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약침이 반복적인 코카인 투여로 인한 행동적 민감화 현상에 미치는 효과
이봄비,양재하,함대현,이혜정,심인섭,Lee, B.B,Yang, C.H.,Hahm, D.H.,Lee, H.J.,Shim, I.S. 대한약침학회 2004 Journal of pharmacopuncture Vol.7 No.1
Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. It has been shown that repeated injections of cocaine produce increase in locomotor activity, expression of the immediate-early gene, c-fos in the nucleus accumbens (NAc), which was one of the main dopaminergic terminal areas. Herbal-acupuncture as a therapeutic intervention has been widely used for the treatment of many functional disorders such as drug abuse. Coptidis Rhizoma (CR) and its main component, berberine (BER) were selected as herbal medicine of herbal-acupuncture. Both medicines have been known to have the therapeutic effect on the central nervous system. In order to investigate the effects of CR and BER herbalacupuncture at shenmen (HT7) point (CR/H and BER/H) on the cocaine-induced behavioral sensitization, the influence of CR/H and BER/H on repeated cocaine-induced locomotor activity, the change of c-Fos expression in the brain by immunohistochemistry were examined. Male SD rats were given CR/H (0.4mg/kg) and BER/H (0.1mg/kg) 30 min before daily injections of cocaine hydrochloride (15mg/kg. i.p.) 10 days. After 3 days withdrawal, rats received a challenge injection of cocaine (15mg/kg, i.p.). Systemic challenge with cocaine produced much larger increased locomotor activity, accumbal Fos-like immunoreactivity in the NAc. Pretreatment with CR/H and BER/H significantly inhibited cocaine-induced locomotor activity, the change of c-Fos expression in the rats. Our data demonstrated that the inhibitory effects of cocaine-induced behavioral sensitization by CR/H and BER/H were closely associated with the reduction of presynaptic dopamine release in the NAc. These results suggest that CR/H and BER/H can be effectively applied to cocaine addiction.
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백서(白鼠)에서 족삼리(足三里) 침 자극이 니코틴 반복처치로 유도된 행동적 민감화 및 뇌(腦)의 측핵에서 c-Fos 발현에 미치는 영향
채윤병 ( Y. B. Chae ),심인섭 ( I. S. Shim ),권영규 ( Y. K. Kwon ),양재하 ( C. H. Yang ),김미려 ( M. R. Kim ),김광중 ( K. J. Kim ),함대현 ( D. H. Hahm ),황은주 ( E. J. Hwang ),이혜정 ( H. J. Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.2
We have previously demonstrated that repeated injections of nicotine produced an increase in locomotor activity, dopamine (DA) release and c-Fos expression in the nucleus accumbens, one of the major projection areas of the central DA system. Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. In order to investigate whether acupuncture has an influence on nicotine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on nicotine-induced behavioral locomotor activity and c-Fos expression as an important marker of the postsynaptic neuronal activity in the nucleus accumbens utilizing the immunocytochemical detection of the Fos protein. The male Sprague-Dawly rats were given repeated daily nicotine injections (0.4 mg/kg s.c., twice daily for 7 days) followed by one challenging injection on the 4th day after the last daily injection. Systemic challenge with nicotine produced a much larger increase in locomotor activity and accumbal Fos-like immunoreactivity(FLI) in nicotine-pretreated rats. During withdrawal period(from 8th day to 11th day) acupuncture at zusanli(ST36), but not at control points(HT7, L3) significantly attenuated expected increase in nicotine-induced locomtor activity and accumbal FLI to subsequent nicotine challenge. These results demonstrated that reduction in locomotor activity by acupuncture may be mediated by reduction of postsynaptic neuronal activity in the nucleus accumbens. Our results suggest that acupuncture may have therapeutic effect on nicotine addiction.
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