족삼리 전침 자극이 초음파로 측정된 위배출능에 미치는 영향 : 건강인 대상 예비연구

하나연,박재우,김진성 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.3

Objective: This study aimed to compare the effects of Zusanli and nonacupoint electroacupuncture stimulation on ultrasonographic gastric emptying and vital signs in eight healthy participants. Gastric emptying and its rate of change were analyzed to search for correlation with physical characteristics such as body mass index (BMI), sternocostal angle, and abdominal wall thickness. Methods: Eight healthy participants with no gastrointestinal disorders were enrolled in this study. Each participant went through three abdominal sonographies for gastric emptying assessment. At the second and third visits, participants received Zusanli and nonacupoint electroacupuncture stimulation in a random order. During the study period, we examined the BMI, sternocostal angle, and abdominal wall thickness of all participants. Vital signs (blood pressure, heart rate, and temperature) were also examined before and after the electroacupuncture stimulation. Results: Electroacupuncture stimulation at Zusanli significantly improved gastric emptying when compared to nonacupoint stimulation. Gastric emptying showed a positive correlation with BMI, sternocostal angle, and abdominal wall thickness, but this correlation was statistically insignificant. The improvement rate of gastric emptying by Zusanli electroacupuncture stimulation showed a positive correlation with BMI and sternocostal angle and a negative correlation with abdominal wall thickness. However, such results were also statistically insignificant. Among vital signs, only heart rate showed a significant decrease according to Zusanli electroacupuncture stimulation. Conclusions: A significant effect of Zusanli electroacupuncture was confirmed through ultrasonographic gastric emptying in healthy participants.

二陳湯加味方을 투여한 불응성 위식도역류질환의 증례군 연구

하나연,한가진,김대준,고석재,박재우,김진성 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.6

Objectives: The purpose of this study was to investigate the efficacy of Lijin-tang-gamibang on refractory gastroesophageal reflux disease (GERD). Methods: This before-and-after study compared the first medical examination and examination at the end of medical treatment. Twelve refractory GERD patients who visited the Department of Digestive Diseases of Kyung Hee University Korean Medicine Hospital from August 14th, 2017 to October 14th, 2017, were treated with Lijin-tang-gamibang for four consecutive weeks. The clinical characteristics of refractory GERD and the efficacy of herbal medical treatment was assessed by questionnaires, the Nepean Dyspepsia Index-Korean version (NDI-K), the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Numerical Rating Scale (NRS), the Korean version of the Perceived Stress Scale (KPSS-10), the Qi Stagnation Questionnaire (QSQ), the Spleen Qi Deficiency Questionnaire (SQDQ), and the Patient Global Impression of Change (PGIC). Prolonged effects were reported upon the follow-up telephone survey two weeks after treatment. Results: After treatment with the herbal medicine Lijin-tang-gamibang, the clinical characteristics of 12 refractory GERD patients were improved, especially in terms of the most common symptoms of acid regurgitation and heartburn. Each symptom score of NDI-K, KGSRS, NRS, SQDQ, and PGIC showed significant advances. Prolonged effects were reported in NDI-K, NRS and PGIC questionnaires two weeks after treatment. Conclusions: These results suggest that Lijin-tang-gamibang is an effective treatment for refractory GERD.

한약 치료를 시행한 재발성 아프타성 구내염 환자의 임상소견에 관한 추적 관찰 연구

하나연,이재형,이정은,남성욱,고휘형,황미니,김진성,Ha, Na-yeon,Lee, Jae-hyung,Lee, Jung-eun,Nam, Seong-uk,Ko, Whee-hyoung,Hwang, Mi-ni,Kim, Jin-sung 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

Objectives: The purpose of this study was to report the long-term efficacy of herbal medicine for treatment of patients with recurrent aphthous stomatitis (RAS). Methods: We reviewed the clinical records of 17 patients with RAS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from September 1st, 2014 to August 29th, 2017. The patients were treated with herbal medicine for more than 3 consecutive weeks, followed by a telephone survey. We evaluated the clinical characteristics of RAS, and compared the short-term and long-term efficacy of herbal medicine treatment. Results: After treatment with herbal medicine, the clinical characteristics improved in the 17 patients with RAS, especially in terms of the duration and interval of recurrence. Prolonged effects were reported upon the follow-up telephone survey. Conclusion: Herbal medicine treatment may have a long-term effect in patients with RAS.

모바일 애플리케이션 마켓에서 온라인 구전 수용에 영향을 미치는 요인에 관한 연구

하나연,김경규,이호,Ha, Na-Yeun,Kim, Kyung-Kyu,Lee, Ho 한국과학기술정보연구원 과학기술정보센터 2012 Journal of Information Science Theory and Practice Vol.43 No.1

본 연구에서는 최근 모바일 산업의 화두인 애플리케이션 마켓에서의 구전 수용 과정에 초점을 두고, 구전 커뮤니케이션의 주요 특성이 구전 정보의 신뢰와 구전 수용 과정에 어떠한 영향을 미치는지 실증적으로 분석하고자 한다. 이를 위해 애플리케이션 시장에 대한 이해와 온라인 구전 커뮤니케이션 및 정교화 가능성 모델에 대한 선행연구를 기반으로 온라인 구전 수용의 영향 요인들을 도출하고, 연구가설을 설정하였다. 모바일 애플리케이션 마켓에서 리뷰를 이용해 본 경험이 있는 스마트폰 사용자를 대상으로 설문조사를 실시한 결과, 모바일 애플리케이션 마켓에서 소비자들이 온라인 리뷰를 수용하기 위한 선행 요인으로 리뷰에 대한 신뢰를 제시하였고, 신뢰를 느끼기 위해서 리뷰내용의 품질에 대한 긍정적 평가와 전달되는 설명의 선명함, 의견의 중립성이 필요함을 실증적으로 증명하였다. 본 연구의 이론적 시사점은 구전에 대한 연구들을 바탕으로 다른 온라인 매체에 비해 상대적으로 의사 결정을 위한 판단 단서가 적은 모바일 애플리케이션 마켓이라는 환경에서 구전 신뢰에 영향을 줄 수 있는 변인들을 찾고 이를 개념화한 데 있으며 실무적 관점에서 보면, 온라인 리뷰 수용의 선행 요인들을 살펴보면서 어떠한 속성을 기업이나 개발자들이 전략적으로 활용할 수 있는지 시사점을 제시했다고 할 수 있다. This study, focusing on process of online Word-of-Mouth(oWOM) adoption in applications market which is a major issue of recent mobile industry, tried to empirically analyze how main characteristics of oWOM affect trust and process of oWOM adoption. To do this, based on understanding about applications market and precedent studies on online communication and Elaboration Likelihood Model(ELM), I developed the research model and proposed seven hypotheses. The subjects were smart phone users who ever used review in mobile applications market. The study method was questionnaire survey. As a result, trust in review was suggested as prerequisite for consumers to accept on-line review in mobile applications market. And it was empirically proved that for the customers to feel trust, these are necessary - positive assessment on argument quality, vividness of delivered explanation, and neutrality of message. The theoretical implications of this study are that based on studies on oWOM, factors affecting trust in review were explored in the environment of mobile applications market with less judgement clues for decision making compared to other on-line media and then, these factors were conceptualized. From the practical view, this study suggested implication on what attributes companies or developers can strategically utilize while investigating prerequisites of oWOM adoption.

구강작열감증후군 환자에서 양도락의 진단적 가치 및 변증과의 상관성 분석

김동윤,하나연,김진성 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.4

Objectives: The aim of this study was to analyze the correlation between Ryodoraku and two pattern-identification questionnaires in patients with Burning Mouth Syndrome (BMS). Methods: The study participants were 30 patients with BMS who visited the Oral Diseases Clinic of Kyung Hee Oriental Medicine Hospital from June to November, 2019. The Ryodoraku test and two pattern-identification questionnaires were administered to all patients. Measurements included the average Ryodoraku score, which is called the Total Average (TA), and each score on the Ryodoraku point scale. The degree of Yin-deficiency, Qi-stagnation, and pain were assessed with the Yin-deficiency Questionnaire (YDQ), Qi-stagnation Questionnaire (QSQ), and Visual Analogue Scale (VAS), respectively. Results: The average TA score was 29.90. The LF5 (p=0.013) and RF5 (p=0.016) scores were lower than the TA scores, and the RH5 (p=0.020) and RH6 (p=0.006) scores were higher than the TA scores. A negative correlation was detected between the YDQ scores and the LH1 (r=-0.366, p=0.046), LH2 (r=-0.507, p=0.004), LH3 (r=-0.374, p=0.042), RH1 (r=-0.361, p=0.050), RH2 (r=-0.403, p=0.027) points. The LF5 (p=0.050) and RF2 (p=0.048) scores were lower in the patients with Qi-stagnation patients than without Qi-stagnation. Conclusions: Our results suggest that low TA and Ryodoraku scores on LF5 and RF5 and high Ryodoraku scores on RH5 and RH6 could be quantitative indicators for the diagnosis of BMS. The LH1, LH2, LH3, RH1, RH2, LF5, and RF2 scores could also be an indicators for diagnosis of Yin-deficiency and Qi-stagnation in patients with BMS.

구강작열감증후군 환자의 임상 특징에 따른 심박변이도 분석

이현진,하나연,고석재,박재우,김진성 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.1

Objectives: This study aimed to identify the characteristics of the heart rate variability (HRV) index in patients with burning mouth syndrome (BMS) and to evaluate the predictive value of HRV for Korean medical treatment responsiveness to tongue pain in BMS. Methods: Among BMS patients who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from January 1, 2018, to May 31, 2021, we reviewed the clinical records of 217 women aged 50 years and over. HRV and unstimulated saliva flow rate (USFR) measurements were carried out, and all patients were asked to indicate their degree of tongue pain using the visual analog scale (VAS). The subjects were classified into subgroups according to the presence or absence of hyposalivation and VAS improvement, and each subgroup was compared using the HRV index. Logistic regression analysis was conducted to confirm whether cause–effect relationships were present between statistically significant values. Results: BMS patients had lower LF and HF than healthy people. Subgroup analysis demonstrated that there were some statistically significant differences in the HRV index according to salivation rate and degree of pain. In addition, as the LF/HF ratio increased, the pain improvement rate decreased after treatment. Conclusion: The autonomic nerve activity of BMS patients was lower than that of healthy people; however, autonomic balance was not impaired. In addition, tongue pain in BMS patients responded more favorably to Korean medical treatment when patients fell within a normal range of the LF/HF ratio, suggesting that autonomic imbalance could be used as one of the predictable factors in clinical practice.

위식도역류질환 변증도구의 신뢰도 및 타당도 평가

조윤재,하나연,고석재,박재우,김진성 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.1

Purpose: The standard tool for the pattern identification is used for identifying patterns in patients using a questionnaire. The purpose of this study is to reorganize the standard tool for the pattern identification of gastroesophageal reflux disease (GERD) developed in 2017 and to analyze the reliability and validity of the standard tool for pattern identification by applying it to GERD patients. Methods: To reorganize the standard tool for the pattern identification of GERD developed in the previous study, we searched the literature in the main databases, OASIS (Oriental Medicine Advanced Searching Integrated System) and CNKI (China National Knowledge Infrastructure). We added the search results to the data used in the previous study and went through the reorganizing courses, such as evaluating the validity of the translation, the Delphi technique, and a small survey. After reorganization, the patients who visited the Kyunghee University Korean Medicine Center for GERD symptoms were provided the questionnaire, including the reorganized standard tool for pattern identification. We analyzed the survey results to evaluate their reliability and validity. Results: Fifty patients completed the questionnaire. Reliability analysis results showed a pattern identification match rate of 86%, Cronbach’s α coefficient of 0.834, and intraclass correlation coefficient of 0.907. The Mann–Whitney U test and logistic regression were implemented to check the relations between the survey questions and pattern identification results; the Pearson correlation, compared with other scales, showed a moderate score. Conclusion: We reorganized the standard tool for the pattern identification of GERD to be updated on current issues and so that it is easily used. The analysis results of the questionnaire showed that the reorganized standard tool had high reliability and moderate validity.

기능성소화불량에 대한 담음 변증설문지 개발과 신뢰도 및 타당도 검정

백소영,하나연,고석재,박재우,김진성 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.4

Objectives: The aim of this study was to develop a Phlegm Pattern Questionnaire for Functional Dyspepsia (PPQ-FD) by modifying a previously developed Phlegm Pattern Questionnaire (PPQ) and to verify its reliability and validity. Further objectives were to obtain the optimal cut-off value for the PPQ-FD for standardization and for clinical use. Methods: The PPQ-FD was developed by extracting the major symptoms of the phlegm pattern in functional dyspepsia and by using the Delphi method to administer a requested importance survey to experts. The reliability, validity, and optimal cut-off value of the PPQ-FD were analyzed by enrolling a total of 60 subjects in this study. Thirty patients were diagnosed with both functional dyspepsia and phlegm pattern and thirty patients were diagnosed with only functional dyspepsia. All participants were requested to fill out the PPQ-FD. Results: No statistically significant differences were detected in the two groups for sex distribution, age, or body mass index. Five of the survey questions negatively affected its reliability; therefore, we decided to exclude those five questions on further inspection. The Cronbach’s α coefficient of the revised PPQ-FD was 0.853, and clinical validity was verified. Construct validity was analyzed by factor analysis and identified four factors. Statistically significant positive correlations were found between the revised PPQ-FD and other dyspepsia scales, such as the SQDQ, SSQD, VAS, NDI-K, and FD-QoL scales. The VAS had particularly strong positive correlations with the PPQ-FD. Conclusions: The PPQ-FD developed in this study has fundamental reliability and validity for use as a pattern-diagnosis questionnaire. The PPQ-FD can help to diagnose the phlegm pattern in patients with functional dyspepsia.

비장도인법(脾腸導引法)을 적용한 복부 팽만감 주소의 기능성소화불량 증례보고

정해인,하나연,김진성,Jeong, Hae-in,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6

A 42-year-old patient with functional dyspepsia had suffered from early satiation and postprandial fullness for 1 year despite Western medicine treatment. We treated her with the Spleen Daoyin method, along with acupuncture, moxibustion, and herbal medicine and scored her symptoms using a 4-point Functional Dyspepsia-related Quality of Life (4p-FD-QoL) questionnaire, the Gastrointestinal Symptom Rating Scale (GSRS), and a visual analogue scale (VAS). A 7-day Spleen Daoyin treatment decreased her 4p-FD-QoL score from 61 to 51, with a marked decrease in the emotional part (18 to 10). Her GSRS score did not change, but her bloating score decreased from 3 to 1. Her VAS score decreased from 6.6 to 4.3 for upper abdomen discomfort, but lower abdomen discomfort was unchanged. The patient showed high compliance and satisfaction with exercise therapy and reported no adverse events. Spleen Dayoin may be a useful therapy for functional dyspepsia, especially when accompanied by psychological problems.

기능성소화불량 환자의 한의 변증 설문과 양도락 결과의 상관성 연구

고휘형,하나연,고석재,박재우,김진성 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.3

Objectives: This study aimed to analyze the correlation between Ryodoraku diagnosis and three pattern identification questionnaires, namely, Spleen Qi Deficiency, Stomach Qi Deficiency, and Food Retention in functional dyspepsia (FD) patients. Methods: Forty FD patients who met the Rome IV diagnostic criteria for FD participated in this study. The Ryodoraku test was conducted, and three pattern identification questionnaires were filled up by all patients. The average Ryodoraku score was called total average (TA), and the scores on the Ryodoraku points were measured. The degree of Spleen Qi Deficiency, Stomach Qi Deficiency, and Food Retention was assessed by Spleen Qi Deficiency questionnaire (SQDQ), Scale for Stomach Qi Deficiency pattern (SSQD), and Food Retention Questionnaire (FRQ). Results: The TA scores in the SQDQ patient group were lower than those in the SQDQ control group (p=0.091). The TA scores in the SSQD patient group were higher than those in the SSQD control group (p=0.651). The TA scores in the FRQ patient group were lower than those in the FRQ control group (p=0.851). The scores on the LH5, RH5, and RH6 points were significantly lower in the SQDQ patient group than in the SQDQ control group. However, no significant difference was found in the Ryodoraku scores among the other groups. Conclusions: The results suggest that the low TA and low Ryodoraku scores on the LH5, RH5, and RH6 points could be a quantitative indicator to diagnose Spleen Qi Deficiency in FD patients in a simpler manner. Larger studies on the Ryodoraku test in FD patients, the health control group, and other pattern identification groups are required.