長에 미치는 영향

        金武剛,金弘善,柳時潤,申台均,李永浩,趙聲煥 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

        The authors studies the effects of Nicotine on the Body weight growth of the developmental chick embryo. On the sixth day of incubation, 0.41mg, 0.82mg and 1.65mg of Nicotine were injected into the chorioallantoic sac of each egg of three groups and one group was injected physiological saline solution as a control, and the eggs were broken for weighting the body weight in every other day from the twelfth day to eighteenth day of incubation. In an attempt to analyze the growth of the body weights, growth formula of Zimmerman and relative growth formula of Huxley were applied. The following results were obtained. 1. The growth of chick embryo boby weight was affected as inhibiting by the Nicotine. The inhibiting effects were in proportion to the injected Nicotine dosage. 2. The growth quantity of the body weight injected 1.65mg was almost half weight of the control group body weight. 3. Growth rate was decreased continuously with tine until 18th day in the 1.65mg injected group but it was increased in 0.41mg and 0.82mg injected group with time lapse from 12th day to 18th day, and 0.41mg injected group was more increased than 0.82mg injected group. 4. Specific growth rate decreased in the all of 0.41mg, 0.82mg and 1.65mg injected group and in the decrease degree 1.65mg and 0.82mg injected group ware severe and 0.41mg injected group was slight. 5. Growth centers of growth gradient were 12th day in the 0.41mg injected group and 18th day in the 0.82mg and 1.65mg injected groups. 6. Relative growth rate was also decreased proportionally in related with injected Nicotine dosage.

      • 鷄胎器官에 미치는 Rifampin의 抑制效果

        金弘善,金武剛,趙聲煥,柳時潤,金純妊,金源式 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2

        In order to analyzed the effects of rifampin on the growth of each organs of embryonated egg, 2mg per egg of rifampin were injected into the chorioallantoic sac on the 6th of embryonated egg. Control and experimental group of eggs was broken on the 18th day of incubation for weighting the body weight and various organs-heart, liver, lung, kidney, and brain of chick embryo, and difference of effects were analyzed by discriminant function method. The results were as follow; 1. By discriminant function method, different effects was conspicuous between control group and rifampin 2mg per egg injected group. 2. Mean of discriminant value was 22.87 in control group and 12.63 in rifampin injected group. 3. Discriminant limit value was 17. 75 and the error of discrimination was 11 percent.

      • Mitomycin C가 鷄胎肝臟成長에 미치는 影響에 關한 硏究

        金武剛,趙聲煥,金弘善,柳時潤,李康伊 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1

        Mitomycin C is well known as antibacterial, antiviral and antitumor by the mechanism of alkylation. The authors intend to analyze the effects of Mitomycin C on the weight of the liver in the chick embryos. On the sixth day of incubation, 8ug and 16㎍ of Mitomycin C were injected into the chorioalantoic sac of each incubated eggs of two groups. Between the twelth day and eighteenth day of incubation a daily total of thirty injected egges of each group was broken for weighting the liver weight of chick embryos. The effects of dose and difference of growth time were analyzed by Zimmerman's growth formula and Huxley's relative growth formula and determination of significance in the levels of difference was made by analysis of variance. The results are summarized as follows: 1. Mitomycin C suppresed growth of the liver in the chick embryos and growth inhibition appeared to be much stronger in the group of 16ug dosage than that of 8ug dosage. 2. Growth rate and specific growth rate were observed to be decreased in the liver with incubation day. 3. Growth center of the growth gradient for injected groups to the control groups in the liver were on the twelfth day. 4. Relative growth of injected groups to the control group were positive allometry in both injected group, and 16㎍ injected group was more remarkable allometry than 8ug injected group.

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