http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
함수지,김태규,류지원,김용식,Ya-Ping Tang,임혜인 대한배뇨장애요실금학회 2018 International Neurourology Journal Vol.22 No.4
Purpose: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer because both involve substrates of γ-secretase. However, numerous clinical studies have reported an inverse correlation between AD and cancer. Interestingly, AD is a neurodegenerative disorder, whereas cancer is characterized by the proliferation of malignant cells. However, this inverse correlation in the PSEN double-knockout (PSEN dKO) mouse model of AD has been not elucidated, although doing so would shed light onto the relationship between AD and cancer. Methods: To investigate the inverse relationship of AD and cancer under conditions of PSEN loss, we used the hippocampus of 7-month-old and 18-month-old PSEN dKO mice for a microRNA (miRNA) microarray analysis, and explored the tumorsuppressive or oncogenic role of differentially-expressed miRNAs. Results: The total number of miRNAs that showed changes in expression level was greater at 18 months of age than at 7 months. Most of the putative target genes of the differentially-expressed miRNAs involved Cancer pathways. Conclusions: Based on literature reviews, many of the miRNAs involved in Cancer pathways were found to be known tumorsuppressive miRNAs, and their target genes were known or putative oncogenes. In conclusion, the expression levels of known tumor-suppressive miRNAs increased at 7 and 18 months, in the PSEN dKO mouse model of AD, supporting the negative correlation between AD and cancer.
해양심층수로 개질한 바이오차의 물리화학적 특성과 수용액 중 인 흡착 효율
장원석,양태희,함지원,허성구,오세진 강원대학교 농업생명과학연구원 2023 강원 농업생명환경연구 Vol.35 No.4
Recently, biomass conversion of by-products into an eco-friendly bio-sorbent such as biochar has been recognized as a promising product to maintain or increase soil productivity, reduce nutrient losses, and improve water purification in the ecosystem. In this study, four different types of biochar pyrolyzed at 500°C (RH: rice husk, BS: bean straw, PS: potato stem, RPS: red pepper stem) were chemically modified through two different methods (RW: raw deep sea water, CW: concentrated deep sea water). Changes in the physicochemical (surface area, elemental compositions, functional group) and morphological (SEM) properties of the modified biochar were measured, and the phosphate adsorption capacity in an aqueous solution was compared and evaluated. The improvements in the biochar properties varied for different feedstock and modification methods. In particular, the surface area of RH was the largest compared to other biochar, and CW modification caused substantial changes in the surface area and functional groups. The adsorption quantities of phosphate by modified biochar were 0.136 and 0.164 mg/g for RH_RW and RH_CW, respectively, and their corresponding adsorption quantities were 0.34 and 0.46 times higher than that of RH. Overall, it was determined that chemically modified biochar using deep sea water is suitable for removing phosphate in an aqueous condition.