상부요로이행상피암의 근치적 수술 후 방광암 재발의 예측인자

하성헌,박진성,홍준혁,김청수,안한종 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.7

Purpose: We investigated the predictors for developing intravesical recurrence following curative surgery for primary upper tract transitional cell carcinoma (UTTCC). Materials and Methods: The data of 207 patients without a prior history of bladder tumor or distant metastasis were analyzed. We evaluated the influence of multiple clinicopathologic parameters, such as age, sex, T stage, N stage, grade, carcinoma-in-situ, anatomical location, multifocality, lymphovascular invasion (LVI), preoperative urine cytology, and operative methods, on intravesical recurrence. Considering the possibility of bias from the effect of adjuvant treatment, the same analyses were performed in 184 patients excluding those who underwent adjuvant therapy. Mean follow-up was 59.7 months. Results: Of 207 patients, 91 (44%) experienced intravesical recurrence at a mean interval of 13.2 months. Among them, 66% (60/91) experienced intravesical recurrence within 12 months postoperatively. Eighty-nine percent of the recurred bladder tumors were superficial tumors and 64% were grade 1 or 2. Among the multiple parameters analyzed, LVI was the only significant predictor for intravesical recurrence in univariate and multivariate analysis (p=0.008; HR=1.911), whereas preoperative urine cytology was marginally significant. Similar results were obtained in the analysis for 184 patients without adjuvant therapy. Ten patients (11%) underwent muscle-invasive bladder tumor recurrence. Muscle-invasive bladder tumor recurrence was significantly associated with the presence of LVI compared with superficial bladder tumor recurrence (70% vs. 30%; p=0.005). Conclusions: LVI in primary UTTCC was a significant predictor of intravesical recurrence after curative surgery, whereas preoperative urine cytology was a possible predictor. Therefore, we recommend more rigorous cystoscopic follow-up in patients with these risk factors. Purpose: We investigated the predictors for developing intravesical recurrence following curative surgery for primary upper tract transitional cell carcinoma (UTTCC). Materials and Methods: The data of 207 patients without a prior history of bladder tumor or distant metastasis were analyzed. We evaluated the influence of multiple clinicopathologic parameters, such as age, sex, T stage, N stage, grade, carcinoma-in-situ, anatomical location, multifocality, lymphovascular invasion (LVI), preoperative urine cytology, and operative methods, on intravesical recurrence. Considering the possibility of bias from the effect of adjuvant treatment, the same analyses were performed in 184 patients excluding those who underwent adjuvant therapy. Mean follow-up was 59.7 months. Results: Of 207 patients, 91 (44%) experienced intravesical recurrence at a mean interval of 13.2 months. Among them, 66% (60/91) experienced intravesical recurrence within 12 months postoperatively. Eighty-nine percent of the recurred bladder tumors were superficial tumors and 64% were grade 1 or 2. Among the multiple parameters analyzed, LVI was the only significant predictor for intravesical recurrence in univariate and multivariate analysis (p=0.008; HR=1.911), whereas preoperative urine cytology was marginally significant. Similar results were obtained in the analysis for 184 patients without adjuvant therapy. Ten patients (11%) underwent muscle-invasive bladder tumor recurrence. Muscle-invasive bladder tumor recurrence was significantly associated with the presence of LVI compared with superficial bladder tumor recurrence (70% vs. 30%; p=0.005). Conclusions: LVI in primary UTTCC was a significant predictor of intravesical recurrence after curative surgery, whereas preoperative urine cytology was a possible predictor. Therefore, we recommend more rigorous cystoscopic follow-up in patients with these risk factors.

자궁 경부암 환자에서 치료전 종양표지 물질 Squamous Cell Carcinoma Antigen 측정의 의의

하성헌,윤 찬,이경희,박만철,임용우,오원섭 한림대학교의료원 1993 人間科學 Vol.17 No.8

유학재월남적전파여영향

하성헌 동양사회사상학회 2002 사회사상과 문화 Vol.5 No.-

霞谷人文思想初探

何成軒 한국양명학회 2005 한국양명학회 학술대회 논문집 Vol.- No.-

儒家學者姜公輔的思想

하성헌 동양사회사상학회 2008 사회사상과 문화 Vol.17 No.-

Gang Gong Bo was a Vietnamese in Dang Dynasty. He was an excellent the prime minister at Hyun Jong in Dang Dynasty. He built a creative theory which combined governing thoughts and political thoughts based on Confucian thoughts. His political philosophy was an unified thoughts of the royalty to the emperor and the ideas of patriotism which was rooted in Confucianism. Gang Gong Bo’s political thoughts included the theory of moderation(中道). He emphasized the common people centered thoughts. His thoughts can contribute to build modern society. His thoughts can provide a new resource in building a new civilization and social reconciliation. Therefore, in this paper, I want to excavate in Gang Gong Bo’s thoughts the resources which can be utilized to develop modern society. 강공보는 당나라 때의 베트남인이다. 그는 당 현종의 재상을 역임하여 당조 명상으로 칭해지고 있다. 그는 유학사상을 토대로 경세사상과 정치철학에 있어 독창적인 이론체계를 세웠다. 그의 정치철학은 유가의 임금에 대한 충성과 애국에 대한 이념을 하나의 통일체적인 사상으로 확립하였다. 강공보의 정치철학사상은 중도설中道說을 포괄하고 있다. ‘법선왕설法先王說’, ‘민본사상民本思想’, ‘의식이 족하고 예의를 세워야 하며’, ‘생태윤리의식’ 등을 중시하였다. 그 가운데 가장 가치가 있는 것은 바로 민본사상이다. 그의 민본사상은 개조와 전환 그리고 창신을 통해 현대사회에 유익한 모범이 될 수 있다. 이와 같은 그의 사상은 오늘날 인류의 정신문명건설과 사회화해를 건립하는 데 있어서 새로운 사상자원을 제공해 줄 수 있다. 그러므로 본 논문에서는 그의 사상 가운데 적극적이고 합리적인 부분을 개발하고 연구하여, 현대사회에 활용할 가치가 있음을 논의해 보고자 한다.

儒學在越南的傳播與影響

何成軒 동양사회사상학회 2002 사회사상과 문화 Vol.5 No.-

儒家學者姜公輔的思想

하성헌 ( He Cheng-xuan ) 동양사회사상학회 2008 사회사상과 문화 Vol.17 No.-

강공보는 당나라 때의 베트남인이다. 그는 당 현종의 재상을 역임하여 당조 명상으로 칭해지고 있다. 그는 유학사상을 토대로 경세사상과 정치철학에 있어 독창적인 이론체계를 세웠다. 그의 정치철학은 유가의 임금에 대한 충성과 애국에 대한 이념을 하나의 통일체적인 사상으로 확립하였다. 강공보의 정치철학사상은 중도설中道說을 포괄하고 있다. ‘법선왕설法先王說’, ‘민본사상民本思想’, ‘의식이 족하고 예의를 세워야 하며’, ‘생태윤리의식’ 등을 중시하였다. 그 가운데 가장 가치가 있는 것은 바로 민본사상이다. 그의 민본사상은 개조와 전환 그리고 창신을 통해 현대사회에 유익한 모범이 될 수 있다. 이와 같은 그의 사상은 오늘날 인류의 정신문명건설과 사회화해를 건립하는 데 있어서 새로운 사상자원을 제공해 줄 수 있다. 그러므로 본 논문에서는 그의 사상 가운데 적극적이고 합리적인 부분을 개발하고 연구하여, 현대사회에 활용할 가치가 있음을 논의해 보고자 한다. Gang Gong Bo was a Vietnamese in Dang Dynasty. He was an excellent the prime minister at Hyun Jong in Dang Dynasty. He built a creative theory which combined governing thoughts and political thoughts based on Confucian thoughts. His political philosophy was an unified thoughts of the royalty to the emperor and the ideas of patriotism which was rooted in Confucianism. Gang Gong Bo’s political thoughts included the theory of moderation(中道). He emphasized the common people centered thoughts. His thoughts can contribute to build modern society. His thoughts can provide a new resource in building a new civilization and social reconciliation. Therefore, in this paper, I want to excavate in Gang Gong Bo’s thoughts the resources which can be utilized to develop modern society.

Long-term Follow-up after Feminizing Genital Reconstruction in Patients with Ambiguous Genitalia and High Vaginal Confluence

박성찬,하성헌,김건석 대한의학회 2011 Journal of Korean medical science Vol.26 No.3

We evaluated the long-term results of feminizing genital reconstruction in patients with genital ambiguity with high vaginal confluence. The medical records of 10 consecutive patients with ambiguous genitalia and high vaginal confluence who underwent feminizing genital reconstruction from 1996 to 2007 were reviewed. Seven patients had congenital adrenal hyperplasia, one had mixed gonadal dysgenesis, one had partial androgen insensitivity, and one had 5-alpha reductase deficiency syndrome. Median age at operation was 21 months (range, 2-47 months). Median follow up was 7.7 yr. Of the six patients who underwent feminizing genital reconstruction with the Gonzalez method, three had good results. Of the other three patients, one had a urethrovaginal fistula and underwent fistula repair 9 yr after, one had distal vaginal stenosis and underwent revision vaginoplasty 9 yr after, and one had a urethrovaginal fistula and urethral stricture. The patient with urogenital mobilization had persistent urogenital sinus. Feminizing genitoplasty using the Gonzalez method showed good long-term results in patients with ambiguous genitalia and Congenital adrenal hyperplasia. The procedure is less invasive than other approaches and results in excellent cosmetic outcomes; and complications can be corrected by relatively simple procedures.

Prevalence and Determinants of High-Risk Human Papillomavirus Infection in Male Genital Warts

박성진,서주형,하성헌,정경우 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.3

Purpose: To evaluate the prevalence and type distribution of high-risk human papillomavirus(HPV) infection in genital warts of Korean men, and for the first time, to describethe risk factors associated with high-risk HPV infection in male genital warts. Materials and Methods: In a single private clinic, 150 consecutive male patients withhistopathologic-confirmed genital warts who underwent HPV genotyping by use of polymerasechain reaction (PCR) were included in this study. We detected HPV DNA inmale genital warts and evaluated HPV type distribution, especially high-risk HPVtypes, by use of PCR. The associations between HPV prevalence and various characteristics,such as age, circumcision status, type of genital warts diagnosis (new vs. recurrent),number of lesions, site of lesions, and gross morphology, were assessed by useof unconditional multiple logistic regression. Results: High-risk HPV types were detected in 31 cases (23.5%), and of these, 27 cases(20.5%) contained both high-risk and low-risk HPV types. The most frequently detectedhigh-risk HPV types were HPV16 (6.8%), HPV33 (4.5%), HPV18 (2.3%), and HPV68(2.3%). In particular, the prevalence of infection with HPV16 and/or HPV18 was 8.3%(11 of 132). In the multivariate analysis, lesions located at sites including the base ofthe penis or the pubic area, papular or mixed genital warts, and lack of circumcisionsignificantly increased the association with high-risk HPV infection in male genitalwarts. Conclusions: The prevalence of high-risk HPV infection was substantial in male genitalwarts. The site and morphology of lesions and circumcision status were significantlyassociated with the prevalence of high-risk HPV infection.

일반연제 발표 : 산과학 ; 10대 임산부의 산과적 합병증에 대한 임상적 고찰

송재천,김현경,하성헌,박만철,남주현,오원섭 대한산부인과학회 1991 대한산부인과학회 학술대회 Vol.68 No.-