임산부사망에 관한 임상적 고찰 : At the St. Mary's Hospital, 6 year Survey (1966-1971)

황순경,황상의 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.10

임신과 심장질환에 대한 임상 통계적 관찰

황순경,송승규 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.8

MAC inhibits c-Myc and induces autophagy by downregulation of CIP2A in leukemia cells

황순경,Yun-Jeong Jeong,Jae-Moon Shin,Junji Magae,CHEORL-HO KIM,장영채 대한독성 유전단백체 학회 2018 Molecular & cellular toxicology Vol.14 No.4

Backgrounds: 4-O-methyl-ascochlorin (MAC) is a methylated derivative of the prenyl-phenol antibiotic ascochlorin, which was isolated from the incomplete fungus Ascochyta viciae. We have recently shown that MAC promotes apoptotic cell death by inhibiting c-Myc expression in K562 leukemia cells, but the effects of MAC on autophagy are still unknown. Methods: Treatment of MAC significantly increased LC3 expression and autophagic vesicle formation by western blot and acridine orange staining. Also, we examined the possible mechanisms underlying MAC induced autophagy. Results: We found that MAC suppressed c-Myc expression by inhibiting CIP2A (regulator of c-Myc) protein synthesis. This result suggests that the downregulation of c-Myc expression plays the role of inducing apoptosis and autophagy by MAC treatment in human leukemia cells. Conclusion: These findings significantly contributed to the understanding of the mechanism that accounts for the anticancer activity of MAC, and it may be novel anti-cancer therapeutic agents for leukemia cells.

산부인과 질환에서의 섬유소 용해효소의 변동

황순경(SK Whang),김창이(CY Kim),허필형(PH Hur),나종구(Rha CG),이헌영(HY Lee) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.9

1) 정상임신부에서 섬유소 용해효소는 비임신부에 비해 임신중에 현저히 증가되나 분만중과 분만후에는 점차적으로 감소한다. 2) 자간증 및 중증 전자간증 환자에서는 플라스미노젠의 전량이 정상임신부에 비해서 임신중, 분만중과 분만후 모두 낮은 수치를 보여주었다. 3) 산후출혈 환자에서는 섬유소 용해효소가 정상분만 산모에 비해서 현저히 낮은 수치 를 보였다. 4) 기능성자궁출혈환자에서는 플라스미노젠의 감소가 현저하였고 2예중 1예에서는 활 성플라스민이 검출되었다. 5) 패혈성 복막염환자에서 섬유소용해효소가 거의 소모되었음을 알 수 있었다. This experimental study was planned to detect the changes of fibrinolytic system in the obstetric and gynecological patients. In this strdy, ENZO-DIFFUSION, fibrin plate Test was used to examine the 3 components of fibrimolytic system; available plasmin (fibrinolytic potential), active plasmin (fibrinolysin) and total plasminogen (profibrinolysin). The results were as follows; 1) In normal pregnancy, profibrinolysin was markedly increased in alte pregnancy, and then gradually decreased in labor and after delivery. fibrinolysin was not detected and fibrinolytkc potential was normal in level in late pregnancy and labor and after delivery. 2) In pre-eclampsia and eclampsia; Fibrinolytic potential was normal in level and fibrinolysin was not detected in late pregnancy, in labor and after delivery. But profibrinolysin was less than that of normal pregnancy. 3) In patient with postpartum hemorrhage, profibrinolysin was markedly reduced in level compared to normal postpartum woman. But fibrinolytic potential was normal in level and fibrinolysin was not detected. 4) In two patients with dysfunctional uterine bleeding, although fibrinolytic potentkal was normal in level, profibrinogen was markedly decreased in % activtty and in one of these, fibrinolysin was detected. 5) In a patient given radical hysterectomy for carcinoma of cervix, profibrinolysin was reduced and fibrinolysin was detected on the lst postoperative day. 6) In a patient with hyaline degeneration and suppuration of myoma uteri and panperitonitis profibrinolysin could not be detected pre-and postoperatively, and also, fibrinolytic potential was absent.

機能性 子宮出血

黃淳璟 中央醫學社 1973 中央醫學 Vol.25 No.6

고령초산부에 대한 임상통계학적 고찰

황순경(SK Whang),김창이(CY Kim),전정일(CI Chun),오원섭(WS O),최광영(KY Choi) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

가톨릭의대 산하 8개 병원에서 만 5년간에 분만한 35세이상의 고령초산부 204예를 임상적으 로 중요한 항목을 같은 수의 대조군과 비교 관찰하여 다음과 같은 결론을 얻었다. 1. 발생빈도는 0.49%(204예)였으며 지역별 차이는 없엇다. 2. 이상태위가 26%(53예)로 대조군의 약 2배이며 이상두위 18.1%(37예) 와 둔위 6.4%(13예) 였다. 3. 분만방법은 술식분만이 62.7%(128예)로서 30.4%(62예)가 제왕절개분만이었고 27.5%(56예) 가 흡입 분만이었다. 4. 제왕절개분만의 적응증은 아두골반불균형과 협소골반의 33.8%(21예)와 선택적 수술의 33.8%(21예)가 가장 많았고 태아가사상태가 19.5%였으며 임신중독증이 8.1%(5예)이었다. 5. 신생아 체중은 평균 3061gm으로 대조군보다 125gm정도 적으며 조산아는 8.7%(18예)를 보였다. 6. 주산기 사망률은 4.9%(10예)로 대조군의 2.9%(6예)보다 높았으며 원인으로는 조산아가 가 장 많았다. 7. 선천성 기형은 1.9%(4예)로 대조군의 0.9%(2예)보다 높앗다. 8. 산전 모성합병증은 대조군에 비하여 약 3배가 많았고 임신중독증, 자궁기증부전, 아두골 반불균형의 순이며, 산후 모성 합병증은 약 2배가 많앗고 경관열상, 산욕열, 산후출혈 및 요 도감염의 순이었다. In this study 204 cases of elderly primiparae among 41272 parturient seen at the Dept. of Obsterics and Gyunecology eight Hospital including. st Mary`s Hospital affiliated catholic medical college from January 1. 1970 to December 31. 1974 were clinically observed and statistically reveiwed. The results were summarized as follows; 1. The number of elderly primiparae was consisted of 204 cases among 41272 parturient. Its incidence was 0.49%. 2. Malpresentation was showed in 26.0% among them the most common type was abnormal vertex and breech presentation. 3. In mode of delivery, operative delivery rate was 62.7% including cesarean section (30.4%) 4. In the view of the indication for cesarean section elective cesarean section was the most common (33.8%) other indications were CPD (29.0%) fetal distress (19.5%) and toxemia (8.1%) in order 5. The average birth weight of infant was 3061 gm and 8.7% of prematurity was encountered. 6. The perinatal mortality rate was 4.9% 7. congenital fetal anomalies were seen in 1.9% 8. Antepartum complications were 3 times and postpartum complications were twice more than the control group. the former was the pre-eclampsia uterine dystocia and CPD etc., and the latter was the laceration puerperal fever and urinary infection etc.

방광결석으로 인한 난산 1예

황상의(SU Hwang),송승규(SK Song),황순경(SK Whang),김승조(SJ Kim) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.4

임신 40주 초산부에서 하나의 큰 방광 결석의 합병으로 태아의 산도통과를 방해하여 난산을 초래함으로써 복식분만 및 결석제거술을 하였다. 본 예는 그외 신수종, 수뇨관수종 및 만성방광염을 동반하였다. A case of dystocia caused by a large bladder stone complicated in term pregnancy was presented. This 30 year-old primipara also was combined with hydronephrosis, hydroureter and chronic cystitis. The textbook and papers concerned to this problems were reviewed briefly.

부갑상선기능저하증을 합병한 임산부의 분만 1례

황순경(SK Whang),길송학(SH Kil),강재화(JH Kang),민병석(BS Min) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.2

A 27-year-old house wife, gravida ii, para 0, developed hypoparathyroidism following subtotal thyroidectomy for follicular adenocarcinoma which had been performed about 4 years previously. Hypoparathyroidism was not adequately controlled apparently owing to lack of cooperation on the part of the patient. Nevertheless, she became pregnant about 3 years postoperatively and was spontaneously delivered of a 2,700 grams living female infant at the 38th week of pregnancy without any maternal complications.After delivery, the infant was found to have craniotabes. All of her skeletons was found to be decalcified and porotic on roentgenogram. Chemical changes in the blood and urine of the mother and the newborn were presented and pertinent lituratures were reviewed.

이상태위에 관한 임상통계학적 고찰

황순경(SK Whang),오원섭(WS O),남궁성은(SE Namkoog),강성원(SW Kang),김기원(KW Kim) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.9

1. 안위의 발생빈도는 72예로서 0.17%(1:573.2)이었다. 2. 분만회수에 따르는 안위의 빈도는 초산부에서 0.16%, 5회이상의 다산부에서 0.48%로 분 만회수가 증가할수록 발생빈도는 높다. 또 연령층으로는 30세를 중심으로 한 연령에서 호 발하며 최연소 연령은 21세, 최고 연령은 48세 이었다. 3. 임신지속주수는 37주에서 40주사이가 55.56%로 제일많고 태아체중은 2,500㎎ 이상 4,000 ㎎ 미만이 84.72%로 대부분을 차지하였다. 4. 원인적인 요소로서는 협골반, 다산, 양막조기파수, 거대아, 조산, 선천성기형, 자궁내태아 사망 등의 순서로 나타났으며 29.7%인 21예에서는 정확한 원인을 알 수 없었다. 5. 하순기판(mentum)에 따른 태아의 위치는 후위 하순기판 (menum posterior) 31.94%이고 횡위 하순기판(mentum transverse)이 13.89%이었다. 6. 분만방식은 자연분만이 48.61%, 제왕절개술이 43.06%, 겸자분만이 8.33%이었다. 또 초산 부와 후위 하순기판(mentum posterior)의 태위에서는 제황절개술에 의한 분만율이 높았고 경산부와 전위 하순기판(mentum anterior)에서는 질식분만이 많았다. 7. 질식분만에서의 제1기 분만기간이 12시간 이내인 경우는 56.10%이었고 43.90%는 12시 간 이상이었다. 제2기 분만시간이 2시간 이상인 예는 7.32%이었다. 8. 모성사망은 없었고 교정 주산기 사망율(corrected perinatal mortality rate) 2.78%이었다. 9. 산전관리를 받은 산모는 48.61%이었고 산전관리를 받지않은 경우는 53.39%이었다. 즉 산전관리가 안위를 예방하는 것에 큰 도움을 주지 못했다. The purpose of the present study is to analyze the face presentations whing occured during the preiod from jan. 1970 through Dec. 1974 at the Catholic Medical College, Dept. of obstetricw and Gynecology and to Discuss the various aspects and difficulties encountered in their management. Thin paper analyzen 72 face presentations in singleton which occured in 41272 deliveries and the results were obtained as follows; 1) the incicence of face presentation was 0.17 per cent (1:573.2) 2) the incidence based on the parity was 0.16 per cent in primigravida and 0.48 percent in grandmultipara (over para V). Age distribution was concentrated on thirty degree and the youngest was 21 years old and the oldest was 48 years old. 3) As to the gestational weeks and fetal body weight, 55.56 per cent was 37 weeks to 40 weeks and 84.72 per cent was 2500gm to 4000gm in body weight. 4) Contracter pelbis, grandmultipara, premature rupture of membrane, excssivesized infants, amall baby, and anencephaly were significant etiologic factors, but 29.17 per cent of face presentations was not known the exact etiological factors. 5) Regarding to the position of the fetal mentum, 54.17 per cent was mentum anterior, 31.94 per cent was mentum posterior and 13.89 per cent was mentum transverse. 60 the method of deliveries were spontaneous delivery (48.61%), cesarean section (43.06%) and forcep delivery (8.33%). the rate of cesarean section was high in primigravida and mentum posterior of fetal position. On the other hand, the method of vaginal delivery was high in multipara and mentum anterior position. 7) As to the duration of labor, 56.10 per cent of all cases was completed within 12 hours in first stage and 7.32 pre cent was over 2 horus in second stage of labor. 8) there was no maternal death and the corrected perinatal mortality rate was 2.78 per cent. 9) Antental care did not help the preventio of the face presentation.

비타민 C 의 수종 암 세포 증식 억제 효과에 관한 연구

김순경,황우익 ( Soon Kyung Kim,Woo Ik Hwang ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.4

This study was designed to observe the effects of vitamin C administration on the division of P 388 and L 1210 cells in vitro and the survival time ef the mice inoculate with sarcoma 180 cells. The cancer cells, P 388 and L 1210, were cultured in vitro by the method of Fischer and Sartorelli, and the growth rate and dose-response of the both cells in the absence or in the presence of the various amounts (15 to 80 ㎍/㎖) of vitamin C were compared. The male Swiss mice (80 heads), weighing about 20 g, were inoculated with the sarcoma 180 cells (1,000 cells), and then divided into seven groups (two are control groups ; I for comparison of survival time, II for sacrificed, and six are vitamin C treated groups, 0.29 to 1.16 ㎎/g once a day). For the survival time, the cell numbers in the ascites and the body weight change were determined during all experimental term. The results obtained are summarized as follows : 1. The division of P 388 and L 1210 cells in vitro were gradually inhibited in proportion to increment of the concentration of the vitamin C added. 2. The survival times of the mice inoculate with the sarcoma 180 cells were significantly extended by administration of vitamin C compared with the control, especially the effects were remarkable in 0.58 ㎎ of vitamin C administered group. 3. The increase cf the body weight caused by ascites, in each vitamin C administered groups were shown similar tendency to the central. 4. The numbers of the P 388 and L 1210 cells in vitro were decreased by the administration cf vitamin C, but th4t cf the sarcoma 180 cells in viva were not shown significant change. From the above results it was found that vitamin C has the inhibitory activity on the division of the leukemic cells (P 388 and L 1210) in vitro and extends survival time cf mice inoculated with sarcoma 180 cells.