압축력을 병용한 하악골 신장술

황영섭,허준,김욱규,박성진,황대석,김용덕,정인교,김규천,Hwang, Young-Seob,Heo, June,Kim, Uk-Kyu,Park, Seong-Jin,Hwang, Dae-Seok,Kim, Yong-Deok,Chung, In-Kyo,Kim, Kyu-Cheon 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.6

The purpose of this study was to investigate the biomechanical, histologic findings of distracted regenerate and TMJ response in modified distraction osteogenesis (DO) technique combined with compression force as biomechanical stimulation method which has been suggested in 2002, and developed thereafter by authors. This study was performed with two experiments. First experiment was designed to explore the optimal ratio of compression force versus distraction force for the new DO technique. Second experiment was planned to evaluate the reaction of TMJ tissue, especially condyle, disc after application of the DO technique with compression force. Total 52 New Zealand adult male-rabbits with 3.0kg body weight were used for the study. For the first study, 30 adult male-rabbits underwent osteotomy at one side of mandibular body and a external distraction device was applied on each rabbit with same manner. In the control group of 10 rabbits, final 8 mm of distraction with 1 mm rate per day was done with conventional DO technique after 5 latency days. For the experimental group of 20 rabbits, a compression force with 1 mm rate per day was added to the distracted mandible on 3-latency day after over-distraction (over-lengthening). As the amount of the rate of compression versus distraction, experimental subgroup I (10 rabbits) was set up as 2 mm compression versus 10 mm distraction (1/5) and experimental subgroup II (10 rabbits) was set up as 3 mm compression versus 11 mm distraction (about 1/3). All 30 rabbits were set up to obtain final 8 mm distraction and sacrificed on postoperative 55 day to analysis on biomechanical, and histologic findings of the bone regenerates. For second study, 22 adult male-rabbits were used to evaluate TMJ response after the DO method application with compression force. In the control group, 10 rabbits was used to be performed with conventional DO method, on the other hand, in a experimental group of 10 rabbits, 10 mm distraction with 2 mm compression (1/5 ratio) was done. The remaining 2 rabbits served as the normal control group. Histomorphologic examinations on both condyle, histological studies on condyle, disc were done at 1, 2, 3, 4, 7 weeks after distraction force application. The results were as follows: 1. On the bone density findings, the experimental group II (force ratio - 1/3) showed higher bone density than the other experimental group (force ratio - 1/5) and control group (control group - $0,2906\;g/cm^2$, experimental group I - $0.2961\;g/cm^2$, experimental group II - $0.3328\;g/cm^2$). 2. In the histologic findings, more rapid bone maturation like as wide lamellar bone site, more trabeculae formation was observed in two experimental groups compared to the conventional DO control group. 3. In morphologic findings of condyle, there were no differences of size and architecture in the condyle in the control and experimental groups. 4. In histologic findings of condyles, there were thicker fiberous and proliferative layers in experimental group than those of control group until 2 weeks after distraction with compression force. But, no differences were seen between two groups on 3, 4, 7 weeks after compression. 5. In histologic findings of disc, more collagen contents in extracellular matrix, more regular fiber bundles, and less elastin fibers were seen in experimental group than control group until 2 weeks after distraction with compression. But, no differences were seen between two groups on 3, 4, 7 weeks after distraction with compression. From this study, we could identify that the new distraction osteogenesis technique with compression stimulation might improve the quality of bone regeneration. The no remarkable differences on TMJ response between control and experimental groups were seen and TMJ tissues were recovered similarly to normal TMJ condition after 3 weeks.

농촌지역개발 지역역량강화사업이 사회적 자본형성과 사업참여의도에 미치는 영향

황영섭 ( Hwang Young Seob ),조동범 ( Cho Tong Buhm ) 한국농촌계획학회 2021 농촌계획 Vol.27 No.1

Social capital is the basis for enabling regional development, and although it is the result of regional development that produces greater productivity through the combination of human and material capital, there is a lack of discussions in connection with rural development. This study saw that the local capacity building project affects the social capital of the local residents and such social network is realized through the rural area development project based on the participation of the residents. As a result of the analysis, the regional capacity building project has a positive influence on the social capital of the region and the willingness to participate in the project, and bridge-type social capital has shown a mediating effect on education and consulting fields. Only when local social capital, especially bridge-type social capital, is cultivated through the regional capacity building project can the project be transformed into one suitable for local conditions through active participation of residents.

골다공증 유도 백서경골에 티타늄 임플란트 매식 시저출력 초음파 적용이 골 치유에 미치는 영향

황영섭(Young-Seob Hwang),전현준(Hyun-Jun Jeon),신상훈(Sang-Hun Shin),정인교(In-Kyo Chung),김규천(Gyoo-Cheon Kim),김철훈(Chul-Hoon Kim),김욱규(Uk-Kyu Kim) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.5

Introduction: Osteoporosis is a major health problem in the elderly that involves changes in the properties of bone as well as impaired bone healing around a titanium implant in both humans and animals. This study examined effect of low intensity pulsed ultrasound (LIPUS) on the bone healing process around a titanium implant in osteoporosis-induced rats. Materials and Methods: Sixteen rats were divided into two groups. A control group with osteoporosis induced by removing both ovaries and an experimental group of rats that were applied with LIPUS after osteoporosis had been induced. A screw type titanium implant (diameter, 2.0 mm: length, 3.5 mm, Cowell-Medi, KOREA) was placed into the tibias of 16 rats. The control and experimental group contained 8 rats each. The rats were sacrificed at 1, 2, 4, and 8 weeks after implantation to examine the histopathology and immunochemistry. Results: The histopathology examination revealed earlier new bone formation in the experimental group than the control group. In particular, at 1 week after implantation, more new bone matrix and collagen were observed around the implant of the experimental group compared to the control group. Immunochemistry analysis showed that the level of OPG expression of the experimental group was higher in the early stages than in the control group. After 8 weeks, the levels of OPG expression were similar in both groups. The expression level of receptor activator of nuclear factor kB ligand (RANKL) was stronger in the experimental group than the control group. After 4 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that the application of LIPUS to implantation can promote bone healing around titanium in osteoporosis animals.

데이터 마이닝 기법을 활용한 산업재해자들에 대한 요인분석

임영문,황영섭,최요한,Leem Young-Moon,Hwang Young-Seob,Choi Yo-Han 대한안전경영과학회 2005 대한안전경영과학회지 Vol.7 No.4

Many researches have been focused on the analysis of industry disasters in order to reduce them. As a similar endeavor, this paper provides a propensity analysis of injured people from various industries using classification and regression tree(CART), a data mining algorithm. The sample for this work was chosen from 25,157data related to various industries during one year ( $2003.2\sim2004.1$ ) at Kangwon-Do in Korea. For the purpose of this paper, eight independent variables (injured date, injured time, injured month, type of Injured person, continuous service period, sex, company size, age)are taken from injured person group. According to the analysis result, it is found that five out of the eight factors that are predicted as significant have salient effects. Factors of season, time/hour, day of the week, or month which disasters happened do not show any significant effect. This paper provides common features of injured people. The provided analysis result will be helpful as a starting point for root cause analysis and reduction of industry disasters and also for development of a guideline of safety management.

CHAID 알고리즘을 이용한 산업재해 특성분석

임영문,황영섭,Leem Young-Moon,Hwang Young-Seob 대한안전경영과학회 2005 대한안전경영과학회지 Vol.7 No.5

The main objective of the statistical analysis about industrial accidents is to find out what is the dangerous factor in its own industrial field so that it is possible to prevent or decrease the number of the possible accidents by educating those who work in the fields for safety tools. However, so far, there is no technique of quantitative evaluation on danger. Almost all previous researches as to industrial accidents have only relied on the frequency analysis such as the analysis of the constituent ratio on accidents. As an application of data mining technique, this paper presents analysis on the efficiency of the CHAID algorithm to classify types of industrial accidents data and thereby identifies potential weak points in accident risk grouping.

데이터마이닝 기법을 이용한 제조업에서의 산업재해 특성 분석

임영문(Leem Young Moon),황영섭(Hwang Young Seob) 한국산업경영시스템학회 2006 한국산업경영시스템학회 학술대회 Vol.2006 No.춘계

The main objective of this study is to provide feature analysis of industrial accidents in manufacturing industries using CART algorithm, a data mining technique. In this study, data on 10,536 accidents were analyzed to create risk groups, including the risk of disease and accident. Also, this paper used the gains chart produced by the decision tree. According to the result, gains chart can be used for a risk analysis for industrial accidents management. The sample for this work chosen from data related to manufacturing industries during three years (2002~2004) in Korea. The resulting classification rules have been incorporated into development of a developed database tool to help quantify associated risks and act as an early warning system to individual industrial accident in manufacturing industries.

무형자산 평가기법을 적용한 소비자 만족도 우선순위

임영문(Leem Young Moon),황영섭(Hwang Young Seob) 한국산업경영시스템학회 2009 한국산업경영시스템학회 학술대회 Vol.2009 No.춘계

Nowaday mobile phone is an essential item for convenient daily life. Mobile phone enables us to obtain a lot of necessary and important things such as communication, information, leisure and entertainment. As the technology of mobile phone has been developed, the function of mobile phone can be compared to small computer. Customer's need of mobile phone has been varied and changed according to individual taste and preference. The main purpose of this research is to analyze priority of mobile phone brands using evaluation method of intangible assets with five major brands.

교육환경 개선을 위한 여자 고등학생 (17세$\sim$19세)의 신체치수에 관한 연구

임영무,방혜경,황영섭,Leem, Young-Moon,Bang, Hey-Kyong,Hwang, Young-Seob 대한안전경영과학회 2007 대한안전경영과학회지 Vol.9 No.3

In general, it is fact that most educational institutions have lots of problems about shift of education facility and equipment because of insufficient budget. However, most high school girls live a lot of period in the school and most of them wear student uniform. Thus, it is necessary that educational environment has to be improved by actual body size of high school girls. The main objective of this study is to provide numerical guideline for the improvement of educational environment about high school girls ($17\sim19$ years) through comparison and analysis on physical standard of nation (report published in 1997). The sample for this work chosen from data which were collected and measured by Size Korea during two years $(2003\sim2004)$. In order to analyze feature of the somatotype of high school girls, analysis was performed about 734 subjects on 25 body parts such as height (7 parts), width (4 parts), thickness (4 parts), circumference (5 parts), length (4 parts) and body weight. For the specific comparison on somatotype, $R\ddot{o}hrer$ index and Mollison's comparison graph were used. The result of this study can be utilized in various fields such as design of classroom, student uniforms, facilities and equipments for education, etc.

Apoptotic Effect of Combination Treatment with a Proteasome Inhibitor, Lactacystin, and a Histone Deacetylase Inhibitor, Trichostatin A, on MCF-7 Cells

김규천(Gyoo-Cheon Kim),신유정(Yoo-Jung Shin),김인령(In-Ryeon Kim),이무형(Moo-Hyung Lee),황영섭(Young-Seob Hwang),길영기(Young-Gi Gil),박봉수(Bong-Soo Park) 대한해부학회 2006 Anatomy & Cell Biology Vol.39 No.6

Proteasome 저해제와 HDAC 저해제의 상호작용에 의한 상승효과가 여러 형태의 암에서 세포자멸사를 일으키는 연구가 많음에도 불구하고, 그 기작에 대해서는 거의 알려진 바가 없다. 본 연구는 proteasome 저해제인 lactacystin과 HDAC 저해제인 TSA의 병용처리가 세포자멸사 유도에 미치는 영향을 알아보고자 시행되었다. TSA를 전처리한 후 연이어 lactacystin을 처리한 군은 강한 항암효과와 핵의 응축현상을 보였다. Western blot 분석에서는 TSA와 lactacystin의 병용 처리는 Bax/Bcl-2 분율변화와 XIAP 수준의 감소 및 caspase-7의 활성화와 PARP의 분절의 결과를 얻었다. 그리고 더 나아가서 병용처리한 실험군에서 cell cycle arrest는 G2/M기에서 일어났으며, proteasome 활성은 사라졌다. 본 연구는 TSA와 lactacystin의 병용처리에 의해 일어나는 세포자멸사의 기작에 대해 설명하였고, 본 연구의 결과 자료는 생체의 항암치료전략에 도움을 줄 수 있을 거라고 생각한다. Although much information has been accumulated about the synergistic interaction of proteasome inhibitors and HDAC inhibitors to induce apoptosis in a certain type of cells, much less is known currently about the underlying mechanism. This study was undertaken to explore the combination effect of a histone deacetylase inhibitor, TSA, and a proteasome inhibitor, lactacystin, on the induction of apoptosis. Pretreatment of TSA and subsequent treatment of lactacystin showed the strong antitumor activity and nuclear condensation. Western blot assay showed that combination treatment of TSA and lactacystin increased Bax/Bcl-2 ratio and decreased level of XIAP. Activation of caspase-7 and cleavage of PARP were demonstrated after the combination treatment. In combination treatment group, cell cycle arrest was induced at G2/M phase and abolished increase in proteasome activity. This study is elucidating the mechanims whereby targeting apoptotic machineries may help in directing therapeutic strategies.

흉요추 이행부 원인에 의한 후장골릉 부근 요통

김우선,최훈,황영섭,오광조 대한통증학회 2000 The Korean Journal of Pain Vol.13 No.1

Pain around the posterior iliac crest area is usually attributed to disorders of the lower lumbar or lumbosacral spine. However, low back pain arising from the thoracolumbar region is common and it is very similar to low back pain of lumbosacral origin. Low back pain of thoracolumbar origin is clinically distinguished from other nonspecific low back pain syndrome. It is characterized by symptoms localized at one posterior iliac crest innervated by posterior branch of Tu spinal nerve. Patients never complain of T12 spontaneous pain at the thoracolumbar junction. Only localized tendemess over involved segments of thoracolumbar junction can be noted. We report two cases of posterior iliac crest pain of thoracolumbar origin which was relieved by the treatment on the thoracolumbar junction.