한약 치료를 시행한 재발성 아프타성 구내염 환자의 임상소견에 관한 추적 관찰 연구

하나연,이재형,이정은,남성욱,고휘형,황미니,김진성,Ha, Na-yeon,Lee, Jae-hyung,Lee, Jung-eun,Nam, Seong-uk,Ko, Whee-hyoung,Hwang, Mi-ni,Kim, Jin-sung 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

Objectives: The purpose of this study was to report the long-term efficacy of herbal medicine for treatment of patients with recurrent aphthous stomatitis (RAS). Methods: We reviewed the clinical records of 17 patients with RAS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from September 1st, 2014 to August 29th, 2017. The patients were treated with herbal medicine for more than 3 consecutive weeks, followed by a telephone survey. We evaluated the clinical characteristics of RAS, and compared the short-term and long-term efficacy of herbal medicine treatment. Results: After treatment with herbal medicine, the clinical characteristics improved in the 17 patients with RAS, especially in terms of the duration and interval of recurrence. Prolonged effects were reported upon the follow-up telephone survey. Conclusion: Herbal medicine treatment may have a long-term effect in patients with RAS.

비장도인법(脾腸導引法)을 적용한 복부 팽만감 주소의 기능성소화불량 증례보고

정해인,하나연,김진성,Jeong, Hae-in,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

A 42-year-old patient with functional dyspepsia had suffered from early satiation and postprandial fullness for 1 year despite Western medicine treatment. We treated her with the Spleen Daoyin method, along with acupuncture, moxibustion, and herbal medicine and scored her symptoms using a 4-point Functional Dyspepsia-related Quality of Life (4p-FD-QoL) questionnaire, the Gastrointestinal Symptom Rating Scale (GSRS), and a visual analogue scale (VAS). A 7-day Spleen Daoyin treatment decreased her 4p-FD-QoL score from 61 to 51, with a marked decrease in the emotional part (18 to 10). Her GSRS score did not change, but her bloating score decreased from 3 to 1. Her VAS score decreased from 6.6 to 4.3 for upper abdomen discomfort, but lower abdomen discomfort was unchanged. The patient showed high compliance and satisfaction with exercise therapy and reported no adverse events. Spleen Dayoin may be a useful therapy for functional dyspepsia, especially when accompanied by psychological problems.

구강작열감증후군 환자의 적외선체열검사와 정량적 평가 특성 : 단면조사연구

고휘형,남성욱,하나연,황미니,백소영,김동윤,김진성,Ko, Whee-hyoung,Nam, Seong-uk,Ha, Na-yeon,Hwang, Mi-ni,Baek, So-young,Kim, Dong-yoon,Kim, Jin-sung 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

Objectives: This study was designed to investigate characteristics of digital infrared thermal imaging (DITI) and quantitative evaluations in patients with burning mouth syndrome (BMS). Methods: We reviewed the clinical records of 38 patients with BMS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from March 1st, 2018 to June 30th, 2018. The subjects were evaluated with digital infrared thermal imaging (DITI) and for heart rate variability (HRV), unstimulated salivary flow rate (USFR), and the proportion of coated tongue. Results: Most patients showed higher temperatures on the central part of the tongue (T2) than on the middle of the forehead (T1). The patients tended to have a high Low frequency/High frequency (LF/HF) ratio. Statistically significant negative correlations were noted between the age of patients and the temperature of T1 and T2. Statistically significant negative correlations were also observed between the LF/HF ratio and 'T1-T2' values. Conclusions: This study suggests that DITI and HRV are useful for the validation of patients with BMS. Correlations between the result values suggest that sympathetic function acceleration is related to temperature distribution and, ultimately, to symptoms.

마이크로블로그 서비스에서 사용자 행동에 미치는 플로우와 정체성의 영향에 대한 연구

신호경(Ho Kyoung Shin),하나연(Na Yeon Ha),이기원(Ki Won Lee) 한국데이타베이스학회 2009 Journal of information technology applications & m Vol.16 No.4

Microblog services are such new communication channels with some considerable potential to improve information sharing. The idea of sharing short messages using multiple access points seems to be appealing to people worldwide. Through the lens of flow and social identity, we explored factors that influence information sharing behaviors in microblog services. With an empirical study, we examined enjoyment and concentration(flow) and self-presentation(social identity) in microblog services like twitter can contribute to the user behaviors. Our aim was to gain insight into ways of creating an environment that facilitating voluntary sharing of information. Our findings suggested that enjoyment, concentration, and selfpresentation were crucial determinants of information sharing behaviors in microblog services. This study has important implications for academic researchers and practitioners who seek to understand why microblog service users share their information with other members in microblog services.

한방 치료로 호전된 흑모설의 임상 증례

남성욱,이재형,이정은,하나연,고휘형,황미니,김진성,Nam, Seong-uk,Lee, Jae-hyung,Lee, Jung-eun,Ha, Na-yeon,Ko, Whee-hyoung,Hwang, Mi-ni,Kim, Jin-sung 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

Black hairy tongue is a benign medical condition, which is characterized by elongated filiform lingual papillae, with a typical carpet-like appearance on the dorsum of the tongue. We describe the case of a 70-year-old Korean female with black hairy tongue, who complained of black hairy tongue accompanied by xerostomia. The patient was treated with Jibaekjihwang-tang-gagambang and electric acupuncture for 13 days. Black hairy tongue was evaluated by its visual appearance and by calculating hue-saturation-brightness (HSB) and red-green-blue (RGB) values of images of the tongue using a photo-edit program. Salivary flow rate (SFR) was evaluated to evaluate oral dryness. After 13 days of treatment, the black fur disappeared, and the brightness and RGB values of the black fur increased. In addition, the SFR increased. We conclude that Korean medicine could be the treatment choice for black hairy tongue.

전통적인 발효 방법으로 제조된 참외식초의 기능적 특성

정경임(Kyung Im Jung),하나연(Na Yeon Ha),최영주(Young Ju Choi) 한국생명과학회 2019 생명과학회지 Vol.29 No.3

본 연구에서는 다양한 방법으로 제조한 참외식초의 이화학적 특성과 항산화 작용, 알코올 대사 효소 활성 및 RAW 264.7 세포에서의 항염증 활성에 미치는 영향을 알아보았다. 각기 다른 방법으로 제조한 참외식초의 총 산도는 MV-1은 4.00%, MV-2는 4.32%, MV-3은 4.35%로 나타났다. 유기산 측정결과 MV-1은 malic acid (58.37 mg/ml), MV-2 (46.95 mg/ml)와 MV-3 (66.70 mg/ml)는 acetic acid가 가장 높게 나타났다. 참외식초의 총 페놀 함량은 MV-3에서 129.74 μg TAE/ml로 가장 높게 나타났다(p<0.05). 참외식초의 DPPH radical 소거능은 농도 의존적으로 증가하였으며(p<0.05), MV-3 40% 농도에서 89.28%로 가장 높게 나타났다. SOD 활성은 농도 의존적으로 증가하였으며(p<0.05), 60% 농도에서의 MV-1와 MV-2 및 MV-3는 각각 40.84%, 52.17%, 72.55%로 나타났다(p<0.05). 참외식초의 ADH 및 ALDH 활성은 농도의존적으로 증가하였으며, 60% 농도에서의 ADH 활성은 MV-1에서 136.58%로 가장 높게 나타났고, ALDH 활성은 MV-2에서 100.25%로 나타났다. 아질산염 소거능 분석에서는 pH 1.2에서 MV-1, MV-2, MV-3 각각 81.58%와 94.72% 및 87.75%로 나타났다. 참외식초의 항염증 활성 측정을 위하여 LPS로 유도된 RAW 264.7 cell의 NO 합성을 측정한 결과, 1%에서 농도에서 MV-1, MV-2, MV-3의 NO 합성은 각각 25.93%와 10.01% 및 79.75% 감소하였다(p<0.05). 이상의 결과와 같이 참외 꼭지를 포함하여 0.5 cm두께로 슬라이스한 참외와 찹쌀고두밥 및 누룩을 이용하여 전통적인 방법으로 제조한 MV-3는 항산화 및 항염증 활성이 높은 것으로 나타났기에 기능성 건강음료로서의 가능성이 높은 것으로 판단된다. This study investigated the physiochemical properties, the anti-oxidant and alcohol metabolism enzyme activities, and the anti-inflammatory effects of three muskmelon vinegars prepared under different fermentation conditions, namely MV-1, MV-2, and MV-3. The total acidity of each vinegar was 4.00%, 4.32%, and 4.35%, respectively. Organic acid analysis showed that malic acid (58.37 mg/ml) was the most prevalent in MV-1 and that acetic acid was most prevalent in both MV-2 (46.95 mg/ml) and MV-3 (66.70 mg/ml). The total phenolic content of the muskmelon vinegars was highest at 129.74 μg tannic acid equivalents (TAE)/ml in MV-3. The DPPH radical scavenging activity of the vinegars increased in a dose-dependent manner (p<0.05) and was 89.28% at MV-3 40% concentration. Similarly, SOD activitity increased in a concentration-dependent manner (p<0.05) so that levels for MV-1, MV-2, and MV-3 at 60% concentrations were 40.84%, 52.17% and 72.55%, respectively (p<0.05). Moreover, the ADH and ALDH activities of muskmelon vinegar were seen to increase in a concentration-dependent manner; ADH activity at 60% concentration was highest at 136.58% in MV-1 and ALDH activity at 60% concentration was highest at 100.25% in MV-2. The nitrite scavenging activities of MV-1, MV-2, and MV-3 at pH 1.2 were found to be 81.58%, 94.72%, and 87.75%, respectively. Anti-inflammatory effects were also examined, using LPS-stimulated RAW 264.7 cells, and nitric oxide production was reduced to 25.93%, 10.01%, and 79.75% by addition of MV-1, MV-2, and MV-3 at 1% concentration, respectively (p<0.05). These results suggest that the MV-3 muskmelon vinegar has great potential as an ingredient for high quality functional health beverages.

기능성소화불량 환자에서 나타나는 정신적 증상의 한약 치료 : 체계적 문헌고찰과 메타분석

조윤재,이하늘,정해인,이현진,금창열,한아람,하나연,김진성,Cho, Yun-jae,Lee, Hanul,Jeong, Hae In,Lee, Hyun-Jin,Keum, Chang-Yul,Han, Aram,Ha, Na-Yeon,Kim, Jinsung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.4

Purpose: Functional dyspepsia (FD) is a chronic syndrome accompanied by repetitive digestive symptoms that appear in the upper gastrointestinal tract and are not caused by specific diseases. Psychological symptoms like anxiety, depression, insomnia, and somatization are frequently observed in FD. The purpose of this study was to review the effect of herbal medicine on the psychological symptoms that accompany FD. Methods: Database search (PubMed, EMBASE, KISS, Kmbase, KoreanMed, NDSL, OASIS, CNKI) was performed on February 24, 2021; a total of 1825 studies were searched. After the screening, 22 studies were included. Results: The studies were assessed by Cochrane RoB 2 and sorted into a table according to psychological symptoms. Meta-analysis was performed to estimate the effect of herbal medicine. Twenty of the twenty-two studies reported that herbal medicine was significantly more effective than the control group. Only three of the studies did not have a high risk of bias. Conclusion: Herbal medicine was significantly effective with or without Western medicine and had fewer adverse effects. Severe adverse effect was not reported. Psychological symptoms in FD affect onset and duration of FD, and some FD patients want to be treated for their anxiety before other symptoms. Reliable information about treatment for the psychological symptoms of FD is lacking. We reviewed the effect of herbal medicine treatment in this study, the results of which could be selected for primary or secondary treatment for FD.

설하 신경 마비로 인한 설마비 환자 치험 1례

이재형,한성준,이엄지,이정은,남성욱,하나연,김진성,Lee, Jae-hyung,Han, Seong-jun,Lee, Eom-jee,Lee, Jung-eun,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.5

Hypoglossal nerve palsy is an uncommon neurologic disorder. We report a 67-year-old Korean male with tongue paralysis due to hypoglossal nerve palsy. He had complaints associated only with tongue paralysis and was treated with herbal medicine and electric acupuncture for 12 days. We evaluated his tongue paralysis severity by a numeric rating scale (NRS) and the angle of tongue deviation. After 12 days of treatment, the NRS score showed improvement of his complaints, and the angle of tongue deviation was decreased. Korean medicine could therefore be an effective treatment choice for hypoglossal nerve palsy.

한약 치료를 시행한 트리메틸아민뇨증 환자 1례 증례보고

이정은,한성준,이엄지,이재형,남성욱,하나연,김진성,Lee, Jung-eun,Han, Seong-jun,Lee, Eom-jee,Lee, Jae-hyung,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: This case reports on the efficacy of herbal medicine treatment for trimethylaminuria.Method: A 29-year-old female Korean patient with trimethylaminuria received herbal medicine treatment for three months. We evaluated her symptoms with the methacholine challenge test and OralChroma.Results: The odor intensity shown in the methacholine challenge test demonstrated improvement.Conclusion: Herbal medicine treatment could improve trimethylaminuria symptoms.

식적으로 진단된 기능성소화불량 환자의 임상적 특성

정해인,이하늘,이현진,조윤재,한아람,금창열,하나연,김진성,Jeong, Hae-in,Lee, Hanul,Lee, Hyun-jin,Cho, Yun-jae,Han, Aram,Keum, Chang-yul,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

Objectives: This study investigated the clinical characteristics of functional dyspepsia (FD) patients with food retention (FR) in regard to the parameters of cutaneous electrogastrography (EGG), Ryodoraku, and heart rate variability (HRV). Methods: This study reviewed the clinical records of 33 FD patients with FR who filled out the FR Questionnaire for FD (FRQ-FD) and underwent EGG for six months from March 1st, 2021. We summarized the clinical characteristics of FD patients with FR and analyzed the correlation between FRQ-FD score and parameters of EGG, Ryodoraku, and HRV. Results: FRQ-FD scores had a positive correlation with percentage of postprandial bradygastria and negative correlation with power ratio, detected on Channel 2, 3 of EGG. The total average (TA) Ryodoraku score was lower, and the high frequency density (HF) of HRV was higher than the normal value. Conclusions: The results of this study suggest that clinicians can use EGG, Ryodoraku, and HRV to increase the accuracy of diagnosing FR in FD patients.