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연속식 투과증발 방법을 이용한 Benzene-Cyclohexane계의 투과 특성 연구
이명환,이승우,한인천 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2
From batch experiment result, it was turned out that the affinity of PVC film to benzene is stronger than that to cyclohexane in pervaporation. Total permeate flux could be approximately presented in the function of temperature and concentration by means of regression. The higher concentration of benzene or temperature was, the more total flux was. The higher concentration of benzene was, the lower selectivity was. However, the selectivity was independent of temperature. Continuous experiment was carrid on Reynolds numbers(Re=7∼47.5). With Re=7∼47.5, as the inlet velocity of mixtures is increased, total permeate flux is increased. Analyzed derivitive form of continuity equation by integration in theory.
Congenital Adrenal Hyperplasia 환자에서 21 - hydroxylase ( CYP21 ) 유전자 돌연변이의 분자 진단에 관한 연구
이형송(Hyoung Song Lee),천강우(Kang Woo Cheon),박용석(Yong Seok Park),한인권(In Kwon Han),강인수(Inn Soo Kang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objective: Congenital adrenal hyperplasia (CAH) is an autosomal recessive diseav which is most often caused by a deficiency in steroid 21-hydroxylase (21-0H), a microsomal enzyme encoded by the CYP21 gene. Although several CAH causing mutations have been identified in the CYP21 gene of patients with 21-OH deficiency, genotyping of the 21-OH locus is quite complex because of the high frequency of gene conversion and the presence of multiple mutations on single CAH alleles. This study was aimed to analyze the complete characterization of the CYP21 gene coding region in a Korean CAH patient and to conform the PCR-based single strand conformation polymorphism (SSCP) and heteroduplex analysis as a diagnostic tool. Methods: We used a highly sensitive, non-radioactive method allowing PCR-based single strand c<formation polymorphism (SSCP) analysis. This method was applied to the characterization of all the exons and intron-exon junctions of the CYP21 gene in one patients affected by the salt wasting form and 4 normal controls. Results: In all samples showing SSCP abnormal band pattems, sequence analysis showed the presence of sequence variants. In particular, one mutation (I172N) which is already known to cause the disease and 3 silent mutations were detected. Conclusion: PCR-based single strand conformation polymorphism (SSCP) and heteroduplex analysis should be useful for the clinical application as a diagnostic tool for the detection of 21-hydroxylase gene mutations.