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익모초 물추출물이 흰쥐 대퇴동맥의 혈관경련에 미치는 영향
정용발 ( Yong Bal Jung ),김형환 ( Hyung Hwan Kim ),이송득 ( Song Deuk Lee ),안덕균 ( Duk Kyun Ahn ),신혜승 ( Hye Seung Shin ),백태현 ( Tae Hyeun Baek ),최호영 ( Ho Young Choi ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objective : In order to study the effect of water extract of Leonuri herba (ELS) on the subarachnoid hemorrhage animal model, the autologous whole blood was applied to the vicinity of the sprague dawley rat right femoral artery. Methods : Following periarterial application of autologous whole blood (PAB) and intraperitoneal injection of ELS (10, 100 and 300 mghg, P.o.), the vasomotor responses to ELS were identified and the histological changes, neovascularized blood vessel were observed. Results : Contractile response to ELS (10, 100 and 300 mg/kg, p.0.) was significantly decreased in the rat femoral arteries of PAB 5 and 7 days. In PAB 5 and 7 days, significantly increased vessel wall thickness and narrowed lumen were observed in comparison with the control group. In the arteries exposed to autologous whole blood for 5 and 7 days, a lot of newly generated capillaries in association with markedly curved blood vessel wall thickness, elastic lamina and irregularly oriented endothelial cells were observed in the periphery of the vessel wall. The number of neovascularized blood vessels were significantly decreased in the periphery of PAB with ELS (10, 100 and 300 mg/kg, p.0.) 5 and 7 days. In VEGF expression, Blood plus ELS (10, 100 and 300 mg/kg, p.0.)-exposed vessel were more weak expression than blood-exposed vessel to vein autologous whole blood for 5 and 7 days. Conclusions : From these results, we concluded that ELS inhibited posthemorrhagic chronic vasospasm and neovascularization in rat femoral artery model.
후박(厚朴)과 토후박(土厚朴)의 소장운동에 미치는 영향에 대한 연구
이경진 ( Kyung Jin Lee ),박근용 ( Geun Yong Park ),박규하,류광현 ( Kwang Hyeon Liu ),김태완 ( Tae Wan Kim ),함인혜 ( In Hye Ham ),부영민 ( Young Min Bu ),최호영 ( Ho Young Choi ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.4
Objectives: Magnoliae officinalis Cortex (MOC) has been used in traditional medicine for digestive diseases in Korea, China and Japan. However, Machili thunbergii Cortex (MTC) also has been used as a substitute of MOC in Korea sometimes. Thus, this study was carried out to investigate and compare the effects of MOC and MTC on intestinal motility of isolated small intestinal segments from ICR mouse. Methods: Changes in motility were recorded via isometric transducers connected to a data acquisition system and amplitude, frequency and area under the curve (AUC) of intestinal spontaneous phasic contraction were compared. Results: The MOC extracts (1~30μg/mL) dose-dependently decreased both amplitudes and frequencies of the spontaneous phasic contraction, but not AUC. However, high concentration of MOC (100 μg/mL) evoked tonic contraction. And it was not inhibited by tetrodotoxin, a sodium channel blocker, and nifedipine, a L-type Ca2+ channel antagonist. These results suggested that MOC (100 μg/mL)-induced tonic contraction is not mediated by nerve or L-type Ca2+ channel. On the other hand, the MTC extracts dose-dependently inhibited amplitude and AUC, but not the frequency. Conclusions:Although both MOC and MTC affected intestinal motility, MOC is more effective on intestinal motility than MTC. And MOC has been used as a traditional medicine for a long time but not MTC. Thus, we suggested that MTC should not be used in Korea as a substitute of MOC and MOC might be useful traditional medicine for gastrointestinal disease. The mechanism of MOC is still remained to elucidate.
Mixed Driving 방식을 이용한 QVGA급 LDI의 Source Driver 설계
김학윤(Hak-Yun Kim),고영근(Young-Keun Ko),이성우(Sung-Woo Lee),최호영(Ho-Yong Choi) 大韓電子工學會 2009 電子工學會論文誌-SD (Semiconductor and devices) Vol.46 No.11
본 논문에서는 mixed driving 방식을 이용하고 이미지 개선을 위해 γ-correction을 수행하는 QVGA급 TFT-LCD driver IC의 Source Driver를 설계한다. 240 RGB x 320 dots resolution을 가진 source driver는 720개의 채널을 통해 TFT-LCD 패널을 구동하고 18-bit의 RGB 데이터를 사용하여 26만 color를 수행한다. Mixed driving 방식은 종전의 좋은 구동력을 가진 channel amp. driving 방식에 저면적이 가능한 gray amp. driving 방식을 혼합한 방식으로서, 영상이 동일 색상을 가지는 worst case를 감지하여 구동력을 높여주는 방식을 사용함으로써 적절한 구동력과 저면적을 구현하는 설계방식이다. 본 Source Driver는 0.35㎛ Magnachip embedded DRAM 공정을 사용하여 설계하였으며 Hspice를 사용하여 시뮬레이션을 하였다. 실험결과, 기존의 gayscale driving 방식에서는 hsync time을 만족시키지 못하는데 비해 17㎲의 channel 구동시간으로 충분한 timing margin을 가지고 액정 channel 을 구동할 수 있으면서, 구동 앰프 78개와 제어회로를 갖는 저면적으로 설계되었다. In this paper, we present the design of a source driver of QVGA scale TFT-LCD driver IC which uses a mixed driving method and performs γ-correction to improve image. The source driver with 240 RGB x 320 dots resolution drives a TFT-LCD panel through 720 channels and implements 262k colors using 18-bit RGB data format. The mixed driving method is a mixture the channel amp. driving method with high drivability and the gray amp. driving method with small area, which remarkably reduces channel driver areas. The driver has been designed using the 0.35㎛ Magnachip embedded DRAM technology and simulated using the HSPICE simulator. The results show that our source driver operates well with γ-correction and the channel driver has 17㎲ channel driving time with only 78 driving amplifiers and control logic.
알코올 및 사염화탄소에 의해 유발된 급만성 간손상에 대한 지구자 열수추출물의 보호효과
김영식 ( Young Sik Kim ),박주연 ( Ju Yeon Park ),권용범 ( Yong Beom Kwon ),임동욱 ( Dong Wook Lim ),송미경 ( Mi Kyung Song ),최호영 ( Ho Young Choi ),김호철 ( Ho Cheol Kim ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.4
Objectives : The purpose of this study was to evaluate the hepatoprotective effect of Hovenia dulcis extract on acute and chronic liver injuries induced by alcohol and CCl4 in mice and rats. Methods : In acute alcohol-induced liver injury, mice were administered Hovenia dulcis extracts (60 and 200 mg/kg) orally before and after alcohol administration. In chronic alcohol-induced liver injury, mice were administered alcohol containing liquid diet for 4 weeks. The mice were administered H. dulcis extracts (60 and 200 mg/kg) mixed with the liquid diet. In acute CCl4-induced liver injury, rats received a single dose of CCl4 (2 mL/kg in olive oil, intraperitoneally). Rats were administered H. dulcis extracts (30, 100 and 300 mg/kg) before and after CCl4 administrations. After the ends of the administrations, the serum levels of AST and ALT were measured using chemical analyzer, and γ-GTP levels were measured using spectrophotometer. Results : In acute alcohol-induced liver injury, H. dulcis extracts treated group showed significant reduction in ALT levels compared to those of control group. In chronic alcohol-induced liver injury, it inhibited weight-loss compared to normal group and showed significant reduction in AST, ALT and γ-GTP levels compared to control group. In acute CCl4-induced liver injury, it also showed significant reduction in AST, ALT levels compared to control group. Conclusions : The results show that H. dulcis extract has hepatoprotective effect in acute and chronic alcohol-induced liver injury and acute CCl4-induced liver injury. These findings suggest that H. dulcis could be a potent hepatoprotective agent.
생쥐의 B 세포에서 anti-CD40과 rIL-4로 유도된 싸이토카인 생산에 대한 자오가의 효과
성일창 ( Il Chang Sung ),김형환 ( Hyung Hwan Kim ),안덕균 ( Duk Kyun Ahn ),이용섭 ( Yong Sup Lee ),서영배 ( Young Bae Seo ),최호영 ( Ho Young Choi ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objectives : In order to study the anti-allegy effect of water extract of Acanthopanacis senticosi Radix (ASR) on the B-cells from healthy Balblc mice. Methods : The cytotoxicity of ASR was measured with the murine normal lung fibroblast cells by modified SRB assay. And the murine splenic B-cells was stimulated with anti-CD40 mAb and rIL4. The various cytokines related with allergy were measured by flow-cytometry and by RT-PCR with electophoresis. Results : The anti-allegy effects to ASR were identified and observed. The cytotoxicity of ASR on mouse lung fibroblast cells showed no significant activities. ASR had inhibitory effect on CD23+, CD69+, and IgE expression by ASR with anti-CD40 mAb plus rL-4-stimulated murine splenic B-cells. ASR had inhibitory effect on cytokines (E-lb, IL-4, IL-6, IL-10, TNF-a, TGF-81, INF-Y) and transcript expression and IgE production by ASR with anti-CD40 mAb plus rIL-4-stimulated murine splenic B-cells. Conclusion : We concluded that ASR showed anti-allegy effect on murine splenic B-cells.