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김주영,전준호,김상준,황규목,최성락,한상덕,손미원,박은석 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.2
The objective of this study was to evaluate thehealing effects of a chitosan-based, film-forming gel containingtyrothricin (TYR) in various rat wound models,including burn, abrasion, incision, and excision models. After solidification, the chitosan film layer successfullycovered and protected a variety of wounds. Wound sizewas measured at predetermined timepoints after woundinduction, and the effects of the film-forming gel werecompared with negative (no treatment) and positive controlgroups (commercially available sodium fusidate ointmentand TYR gel). In burn, abrasion and excision woundmodels, the film-forming gel enabled significantly betterhealing from 1 to 6 days after wound induction, comparedwith the negative control. Importantly, the film-forming gelalso enabled significantly better healing compared with thepositive control treatments. In the incision wound model,the breaking strength of wound strips from the grouptreated with the film-forming gel was significantlyincreased compared with both the negative and positivecontrol groups. Histological studies revealed advancedgranulation tissue formation and epithelialization inwounds treated with the film-forming gel. We hypothesizethat the superior healing effects of the film-forming gel aredue to wound occlusion, conferred by the chitosan film. Our data suggest that this film-forming gel may be useful intreating various wounds, including burn, abrasion, incisionand excision wounds.
Preparation and in vivo evaluation of immediate-release pellet containing celecoxib solid dispersion
Chun-Woong Park,Nguyen-Thach Tung,Dao-Danh Son,김주영,이윤석,Seung-Yeop Kang,Shin-Ae Park,황규목,오택운,하정명,Sang-Cheol Chi,박은석 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.3
The aim of this study was to make use of small size of immediate-release (IR) pellet and amorphous state of solid dispersion to increase solubility of celecoxib (CLX), a drug in BCS class II. Primary, binary and ternary solid dispersions were developed to choose the final components for solid dispersion. A ternary novel solid dispersion was prepared by incorporation of one aqueous soluble polymer (povidone k17; PVP 17PF), Methacrylate copolymer-based gastric soluble polymer (Eudragit EPO) and one pH modulator (MgO). This combination was effective to increase solubility in pH 1.2 up to 25–30 %. The mechanismof solubility enhancement was proven by DSC, PRXD, and FT-IR. Accordingly, hydrogen bonding or electrostatic interaction of CLXwithPVP/EudragitEPOwas themain cause to formthe amorphous state of CLX within polymer cluster which increasing solubility of drug. Besides, MgO played an important role to change microenviroment for solid dispersion. Pellets containing this solid dispersion were prepared by extrusion and spheronization technique. Effect of four kinds of additive (calciumhydrogen phosphate dihydrate,NaHCO3,crospovidone, and sodium dodecyl sulfate) on dissolution of CLX from IR pellet was also determined. Because of highest dissolution rate, formulation using sodium dodecyl sulfate was used for pharmacokinetics study. Solid dispersion-IR pellet formulation presented bioequivalence and lower variability in comparison with reference product.