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양성 및 음성 정신분열병 아형에서 사고의 정신병리적 특성에 관한 비교연구
김종숙,함웅,홍광화 대한신경정신의학회 1994 신경정신의학 Vol.33 No.3
The authors have studied the content and severity of thought disorder between the subjects of the positive and negative subtypes of schizophrenia. It's hypothetical ground is that the positive and negative subtypes of schizophrenics might bear highly significant differences in the pathogenesis, pathophysiology, psychopathology, also therapeutic and prognostic terms. In that regards, the author reported the neuropsychological significance in differentiating the two subtypes from each other, such that the negative subtype showed the worse function in the short-term recall against the auditory stimuli than the positive. To comparatively analyze the content and severity of thought disorder between the two subtypes, the authors utilized the Thought Discorder Index(TDI) scores and Holt's scale of the primary process thinking content. The results were as follows: 1) The total score of TDI as a whole, showed somewhat more thought disorder in the positive subtype subjects than the negative, though this failed to reach the statistical significance. In 0.75 level of TDI, the positive subtype subjects showed statistically significantly worse thought disorder than the negative. 2) In the comparative study of the primary process thinking content, the positive subtype subjects showed degree in the aggressive content but lower degree in the anxiety content than the negative subtype subjects with statistical significance. 3) In the correlation study, 0.5 level of TDI correlated with the libidinal content of the primary process with blunted affect and the aggressive content with lack of spontaneity and flow of conversation. The above result might suggest that the positive subtype of schizophrenia demonstrated more severe thought disorder, if we regard that responses scored at the 0.75 level of TDI represent clear thought disturbances. The negative subtype of schizophrenia tends to possess higher anxious and libidinal content of the primary process thinking.
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정신분열증환자에서 Nemonapride와 Haloperidol의 치료결과 및 내약성에 대한 비교분석
성상경,홍광화,Sung, Sang Kyung,Hong, Kwang Wha 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1
A single-blind comparative study was performed using haloperidol as a reference drug in order to evaluate the efficacy and safety of nemonapride, a new benzamide derivative, in sixty-nine Korean schizophrenic patients. the total period of the study was 8 weeks, maximum dosage of nemonapride was 36mg and that of haloperidol was 24mg. Psychopathology and extrapyramidal symptoms were assessed every week or four weeks until the end of the 8th week using the PANSS, BPRS, and 4 point general side effect check list, The drug safety was assessed every week until the end of the 8th week using vital sign, body weight, EEG, EKG, and blood chemistry. In total. one patient discontinued nemonapride treatment and seven patients discontinued haloperidol treatment before the end of the study. Therefore sixty-one patients(88 %) completed the study. PNASS and BPRS scores of the two groups on the end study point demonstrated a significant improvement compared with baseline score. The number of patients who had a clinical improvement of at least 20% in baseline score was similiar in both treatment groups. The difference of Simpson's rating scale socres were significant in both groups, and mean scores were more high in the haloperidol group than in nemonapride group. No significant EKG, EEG changes were induced, no relevant change in body weight or clinical laboratory parameters were observed in the sixty-one patients during 8 weeks and no Significant difference in the both groups. From these results, nemonapride is considered to be a clinically useful drug having a wide range of antipsychotic effect in schzophrenic patients.
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