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Zea mays 불검화추출물을 함유하는 정제의 제제설계 및 평가
한용해,정연복,한건,정석재,박만기,심창구,Han, Yong-Hae,Chung, Youn-Bok,Han, Kun,Chung, Suk-Jae,Park, Man-Ki,Shim, Chang-Koo 대한약학회 2000 약학회지 Vol.44 No.6
The purpose of the present study was to design and prepare the optimum formulation for the oral administration of titrated extract of the unsaponifiable fraction of Zea mays L. (ETIZM). For this purpose, we simulated the blood concentration of ETIZM after its oral administration, changing the dissolution rate constants $(0.05{\sim}20\;hr^{-1})$. In vivo parameters, such as absorption rate constant $(k_a)$, elimination rate constant (k) and volume of distribution (Vd), were incorporated in the simulation on the basis of the experiments and literatures. When the dissolution rate constant $(k_r)$ is over $5\;hr^{-1}$, the absorption process appears to be the rate limiting step for the transport of ETIZM from the G.I. ract to the blood circulation. While less than $5\;hr^{-1}$, the dissolution rate considered to be the rate limiting step. Moreover, the optimum blood concentration was shown in the range from 1 to $5\;hr^{-1}$ of $k_r$ in the simulation. To design and prepare the tablets on the basis of the above results, 7 formula containing HPMC, PEG 4000 and PEG 6000 (1-5%, respectively) were prepared and evaluated. The tablets containing PEG 4000 (1%), PEG 6000 (1%) or PEG 4000 (5%) satisfy the optimum $k_r$ range ($1-5\;hr^{-1}$). These formulations, therefore, will be able to show the more effective blood concentration, compared with the commercial products after the oral administration.
한용만(Yong-Man Han),유해영(Hae-Young Yoo) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1B
새로운 비즈니스 환경 변화에 가장 빠르게 대응할 수 있는 최적의 대안으로 각광받고 있는 SOA(Service Oriented Architecture)는 현재 비즈니스 시장의 혁신과 변화를 주도하고 있다. 하지만 웹 기반인 SOA 기반 시스템은 품질평가에 대한 명확한 표준안이 제안되어 있지 않으며, 기존 소프트웨어 품질 평가를 통한 SOA 기반 시스템의 평가는 적절하지 않다. 본 논문에서는 기존 소프트웨어 품질 특성인 ISO/IEC 25000을 연구하고, AHP(Analytic Hierarchy Process) 기법을 통하여 SOA 기반 시스템에 알맞은 품질 특성을 도출하였다. 이를 통하여 SOA 기반 소프트웨어 개발 시 우선순위를 토대로 요구사항 분석이나 설계에 반영하여 최적화된 SOA 기반 시스템 구축이 가능하다.
이승학,김문경,한용해,심창구,Lee, Sung-Hack,Kim, Moon-Kyoung,Han, Yong-Hae,Shim, Chang-Koo 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.3
In the present study, quantitative and qualitative histology was used to assess the effects of ibuprofen suppositories with various treatments on the rectal mucosa of rats. Two suppositories were prepared with Witepsol W35 and compared with two commercial ibuprofen suppositories Reference I (Showa Pharm.ind., Tokyo, Japan), Reference II (P.Pharm., Seoul, Korea). Single and multiple dose(dosing interval 4 hr, n=4) studies were conducted. All suppositories significantly increased epithelial cell loss, but the extent of rectal irritation was variable. These studies showed that the incorporation of ibuprofen into the suppository bases increases the morphological change in rectal tissue both for the single and multiple administrations of suppositories, but which was significantly recovered within 24 hr although the interanimal variability in scores was very substantial. Multiple administration of ibuprofen suppositories caused significant damage to rectal mucosa, but it must be considered that these were under the severe condition, that is, interval of administration (4 hr) was three times shorter than normal interval of administration and dose was fifteen times larger than usual human dose. Aluminum oxide $(Al_2O_3)$, a dispersing agent, slightly increased the irritation of rectal mucosa in rats at 5 hr and 24 hr after multiple administration, but it was possible to ignore the difference of irritation in the data at 5hr and 24hr after single administration. Finally, it was concluded that Witepsol W35 and ibuprofen had a slight rectal mucosa-irritating effect on the usual human dose, and ibuprofen suppositories prepared with Witepsol W35 or Witepsol W35, $Al_2O_3$ showed almost similar extent of rectal irritation with commercial ibuprofen products.
아르기닌 또는 인산일수소나트륨이 수용액중에서 오메프라졸의 안정성에 미치는 영향 비교
심창구,한용해,우종수,이창현 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.4
The stability of omeprazole in the aqueous solutions containing arginine or sodium phosphate dibasic(SPD) was examined at 30, 40 and 50℃. Arginine or anhydrous SPD was added to omeprazoie solution (200㎍/㎖ in distilled water) to yield 100㎍/㎖ concentration of each. Then, the solution was kept at 30, 40 or 50℃ for 90 hrs. Aliquots of the solution were withdrawn at specified time intervals and assayed by HPLC for intact omeprazole. The remaining percentage-time curves revealed that omeprazole was degraded rapidly as functions of time and temperature following pseudo first-order kinetics. The rate constant in the SPD solution was much higher than in the arginine solution. In other words. the degradation half-lives of omeprazole at 30℃, for example, was 148 and 76 hr in arginine and SPD solutions respectively. The initial pH of the solution containing 100㎍/㎖ of arginine or SPD was 9.7 or 8.7, respectively. Since omeprazole is more stable as the pH of its solution becomes more alkaline, the longer half-life of omeprazole in arginine solution could be explained by the more alkaline characteristics of arginine than SPD In the solution. The activation energy necessary for the degradation reaction was almost identical in both solutions, indicating similar degradation mechanisms of omeprazole in the solutions. In conclusion, omprazole was more stable in the presence of arginine than of SPD.
심창구,한용해,김현지 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.3
The effect of omeprazole (OPZ) suppository on rat rectal mucosa was investigated microscopically. The suppository was prepared with Witepsol H15 base by molding method. Rectal irritation was evaluated according to defined pathological features. The suppository produced a slight damage to the rectal mucosa at 1 hr after the interectal administration, which was almost completely recovered within 24 hr. The damage was not due to OPZ but due to suppository base, Witepsol H15, itself, since Witepsol H15 suppository without OPZ produced the same damage. Therefore, it was concluded that OPZ itself has no rectal mucosa-irritating effect and thus can be developed as a suppository dosage form without any further toxicity problems.