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한국인의 인슐린비의존형 당뇨병과 정상 대조군간의 Leptin 농도 차이
김상훈,이화영,김준영,심대중,김신연,정을순,최홍업,최윤상,이상종 대한비만학회 1999 The Korean journal of obesity Vol.8 No.2
Background: Obesity is risk factor for a number of chronic disease, including NIDDM, hypertension, cardiovascular disease. The etiology of obesity is unclear, although it appears that both genetic and enviromental factors contribute to develope. Identification of the ob gene and its product, Leptin, has increased our understanding of the pathophysiology of obesity. Change in glycemia precedes change in body weigth, suggesting that insulin may have a direct effect on Leptin. another, insulin may have a direct effect on Leptin. authors questioned whether NIDDM patients altered regulation of serum Leptin levels. We compared diabetic patients and norrnal persons with serum Leptin level and other metabolic profiles. Methods: Using radioimmunoassay, we measured serum Leptin concentrations in 80 NIDDM patients (male 40, female 40) and 80 controls (male 40, female 40) matched by age, sex and BMI. The data were using t-test of difference in serum Leptin concentration and other factors means between two groups. The association between serum Leptin concentration and other factors were measured by correlation analysis. Results: 1) NIDDM patients had a slightly high body mass index and Leptin concentration than controls, although these were not stastically significant (p$gt;0.05). 2) Women had significant higher Leptin concentration than men (p$lt;0.05). 3) Old age groups had higher Leptin concentrations than young groups (p$lt;0.05), 4) A significant correlation between serum Leptin concentration with age (r=0.173, p$lt;0.05), female sex (r=0.599 p$lt;0,01), BMI (r=0.355, p$lt;0.01) was observed in NIDDM patients. 5) Serum Leptin concentration did not differ by diabetic status. Conclusion: Leptin concentration did not differ by diabetic status. serum Leptin concentrations were significantly correlated with age, sex, BMI. we concluded serum Leptin concentrations were not different in diabetic and non diabetic subjects.