99mTc - RBC SPECT 를 이용한 간혈관종의 진단

홍기석(Kee Suk Hong),문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee),조시만(Shee Man Cho),양석균(Suck Kyun Yang),정영화(Young Hwa Chung),이영상(Yung Sang Lee),신성해(Sung Hae Shin) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1

N/A The value of 99mTc-RBC scintigraphy and SPECT in the diagnosis of hepatic hemangioma was evaluated in 27 patients with 38 hemangiomas and 13 patients with 15 nonhemangiomas. Twenty four (63.2%) of 38 hemangiomas were detected by planar delayed RBC imaging, whereas 30 (78.9%) hemangiomas were detected by the delayed RBC SPECT. Increase in sensitivity was noted in nodules less than 2 cm in diameter. The smallest hemangioma shown by delayed RBC SPECT was 0.9 cm in diameter. All of nonhemangiomatous lesions show normal or decreased activity in delayed blood pool images. We concluded that 99mTc-RBC SPECT is an accurate method for the detection of hepatic hemangioma and is more sensitive than planar imaging in depicting small lesions.

증례 : 갑상선수질암 2 예 / 증례보고 및 문헌고찰

고창순 ( Chang Soon Koh ),이문호 ( Mun Ho Lee ),이홍규 ( Hong Kyu Lee ),홍기석 ( Kee Suk Hong ),김성권 ( Shung Gwon Kim ),정순일 ( Soon Il Chung ) 대한내과학회 1979 대한내과학회지 Vol.22 No.1

결핵에 있어서 Ferritin의 동태

최두혁 ( Choi Du Hyok ),송계용 ( Song Kye Yong ),홍기석 ( Hong Kee Suk ),안상섭 ( Ahn Sang Sup ),유흥철 ( Yoo Heung Chul ),최정수 ( Choi Jeong Soo ) 국군의무사령부 1981 대한군진의학학술지 Vol.12 No.1

결핵환자에서 혈청철과 Ferritin치의 상관성에 관한 연구

최두혁,홍기석,송계용,최태열 중앙대부설한국의과학연구소 1981 한국의과학 Vol.13 No.3

99mTc-HIDA 를 이용한 원발성간세포암전이 병소의 진단

홍성운,이진오,강태웅,홍기석,허대석 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.1

Tc-99m-Sulfur Colloid is concentrated in Kupffer cells of the liver, whereas the new biliary agents such as Tc-99m-HIDA are processed by hepatic parenchymal cells. The distant metastatic lesions in skull and lung of the primary hepatoceullar carcinoma in 38-year old Korean male were detected with Tc-99m-HIDA scintigraphy. The chest PA, skull bone X-ray and radionuclide scintigraphic studies are illustrated. This observation suggests that Tc-99m-HIDA scintigraphy is useful for detection of distant metastases of primary hepatocellular carcinoma.

惡性腫瘍에 倂發한 感染症에 對한 Amikacin Sulfate(Amikin^(�))의 效果

朴正植,朴宣陽,洪基碩,金聖權,李弘揆,李文鎬 최신의학사 1978 最新醫學 Vol.21 No.7

간스캔상 체위변동에 따른 간형태 변화에 대한 고찰

양영태,고창순,홍기석,최두혁 대한핵의학회 1982 핵의학 분자영상 Vol.16 No.1

식도의 과립세포종 5예에 대한 임상-병리학적 검색과 국내 문헌 고찰

송인성,김용일,오영륜,홍기석 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.2

Granular cell tumor(GCT) has been identified in all organ systems, most often in the oral cavity and subcutaneous tissue. GCT of the esophagus has been considered rare. However, this neoplasm is being recognized with increased frequency since the use of fiberoptic endoscopy has become widespread. We report 5 cases of granular cell tumors involving the esophagus, all of which were incidentally found. Four additional cases of GCT which appeared in the Korean literature were reviewed.

철결핍빈혈에서 Cobalt(58Co) 배설율 검사의 진단적 가치

이문호,송인경,고창순,조경삼,홍기석,신현정 대한핵의학회 1976 핵의학 분자영상 Vol.10 No.1

철결핍빈혈에서 cobalt 배설율검사의 진단적 가치를 검토할 목적으로 1974년 4월부터 1976년 4월까지 서울대학교 의과대학 부속병원 내과와 원자력병원에 입원하였던 철결핍성빈혈 22예, 재생불량성빈혈 3예, 용혈성빈혈 2예, 기타 각종질환 58예, 대조군 11예, 총계 96예를 대상으로 58CoCl2는 이용하여 cobalt 배설율검사를 시행하는 한편, 적혈구형태, 적혈구지수, 혈청철, 총철결합능, 골수철검사와 비교관찰하여 다음과 같은 결론을 얻었다. 1) 철대사와 혈액학적으로 정상이라고 생각되는 대조군의 6시간 cobalt 배설율은 평균 2.8±1.77%(1.0∼6.8%)이었으며, 24시간 cobalt 배설율은 평균 6.1±4.31%(1.9∼15.2%)였다. 2) 철결핍성빈혈의 경우에는 6시간 cobalt 배설율이 평균 18.3±5.88%(10.2∼25.0%)이었으며, 24시간 cobalt 배설율은 평균 41.8±6.83%(29.0∼54.5%)로서 대조군과 비교하여 6배이상 증가돼 있었다. 3) 골수철함량이 정상인 증례에서는 빈혈이 유무에 관계없이 6시간 및 24시간 cobalt 배설율은 모두 대조군과 유의한 차이가 없었다. 4) 6시간 cobalt 배설율과 24시간 cobalt 배설율간에는 밀접한 상관관계를 볼 수 있었으나, 실제적인 면에 있어서는 24시간 cobalt 배설율검사가 더 정확한 것으로 생각되었다. 5) 골수철함량이 정상인 증례의 24시간 cobalt 배설율은 1.2∼26.6%의 동요범위를 보인 반면, 철결핍성빈혈예의 24시간 cobalt 배설율은 29.0∼54.5%의 동요범위를 보였으며 양군간에 중복을 볼 수 없었다. 그러므로 빈혈환자에서 24시간 cobalt 배설율이 27%이상이면 철결핍성빈혈을 의심할 수 있는 것으로 생각되었다. 6) Cobalt 배설율은 골수철함량이 감소함에 따라 대체로 증가하는 경향을 보였으나 상당한 중복을 볼 수 있었고, 특히 골수철함량이 1+인 경우는 철결핍이나 골수철함량이 정상인 경우와 중복되어 통계학적으로 유의한 차이를 볼 수 없었다. 7) 골수철검사로 확인된 철결핍성빈혈의 경우, cobalt 배설율은 전예에서 증가된 반면, 적혈구형태는 40%에서, 적혈구지수는 30∼60%에서, transferrin 포화율은 70%에서 이상소견을 보였다. 이상의 성적을 종합하면 cobalt 배설율검사는 철결핍성빈혈을 진단하는데 간단하고 민감하며 정확한 검사법으로 골수철검사의 실제적인 대체검사로 이용될 수 있는 것으로 생각된다. The diagnosis of iron deficiency rests upon the correct evaluation of body iron stores. Morphological interpretation of blood film and the red cell indices are not reliable and often absent in mild iron deficiency. Serum iron levels and iron-binding capacity are more sensitive indices of iron deficiency, but they are often normal in iron depletion and mild iron deficiency anemia. They are also subject ro many variables which may introduce substantial errors and influenced by many pathologic and physiologic states. Examination of the bone marrow aspirate for stainable iron has been regarded as one of the most sensitive and reliable diagnostic method for detecting iron deficiency, but this also has limitations. Thus, there is still need for a more practical, but sensitive and reliable substitute as a screening test of iron deficiency. Pollack et al. (1965) observed that the intestinal absorption of cobalt was raised in iron, deficient rats and Valberg et al. (1969) found that cobalt absorption was elevated in patients with iron deficiency. A direct correlation was demonstrated between the amounts of radioiron and radiocobalt absorbed. Unlike iron, excess cobalt was excreted by the kidney, the percentage of radioactivity in the urine being directly related to the percentage absorbed from the gastro-intestinal tract. Recently a test based on the urinary excretion of an oral dose of 57Co has been proposed as a method for detecting iron deficiency. To assess the diagnostic value of urinary cobalt excretion test cobaltous chloride labelled with 1 μCi of 58Co was given by mouth and the percentage of the test dose excreted in the urine was measured by a gamma counter. The mean 24 hour urinary cobalt excretion in control subjects with normal iron stores was 6.1%(1.9∼15.2%). Cobalt excretion was markedly increased in patients with iron deficiency and excreted more than 29% of the dose. In contrast, patients with anemia due to causes other than iron deficiency excreted less than 27%. Hence, 24 hour urinary cobalt excretionf 27% or less in a patient with anemia suggets that the primary cause of the anemia is not iron deficiency. A value greater than 27% in an anemic subject suggests that the anemia is caused by iron deficiency. The cobalt excretion test is a simple, sensitive and accurate method for the assessment of body iron stores. It may be particularly valuable in the epidemiological studies of iron deficiency and repeated evaluations of the body iron stores.

CA 19-9 방사면역측정법의 기본적 검토 및 악성종양환자에서의 혈청 CA 19-9치의 임상적 의의에 관한 연구

이문호,홍성운,송영기,조보연,고창순,김상은,김노경,홍기석 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.1

To evaluate the performance characteristics of CA 19-9 radioimmunoassay and the clinical significance of serum CA 19-9 assay in patients with malignancy, serum. CA 19-9 levels were measured by radioimmunoassay using monoclonal antibody in 135 normal controls, 81 patients with various untreated malignancy, 9 patients of postoperative colon cancer without recurrence and 20 patients with benign gastrointestinal diseases, who visited Seoul National University Hospital from June, 1984 to March, 1985. The results were as follows; 1) The CA 19-9 radioimmunoassay was simple to perform and can be completed in one workd day. And the between-assay reproducibility and the assay recovery were both excellent. 2) The mean serum CA 19-9 level in 135 normal controls was 8.4±4.2U/mL. Normal upper limit of serum CA 19-9 was defined as 21.0U/mL. 4 out of 135 (3.0%) normal controls showed elevated CA 19-9 levels above the normal upper limit. 3) One out of 20 (5.0%) patients with benign gastrointestinal diseases showed elevated srum CA 19-9 level above the normal upper limit. 4) In 81 patients with various untreated malignancy, 41 patients (50.6%) showed elevated serum CA 19-9 levels. 66.7% of 18 patients with colorectal cancer, 100% of 2 patients with pancreatic cancer, 100% of 3 patients with common bile duct cancer, 47.1% of 17 patients with stomach cancer, 28.6% of 28 patients with hepatoma and 60.0% of 5 gastrointestinal tract cancers showed elevated serum CA 19-9 levels. 5) The sensitivities of serum CA 19-9 related to respectability in colorectal and stomach cancer were 33.3% in resectable colorectal cancer, 83.3% in unresectable colorectal cancer, 41.7% in resectable stomach cancer, 60.0% in unresectable stomach cancer respectively. 6) The sensitivity of serum CA 19-9 in 9 patients of postoperative colorectal cancer without recurrence were 33.3% and significantly decressed compared with that of untreated colorectal cancer, 66.7% (p〈0.05). 7) In Patients with colorectal cancer, simultaneous measurement of serum CA 19-9 and seum CEA levels increased sensitivities. From above results, we concluded that serum CA 19-9 radiommunoassay is simple to perform and reproducible, and is a useful indicator reflecting tumor exent and responses to the treatment in patients with malignancy.