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요로감염에서 Ofloxacin(DL-8280)의 임상효과
정경우,정문기,윤진한,윤종병 中央醫學社 1987 中央醫學 Vol.52 No.10
Ofloxacin (DL-8280), a new quinolone derivative, was evaluated clinically for its effi-cacy and antimicrobial activity in the treatment of 32 cases with UTI. There were 12 of cystitis, 6 of gonorrheal urethritis, 9 of non-gonorrheal urethritis and 5 of complicated UTI. A total of 37 specimens was evaluated for the drug susceptibility of ofloxacin in vitro. The results were summarized as follows: 1. The drug susceptibility of Ofloxacin in vitro showed good sensitivity in 37 spe-cimens. The organism were 16 cases of E. coli, 7 of p. aeruginosa, 4 of Serratia marscens, 3 of K. pneumonia, 2 of S. aureus, 2 of P. mirabilis, and 1 in each of K. oxytoca, P. vulgaris, Citrobacter freundi, Morganella morgani, and Providentia rettgeri in total. In 10?g/ml, all the organism showed good sensitivity. In 2?g/ml, most of organisms showed good sensitivity, and two of each organisms of E. coli, P. aeruginosa and Serratia marscens showed interme-diate sensitivity. However, two cases of P. aeruginosa showed resistance. In 0.5?g/ml, the sensitivity in each organism was variable and unremarkable. 2. In 12 cases with cystitis, the clinical response was excellent in 9, good in 2 and poor in one with overall efficacy rate of 92.0%. In 6 cases with gonorrheal urethritis, the clinical response was excellent in 5, and good in one with overall efficacy rate of 100%. In 9 cases with non-gonorrheal urethritis, the clinical response was excellent in 6, good in 2 and poor in one with overall efficacy rate of 89.0%. In 5 cases of complicated UTI, the clinical re-sponse was excellent in 3 and good in 2 with overall efficacy rate of 100%. 3. Side reaction associated with ofloxacin intake was minor with mild indigestion, headache, insomnia and none of the case was severe enough to discontinue Oflaxin medication.