진피내 멜라닌세포성 병변에서 Integrin 표현과 아포프토시스 세포에 관한 연구

홍문희 ( Moon Hee Hong ),정병수 ( Byound Soo Chung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1

Background: Many mammals normally have a population of dermal melanocytes but these are not found in man, In humans, persistent dermal melanocytes can occur in the Mongolian spot, the nevus of Ota, and the blue nevus. Mongolian spot develops in the fetal or neonatal time and disapperars almost invariably during childhood. In contrast, nevus of Ota and blue nevus are not usually present at birth and persists in adult life. Recently, it was established that apoptosis can be involved in the development of melanocytes. The integrins mediate cell-cell and cell-matrix interactions, and apoptosis can be induced by disruption of cell-matrix interactions. Objective : The purpose of this study was to investigate the expression of integrins (a2 , a3 , ar) and in situ detection of fragmented DNA in Mongolian spot, nevus of Ota, and blue nevus. Methods : Formalin-fixed and paraffin-embedded tissues from 8 cases of Monglian spot, 5 cases of nevus of Ota, and 4 cases of blue nevus were immunolabelled with monoclonal antibodies TM directed against az, ay, and av integrin, and stained with ApopTag in situ using an Apoptosis Detection kit. The cases of Mongolian spot were divided into two groups in which group A represented the the cases of more than 45 melanocytes and group B represented the cases of less than 10 melanocytes in a tissue section of 4-mm taken from punch biopsy specimens. Results: Blue nevi showed az and e integrin expressions in dermal melanocytes and weak to negative staining of g v integrin in comparison with all positive expressions of a z, a s, and g y integrin in A group-Mongolian spots and nevi of Ota. The B group-Mongo]ian spots showed the continuous expressions of a z and a y integrin with negative expressions of a v integrin. The ApopTag kit staining was all negative in the Mongolian spots, nevi of Ota, and blue nevi. Conclusion . Our results support the view that dermal melanocytic tumors, such as the Mongolian spot, the nevus of Ota, and the blue nevus, might be induced by the disturbance or inhibition of the apoptotic process of the melanocytes, and that the spontaneous disappearance of the Mongolian spot may not be related to the apoptosis. (Korean J Dermatol 1998;36(1): 52-58)

A Model Describing the Growth Kinetics of Passivating Oxide Film Prepared under Potentiostatic Condition

MOON-HEE HONG(홍문희),SU-IL PYUN(변수일) 한국표면공학회 1991 한국표면공학회 학술발표회 초록집 Vol.1991 No.-

The Repassivation Kinetics of Pure Nickel in Na₂SO₄ Solution Using Abrading Electrode Technique

MOON-HEE HONG(홍문희),SU-IL PYUN(변수일) 한국표면공학회 1991 한국표면공학회 학술발표회 초록집 Vol.1991 No.-

간호사의 의료기관인증제 인식, 감염관리 인지도 및 수행도

홍문희(Hong, Moon-Hee),박주영(Park, Ju-Young) 한국간호행정학회 2016 간호행정학회지 Vol.22 No.2

Purpose: This study was conducted to provide basic data necessary to develop a program to improve infection control by examining nurses" perception of accreditation and by identifying its relationship with awareness and performance of infection control. Methods: This cross-sectional study was performed using questionnaires. Data were collected from 210 nurses who were working at one hospital between May 14 and May 19, 2015. Data were analyzed using SPAW. Results: The mean score for nurses’ perception of accreditation was 3.10 points out of 5 points. Score for awareness of infection control was 4.63±0.39 points and for performance of infection control, 4.39±0.39 points. There were significant positive correlation among perception of accreditation, awareness of infection control, and performance of infection control. In the regression analysis, performance of infection control was influenced by awareness of infection control which accounted for 42.6% of the variance. It also showed additional improvement of 1.4% of the variance by when perception of accreditation was added. Conclusion: The result of this study show that nurses’ perception of accreditation is relatively positive and that performance of infection control is highly enhanced according to nurses" positive recognition of accreditation as well as attaching importance to accreditation.

성인에서 발생된 황색육아종

홍문희,한경표,정병수 ( Moon Hee Hong,Kyoung Pyo Han,Byoung Soo Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Clinically adult-onset xanthogranuloma is somewhat different to that of juvenile xanthogranuloma. There seems to be no definitive sites of predilection and concomitant extracutaneous lesions, and spontaneous resolution does not occur in the adult form. The lesions of the adult form are usually asymmetric or solitary. We describe an adult with a solitary xanthogranuloma on the left shoulder. Histological findings of this case show minor differences from juvenile xanthogranuloma but immunohistochemical findings were very similar to those of juvenile xanthogranuloma. (Kor J Dermatol 1997;35(4): 786-789)

한방간호중재개발을 위한 이침요법(耳鍼療法)적용에 대한 문헌연구

문희자 ( Hee Ja Moon ),김귀분 ( Kwuy Bun Kim ),석소현 ( Hyune Sok So ),홍경화 ( Kyung Hwa Hong ) 경희대학교 동서간호학연구소 1999 동서간호학연구지 Vol.4 No.1

The auricular acupuncture therapy is stimulus treat method that acupuncts or moxibusts at the reaction blood vessel point of various diseases in the upper portion of ear. And this effects from the reaction blood vessel point of an ear to the meridian of whole body system through blood stream. The auricular acupuncture has cured and cared signs and symptoms of many diseases and pathologic problems. And this treatment heels abnormal reactions, nursing focuses so it was examined through literature review that nurses use many portions of the auricular acupuncture in their clinical cares of oriental medicine. This study was proved that the Mae-Chim acupuncture method among various methods of the auricular acupuncture is easy and simple so this method can be used by nurses. And the ear acupuncture site which controls diarrhea, insomnia, migraine, stress vomiting, dyspepsia, high fever, insufficient lactation, bowel dysfunction, menoxenia, anxiety, pruritus and can be found easily and is few the number of acupuncture so the oriental maedicine nurses can apply easily to their clients. Therefore the independant oriental medicine nursing intervention can be developd by application of the auricular acupuncture therapy on the oriental medicine clinical nursing and home care in our community.

일반논문 : 절충교역 계약 소요기간 영향요인

홍석수 ( Seok Soo Hong ),정태윤 ( Tae Yun Joung ),서재현 ( Jae Hyun Seo ),홍문희 ( Moon Hee Hong ) 기술경영경제학회 2012 Journal of Technology Innovation Vol.20 No.1

우리나라는 1983년에 절충교역 제도를 도입하여 국방 전력증강의 효율적 수단으로 활용하여 왔다. 그런데 절충교역은 계약체결이 획득기술에 대한 가치평가 결과를 근거로 이루어지기 때문에 국외업체와의 협상 등 업무과정상 지연될 가능성이 존재한다. 절충교역 계약체결이 지연되면 무기체계 구매사업이 늦어져 국방 전력증강에 심각한 악영향을 주게 된다. 따라서 본 연구에서는 절충교역 계약 과정, 특히 계약 소요기간에 영향을 미치는 요인들을 통계적으로 분석하여 소요기간을 결정하는 요인을 규명하고자 하였다. 영향 요인으로는 국외업체국적, 사업진행 형태 (경쟁/단독 입찰), 사업 특성 (최초/계속 사업), 최초 제안기술의 수, 국내무기체계 분야별 국방과학기술수준, 기본사업 규모 등 6개를 고려하였다. 가설 검증은 절충교역 계약이 체결된 25개 사업을 대상으로, 상관분석 및 다중회귀분석을 통하여 이루어졌다. 상관분석 결과에 의하면, 기본사업 규모, 최초 제안기술의 수, 사업 특성 등이 종속변수인 절충교역 계약 기간과 양의 상관관계를 갖고 있음을 알 수 있었다. 다중회귀분석 결과에서는 기본사업 규모와 사업진행 형태가 절충교역 계약 소요기간에 유의한 영향을 미치는 것으로 나타났다. Republic of Korea has been applying offset to defense acquisition program for some benefits such as modernization of defense industry and enhancement of R&D capabilities since 1983. But in point of implementation, there is the possibility of delay of offset agreements based on the value of proposed technologies. As it often happens that the delay of offset agreement negatively affects the time schedule of main defense deal, it is necessary to prepare for this issue. The purpose of this study is to extract some factors affecting the duration of offset agreement by statistical analysis. Reviewing existing papers and contract process, nationality of enterprise, the number of project participants, properties of project, the number of technologies in the first proposal, level of domestic defense technology in each weapons system, the amount of main contract were used as independent variable and duration of agreement as dependent variable. To hypothesis testing, correlation and multiple regression analysis were conducted using the previous 25 contract cases. As a result of correlation analysis, the amount of main contract, the number of technologies in the first proposal and properties of project have positive relationships with dependent variable. In multiple regression, the amount of main contract and the number of project participants have significant effect on the duration of offset agreement.

금융 차세대시스템 구축방식의 의사결정에 대한 연구

홍정식 ( Jung Sik Hong ),문희진 ( Hee Jin Moon ),조남욱 ( Nam Wook Cho ) LGCNS 엔트루정보기술연구소 2010 Entrue Journal of Information Technology Vol.9 No.1

최근 금융업계의 차세대시스템 구축이 본격화됨에 따라 구축방식의 의사결정에 대한 체계적인 접근법이 요구되고 있다. 본 논문에서는 금융 차세대시스템 구축 프로젝트 수행에 요구되는 소요시간과 투자비용에 따라 차세대시스템 구축 접근방법을 혁신적(Big Bang) 방식과 단계적(Phase) 방식으로 구분하고, 시스템 구축 단계에서 두 가지 대안을 체계적으로 비교하기 위하여 AHP(Analytical Hierarchy Process) 기법을 적용한 금융권 차세대시스템 구축방식 평가방법론을 제시하였다. 계층적 평가지표 도출을 위해 비용, 성과, 위험을 최상위 기준으로 설정하고 각각의 세부 평가 항목을 3단계까지 도출하였다. 도출된 평가 항목을 토대로 설문조사 대상자를 금융회사의 내부 현업 담당자와 외부 SI업계 전문가를 구분하여 금융 차세대시스템의 구축방식 선호도에 대한 비교분석을 수행하였다. 부석 결과 과거 국내 금융회사에서 많이 이루어진 혁신적 방식보다 단계적 방식에 대한 선호도가 높게 나타났다. 이러한 결과는 아키텍처 중심의 청사진을 통해 단계적으로 시스템을 구축하고자 하는 최근의 경향이 반영된 결과라 할 수 있다. 또한 회사유형에 따라 평가 항목별 가중치에 대한 차이가 나타났다. 즉, 금융회사는 시스템을 운영하는 입장에서 위험을 회피하고 안정성을 강조한 반면에 IT서비스회사는 차세대시스템을 구축하기 위한 비용과 그에 따른 성과를 강조하는 경향이 나타났다. 본 연구는 향후 금융 차세대시스템의 구축방법 결정시 가이드라인으로 활용될 것으로 기대된다. This study defines the Next Generation System(NGS) built by domestic financial businesses and classifies their architecture into two typical types according to the duration of the project and the relative cost of IT investment in the short term: the Big Bang approach and the Phase approach. Herein, we study the two approaches as alternatives in developing the Next Generation System, and derive the factors that are to be considered in the evaluation of the two alternatives for financial businesses. The set of standards for the choice between the two models are grouped into categories that constitute performance evaluation for IT-Cost, Performance and Risk. We drill down further into each category to second and third subordinate levels to derive detailed selection criteria. Based on the criteria drawn from the study, we conduct a survey with information system planners, IT managers and specialists at financial companies who are currently planning, developing or have completed a NGS. Results are analyzed using the AHP methodology to compare and understand the different approach in the implementation of NGS for financial business. According to the research result, survey respondents showed the different evaluation weight between alternatives by industry, but the Phase approach showed higher preference than the Big Bang approach in the building method.

고체모터의 인히비터에 의한 압력 진동 특성 LES 연구

홍지석(Ji-Seok Hong),문희장(Hee-Jang Moon),성홍계(Hong-Gye Sung) 한국추진공학회 2015 한국추진공학회지 Vol.19 No.1

고체로켓모터의 비선형 연소 불안정성 예측 기법

홍지석(Ji-Seok Hong),문희장(Hee-Jang Moon),성홍계(Hong-Gye Sung),엄원석(Won-Seok Um),서성현(Seonghyeon Seo),이도형(Do-hyung Lee) 한국추진공학회 2016 한국추진공학회지 Vol.20 No.1