소장암에 관한 임상적 고찰

홍성국(Sung Kuk Hong) 대한외과학회 1976 Annals of Surgical Treatment and Research Vol.18 No.9

Omphalomesenteric Duct 畸形으로 因한 腸閉塞症 2例 報告

崔泳吉(Young Kil Choi),洪性國(Sung Kuk Hong) 대한외과학회 1976 Annals of Surgical Treatment and Research Vol.18 No.6

위장관 ( 胃腸管 ) : 조기 대장암

김진복(Jin Pok Kim),송인성(In Sung Song),최규완(Kyoo Wan Choi),최병인(Byung Ihn Choi),박재갑(Jae Gahb Park),김영우(Young Woo Kim),김용일(Yong Il Kim),정현채(Hyun Chae Jung),홍성국(Song Cook Hong),이건욱(Kuhn Uk Lee),최국진(Kuk Jin Ch 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

N/A To increase the survival rate of colorectal cancer, which represents 6% of all malignancies in Korea, early diagnosis is most important. We analyzed the 31 cases of early colorectal cancer who were admitted to Department of Surgery, Seoul National University Hospital from January 1970 to December 1989. The results were follows; 1) The incidence of early colorectal cancer among surgically treated colorectal cancer was 1.9% (31 cases out of 1615 cases). 2) The common symptoms were anal bleeding (81%), constipation (41%), and small caliber stool (26%). 3) The 17 cases out of 18 cases (95%) which were located within 12cm from anal verge were palpated as mass by digital examination, and 24 cases out of 27 cases (82%) were detected as mass by colon study, and 25 cases out of 28 cases (90%) were diagnosed as malignancy by sigmoidoscopic biopsy. 4) In early colorectal cancer with polyp remnant, 8 cases out of 27 cases (30%) were confined to mucosa and 18 cases out of 27 cases (70%) were confined to submucosa. In early colorectal cancer without polyp remnant all 4 cases (100%) were confined to submucosa. 5) In early colorectal cancer with polyp remnant, histologic type of polyp were tubular polyp in 9 cases (33%), villotubular polyp in 6 cases (22%), and villous polyp in 12 cases (45%). 6) The size of tumor were 1.4 cm (1 case), from 1 cm to 2 cm (5 cases), from 2 cm to 4 cm (14 cases) from 4 cm to 6 cm (5 cases), 7 cm (1 case), 8 cm (2 cases) and 13 cm (1 case). 7) Thirteen patients were operated more than 5 years ago and two of them died. One died of pulmonary metastasis of cervix cancer, and the other of unknown cause. 8) Eighteen patients were operated during recent 5 years and one of them died of chronic renal failure.

위장관 ( 胃腸管 ) : 고유근층 대장암의 임상적 고찰

김진복(Jin Pok Kim),송인성(In Sung Song),최규완(Kyoo Wan Choi),최병인(Byung Ihn Choi),박재갑(Jae Gahb Park),김용일(Yong Il Kim),김영우(Young Woo Kim),정현채(Hyun Chae Jung),홍성국(Song Cook Hong),이건욱(Kuhn Uk Lee),최국진(Kuk Jin Ch 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2

N/A If detected in early stage and appropriate treatment ensued immediately, the cure rate of colorectal cancer would be increased. But, the proportion of early colorectal cancer in Seoul National Uneversity Hospital was only 1.9% of operated cases. We reviewed the medical records of 192 patients underwent curative resection for proper muscle (PM) colorectal cancer between 1970 and 1989 retrospectively speculating that these lesions are more advanced than early colorectal cancer but earlier than advanced colorectal cancer. Follow-up information for survival data was available for 151 patients (93%) among 163 patients between 1980 and 1989. The results for the PM colorectal cancer are followings. 1) The proportion was not increasing. Mean proportion between 1970 and 1989 was 12%. 2) The tumor smaller than 2 cm occupied 10% of PM colorectal cancer comparing to 0.86% in total colorectal cancer in the same duration. 3) Node negative lesion comprised 77% comparing to 52%. in total colorectal cancer. 4) Five year survival rate was 84% overall (n=163, 1980-1989), 88% in node negative group (n= 125), 69% in node positive group (n =38) (p value<0.05). 5) The overall recurrence rate was 13.5%(26/192). The recurrence rate as to tumor size was 6.7% in the group which had the lesion smaller than 2 cm, 11% in the group with 2 to 5 cm, 199. in the group larger than 5 cm. Node negative group had recurrence rate of 9.5% (14/148), on the contrary, 27% in node positive group (12/44). 6) In node negative group, the subgroup with the lesion smaller than 2 cm had no recurrence and had 92%: five year survival rate but, the subgroup with larger than 2 cm had 10%: recurrence rate and 85%, five year survival rate. As a conclusion, PM colorectal cancer without lymph node metastasis and smaller than 2 cm size had no recurrence and survived well above 90%. And it is reasonable to consider the possibility of systemic spread even in lymph node negative PM colorectal cancer if the trmor size exceeds 2 cm.

대장 폐색증의 임상적 고찰

이건욱(Kuhn UK Lee),정중기(Jung Kee Chung),홍성국(Sung Kuk Hong),김수태(Soo Tae Kim) 대한외과학회 1982 Annals of Surgical Treatment and Research Vol.24 No.2

대장암에 대한 5 - Flurouracil 지속주입 및 Cisplatin ( FP ) 복합화학요법의 치료효과

서철원(Cheol Won Suh),김시영(Si Young Kim),방영주(Yung Ju Bang),김노경(Noe Kyeong Kim),박재갑(Jae Gahb Park),이건욱(Kuhn Uk Lee),홍성국(Sung Kuk Hong),최국진(Kuk Jin Choe),김수태(Soo Tae Kim),하성환(Sung Hwan Ha),박찬일(Chan Il Park) 대한내과학회 1988 대한내과학회지 Vol.35 No.4

N/A Between August 1986 and February 1988, 60 patients with metastatic or recurrent colorectal cancer were treated with a combination chemotherapy consisting of 5-fluorouracil, 1,000 mg/m² iv continuous infusion over 12 hours on Days 1-5 and cisplatin,.60 mg/m² iv on Day 1; cycled every 3 weeks, Among 36 patients with measurable disease, none achieved complete response and 9 (25%) had partial responses, thus this combination chemotherpay regimen showed modest action on the advanced colorectal cancer. The median duration of response was 20 weeks. Median survival was 52 weeks for all patients who could be evaluated for response and/or toxicity; 61 weeks for patients with response, 48 weeks for those with stable disease and 17 weeks for those with progressive disease. In the analysis of the response according to the various pretreatment characteristics of the patients, those without a history of previous anticancer chemotherapy showed response rate of 36% which is better than 7% for those with prior chemotherapy. The patients with metastatic sites in the liver had a response rate of 47%, which is significantly better than 7 96 for those with metastatic site in the lung and 0% for those with any other sites of metastasis. Toxicity was common, but generally mild to moderate and rapidly reversible.

정신분열증 환자의 아동기 특징

홍성국,서광윤,이병윤 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1

This study was performed to evaluate the characteristics of childhood in schizophrerucs. Using the questionnaire to 107(53 male, 54 female) schizophrenics and 108(54 male, 54 female) controls, the results were obtained as follows. 1. In schizophrenics, the family size was larger, the economical state at present was poorer, and the genetic loading both in nuclear family and extended family were higher than controls. The mothers of schizophrenics had more difficult problems involved with pregnancy and delivery than controls. The schizophrenics had more difficult temperaments such as lower response to stimulation and more irregular pattern in activity level in their childhood than controls. In neurointegrative functioning, the schizophrenics had more abnormalities such as delayed developmental milestones and abnormal integrative motor functions than controls. Disturbances in social functioning at each developmental stages were found more frequently in schizophrenics than controls. In developmental problems, the schizophrenics showed more difficulties especially involved with control of excretory functions than controls. The schizophrenics were more subjected to negative family environment and had more separation experiences with parents before 7 years of their age. The parents of schizophrenics had low expectation for their children's achievement and showed lax discipline and marital discord. The schizophrenics has poor family relationship and residential environment. In general stressors, the schizophrenics were more exposed to physical i11ness, physical or sexual threats, emotional shock, and social traumatic experience than controls. In protective factors, the schizophrenics had negative and passive personal disposition, poor supportive family milieu and external support system. 2. Delivery complication, separation with parents before 7 years of their age, and sexual threat were found more freguently in female schizophrenics than male schizophrenics. On the other hand, the parental overexpectation and intrusion to their child and residential moving out were found more freguently in male schizophrenics than female schizophrenics. 3. The differences in neurointegrative functioning between the schizophrenics and controls were seen significantly in infancy, the differences in social functioning were in early childhood, and the differences in developmental problems were in middle childhood. 4. In discriminating schizophrenics from controls, the external support system had the highest discriminant function coefficients. And the factors of family size, genetic loading in nuclear family, family stressors, temperaments, positive personal disposition, general stressors, neurointegrative functioning, genetic loading in extended family, and social functioning had next discriminant function coefficients in this order. With above selected factors, probability to discriminate patient groups from controls was 89.81%.