http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 황순경(Soon Kyung Hwang) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
비타민 C 의 수종 암 세포 증식 억제 효과에 관한 연구
김순경,황우익 ( Soon Kyung Kim,Woo Ik Hwang ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.4
This study was designed to observe the effects of vitamin C administration on the division of P 388 and L 1210 cells in vitro and the survival time ef the mice inoculate with sarcoma 180 cells. The cancer cells, P 388 and L 1210, were cultured in vitro by the method of Fischer and Sartorelli, and the growth rate and dose-response of the both cells in the absence or in the presence of the various amounts (15 to 80 ㎍/㎖) of vitamin C were compared. The male Swiss mice (80 heads), weighing about 20 g, were inoculated with the sarcoma 180 cells (1,000 cells), and then divided into seven groups (two are control groups ; I for comparison of survival time, II for sacrificed, and six are vitamin C treated groups, 0.29 to 1.16 ㎎/g once a day). For the survival time, the cell numbers in the ascites and the body weight change were determined during all experimental term. The results obtained are summarized as follows : 1. The division of P 388 and L 1210 cells in vitro were gradually inhibited in proportion to increment of the concentration of the vitamin C added. 2. The survival times of the mice inoculate with the sarcoma 180 cells were significantly extended by administration of vitamin C compared with the control, especially the effects were remarkable in 0.58 ㎎ of vitamin C administered group. 3. The increase cf the body weight caused by ascites, in each vitamin C administered groups were shown similar tendency to the central. 4. The numbers of the P 388 and L 1210 cells in vitro were decreased by the administration cf vitamin C, but th4t cf the sarcoma 180 cells in viva were not shown significant change. From the above results it was found that vitamin C has the inhibitory activity on the division of the leukemic cells (P 388 and L 1210) in vitro and extends survival time cf mice inoculated with sarcoma 180 cells.
-
비타민 C의 수종(數種) 암 세포 증식 억제 효과에 관한 연구
김순경,황우익,Kim, Soon-Kyung,Hwang, Woo-Ik 생화학분자생물학회 1981 한국생화학회지 Vol.14 No.4
시험관 및 생체 내에서 암 세포 증식에 미치는 비타민 C의 영향을 관찰하기 위하여 20g 내외의 Swiss mice 80마리를 대상으로하여 비타민 C를 체중 1g 당 1회 0.29mg, 0.39mg, 0.58mg, 1.16mg 씩 10회 투여한 4개군과 대조군 등 5개 군으로 나누어 사육하면서 생존기간, 복수로 인한 체중 증가, 암 세포수의 변동 등을 비교 관찰하여 다음과 같은 결과를 얻었다. 1. 시험관 내에서 P 388과 L 1210 세포의 증식은 비타민 C의 투여량에 따라 비례적으로 억제되었다. 2. Sarcoma 180 세포를 주사한 동물의 생존기간은 비타민 C 투여군이 대조군에 비하여 월등히 연장되었으며, 그 가운데 체중 1g 당 1회 비타민 C 0.58mg 투여군이 연장율이 가장 높았다. 그러나 체중 1g 당 1회 비타민 C 1.16mg 투여군은 다른 농도의 비타민 C 투여군에 비하여 생존기간 연장율이 낮게 나다났다. 3. 복수로 인한 체중의 변동은 대조군과 각 투여량 별 비타민 C 투여군이 거의 같은 비율로로 증가되었다. 4. 비타민 C 투여에 의하여 시험관 내에서 배양된 P 388 및 L 1210 세포의 증식은 대조군에 비하여 억제되었으나 mice 체내에서 배양된 sarcoma 180 세포수에는 큰 영향이 없었다. 이 상의 결과로부터 비타민 C에는 시험관 내 P 388 및 L 1210 세포의 증식을 억제시키는 작용이 있으며 sarcoma 180 세포를 주사한 mice의 수명 연장 효과가 있음을 알 수 있었다. This study was designed to observe the effects of vitamin C administration on the division of P 388 and L 1210 cells in vitro and the survival time of the mice inoculate with sarcoma 180 cells. The cancer cells, P 388 and L 1210, were cultured in vitro by the method of Fischer and Sartorelli, and the growth rate and dose-response of the both cells in the absence or in the presence of the various amounts (15 to 80 ${\mu}g/ml$) of vitamin C were compared. The male Swiss mice (80 heads), weighing about 20 g, were inoculated with the sarcoma 180 cells (1,000 cells), and then divided into seven groups (two are control groups ; I for comparison of survival time, II for sacrificed, and six are vitamin C treated groups, 0.29 to 1.16 mg/g once a day). For the survival time, the cell numbers in the ascites and the body weight change were determined during all experimental term. The results obtained are summarized as follows : 1. The division of P 388 and L 1210 cells in vitro were gradually inhibited in proportion to increment of the concentration of the vitamin C added. 2. The survival times of the mice inoculate with the sarcoma 180 cells were significantly extended by administration of vitamin C compared with the control, especially the effects were remarkable in 0.58 mg of vitamin C administered group. 3. The increase of the body weight caused by ascites, in each vitamin C administered groups were shown similar tendency to the central. 4. The numbers of the P 388 and L 1210 cells in vitro were decreased by the administration of vitamin C, but that of the sarcoma 180 cells in viva were not shown significant change. From the above results it was found that vitamin C has the inhibitory activity on the division of the leukemic cells (P 388 and L 1210) in vitro and extends survival time of mice inoculated with sarcoma 180 cells.
-
Astaxanthin 함유 기능성 식품소재의 유전독성 및 항산화능 검사
김준성(Jun-Sung Kim),박진홍(Jin Hong Park),김화(Hua Jin),조현선(Hyun Sun Cho),황순경(Soon Kyung Hwang),나운성(Woon Seong Nah),강환구(Hwan Goo Kang),안길환(Gil-Hwan An),조명행(Myung-Haing Cho) 한국독성학회 2006 Toxicological Research Vol.22 No.4
Astaxanthine is a pigment that belongs to the family of the xanthophylls, the oxygenated derivatives of carotenoids whose synthesis in plants derives from lycopene. Astaxanthine is also a carotenoid widely used in salmonid and crustacean aquaculture to provide the pink color characteristic of that. Recent study reported that astaxanthine has the role as a detoxicant against the free radicals. In our study, we estimated the genotoxicity in ICR mice and possibility as antioxidant reagents of mutant Phaffia rhodozyma strain over expressing the astaxanthine by gamma-lay and carophyll pink including astaxanthine in apoE knock out mice, respectively. In our study, we administered Phaffia rhodozyma (2 ㎎ and 3 ㎎) and carophyll pink for 4 and 8 week. The clinical sign and mortality were not detected compared with control groups. In the mutant frequency of hprt gene and chromosome aberration in splenic cells, there was not detected abnormality. There was not critical change in hematological and serum biochemical test compared to control. In expression level of repair enzyme, increase of catalase were detected and increase of expression level of Nrf-2 was detected in Phaffia rhodozyma (3 ㎎) and carophyll pink in 8 week treated group. In GSH level, the group of treated with Phaffia rhodozyma (3 ㎎) showed the increase of the GSH. In conclusion, mutant Phaffia rhodozyma and caphyll pink may be applied to the effective food additives to reduce the free radical.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
