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Astaxanthin 함유 기능성 식품소재의 유전독성 및 항산화능 검사
김준성(Jun-Sung Kim),박진홍(Jin Hong Park),김화(Hua Jin),조현선(Hyun Sun Cho),황순경(Soon Kyung Hwang),나운성(Woon Seong Nah),강환구(Hwan Goo Kang),안길환(Gil-Hwan An),조명행(Myung-Haing Cho) 한국독성학회 2006 Toxicological Research Vol.22 No.4
Astaxanthine is a pigment that belongs to the family of the xanthophylls, the oxygenated derivatives of carotenoids whose synthesis in plants derives from lycopene. Astaxanthine is also a carotenoid widely used in salmonid and crustacean aquaculture to provide the pink color characteristic of that. Recent study reported that astaxanthine has the role as a detoxicant against the free radicals. In our study, we estimated the genotoxicity in ICR mice and possibility as antioxidant reagents of mutant Phaffia rhodozyma strain over expressing the astaxanthine by gamma-lay and carophyll pink including astaxanthine in apoE knock out mice, respectively. In our study, we administered Phaffia rhodozyma (2 ㎎ and 3 ㎎) and carophyll pink for 4 and 8 week. The clinical sign and mortality were not detected compared with control groups. In the mutant frequency of hprt gene and chromosome aberration in splenic cells, there was not detected abnormality. There was not critical change in hematological and serum biochemical test compared to control. In expression level of repair enzyme, increase of catalase were detected and increase of expression level of Nrf-2 was detected in Phaffia rhodozyma (3 ㎎) and carophyll pink in 8 week treated group. In GSH level, the group of treated with Phaffia rhodozyma (3 ㎎) showed the increase of the GSH. In conclusion, mutant Phaffia rhodozyma and caphyll pink may be applied to the effective food additives to reduce the free radical.
정경배 ( Kyung Bae Chung ),박민영 ( Min-young Park ),이시형 ( Si-hyung Lee ),장민수 ( Min Soo Jang ),최미라 ( Mira Choi ),김민수 ( Min-soo Kim ),윤현선 ( Hyun-sun Yoon ),황신원 ( Shinwon Hwang ),정진호 ( Jin Ho Chung ),오상호 ( Sa 대한피부과학회 2020 대한피부과학회지 Vol.58 No.10
Background: Chronic actinic dermatitis is a rare, acquired, persistent eczematous eruption of photo-distributed areas. There are limited data available on the clinical characteristics of Korean patients diagnosed with chronic actinic dermatitis. Objective: To evaluate the clinical features and prognosis of chronic actinic dermatitis patients in Korea. Methods: Sixty-two Korean patients diagnosed with chronic actinic dermatitis through clinical findings, phototesting, and skin biopsy from six hospitals were included in this study, and their clinical characteristics were evaluated. Results: Among the 62 patients, 51 were men, and the mean age at diagnosis was 60.3±12.8 years. Phototesting was performed for 27 patients, with results available for 18 patients. Patch tests were performed for only 4.8% of the patients. Skin pathology tests were performed for 47 patients and showed the following: spongiosis, acanthosis, actinic elastosis, and pseudo-lymphomatous change. Twelve patients were clinically diagnosed without using diagnostic tools such as phototesting, patch testing, and skin biopsy. The most commonly used systemic treatments were antihistamine, cyclosporine, steroid, and azathioprine. Although avoiding ultraviolet irradiation and outdoor activities are critical, only 22.6% of patients used sunscreen. Conclusion: Although phototesting is highly recommended for diagnosing chronic actinic dermatitis, phototesting was performed for less than half of the patients to diagnose chronic actinic dermatitis. Patch tests and photopatch tests are also recommended to disclose a causative agent. (Korean J Dermatol 2020;58(10):674∼680)